European Journal of Internal Medicine最新文献

{"title":"High-flow nasal oxygen therapy in patients with hypercapnic respiratory failure: A systematic review and meta-analysis.","authors":"Lili Guan, Jianyi Niu, Qiaoyun Huang, Shanshan Zha, Zhenfeng He, Jieying Hu, Shengchuan Feng, Luqian Zhou, Rongchang Chen","doi":"10.1016/j.ejim.2025.02.015","DOIUrl":"https://doi.org/10.1016/j.ejim.2025.02.015","url":null,"abstract":"<p><strong>Background: </strong>Noninvasive ventilation (NIV) is recommended as the first-line respiratory support method for patients with hypercapnic respiratory failure (HRF). However, the need for well-trained operators and the occurrence of treatment discomfort may limit its efficacy. High-flow nasal oxygen therapy (HFNO) is a convenient respiratory support with user-friendly operation, high comfort, and good compliance. This systematic review and meta-analysis was performed to compare the therapeutic effects of HFNO and other noninvasive respiratory support methods [NIV or conventional oxygen therapy (COT)] in patients with acute HRF (AHRF) or chronic HRF (CHRF).</p><p><strong>Methods: </strong>We searched the PubMed, Web of Science, Embase, and Cochrane Library databases from inception to May 2024 to identify randomized clinical trials comparing the impact of HFNO and NIV/COT in adults with HRF.</p><p><strong>Results: </strong>Sixteen studies (1630 patients) were included. Compared with NIV, HFNO did not improve the primary outcome of PaCO₂ in patients with AHRF or CHRF [AHRF: MD = -0.81, 95 % CI = -3.40 to 1.77; CHRF: MD = 1.82, 95 % CI = 0.44 to 3.20]. However, HFNO showed advantages over COT (AHRF: MD = -2.03, 95 % CI = -3.48 to -0.59; CHRF: MD = -2.64, 95 % CI = -4.24 to -1.03).</p><p><strong>Conclusions: </strong>The evidence of its clinical efficacy in hypercapnic patients remains inconclusive. Further studies are needed to generate more evidence for the application of HFNO in patients with HRF and to determine the subset of patients for whom may be preferable.</p>","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rising ischemic stroke-related mortality among young adults in the United States: Insights from CDC WONDER.","authors":"Usama Qamar, Farhan Naeem, Maaz Asif, Waleed Qamar, Eisha Mazhar","doi":"10.1016/j.ejim.2025.02.008","DOIUrl":"https://doi.org/10.1016/j.ejim.2025.02.008","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reevaluating hypoxia and cancer as determinants of prognosis in COPD and Takotsubo syndrome. Author's reply.","authors":"Luca Arcari, Giacomo Tini, Beatrice Musumeci, Emanuele Barbato, Luca Cacciotti","doi":"10.1016/j.ejim.2025.02.012","DOIUrl":"https://doi.org/10.1016/j.ejim.2025.02.012","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bedside CEUS: A feasible option to consider.","authors":"Andrea Boccatonda, Alice Brighenti, Valeria Tiraferri, Rossella Loiacono, Carla Serra","doi":"10.1016/j.ejim.2025.02.001","DOIUrl":"https://doi.org/10.1016/j.ejim.2025.02.001","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143371131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining risk assessment for intra-abdominal infections in immunocompromised intensive care unit patients. Author's reply.","authors":"Stijn Blot, Mieke Deschepper, José Artur Paiva","doi":"10.1016/j.ejim.2025.02.005","DOIUrl":"https://doi.org/10.1016/j.ejim.2025.02.005","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143371134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the gap: Time to integrate sex and gender differences into research and clinical practice for improved health outcomes.","authors":"Roberta Gualtierotti","doi":"10.1016/j.ejim.2025.01.030","DOIUrl":"https://doi.org/10.1016/j.ejim.2025.01.030","url":null,"abstract":"<p><p>The integration of sex and gender in medical research and clinical practice is increasingly recognized as a cornerstone for achieving equitable health outcomes. Biological sex and gender influence the manifestation, progression, and treatment response in numerous diseases. Biological sex influences health and disease outcomes through genetic, hormonal, and physiological factors, while gender impacts them via identity, societal roles and behaviors. Historically, medical research has focused predominantly on the male body, leading to diagnostic and therapeutic gaps for women and gender-diverse populations. In particular, women remain underrepresented in clinical trials, leading to suboptimal treatment strategies and outcomes. In addition, in many conditions, such as cardiovascular, metabolic and neurological diseases, sex-specific variations in risk factors and disease presentation are prominent. The present review discusses the critical importance of distinguishing between sex and gender in preclinical and clinical research, and the necessity of incorporating these variables across all stages of research, from study design to analysis and reporting of preclinical studies and clinical trials. By incorporating sex and gender as distinct but interacting variables, we propose a framework to advance health equity and foster personalized, inclusive healthcare. This approach will promote the development of gender-sensitive clinical guidelines, enhance the accuracy of diagnostic tools, and ultimately contribute to improved health outcomes for all individuals, regardless of their sex or gender identity.</p>","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disability and caregivers in Italy: Results from an online survey.","authors":"Sergio Harari, Antonella Caminati, Luigi Ripamonti, Paolo Marveggio, Pier Mannuccio Mannucci","doi":"10.1016/j.ejim.2025.01.029","DOIUrl":"https://doi.org/10.1016/j.ejim.2025.01.029","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tecovirimat and mpox: A regulatory balancing act between hope, hurdles, and high-risk populations.","authors":"John G Rizk, Giuseppe Lippi, Brandon M Henry, Kin Israel Notarte, Youssef Rizk","doi":"10.1016/j.ejim.2025.01.031","DOIUrl":"https://doi.org/10.1016/j.ejim.2025.01.031","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linear lesions on the chest.","authors":"Pei-Chun Weng, Pei-Rong Gao","doi":"10.1016/j.ejim.2025.01.023","DOIUrl":"https://doi.org/10.1016/j.ejim.2025.01.023","url":null,"abstract":"","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External validation of a prognostic score to identify low-risk outpatients with acute deep venous thrombosis in the lower limbs","authors":"Francisco Galeano-Valle ,&nbsp;Rubén Alonso-Beato ,&nbsp;Sergio Moragón-Ledesma ,&nbsp;Tatiana Pire-García ,&nbsp;Olaya Huergo-Fernández ,&nbsp;Lucía Ordieres-Ortega ,&nbsp;Crhistian-Mario Oblitas ,&nbsp;Luis Antonio Alvarez-Sala Walther ,&nbsp;Pablo Demelo-Rodríguez","doi":"10.1016/j.ejim.2024.10.007","DOIUrl":"10.1016/j.ejim.2024.10.007","url":null,"abstract":"<div><h3>Background</h3><div>Current clinical guidelines suggest home treatment for patients diagnosed with acute deep venous thrombosis (DVT). A prognostic score has been proposed to identify low-risk patients; however, its validation remains limited.</div></div><div><h3>Method</h3><div>This prospective observational study aimed to externally validate the prognostic score in selecting low-risk outpatients with acute DVT in the lower limbs. Consecutive outpatients diagnosed with acute DVT in a tertiary hospital were included. The score included 6 variables: heart failure, kidney failure, recent major bleeding, altered platelet count, immobilization, and cancer. The primary outcome was the incidence of a composite outcome, including confirmed diagnosis of PE, major bleeding, or all-cause death at 7 days. Patients meeting zero criteria were considered low risk.</div></div><div><h3>Results</h3><div>Among the 1035 patients included, 485 (46.9 %) met zero criteria. Of these, 0.2 % (95 % CI 0.0–1.1 %) and 0.4 % (95 % CI, 0.0–1.5 %) patients experienced the composite outcome at 7 and 30 days, respectively. Among patients who met 1 or more criteria for admission, 344 patients (62.5 %) were discharged. Among these, the composite outcome at 7 and 30 days occurred in 2 (0.6 %) and 5 (1.4 %) patients, respectively. The C-statistics of the score were 0.68 (95 % CI, 0.57–0.79) and 0.69 (95 % CI, 0.64–0.76) at 7 and 30 days, respectively.</div></div><div><h3>Conclusion</h3><div>This study demonstrates the efficacy of the prognostic score in identifying low-risk outpatients with acute DVT. It also suggests that a considerable proportion of patients with acute DVT may benefit from outpatient treatment despite having some risk criteria, highlighting the potential for optimizing ambulatory care pathways.</div></div>","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"132 ","pages":"Pages 76-83"},"PeriodicalIF":5.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}