Asian Journal of Pharmaceutical and Clinical Research最新文献

{"title":"MORPHO-ANATOMICAL PROFILE OF ELAEOCARPUS TUBERCULATUS ROXB","authors":"I. Jayashree, Geetha Dh","doi":"10.22159/ajpcr.2024.v17i5.50468","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.50468","url":null,"abstract":"Objective: The anatomical studies of Elaeocarpus tuberculatus Roxb. (Elaeocarpaceae), an indigenous medicinal plant in the Indian pharmacopoeia.\u0000Methods: Fresh leaf and stem samples of E. tuberculatus were scrutinized macroscopic and microscopically by standard procedures.\u0000Results: Macroscopically, the leaves are simple, long, coriaceous, and rusty below, base obtuse, margin serrate, apex obtuse and petiole 3 cm long. Microscopically, the leaf showed the presence of four prominent collateral bundles. Paracytic stomata were distributed in the abaxial epidermis whereas the adaxial epidermis was apostomatic. The petiole was four-angled including wing bundles. The stem exhibited fissured periderm, wide secondary phloem, secondary xylem with incipient growth ring and abundant calcium oxalate crystals. Powdered microscopic study of the leaf revealed the presence of long whip-like epidermal trichomes, crystals, vessel elements showing pits and fiber-like sclereids. The stem powder showed thick-walled fibers with wide lumen, narrow fibers and a sclerenchyma cell showing wide pits.\u0000Conclusion: The results of the study can serve as a valuable source of information and provide suitable standards for the identification of E. tuberculatus in future investigations and applications","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"3 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141005524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INFLUENCE OF DURATION OF UNTREATED PSYCHOSIS ON THE SHORT-TERM OUTCOME IN FIRST-EPISODE SCHIZOPHRENIA","authors":"B. K, P. K., B. K, P. D","doi":"10.22159/ajpcr.2024.v17i5.50217","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.50217","url":null,"abstract":"Objectives: Schizophrenia is a devastating disease and many patients present late for treatment due to difficulty in identifying symptoms by family members. The objective of this study is to find if there is an association between a longer duration of untreated psychosis (DUP) and poor treatment outcome in first-episode Schizophrenics and to find if there is an association between premorbid social adjustment on DUP.\u0000Methods: Anti-psychotic-naïve patients with an international classification of diseases-10 schizophrenia were evaluated 12 weeks after their first in-patient hospitalization. Association between untreated initial psychosis duration (measured from the beginning of first symptom as well as from first hospital admission) was examined by conducting the clinical interview, symptom severity by positive and negative syndrome scale, and clinical global impression scale, pre-morbid social adjustment by premorbid social adjustment (PSA) scale; and symptoms improvement after treatment by CGI-I scale.\u0000Results: Of the 57 patients studied, 57.9% showed improvement after treatment, paranoid type was more common, patients responded better when treated with combined typical and atypical antipsychotics and improvement was better when DUP was <2 years. There was a major negative correlation between positive syndrome scores and DUP. There was no association of DUP with negative syndrome score, psychopathology score and PSA score.\u0000Conclusion: DUP was an independent predictor of treatment outcome and early intervention is necessary for better prognosis.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"68 s274","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141002301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ROLL OF LOCAL FLAP TECHNIQUE IN THE MANAGEMENT OF COMPOUND INJURIES OF LEG","authors":"Raghvendra Sadh, Vishnu Pal","doi":"10.22159/ajpcr.2024.v17i5.49707","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.49707","url":null,"abstract":"Objective: The objective of this study was to study the feasibility of local flaps in management of soft-tissue defects with exposed fracture bone fragments in lower extremity (particularly the leg) due to trauma.\u0000Methods: The present study included 20 cases of traumatized lower extremity having a soft-tissue defect and an exposed bone with or without associated fractures. Study was conducted from January 1989 to August 1990. Local flaps provide a reliable single stage procedure for coverage of lower extremity soft-tissue defects. Distant flap provides good coverage but these procedures are long drown out and tedious. Only those cases were selected in which wound was found to be preferably, in the upper 1/3rd, middle 1/3rd and the upper most part of the lower third of the leg due to easy accessibility and placement of the flaps to these area. (As flaps can easily be transposed to these areas). All flaps, that is, Fasciocutaneous, Musculocutaneous, or local Muscle flaps were under taken as a delayed procedure after careful evaluation of traumatized limb, that is, repeated dressing, debridement and control of infection.\u0000Results: In this study, stable wound coverage was achieved in all patients. Most of the patients were in the age group of 18 to 42 (55%), of these 90% were male. The longest duration of follow-up was 14 months and shortest was 3 months. Excellent result were obtained in Muscle and Musculocutaneous flaps while good result was obtained in 10% cases of Fasciocutaneous flap.\u0000Conclusion: Stable coverage can be achieved by flap techniques using Fasciocutaneous Muscle of Musculocutaneous flaps. Coverage of exposed cartical bones, tendon and major vessels and adequate control of infection can be achieved by Muscle and Musculocutaneous flap in post traumatized limb. Fasciocutaneous flap (Ponten super flap) is very useful in repair of soft-tissue defect asit is a much simpler, easy to design and construct large flaps are safe due to good circulations, requires less time without any functional loss. Post-operative management is simple for both patient and staff.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"138 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141001988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFICACY AND TOLERABILITY OF FLUPIRTINE MALEATE VERSUS DICLOFENAC IN MECHANICAL LOW BACK PAIN – A PROSPECTIVE COMPARATIVE STUDY","authors":"R. R, R. S, L. V, N. S","doi":"10.22159/ajpcr.2024.v17i5.50317","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.50317","url":null,"abstract":"Objective: Low back pain (LBW) is one of the most common reasons for adults visiting orthopedic outpatient clinics in our country. The objective of the study was to compare the safety and efficacy of flupirtine, a selective neuronal potassium channel opener, with diclofenac, a widely used NSAIDs analgesic, in patients with mechanical LBW (MLBP).\u0000Methods: This prospective, open-labeled, and randomized comparative clinical study included 100 patients with MLBP for more than 6 weeks. Fifty patients received flupirtine 100 mg, and 50 patients received diclofenac 100 mg for 7 days. Follow-up was done on day 8 and day 30. Assessments of functional improvement by the Oswestry Disability Index (ODI), pain relief by the Visual Analog Scale (VAS), Numerical Rating Scale (NRS), and Pain Relief Rate (PRR) were recorded. Safety and tolerability were also assessed. Data were analyzed using the Chi-square and Paired student t-tests.\u0000Results: VAS, NRS, and ODI scores were assessed for each visit (0, 1, and 2), and PRR was assessed on visits 1 and 2. VAS (p<0.05), NRS (p<0.05) scores, and sustained effect after stoppage of the drug were found to be better in the flupirtine group compared to the diclofenac group. Flupirtine was well tolerated. More patients reported adverse events in diclofenac than in the flupirtine group.\u0000Conclusion: Flupirtine may have a superior sustained effect compared to diclofenac in MLBP.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141002910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AN OBSERVATIONAL STUDY OF LIVER FUNCTIONS IN MULTIPLE TRANSFUSED THALASSEMIA PATIENTS ON REGULAR CHELATION THERAPY VERSUS IRREGULAR CHELATION THERAPY IN A TERTIARY CARE CENTER OF JAIPUR, RAJASTHAN","authors":"R. S. Yadav, Nikita Pal, Trapta Goyal, Sandip Ray, S. Yadav, Abhishek Kumar Sharma","doi":"10.22159/ajpcr.2024.v17i5.50630","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.50630","url":null,"abstract":"Objectives: The aim of our study was to determine liver functions in thalassemia patients on regular versus irregular chelation therapy.\u0000Methods: This was an observational study conducted in the department of pediatrics in a tertiary care hospital, Jaipur, Rajasthan. All those patients who received more than 50 blood transfusions are considered as multiple transfused patients and were included in this study.\u0000Results: A total of 50 patients were enrolled in this study. Ninety percent of patients were under 15 years of age and the male-to-female ratio was 2.85:1. In 82.35% regular chelation therapy, patients have normal liver functions as compared to 49.5% in irregular chelation therapy patients.\u0000Conclusion: Patients having abnormal liver functions in thalassemia patients due to iron overload. As a result of chelation therapy, serum glutamic oxalocetic transaminase and serum glutamic pyruvic transaminase levels were significantly reduced. In the study, regular chelation therapy should be started as early as indicated in thalassemia patients.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141002616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVALUATION OF COMPARATIVE IN VITRO FREE RADICAL SCAVENGING POTENTIAL OF BARK EXTRACTS OF ACACIA CATECHU","authors":"Archana Tiwari, Avinash Tiwari","doi":"10.22159/ajpcr.2024.v17i5.49735","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.49735","url":null,"abstract":"Objective: This study was aimed at investigating the comparative 1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging potential of different bark extracts of Acacia catechu. The assessment was conducted following concentration-dependent and seasonal-dependent impacts of the same using samples collected in different seasons over 2 successive years.\u0000Methods: In this, six extracts using ethanol, methanol, aqueous, acetone, chloroform, and benzene solvents were prepared. For the in vitro study, a standard DPPH solution (0.15 mM) was used to check how well the test samples got rid of free radicals. The major biochemical components of test plants, such as quercetin, gallic acid, and catechin, were used as standard drugs.\u0000Results: Among all test drug concentrations, 31.5–500 μg/mL drug concentrations were observed to be effective, whereas 15.25, 750, and 1000 μg/mL concentrations exerted negligible scavenging effects, and 125 μg/mL concentrations were found to be most effective (p<0.01 or more). The order of scavenging potential of different extracts is seen to be methanolic≥ethanolic>aqueous>acetone>chloroform>benzene. The samples collected during the rainy season were the least effective. Samples collected during the winter and summer seasons, on the other hand, were both more effective (p<0.05) at removing DPPH free radicals.\u0000Conclusion: This study helps to provide primary data on the concentration range, impact of the extraction medium, and sample collected in different seasons. Probably, these findings signify a notable progression in the investigation of the utilization of native plant species for medicinal purposes.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"1 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141004502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TO EVALUATE THE INFLAMMATORY MARKERS IN TYPE 2 DIABETES MELLITUS AND COMPARED IT WITH NORMAL HEALTHY CONTROLS","authors":"Jaswant Kaur, Shweta, Mohit Sharma, Seema, Mohammed Nadeem Shaikh","doi":"10.22159/ajpcr.2024.v17i5.50194","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.50194","url":null,"abstract":"Objective :To evaluate the serum levels of Interleukin -6, Tissue Necrosis factor – α, C- reactive Protein  ( IL-6, TNF- α , CRP) in type 2 diabetes mellitus in North Population\u0000 Method: A total of 200 participants were selected in this study among them 100 were recruited as Cases who were suffering from T2DM and 100 were healthy controls. Biochemical parameters were analyzed by fully autoanalyser. Serum levels of inflammatory cytokines, TNF-α ,CRP and IL-6  were estimated by ELISA . Data was analyzed using statistical ‘software SPSS 15. TheP<0.05 were considered as statistically significant.\u0000Result:  in our study we observed that serum levels of candidate cytokines, TNF-α, IL-6 and  CRP were highly significant (p<0.001) in T2DM as compared to healthy control. Fasting blood sugar, HbA1c and lipid profile parameters were recorded highly significant (p<0.001) in T2DM as compared to normal healthy controls.\u0000Conclusion: Inflammatory cytokines play a significant role in the pathogenesis of T2DM. Hence, these cytokines can be used as early prediction biomarkers which may be helpful in the reduction of mortality rate of T2DM.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"53 s184","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141002394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL PROFILE AND SPUTUM POSITIVITY RATE OF SUSPECTED PULMONARY TUBERCULOSIS PATIENTS PRESENTING TO A TERTIARY CARE HOSPITAL IN SOUTHERN RAJASTHAN","authors":"Amit Satish Gupta, Hirenkumar Punjabhai Hadiya, Amar Gahlot","doi":"10.22159/ajpcr.2024.v17i5.51056","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.51056","url":null,"abstract":"Objective: The purpose of the study is to understand the sputum acid-fast bacilli (AFB) positivity rate among suspected pulmonary tuberculosis (TB) patients presenting to tertiary care hospital in Southern Rajasthan with symptoms of chronic cough for more than 2 weeks.\u0000Methods: It is a retrospective observational study. Data from June 2021 to March 2024 were collected from registers maintained by the respiratory medicine department and analyzed.\u0000Results: Out of 1720 sputum samples of suspected pulmonary TB patients that were sent for microscopy 344 were AFB positive (20%) and 292 patients (16.97%) were GeneXpert positive. A total of 21 patients (1.22%) were found to have multidrug-resistant (MDR)-TB based on sputum GeneXpert testing. Most of the patients in our study were males and the sputum positivity rate was higher among diabetic and HIV-positive patients.\u0000Conclusion: In this study out of 1720 sputum samples analyzed for suspected pulmonary TB patients, 344 were sputum AFB positive (20%) and 21 were MDR-TB (1.22%).","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"113 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141001846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"USE OF STERILE WATER FOR INJECTION IN THE MANAGEMENT OF LABOR PAIN: A RANDOMIZED CONTROLLED TRIAL","authors":"Palash Mazumder, Swadha Pandey, Debjit Mandi, Shyamali Dutta","doi":"10.22159/ajpcr.2024.v17i5.50495","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.50495","url":null,"abstract":"Objectives: The objectives of the study are to assess the efficacy of sterile water for injection (SWI) in reducing labor pain, compare it with a saline procedure, and see which one is superior. Parameters assessed were pain relief based on the numeric pain rating scale (NPRS) and duration of labor from intervention to delivery associated with administration of subcutaneous SWI versus normal saline injection (NSI).\u0000Methods: This is a prospective randomized interventional hospital-based comparative study of mothers who were in active labor with back pain and undergoing treatment in the labor room of Eden Hospital, Medical College and Hospital, Kolkata. The study was conducted on 66 willing pregnant mothers, divided into two groups of 33 each with one injected with normal saline and the other with sterile water.\u0000Results: The NPRS score was almost equal in 2 groups at 15 min, but with an increase in duration, it was seen that the score was low in the sterile water group compared to the normal saline group. The association was statistically significant (p<0.05).\u0000Conclusion: This study hypothesized that subcutaneous SWI for relieving labor pain is better than subcutaneous NSI. Based on this study, it is concluded that both the SWI and NSI reduce labor pain, but the SWI produced a significantly greater reduction of pain as measured by the numeric pain rating score and also better satisfaction. Therefore, SWI is a safe, simple, and cost-effective method and can be used as a pain-relieving method, especially in the absence of other pain-relieving options.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"94 s389","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141002882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TIMING OF THE STOMA REVERSAL, WHAT IS THE SAFE PERIOD?: A RETROSPECTIVE OBSERVATIONAL STUDY","authors":"Giridhar Ashwath, Eshwar Kathiresan Manasijan, Anthony P. Rozario","doi":"10.22159/ajpcr.2024.v17i5.51172","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.51172","url":null,"abstract":"Objective: The objective of the study is to determine the most suitable timing for the reversal of enteric stomas and to investigate the complications associated with the presence and reversal of stomas among different age groups and genders.\u0000Methods: This was a retrospective study conducted in the Department of General Surgery of a tertiary care medical institute. The institutional ethical committee approved the study. We reviewed the digitally recorded data of patients who had undergone both the creation and reversal of stomas at our institution over various time intervals spanning from January 2017 to December 2022. Beyond the electronically stored clinical data encompassing patient demographics, stoma type, and complications encountered between stoma insertion and reversal, we conducted a thorough review of the database containing information on outpatient follow-ups for a month. The gender and age distribution, indications for surgery, type of stoma, and its correlation with age and gender were analyzed. Duration from surgery to stoma reversal and complications were also analyzed. Categorical data were presented as frequency and percentage, whereas quantitative data were summarized using the mean and standard deviation. Closure of the stoma after surgery was compared based on age and sex, employing an independent t-test.\u0000Results: In this study 82 patients undergoing stoma surgery, 68.29% were male and 31.71% were female. The mean age of male and female patients was found to be 44.26 and 35.96 years, respectively. Males had a higher median duration for ileostomy and jejunostomy reversals at 14 and 17 weeks, respectively, whereas females showed longer durations for ileostomy at 15 weeks. Common indications for surgery included intestinal obstruction (32.9%) and peritonitis (20.7%). Post-stoma closure 50% of the patients experienced complications, with 24% occurring within 1 month of reversal. Major complications occurred in 41% of cases, including parastomal hernia and suspected anastomotic leaks. Minor complications were observed in 28 patients, representing 35% of all surgeries.\u0000Conclusion: Stoma reversal between 8 and 12 weeks post-surgery is recommended for minimizing complications and avoiding psychological burden. While early closure may reduce hospital stay, it increases the risk of infections. Optimal timing for stoma closure is complex, requiring personalized, collaborative decision-making.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"104 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141003582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}