Asian Journal of Pharmaceutical and Clinical Research最新文献

{"title":"COMPLETE AND INCOMPLETE BONY BRIDGES NEAR FORAMEN OVALE WITH POTENTIAL SURGICAL AND CLINICAL IMPLICATIONS","authors":"Ritubhi Mehta, Jagmohan Sharma, Pankaj Kumar Singh, P. K. Chhabra","doi":"10.22159/ajpcr.2024.v17i5.50142","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.50142","url":null,"abstract":"Objectives: Pterygospinous or Pterygoalar ligaments may pose mandibular nerve compression by when present near foramen ovale. The presence of ossified pterygospinous or pterygoalar ligaments might cause trouble to surgeons in performing percutaneous rhizotomy for trigeminal neuralgia, electroencephalographic procedures, or taking biopsy from cavernous sinus tumors. The present study aims to find the incidence and specific morphological variations related to the ossification of pterygospinous and pterygoalar ligaments.\u0000Methods: The study was conducted on 200 dried adult human cadaveric skull of unknown age and sex in the department of Anatomy, Mahatma Gandhi Medical College and Hospital, Jaipur. Skulls were obtained from different medical colleges of the Rajasthan region. The study included fully dried, intact, adult human skull bones with no structural defects. Damaged, fractured, skull with the developmental anomaly, injured or pathologically malformed skull especially at or near the foramen ovale on either side were excluded from the study. Ossification of pterygospinous and pterygoalar bar was studied on both sides. Statistical analyses were performed using SPSS Version 26 software.\u0000Results: Ossified ligaments were studied in 400 sides of 200 skulls. The ossification of pterygospinous bar was observed in 53 cases (13.25%). The pterygospinous bar was complete in twelve (3%) cases and incomplete in 41 cases (10.25%). The ossified pterygoalar ligament was observed in 62 cases (15.5%). Ossification was complete in 15 cases (3.75%) and incomplete in 47 cases (11.75%).\u0000Conclusion: Ossification of pterygospinous and pterygoalar bars was observed in skulls obtained from medical colleges in the Rajasthan region. Knowledge of such morphological variations of the skull base will improve the therapeutic outcomes in the treatment of trigeminal neuralgia.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"27 31","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141005476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MORBIDITY AND MORTALITY PROFILE OF NEONATES ADMITTED IN NEONATAL INTENSIVE CARE UNIT IN A TERTIARY CARE HOSPITAL, SOUTH-EASTERN RAJASTHAN, JHALAWAR MEDICAL COLLEGE, JHALAWAR: A RETROSPECTIVE STUDY","authors":"Naresh Kumar Meena, H. Punia, Akansha Sharma, N. Meena","doi":"10.22159/ajpcr.2024.v17i5.50552","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i5.50552","url":null,"abstract":"Objective: The objective of this study was to study the morbidity and mortality patterns in a special newborn care unit (SNCU)/neonatal intensive care unit (NICU) of a tertiary care teaching hospital.\u0000Methods: A retrospective study was carried out in the SNCU/NICU of Jhalawar Medical College, Jhalawar. The duration of the study was 3 years. A retrospective case record review and analysis was done. Secondary data collected from the online SNCU Software (National Health mission Government of India).\u0000Results: Eight thousand seven hundred and forty-eight neonates were admitted in NICU. 2488 (59.9%) were male and 1657 (40.1%) were female, 4047 (46.3%) were normal birth babies, and 4701 (53.7%) were low birth weight babies. According to the outcome, total 6753 (77.19%) were discharged successfully, 1464 (16.66%) died, 382 (4.36%) were referred, and 149 (1.7%) were leave against medical advice. Birth asphyxia was the most common morbidity 2404 (27.36%) followed by neonatal sepsis (18.06%) and neonatal jaundice (15.44%). Birth asphyxia were more in inborn unit (p<0.0001). Sepsis is more prevalent in out born unit (p<0.0001). Hypoxic ischemic encephalopathy/moderate-to-severe birth asphyxia was the most common cause of death (28.23%), followed by neonatal sepsis (20.62%) and respiratory distress syndrome (19.35%), and major congenital malformations were cause of death in 106 (7.24%). Mortality due to neonatal sepsis was significantly high in outborn unit (p<0.0001).\u0000Conclusion: Birth asphyxia, neonatal sepsis, and respiratory distress syndrome were the leading causes of mortality in this study. These leading causes of mortality in the study could be prevented by adequate training of nursing staff and doctors, timely referral to tertiary care if required.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"81 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141003157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXPLORING LIPID VARIATIONS IN UMBILICAL CORD BLOOD ACROSS DIFFERENT DELIVERY MODES","authors":"A. Jadhao, T. Ramteke, Amit R Barapatre","doi":"10.22159/ajpcr.2024.v17i3.50533","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i3.50533","url":null,"abstract":"Objective: The mode of delivery (vaginal or cesarean) may affect the lipid profile of the newborn, which has implications for their future health.\u0000Methods: The study included 150 mothers who gave birth vaginally and 50 mothers who underwent elective cesarean sections. All mothers were aged between 21 and 44 years. The main outcome measures were the serum lipid levels of umbilical cord blood of newborns. The lipid levels included total cholesterol (TC), triglycerides, high-density lipoprotein cholesterol, very low-density lipoprotein (VLDL-D), and low-density lipoprotein (LDL-C). The study compared the obstetric variables and the serum lipid levels between the two groups of mothers.\u0000Results: The two groups did not differ significantly in terms of maternal age, neonatal weight, gestational duration, placental weight, and neonatal gender distribution. The newborns delivered by normal vaginal delivery had higher levels of total cholesterol, triglycerides, high-density lipoprotein cholesterol, VLDL-D, and LDL-C than those delivered by cesarean section, but the difference was not statistically significant.\u0000Conclusions: This study suggests that the mode of delivery does not have a significant impact on umbilical cord serum lipid levels. However, the sample size was small, and the results may not be generalizable to other populations.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"22 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140397217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HISTOMORPHOLOGICAL STUDY OF TRANSURETHRAL RESECTION OF PROSTATE SPECIMENS","authors":"V. Suparna, Deepak Suvernakar, N. P. I. Sadhu","doi":"10.22159/ajpcr.2024.v17i2.50523","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i2.50523","url":null,"abstract":"Objectives: (The objectives of the study are as follows: 1) To study various histomorphological patterns of transurethral resection of prostate specimens. (2) To classify malignant lesions with Gleason’s grading and to do Prostate-specific antigen (PSA) level and immunohistochemistry as required.\u0000Methods: It was a cross-sectional study conducted from January 2022 to June 2023 in a tertiary care hospital. Fifty-seven patients study who underwent transurethral resection of the prostate (TURP) surgery with hypertrophied prostate during the study period were included in the study on the basis of a predefined inclusion and exclusion criteria. Demographic characteristics of all the cases were analyzed. Clinical features, presenting complaints, histopathological findings, and the final diagnosis were studied. For statistical purposes, p value < 0.05 was taken as statistically significant.\u0000Results: The majority of the participants were in the age group of 60–69 years (42.11%) followed by people in the age group of 70–79 years (35.09%). Benign disease of prostrate was common than the malignant disease. BHP was the most common disease encountered and was seen in 37 (64.91%) cases. Among 37 patients with BHP, 70.27% (26) patients had increased PSA levels. Among 10 patients of BHP with CP 8 (80%) patients had increased levels of PSA. Serum PSA levels were increased in all the cases of malignancy, Adenocarcinoma prostate and PIN.\u0000Conclusion: In patients undergoing TURP modified Gleason scoring patterns and prognostic grade grouping should be done in conjunction for assessing prognosis and management. Immunohistochemistry and molecular genetic analysis are valuable adjuncts to the diagnosis in these cases.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"143 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140460574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STUDY OF CORRELATION OF PLATELET INDICES IN THE MANAGEMENT OF CORONARY ARTERY DISEASE","authors":"MOHAMMED IMRAN KHAN, AIZAZ FATIMA, SURYA TIWARI","doi":"10.22159/ajpcr.2024.v17i2.50541","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i2.50541","url":null,"abstract":"Objectives: The current study aimed to assess whether platelet parameters are associated with the severity of coronary artery disease (CAD) and may be regarded as risk factors; therefore, this study was done to evaluate platelet parameters in patients with CAD.\u0000Methods: This study was carried out in the Department of Medicine of Index Medical College, Hospital and Research Center. 60 CAD patients were enrolled in the study and were compared with 60 normal, healthy individuals of the same age. Those fulfilling inclusion and exclusion criteria were enrolled in the study, and the blood samples were analyzed for platelet indices firstly at the time of admission and then repeated following antiplatelettherapy.\u0000Results: Significantly higher concentrations of mean platelet volume (p<0.001) and platelet distribution width (p<0.001) were found in cases beforetreatment when compared with the controls. A significantly lower value of total platelet count (p<0.001) was found in cases before treatment when compared with the controls.\u0000Conclusion: Platelets have been associated with the development of cardiovascular diseases such as atherosclerosis and its severe outcomes such as acute myocardial infarction, unstable angina, and sudden cardiac death. The evaluation of platelet indices is considered an important factor in determining the functionality of platelets and is recognized as a promising risk indicator for atherothrombosis.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"149 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140460600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A PROSPECTIVE OBSERVATIONAL STUDY OF INTRAVENOUS ONDANSETRON AND PALONOSETRON IN ATTENUATING HYPOTENSIVE RESPONSE FOLLOWING SPINAL ANESTHESIA IN PATIENTS UNDERGOING ELECTIVE CESAREAN SECTION","authors":"Tirthasish Mandal, Debasri Sarkar, Debayan Biswas, Bhattacharya","doi":"10.22159/ajpcr.2024.v17i2.50492","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i2.50492","url":null,"abstract":"Objective: To compare the efficacy of prophylactic administration of intravenous ondansetron and palonosetron in attenuating hypotensive response following spinal anesthesia in patients undergoing elective cesarean section.\u0000Methods: This was a comparative study in which 84 patients aged 18–35 years of American Society of Anesthesiologists physical status II, scheduled for elective cesarean section under spinal anesthesia (SA) were included based on predefined inclusion and exclusion criteria. 84 patients undergoing elective cesarean sections were divided into two groups to receive either ondansetron or palonosetron before SA. Vital signs were monitored, with interventions for hypotension or bradycardia. Data on vital signs, vasopressor use, neonatal Apgar scores, and post-operative symptoms were collected and analyzed. For statistical purposes, a P value less than 0.05 was taken as statistically significant.\u0000Results: The mean ages and body mass indexes (BMIs) of the groups were similar, with no significant statistical difference (p=0.674 and p=0.3583, respectively). Heart rates, systolic and diastolic blood pressures showed minor differences, but only a few instances were statistically significant. Mean arterial pressures differed significantly at multiple intervals, but no clinical hypotension was observed. SPO2 levels remained stable and comparable in both groups. Average phenylephrine usage was also similar, with no significant difference. The incidence of hypotension, sedation scores, and incidence of bradycardia were comparable. Neonatal outcomes, measured by APGAR scores, showed no significant difference, indicating similar newborn health status in both groups.\u0000Conclusion: Prophylactic ondansetron, as well as palonosetron, were equally effective in reducing the incidence and severity of hypotension in healthy parturients following spinal anesthesia with hyperbaric bupivacaine for elective LSCS.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"153 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140460537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MORPHOLOGICAL STUDY OF ANTERIOR INFERIOR ILIAC SPINE IN A SAMPLE OF HEMIPELVIS FROM SOUTH INDIAN POPULATION","authors":"Arunprasath B, Saravanan S","doi":"10.22159/ajpcr.2024.v17i1.50034","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i1.50034","url":null,"abstract":"Objective: Abnormal morphology of anterior inferior iliac spine (AIIS) contributing to repeated femoroacetabular impingement, leading to functional limitation at the hip joint and chronic groin pain has been reported recently. The present study examines the prevalence of the morphologically different AIIS in south Indian population.\u0000Methods: This was an observational and cross-sectional study conducted by analyzing dry hemipelvises of South Indian population at the Department of Anatomy of a tertiary care teaching hospital between July 2022 and June 2023. The specimens were analyzed independently by first and second authors, to determine the prevalence of different morphologies of AIIS based on Morales-Avalos classification. Data were entered into Microsoft Excel and analyzed.\u0000Results: A total of 150 hemipelvises were analyzed. Type 2A was observed in 46.42% (n=65/140). Abnormal morphology was seen more on the left side hemipelvises (41.42%, n=58/140).\u0000Conclusions: Type 2A of AIIS was more prevalent in South Indian population and more prevalent on the left side hemipelvis. Demonstrating the different morphologies of AIIS helps in understanding their role in subspine hip impingement.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"26 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140513008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARATIVE STUDY OF BUPIVACAINE WITH DEXMEDETOMIDINE VERSUS BUPIVACAINE WITH CLONIDINE FOR SUPRACLAVICULAR BRACHIAL PLEXUS BLOCK FOR UPPER LIMB SURGERIES","authors":"KALLURI SAIPRIYANKA, NAGAJYOTHI J","doi":"10.22159/ajpcr.2024.v17i1.50323","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i1.50323","url":null,"abstract":"Objective: To compare the efficacy of clonidine with dexmedetomidine as an adjunct to bupivacaine in patients undergoing upper limb surgeries under supraclavicular brachial plexus block.\u0000Methods: This was a prospective comparative study conducted in the department of anesthesiology of a tertiary care medical institute. 80 patients undergoing various upper-limb surgeries were included in this study. Patients were divided into two groups on the basis of whether they received Clonidine (Group C) or Dexmedetomidine (Group D) as an adjuvant to Bupivacaine for supraclavicular block. The onset as well as duration of sensory and motor blockade, duration of analgesia, quality of anesthesia, hemodynamics, and adverse effects were compared between the two groups. p<0.05 was considered statistically significant.\u0000Results: The gender distribution of cases in Group C and Group D was found to be comparable, with no statistically significant difference. The mean age of patients in both groups was found to be comparable with no significant difference (p=0.5671). The most common types of surgeries in the studied cases were those of the lower radius and ulna (28.75%), followed by the lower humerus (21.25%), upper radius, and ulna (20%). The mean duration of sensory and motor block and duration of analgesia were found to be higher in group D as compared to group C, and the difference was found to be statistically highly significant (p<0.0001). The quality of anesthesia was better in patients who received dexmedetomidine as compared to those who received clonidine with Bupivacaine.\u0000Conclusion: Dexmedetomidine used as an adjuvant with bupivacaine for brachial plexus block is associated with prolonged duration of sensory as well as motor block and duration of analgesia as compared to when clonidine is used as an adjuvant. It is also associated with a better quality of anesthesia.","PeriodicalId":504156,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":"56 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140513068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}