{"title":"DIAGNOSIS OF MELANOMA: CURRENT STATE AND PROSPECTS (literature review)","authors":"A. Guseynov, T. Guseynov, S. Sedov","doi":"10.12737/2409-3750-2023-9-3-17-25","DOIUrl":"https://doi.org/10.12737/2409-3750-2023-9-3-17-25","url":null,"abstract":"The article reflects the main factors influencing the survival of patients. The basic principles of diagnosing melanoma are presented. Methods for diagnosing skin melanoma, including invasive and non-invasive methods, are presented in detail and with justification. Among non-invasive methods for diagnosing skin melanoma, the role of physical examination and dermatoscopy in cases of suspected melanoma is emphasized. Among instrumental examination methods, the use of such research methods as ultrasound, computed tomography, magnetic resonance imaging, positron emission tomography is considered. Among laboratory methods, methods of molecular genetic research and determination of biomarkers of skin melanoma are presented. Among the invasive methods, the use of such biopsy methods as excisional and incisional biopsy is considered, with clarification of the indications and contraindications for their use. At the end of the work, the basic requirements for the early diagnosis of skin melanoma are listed. In conclusion, the latest trends in the diagnosis of skin melanoma, new non-invasive methods and an algorithm for diagnosing skin melanoma are identified.","PeriodicalId":503376,"journal":{"name":"Clinical Medicine and Pharmacology","volume":"23 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139156142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"CLINICAL CASE OF LATE DIAGNOSIS OF CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION","authors":"Natal'ya Kinyasheva, E. Malyutina","doi":"10.12737/2409-3750-2023-9-2-10-14","DOIUrl":"https://doi.org/10.12737/2409-3750-2023-9-2-10-14","url":null,"abstract":"The article is devoted to chronic thromboembolic pulmonary hypertension, the mechanisms of its development, the features of its diagnosis and specific treatment. As an illustration, a clinical case of chronic thromboembolic pulmonary hypertension is presented in a patient with repeatedly recurrent pulmonary embolisms against the background of chronic thrombophlebitis of the veins of the lower extremities, breast cancer and chemotherapy. The importance of timely diagnosis of the disease under discussion and determining the correct tactics for managing such patients to improve their prognosis and survival are outlined.","PeriodicalId":503376,"journal":{"name":"Clinical Medicine and Pharmacology","volume":"7 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139182452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Osteoarthritis and comorbidity: pathogenetic links","authors":"A. Fatenko, E. Belyaeva","doi":"10.12737/2409-3750-2023-9-2-31-36","DOIUrl":"https://doi.org/10.12737/2409-3750-2023-9-2-31-36","url":null,"abstract":"Secondary inflammatory processes, primarily synovitis, accompany the course of osteoarthritis, play a significant role in the formation of both clinical manifestations of the disease and further destruction of articular structures. In a patient with osteoarthritis over the age of 50, more than 5 diseases coexist simultaneously and there are practically no persons who do not have concomitant somatic diseases. Atherosclerosis refers to inflammatory diseases in which inflammation is associated with dyslipidemia and chronic immune dysregulation. It has been established that one of the main elements of atherothrombosis is an increase in the synthesis of proinflammatory cytokines. Common risk factors for primary osteoarthritis and cardiovascular diseases: age, overweight, heredity, metabolic disorders (high cholesterol, glucose tolerance, diabetes mellitus).","PeriodicalId":503376,"journal":{"name":"Clinical Medicine and Pharmacology","volume":"31 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139182805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Features of marketing in the pharmacological business in the postcovid period","authors":"Mariya Novikova","doi":"10.12737/2409-3750-2023-9-2-18-22","DOIUrl":"https://doi.org/10.12737/2409-3750-2023-9-2-18-22","url":null,"abstract":"Pharmaceutical marketing is an activity for the development, production and marketing of medicines based on a preliminary study of the needs of the pharmaceutical market. The active development of the digitalization of the pharmaceutical market was given by 2020, it marked the beginning of remote trade in medicines, closer contacts of company representatives with medical professionals through videoconferences, an increase in e-mail newsletters, an explosive growth in the volume of advertising on the Internet, the development of native advertising. Currently, promotion via the Internet plays a huge role, but the standard way of making a purchase decision remains. The buyer still goes through the stages of making a purchase: knowledge, interest, research, action, commitment. But the path from obtaining primary knowledge about the product to making a purchase becomes more difficult, since in addition to advertising, the recommendation of a doctor or pharmacist, the buyer studies the product using the Internet.","PeriodicalId":503376,"journal":{"name":"Clinical Medicine and Pharmacology","volume":"28 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139182538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rules of blood sampling for laboratory tests","authors":"Ol'ga Novikova","doi":"10.12737/2409-3750-2023-9-2-15-17","DOIUrl":"https://doi.org/10.12737/2409-3750-2023-9-2-15-17","url":null,"abstract":"There are rules that are mandatory when taking biological material for laboratory research. For the results of the study, not only the age, gender, race of the patient, factors of biological variation are important, but also the time of blood collection, physical activity, emotional state, the use of certain products, pharmacological preparations and biological additives. Analysis of a sample taken with a violation may be more dangerous for the patient than the absence of a study. This is fraught with incorrect tactics of the doctor when monitoring the course and pharmacotherapy of an already known disease and diagnostic errors in primary and / or differential diagnosis.","PeriodicalId":503376,"journal":{"name":"Clinical Medicine and Pharmacology","volume":"68 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139182258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ANEMIA IN PATIENTS WITH MALIGNANT NEOPLASMS (literature review)","authors":"E. Kel'berer","doi":"10.12737/2409-3750-2023-9-2-23-30","DOIUrl":"https://doi.org/10.12737/2409-3750-2023-9-2-23-30","url":null,"abstract":"Anemia is a common complication of both oncopathology itself and ongoing drug and chemoradiotherapy. Anemia not only worsens the quality of life of patients, but also negatively affects the effectiveness of specific treatment and patient survival rates. The frequency of anemia varies from 20 to 90% depending on the nosology, the stage of the disease, and the antitumor treatment being carried out. In cancer patients, anemia has a complex origin and can be caused by various reasons. As a rule, there are a number of factors at once, among which the suppressive effect of proinflammatory cytokines on erythropoiesis, synthesis of endogenous erythropoietin, sensitivity of erythropoietin receptors, as well as increased formation of hepcidin with the development of functional iron deficiency prevail. A detailed understanding of the pathogenesis of anemia caused by a tumor or chronic disease will allow the clinician to build a competent tactic for correcting the anemia syndrome, which will timely prevent the development of clinical symptoms and aggravation of the severity of the cancer patient's condition.","PeriodicalId":503376,"journal":{"name":"Clinical Medicine and Pharmacology","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139181964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"CLINICAL CASE OF THROMBOANGIITIS OBLITERANS IN A MIDDLE-AGED MAN","authors":"T. Il'ina","doi":"10.12737/2409-3750-2023-9-2-6-9","DOIUrl":"https://doi.org/10.12737/2409-3750-2023-9-2-6-9","url":null,"abstract":"The article presents a clinical case of a patient with thromboangiitis obliterans with such obvious clinical manifes tations as cyanosis, numbness of the toes, intermittent claudication, trophic changes in the skin of the hands, feet and legs. Despite the verified diagnosis and the patient’s adherence to treatment, a progressive course of the disease is noted.","PeriodicalId":503376,"journal":{"name":"Clinical Medicine and Pharmacology","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139182037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"CONSERVATIVE TREATMENT OF BREAST C YSTS: POSSIBILITIES OF USING INDINOLE FORTO","authors":"A. Guseynov, T. Guseynov, M. Bobkov, V. Blincov","doi":"10.12737/2409-3750-2023-9-2-2-5","DOIUrl":"https://doi.org/10.12737/2409-3750-2023-9-2-2-5","url":null,"abstract":"Among the drugs used in the conservative therapy of breast cysts and fibrocystic mastopathy, phytopreparations are mainly used in clinical practice. The drug Indinol Forto, obtained from plants of the cruciferous family, contains indolecarbinol, the effect of which is associated with the regulation of estrogen metabolism, inhibition of pathological proliferation, blockade of the formation of inflammatory cytokines, activation of apoptosis of transformed cells, reduction of breast cysts. The paper presents the results of a study of the pharmacological effect of the drug Indinol Forto on cystic formations of the breast. A comparative study of the use of the drug Indinol Forto showed its high effectiveness in the treatment of breast cysts, which consists in reducing the number and size of cystic formations of the breast. The drug Indinol Forto in the conservative treatment of breast cysts showed its effectiveness after 3 months of use: there was a decrease in the number of cysts (complete regression) by 3±0,5 in 13 (28,9%) patients and a partial regression of cysts with a decrease in their size by 28,7±5,8% in 16 (35,6%) patients. The optimal effect of Indinol Forto manifested itself after 6 months of use: the number of cysts decreased by 5±1,1 in 19 (42,2%) patients, and in 22 (48,9%) patients, a partial regression was noted with their reduction in size by almost half – by 49,0±7,2%. The results of the conducted studies have shown that Indinol Forto is the optimal drug that positively affects the dynamics of cystic formations of the breast. The drug Indinol Forto is well tolerated when taken orally, has no clinically identified side effects, which justifies the safety of long-term use.","PeriodicalId":503376,"journal":{"name":"Clinical Medicine and Pharmacology","volume":"85 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139182192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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