IET Systems Biology最新文献_第10页

Using sliding mode observers to estimate BtuB concentration from measured vitamin B12 concentration 使用滑模观察器从测量的维生素B12浓度估计BtuB浓度

IF 2.3 4区生物学

IET Systems Biology Pub Date : 2020-09-29 DOI: 10.1049/iet-syb.2020.0007

Mohammad Abbadi, Sarah Spurgeon, Martin Warren, Naziyat Khan, Bernhard Kräutler

{"title":"Using sliding mode observers to estimate BtuB concentration from measured vitamin B12 concentration","authors":"Mohammad Abbadi, Sarah Spurgeon, Martin Warren, Naziyat Khan, Bernhard Kräutler","doi":"10.1049/iet-syb.2020.0007","DOIUrl":"10.1049/iet-syb.2020.0007","url":null,"abstract":"<div>\u0000 <p>A simple model for the B<sub>12</sub> -riboswitch regulatory network in <i>Escherichia coli</i> is first described and the same analysis is applied when changing the strain to <i>Salmonella enterica</i>. Model validation is undertaken by linking the dynamics of the riboswitch model to bacterial growth and comparing the results obtained with in vivo experimental measurements. Measurements of bacterial growth are relatively straightforward to obtain experimentally, but experimental measurements relating to the operation of the riboswitch are more difficult. Using the validated model, sliding mode observer design methods are used to estimate <i>BtuB</i> given measurements of the concentration of vitamin B<sub>12</sub>. The sliding mode approach is selected because of its inherent robustness properties as well as for the ease of implementation. Validation of the estimates of <i>BtuB</i> produced by the observer is undertaken by comparing the <i>BtuB</i> and vitamin B<sub>12</sub> concentrations estimated from the observer with green fluorescent protein production and the concentration of vitamin B<sub>12</sub> obtained experimentally. These experimental results also provide further validation of the underpinning mathematical model. The results establish that using a sliding mode observer as a soft sensor is a useful approach to explore the operation of a vitamin B<sub>12</sub> riboswitch given measurements of the concentration of vitamin B<sub>12</sub>.</p>\u0000 </div>","PeriodicalId":50379,"journal":{"name":"IET Systems Biology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2020-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687388/pdf/SYB2-14-334.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38783046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic alternative splicing signature in cervical squamous cell carcinoma 宫颈鳞状细胞癌预后的选择性剪接特征

IF 2.3 4区生物学

IET Systems Biology Pub Date : 2020-09-21 DOI: 10.1049/iet-syb.2019.0095

Hua-yu Wu, Qi-qi Li, Liang Liang, Lan-lan Qiu, Hong-wei Wei, Bing-ying Huang, Chen Gang-, Rong-quan He, Zhi-guang Huang, Wei Hou, Qi-ping Hu, Shang-ling Pan

{"title":"Prognostic alternative splicing signature in cervical squamous cell carcinoma","authors":"Hua-yu Wu, Qi-qi Li, Liang Liang, Lan-lan Qiu, Hong-wei Wei, Bing-ying Huang, Chen Gang-, Rong-quan He, Zhi-guang Huang, Wei Hou, Qi-ping Hu, Shang-ling Pan","doi":"10.1049/iet-syb.2019.0095","DOIUrl":"10.1049/iet-syb.2019.0095","url":null,"abstract":"<div>\u0000 <p>Basing on alternative splicing events (ASEs) databases, the authors herein aim to explore potential prognostic biomarkers for cervical squamous cell carcinoma (CESC). mRNA expression profiles and relevant clinical data of 223 patients with CESC were obtained from The Cancer Genome Atlas (TCGA). Correlated genes, ASEs and percent-splice-in (PSI) were downloaded from SpliceSeq, respectively. The PSI values of survival-associated alternative splicing events (SASEs) were used to construct the basis of a prognostic index (PI). A protein–protein interaction (PPI) network of genes related to SASEs was generated by STRING and analysed with Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Consequently, 41,776 ASEs were discovered in 19,724 genes, 2596 of which linked with 3669 SASEs. The PPI network of SASEs related genes revealed that TP53 and UBA52 were core genes. The low-risk group had a longer survival period than high-risk counterparts, both groups being defined according to PI constructed upon the top 20 splicing events or PI on the overall splicing events. The AUC value of ROC reached up to 0.88, demonstrating the prognostic potential of PI in CESC. These findings suggested that ASEs involve in the pathogenesis of CESC and may serve as promising prognostic biomarkers for this female malignancy.</p>\u0000 </div>","PeriodicalId":50379,"journal":{"name":"IET Systems Biology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2020-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687194/pdf/SYB2-14-314.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38783044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Identification of robust genes in transcriptional regulatory network of Mycobacterium tuberculosis 结核分枝杆菌转录调控网络中稳健基因的鉴定

IF 2.3 4区生物学

IET Systems Biology Pub Date : 2020-09-21 DOI: 10.1049/iet-syb.2020.0039

Prithvi Singh, Mohd Amir, Upasana Chaudhary, Fozail Ahmad, Sachin Bhatt, Shweta Sankhwar, Ravins Dohare

{"title":"Identification of robust genes in transcriptional regulatory network of Mycobacterium tuberculosis","authors":"Prithvi Singh, Mohd Amir, Upasana Chaudhary, Fozail Ahmad, Sachin Bhatt, Shweta Sankhwar, Ravins Dohare","doi":"10.1049/iet-syb.2020.0039","DOIUrl":"10.1049/iet-syb.2020.0039","url":null,"abstract":"<div>\u0000 <p>About 30% of the world population is infected with Mycobacterium tuberculosis (MTB). It is well known that the gene expression in MTB is highly variable, thus screening of traditional single-gene in MTB has been incapable to meet the desires of clinical diagnosis. In this report, the authors systemically analysed the transcription regulatory network (TRN) in MTB <i>H37Rv.</i> The complex interplay of these gene interactions has been revealed using exhaustive topological and global analysis of TRN using parameters including indegree, outdegree, degree, directed and undirected average path length (APL), and randomly performed. Results from indegree analysis reveal a set of important genes, including <i>papA5</i> and <i>Rv0177</i> which are associated with high indegree values. Gene ontology analysis suggested their importance in the virulence of MTB. In addition, APL and analysis of highly significant genes further identified some critical genes with different APL values. Among the list of genes identified, the<i>csoR</i> gene has the shortest directed APL score and high outdegree value, thus suggesting their importance in maintaining network topology. This study provides a comprehensive analysis of TRN and offers a good basis of understanding for developing experimental study in search of new therapeutic targets against MTB H37Rv pathogen.</p>\u0000 </div>","PeriodicalId":50379,"journal":{"name":"IET Systems Biology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2020-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687171/pdf/SYB2-14-292.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38618109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Formal reasoning about synthetic biology using higher-order-logic theorem proving 用高阶逻辑定理证明合成生物学的形式推理

IF 2.3 4区生物学

IET Systems Biology Pub Date : 2020-09-16 DOI: 10.1049/iet-syb.2020.0026

Sa'ed Abed, Adnan Rashid, Osman Hasan

{"title":"Formal reasoning about synthetic biology using higher-order-logic theorem proving","authors":"Sa'ed Abed, Adnan Rashid, Osman Hasan","doi":"10.1049/iet-syb.2020.0026","DOIUrl":"10.1049/iet-syb.2020.0026","url":null,"abstract":"<div>\u0000 <p>Synthetic biology is an interdisciplinary field that uses well-established engineering principles for performing the analysis of the biological systems, such as biological circuits, pathways, controllers and enzymes. Conventionally, the analysis of these biological systems is performed using paper-and-pencil proofs and computer simulation methods. However, these methods cannot ensure accurate results due to their inherent limitations. Higher-order-logic (HOL) theorem proving is proposed and used as a complementary approach for analysing linear biological systems, which is based on developing a mathematical model of the genetic circuits and the bio-controllers used in synthetic biology based on HOL and analysing it using deductive reasoning in an interactive theorem prover. The involvement of the logic, mathematics and the deductive reasoning in this method ensures the accuracy of the analysis. It is proposed to model the continuous dynamics of the genetic circuits and their associated controllers using differential equations and perform their transfer function-based analysis using the Laplace transform in a theorem prover. For illustration, the genetic circuits of activated and repressed expressions and autoactivation of protein, and phase lag and lead controllers, which are widely used in cancer-cell identifiers and multi-input receptors for precise disease detection, are formally analyzed.</p>\u0000 </div>","PeriodicalId":50379,"journal":{"name":"IET Systems Biology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2020-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687371/pdf/SYB2-14-271.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38521223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Bifurcation and oscillatory dynamics of delayed CDK1-APC feedback loop 延迟CDK1-APC反馈回路的分岔和振荡动力学

IF 2.3 4区生物学

IET Systems Biology Pub Date : 2020-09-15 DOI: 10.1049/iet-syb.2020.0050

Shenshuang Zhou, Wei Zhang, Yuan Zhang, Xuan Ni, Zhouhong Li

{"title":"Bifurcation and oscillatory dynamics of delayed CDK1-APC feedback loop","authors":"Shenshuang Zhou, Wei Zhang, Yuan Zhang, Xuan Ni, Zhouhong Li","doi":"10.1049/iet-syb.2020.0050","DOIUrl":"10.1049/iet-syb.2020.0050","url":null,"abstract":"<div>\u0000 <p>Extensive experimental evidence has been demonstrated that the dynamics of CDK1-APC feedback loop play crucial roles in regulating cell cycle processes, but the dynamical mechanisms underlying the regulation of this loop are still not completely understood. Here, the authors systematically investigated the stability and bifurcation criteria for a delayed CDK1-APC feedback loop. They showed that the maximum reaction rate of CDK1 inactivation by APC can drive sustained oscillations of CDK1 activity ( ) and APC activity ( ), and the amplitude of these oscillations is increasing with the increase of the reaction rate over a wide range; a certain range of the self-activation rate for CDK1 is also significant for generating these oscillations, for too high or too low rates the oscillations cannot be generated. Moreover, they derived the sufficient conditions to determine the stability and Hopf bifurcations, and found that the sum of time delays required for activating CDK1 and APC can induce and to be oscillatory, even when the and settle in a definite stable steady state. Furthermore, they presented an explicit algorithm for the properties of periodic oscillations. Finally, numerical simulations have been presented to justify the validity of theoretical analysis.</p>\u0000 </div>","PeriodicalId":50379,"journal":{"name":"IET Systems Biology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2020-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687261/pdf/SYB2-14-297.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38618110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combinatorial dynamics of protein synthesis time delay and negative feedback loop in NF-κ B signalling pathway NF-κ B信号通路中蛋白质合成时滞和负反馈回路的组合动力学

IF 2.3 4区生物学

IET Systems Biology Pub Date : 2020-09-15 DOI: 10.1049/iet-syb.2020.0034

Fang Yan, Li Liu, Qingyun Wang

{"title":"Combinatorial dynamics of protein synthesis time delay and negative feedback loop in NF-κ B signalling pathway","authors":"Fang Yan, Li Liu, Qingyun Wang","doi":"10.1049/iet-syb.2020.0034","DOIUrl":"https://doi.org/10.1049/iet-syb.2020.0034","url":null,"abstract":"<div>\u0000 <p>The transcription factor NF-<i>κ</i> B links immune response and inflammatory reaction and its different oscillation patterns determine different cell fates. In this study, a mathematical model with I<i>κ</i> B<i>α</i> protein synthesis time delay is developed based on the experimental evidences. The results show that time delay has the ability to drive oscillation of NF-<i>κ</i> B via Hopf bifurcation. Meanwhile, the amplitude and period are sensitive to the time delay. Moreover, the time delay threshold is a function of four parameters characterising the negative feedback loop. Likewise, the parameters also have effects on the amplitude and period of NF-<i>κ</i> B oscillation induced by time delay. Therefore, the oscillation patterns of NF-<i>κ</i> B are collaborative results of time delay coupled with the negative feedback loop. These results not only enhance the understanding of NF-<i>κ</i> B biological oscillation but also provide clues for the development of anti-inflammatory or anti-cancer drugs.</p>\u0000 </div>","PeriodicalId":50379,"journal":{"name":"IET Systems Biology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2020-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ietresearch.onlinelibrary.wiley.com/doi/epdf/10.1049/iet-syb.2020.0034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92295922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Estimation of skin impedance models with experimental data and a proposed model for human skin impedance 用实验数据估计皮肤阻抗模型，并提出一种人体皮肤阻抗模型

IF 2.3 4区生物学

IET Systems Biology Pub Date : 2020-09-15 DOI: 10.1049/iet-syb.2020.0049

Dhruba Jyoti Bora, Rajdeep Dasgupta

{"title":"Estimation of skin impedance models with experimental data and a proposed model for human skin impedance","authors":"Dhruba Jyoti Bora, Rajdeep Dasgupta","doi":"10.1049/iet-syb.2020.0049","DOIUrl":"10.1049/iet-syb.2020.0049","url":null,"abstract":"<div>\u0000 <p>The skin is a complex biological tissue whose impedance varies with frequency. The properties and structure of skin changes with the location on the body, age, geographical location and other factors. Considering these factors, skin impedance analysis is a sophisticated data analysis. However, despite all these variations, various researchers have always worked to develop an equivalent electrical model of the skin. The two most important categories of electrical models are RC-based model and CPE-based model which focus on the physiological stratification and biological properties of skin, respectively. In this work, experimental skin impedance data is acquired from ten sites on the body to find the fitting model. It is observed that a hybrid of fractional-order CPE-based model and higher-order RC layered-based model can provide the best fitting electrical model of skin. A new model is developed with this hybrid orders. Genetic algorithm is used for the extraction of parameter components. Least error of fitting has been observed for the proposed model as compared with the other models. This model can be used in correlating many skin problems and in the development of diagnostic tools. It will offer an additional supportive tool in-vitro to the medical specialist.</p>\u0000 </div>","PeriodicalId":50379,"journal":{"name":"IET Systems Biology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2020-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687349/pdf/SYB2-14-230.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38521219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Integrated expression analysis revealed RUNX2 upregulation in lung squamous cell carcinoma tissues 综合表达分析显示RUNX2在肺鳞癌组织中表达上调

IF 2.3 4区生物学

IET Systems Biology Pub Date : 2020-09-15 DOI: 10.1049/iet-syb.2020.0063

Da-Ping Yang, Hui-Ping Lu, Gang Chen, Jie Yang, Li Gao, Jian-Hua Song, Shang-Wei Chen, Jun-Xian Mo, Jin-Liang Kong, Zhong-Qing Tang, Chang-Bo Li, Hua-Fu Zhou, Lin-Jie Yang

{"title":"Integrated expression analysis revealed RUNX2 upregulation in lung squamous cell carcinoma tissues","authors":"Da-Ping Yang, Hui-Ping Lu, Gang Chen, Jie Yang, Li Gao, Jian-Hua Song, Shang-Wei Chen, Jun-Xian Mo, Jin-Liang Kong, Zhong-Qing Tang, Chang-Bo Li, Hua-Fu Zhou, Lin-Jie Yang","doi":"10.1049/iet-syb.2020.0063","DOIUrl":"10.1049/iet-syb.2020.0063","url":null,"abstract":"This study aimed to investigate the clinicopathological significance and prospective molecular mechanism of RUNX family transcription factor 2 (RUNX2) in lung squamous cell carcinoma (LUSC). The authors used immunohistochemistry (IHC), RNA-seq, and microarray data from multi-platforms to conduct a comprehensive analysis of the clinicopathological significance and molecular mechanism of RUNX2 in the occurrence and development of LUSC. RUNX2 expression was significantly higher in 16 LUSC tissues than in paired non-cancerous tissues detected by IHC (P < 0.05). RNA-seq data from the combination of TCGA and genotype-tissue expression (GTEx) revealed significantly higher expression of RUNX2 in 502 LUSC samples than in 476 non-cancer samples. The expression of RUNX2 protein was also significantly higher in pathologic T3-T4 than in T1-T2 samples (P = 0.031). The pooled standardised mean difference (SMD) for RUNX2 was 0.87 (95% CI, 0.58-1.16), including 29 microarrays from GEO and one from ArrayExpress. The co-expression network of RUNX2 revealed complicated connections between RUNX2 and 45 co-expressed genes, which were significantly clustered in pathways including ECM-receptor interaction, focal adhesion, protein digestion and absorption, human papillomavirus infection and PI3K-Akt signalling pathway. Overexpression of RUNX2 plays an essential role in the clinical progression of LUSC.","PeriodicalId":50379,"journal":{"name":"IET Systems Biology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2020-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687175/pdf/SYB2-14-252.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38521221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Pseudo-spectral method for controlling the drug dosage in cancer 伪光谱法控制肿瘤用药剂量

IF 2.3 4区生物学

IET Systems Biology Pub Date : 2020-09-15 DOI: 10.1049/iet-syb.2020.0054

Mostafa Nazari, Morteza Nazari, Mohammad Hadi Noori Skandari

{"title":"Pseudo-spectral method for controlling the drug dosage in cancer","authors":"Mostafa Nazari, Morteza Nazari, Mohammad Hadi Noori Skandari","doi":"10.1049/iet-syb.2020.0054","DOIUrl":"10.1049/iet-syb.2020.0054","url":null,"abstract":"<div>\u0000 <p>A mixed chemotherapy–immunotherapy treatment protocol is developed for cancer treatment. Chemotherapy pushes the trajectory of the system towards the desired equilibrium point, and then immunotherapy alters the dynamics of the system by affecting the parameters of the system. A co-existing cancerous equilibrium point is considered as the desired equilibrium point instead of the tumour-free equilibrium. Chemotherapy protocol is derived using the pseudo-spectral (PS) controller due to its high convergence rate and simple implementation structure. Thus, one of the contributions of this study is simplifying the design procedure and reducing the controller computational load in comparison with Lyapunov-based controllers. In this method, an infinite-horizon optimal control problem is proposed for a non-linear cancer model. Then, the infinite-horizon optimal control of cancer is transformed into a non-linear programming problem. The efficient Legendre PS scheme is suggested to solve the proposed problem. Then, the dynamics of the system is modified by immunotherapy is another contribution. To restrict the upper limit of the chemo-drug dose based on the age of the patients, a Mamdani fuzzy system is designed, which is not present yet. Simulation results on four different dynamics cases how the efficiency of the proposed treatment strategy.</p>\u0000 </div>","PeriodicalId":50379,"journal":{"name":"IET Systems Biology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2020-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687205/pdf/SYB2-14-261.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38521222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sliding mode control for a fractional-order non-linear glucose-insulin system 分数阶非线性葡萄糖-胰岛素系统的滑模控制

IF 2.3 4区生物学

IET Systems Biology Pub Date : 2020-09-15 DOI: 10.1049/iet-syb.2020.0030

Muhammad Waleed Khan, Muhammad Abid, Abdul Qayyum Khan, Ghulam Mustafa, Muzamil Ali, Asifullah Khan

{"title":"Sliding mode control for a fractional-order non-linear glucose-insulin system","authors":"Muhammad Waleed Khan, Muhammad Abid, Abdul Qayyum Khan, Ghulam Mustafa, Muzamil Ali, Asifullah Khan","doi":"10.1049/iet-syb.2020.0030","DOIUrl":"10.1049/iet-syb.2020.0030","url":null,"abstract":"<div>\u0000 <p>By providing the generalisation of integration and differentiation, and incorporating the memory and hereditary effects, fractional-order modelling has gotten significant attention in the past few years. One of the extensively studied and utilised models to describe the glucose–insulin system of a human body is Bergman's minimal model. This non-linear model comprises of integer-order differential equations. However, comparison with the experimental data shows that the fractional-order version of Bergman's minimal model is a better representative of the glucose–insulin system than its original integer-order model. To design a control law for an artificial pancreas for a diabetic patient using a fractional-order model, different techniques, including feedback linearisation, have been applied in the literature. The authors’ previous work shows that the fractional-order version of Bergman's model describes the glucose–insulin system in a better way than the integer-order model. This study applies the sliding mode control technique and then compares the obtained simulation results with the ones obtained using feedback linearisation.</p>\u0000 </div>","PeriodicalId":50379,"journal":{"name":"IET Systems Biology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2020-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687314/pdf/SYB2-14-223.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38521218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10