European Journal of Internal Medicine最新文献

{"title":"Venous thromboembolism provoked by transient risk factors in women: Towards improved personalized risk assessment.","authors":"Luuk J J Scheres, Jenneke Leentjens, Saskia Middeldorp","doi":"10.1016/j.ejim.2025.106535","DOIUrl":"https://doi.org/10.1016/j.ejim.2025.106535","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":" ","pages":"106535"},"PeriodicalIF":6.1,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotype-phenotype correlations and resistance to colchicine in a familial Mediterranean fever cohort in southwestern Spain","authors":"Carlos Hernández Quiles , Ana Casado Díaz , Aurora González Estrada , Marco Antonio Montes Cano , José Salvador García Morillo","doi":"10.1016/j.ejim.2025.05.002","DOIUrl":"10.1016/j.ejim.2025.05.002","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"140 ","pages":"Article 106337"},"PeriodicalIF":6.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abrupt fluoroquinolone-associated suicides: a SONAR report from North America, Europe, Australia, and Asia","authors":"Charles L. Bennett, Mia Lynch, Gretchen LeFever Watson, Linda Martin, June M. McKoy","doi":"10.1016/j.ejim.2025.04.041","DOIUrl":"10.1016/j.ejim.2025.04.041","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"140 ","pages":"Article 106334"},"PeriodicalIF":6.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of different acute kidney injury scores in patients undergoing transcatheter aortic valve implantation","authors":"Andrea Milzi , Antonio Landi , Daniel Sürder , Giovanni Pedrazzini , Marco Valgimigli","doi":"10.1016/j.ejim.2025.05.003","DOIUrl":"10.1016/j.ejim.2025.05.003","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"140 ","pages":"Article 106338"},"PeriodicalIF":6.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of beta-blockers in patients with comorbid chronic obstructive pulmonary disease and cardiovascular disease","authors":"Tejuss Kakarla , Yash Vardhan Trivedi , Parth Munjal , Avi Kumar , Rohit Jain","doi":"10.1016/j.ejim.2025.06.018","DOIUrl":"10.1016/j.ejim.2025.06.018","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"140 ","pages":"Article 106389"},"PeriodicalIF":6.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of time to first palliative care consultation in hospitalized patients with advanced or terminal illness – A retrospective analysis","authors":"Christopher Paschen ,&nbsp;Franziska Ecker ,&nbsp;Patrick Haider ,&nbsp;Claudia Wenzel ,&nbsp;Eva Katharina Masel","doi":"10.1016/j.ejim.2025.06.013","DOIUrl":"10.1016/j.ejim.2025.06.013","url":null,"abstract":"<div><h3>Background</h3><div>Diagnosis and sex-related biases can affect clinical decision-making in serious illness, including the recognition of palliative needs. Such biases may influence when and how patients receive palliative care (PC). This study aimed to investigate differences in timing and frequency of PC consultations by diagnosis, comorbidities, age, and sex among hospitalized patients.</div></div><div><h3>Methods</h3><div>This study retrospectively analyzed 918 patients (50.5 % female) who received a PC consultation during hospitalization between 2016 and 2022. Time from admission to first PC consultation was analyzed using a Cox proportional hazards model adjusted for primary diagnosis, comorbidities, age, and sex. Further analysis included number of follow-up consultations, time from primary disease onset to first PC consultation, and from consultation to discharge or death.</div></div><div><h3>Results</h3><div>Inpatients with organ failure (HR: 0.7 [95 %-CI: 0.5–0.9]; <em>p</em> = 0.02) or neurological diseases (HR: 0.7 [95 %-CI: 0.5–1.0]; <em>p</em> = 0.03) received later PC consultations than those with solid organ tumors or hematologic malignancies. Higher comorbidity burden was associated with earlier PC consultation (HR: 1.04 [CI: 1.01–1.07]; <em>p</em> = 0.02), while age was not linked to consultation timing (HR: 0.997 [CI: 0.992–1.002]; <em>p</em> = 0.20). Women received earlier PC consultations than men (HR: 1.3 [95 %-CI: 1.1–1.4]; <em>p</em> &lt; 0.001). Only 9.4 % of individuals received a follow-up consultation, with the lowest proportion in subjects with organ failure (4.7 %).</div></div><div><h3>Conclusions</h3><div>This study highlights earlier PC consultation requests during hospitalization for individuals with malignant diseases and for women. The low rate of follow-up PC consultations indicates that the importance of regular PC involvement to improve patient’s outcomes still did not permeate into clinical practice.</div></div>","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"140 ","pages":"Article 106384"},"PeriodicalIF":6.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in ECG interpretation: Promise and pitfalls of AI in modern medicine","authors":"Silvia Magnani,&nbsp;Maria Giovanni Bucci,&nbsp;Hussam Ali,&nbsp;Riccardo Cappato","doi":"10.1016/j.ejim.2025.106441","DOIUrl":"10.1016/j.ejim.2025.106441","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"140 ","pages":"Article 106441"},"PeriodicalIF":6.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing PCSK9 inhibitor therapy: Understanding and managing suboptimal LDL-C response in clinical practice","authors":"Filippo Giorgio Di Girolamo ,&nbsp;Lisa Pellin ,&nbsp;Chiara Roni ,&nbsp;Gianni Biolo ,&nbsp;Gianfranco Sinagra ,&nbsp;Enrico Fabris","doi":"10.1016/j.ejim.2025.106442","DOIUrl":"10.1016/j.ejim.2025.106442","url":null,"abstract":"<div><div>Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9-i) represent a major advancement in lipid-lowering therapy, offering robust reductions in low-density lipoprotein cholesterol (LDL-C), and now play a pivotal role in lipid management, especially for patients with atherosclerotic cardiovascular disease at high or very high risk. Despite their proven efficacy in clinical trials, a subset of patients exhibits a suboptimal LDL-C response, especially in real-world settings. Under-response may result from insufficient drug exposure due to non-adherence, suboptimal injection technique, or discontinuation of background lipid-lowering therapy, and biological factors that limit drug efficacy despite adequate exposure. This review explores the frequency and mechanisms of under-response to PCSK9-i, and provide a practical guide for clinicians to identify and address causes of PCSK9-i under-response, ensuring appropriate intervention for a sustained cardiovascular risk reduction.</div></div>","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"140 ","pages":"Article 106442"},"PeriodicalIF":6.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Senolytic drugs to slow down aging: The Fountain of Youth, revisited","authors":"Raffaele Antonelli Incalzi ,&nbsp;Claudio Pedone","doi":"10.1016/j.ejim.2025.106460","DOIUrl":"10.1016/j.ejim.2025.106460","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"140 ","pages":"Article 106460"},"PeriodicalIF":6.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When the discovery of a biomarker stimulates basic interdisciplinary work on disease’s biology and pathophysiology","authors":"Vittorio Bellotti","doi":"10.1016/j.ejim.2025.106487","DOIUrl":"10.1016/j.ejim.2025.106487","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"140 ","pages":"Article 106487"},"PeriodicalIF":6.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}