发布求助
文献互助 智能选刊 最新文献

Clinical Medicine and Pharmacology最新文献

筛选
英文 中文
THE IMPORTANCE OF P16 GENE EXPRESSION AS A FACTOR OF TUMOR BLAST CELL TRANSFORMATION (literature review) P16 基因表达作为肿瘤突变细胞转化因素的重要性（文献综述）
Clinical Medicine and Pharmacology Pub Date : 2024-01-30 DOI: 10.12737/2409-3750-2024-9-4-2-7
Tat'yana Subbotina, A. Guseynov, E. Gol'cova, V. Chizhova, A. Rudneva
{"title":"THE IMPORTANCE OF P16 GENE EXPRESSION AS A FACTOR OF TUMOR BLAST CELL TRANSFORMATION (literature review)","authors":"Tat'yana Subbotina, A. Guseynov, E. Gol'cova, V. Chizhova, A. Rudneva","doi":"10.12737/2409-3750-2024-9-4-2-7","DOIUrl":"https://doi.org/10.12737/2409-3750-2024-9-4-2-7","url":null,"abstract":"For a more accurate prediction of tumor behavior and individualization of treatment approach, it is necessary to improve new methods of early diagnosis of precancerous conditions. The article provides an overview of the modern understanding of the mechanisms of gene p16 expression as a factor in tumor growth. Data on the relevance of studying the pathogenesis of tumor blast transformation in invasive breast cancer are presented. These tumors require the combined interdisciplinary work of highly qualified specialists and ultra-modern technologies to achieve a positive result. The link between the formation of malignant breast tumors and human papillomavirus is described. \u0000The purpose of this study was to review the futuristically significant immunohistochemical analysis of p16 in patients of different age groups with common cervical cancer and breast cancer. \u0000The possibility of using the determination of p16 expression as a prognostic marker for breast cancer is shown, as well as the results of studying the expression of p16 and p53 in triple-negative breast cancer. The data reflecting the dependence of the suppressor function efficiency on the localization of p16 expression in squamous cell carcinoma of the cervix are analyzed. The dependence of p16INK4a expression on the severity of malignant cervical lesions is indicated, and the effect of chemotherapy on p16 expression is considered. By studying and applying information on the ontogenetic variability of the p16 gene, it is possible to significantly increase the accuracy of predicting the clinical and pathomorphological course of cancer of any nature of occurrence and to select adequate therapy: gene, chemotherapy, radiation therapy.","PeriodicalId":503376,"journal":{"name":"Clinical Medicine and Pharmacology","volume":"384 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140480163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IDIOPATHIC APLASTIC ANEMIA 特发性再生障碍性贫血
Clinical Medicine and Pharmacology Pub Date : 2024-01-30 DOI: 10.12737/2409-3750-2024-9-4-24-26
A. Ogneva
{"title":"IDIOPATHIC APLASTIC ANEMIA","authors":"A. Ogneva","doi":"10.12737/2409-3750-2024-9-4-24-26","DOIUrl":"https://doi.org/10.12737/2409-3750-2024-9-4-24-26","url":null,"abstract":"A clinical case of idiopathic aplastic anemia in a patient with the disease debut at the age of 12 years is presented. The significance of standard methods of examination of patients with mild symptoms, the importance of alertness of primary care physicians of all specialties is clearly shown. The limited use of existing methods of treatment for patients with this disease is emphasized.","PeriodicalId":503376,"journal":{"name":"Clinical Medicine and Pharmacology","volume":"1 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140483415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GOUT ARTHRITIS IN A MULTIMORbid PATIENT 多发性痛风病人的痛风性关节炎
Clinical Medicine and Pharmacology Pub Date : 2024-01-30 DOI: 10.12737/2409-3750-2024-9-4-27-32
K. Alpenidze
{"title":"GOUT ARTHRITIS IN A MULTIMORbid PATIENT","authors":"K. Alpenidze","doi":"10.12737/2409-3750-2024-9-4-27-32","DOIUrl":"https://doi.org/10.12737/2409-3750-2024-9-4-27-32","url":null,"abstract":"Gout is a systemic disease associated with the deposition of sodium monaurate crystals in various tissues, which leads to the development of inflammation. Given that the main clinical manifestation of gout is acute arthritis, it is necessary to carry out differential diagnosis with other diseases with similar clinical symptoms. A reliable diagnosis can be made when sodium monaurate crystals are detected in synovial fluid, but this is not always available in practice. Therefore, it is necessary to use a comprehensive assessment: clinical, laboratory, instrumental. Due to the frequent concomitant metabolic disorders that occur in gout, a multidisciplinary approach to the management of such patients is important.","PeriodicalId":503376,"journal":{"name":"Clinical Medicine and Pharmacology","volume":"224 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140484486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vitamin B12 deficiency anemia: diagnosis and treatment 维生素 B12 缺乏性贫血：诊断和治疗
Clinical Medicine and Pharmacology Pub Date : 2024-01-30 DOI: 10.12737/2409-3750-2024-9-4-14-20
K. Petruhina
{"title":"Vitamin B12 deficiency anemia: diagnosis and treatment","authors":"K. Petruhina","doi":"10.12737/2409-3750-2024-9-4-14-20","DOIUrl":"https://doi.org/10.12737/2409-3750-2024-9-4-14-20","url":null,"abstract":"Vitamin B12 deficiency is a common condition that can manifest with nonspecific clinical symptoms and, in severe cases, neurologic and hematologic abnormalities. Currently, vitamin B12 deficiency occurs most commonly due to malabsorption of food-associated cobalamin. Because lack of diagnosis can lead to potentially serious complications including spinal cord degeneration and pancytopenia, vitamin B12 deficiency should be diagnosed early and treated accordingly. Treatment for vitamin B12 deficiency is simple but can last a lifetime.","PeriodicalId":503376,"journal":{"name":"Clinical Medicine and Pharmacology","volume":"53 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140481826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetically engineered biological drugs in therapeutic practice 治疗实践中的基因工程生物药物
Clinical Medicine and Pharmacology Pub Date : 2024-01-30 DOI: 10.12737/2409-3750-2024-9-4-8-13
M. Dolgopolov
{"title":"Genetically engineered biological drugs in therapeutic practice","authors":"M. Dolgopolov","doi":"10.12737/2409-3750-2024-9-4-8-13","DOIUrl":"https://doi.org/10.12737/2409-3750-2024-9-4-8-13","url":null,"abstract":"Therapy with genetically engineered biological drugs is a new approach to the treatment of autoimmune and allergic diseases in pulmonology, hematology, gastroenterology, neurology, and oncology. Today, thanks to them, it is possible to radically improve the quality of life of patients with diseases that were previously considered incurable and poorly controlled. In some cases, the use of therapy can achieve long-term and stable remission. The article provides an overview of genetically engineered biological drugs used in various therapeutic areas and the mechanisms of their action.","PeriodicalId":503376,"journal":{"name":"Clinical Medicine and Pharmacology","volume":"91 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140484763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ankylosing spondylitis in a young woman 一名年轻女性的强直性脊柱炎
Clinical Medicine and Pharmacology Pub Date : 2024-01-30 DOI: 10.12737/2409-3750-2024-9-4-21-24
M. Rapcun
{"title":"Ankylosing spondylitis in a young woman","authors":"M. Rapcun","doi":"10.12737/2409-3750-2024-9-4-21-24","DOIUrl":"https://doi.org/10.12737/2409-3750-2024-9-4-21-24","url":null,"abstract":"A clinical case of ankylosing spondylitis diagnosis in a young female patient is presented. The importance of correct differential diagnosis of back pain is shown.","PeriodicalId":503376,"journal":{"name":"Clinical Medicine and Pharmacology","volume":"4 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140485613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detralex and detragel drugs in the treatment of chronic venous disease 治疗慢性静脉疾病的 Detralex 和 detragel 药物
Clinical Medicine and Pharmacology Pub Date : 2023-12-26 DOI: 10.12737/2409-3750-2023-9-3-13-16
Mariya Novikova
{"title":"Detralex and detragel drugs in the treatment of chronic venous disease","authors":"Mariya Novikova","doi":"10.12737/2409-3750-2023-9-3-13-16","DOIUrl":"https://doi.org/10.12737/2409-3750-2023-9-3-13-16","url":null,"abstract":"Chronic venous disease is one of the most discussed diagnoses in surgery and occurs in about 25-50% of the adult population. The high prevalence of chronic venous disease in our country underlines the importance of accurate and modern diagnosis of this pathology, the need to use treatment technologies that can be applied as widely as possible, not only by cardiovascular doctors, phlebologists, but also specialists in general surgery and even doctors of other specialties. The Detralex line of drugs was created for the treatment of venous diseases: varicose veins and hemorrhoids. Detralex helps to relieve pain, swelling and heaviness in the legs in chronic venous disease, and in addition, helps to eliminate the symptoms of both acute and chronic hemorrhoids: discomfort, pain and bleeding.","PeriodicalId":503376,"journal":{"name":"Clinical Medicine and Pharmacology","volume":"23 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139156899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A clinical case of iron deficiency anemia in an elderly patient with a complicated cardiovascular history 一名有复杂心血管病史的老年患者缺铁性贫血的临床病例
Clinical Medicine and Pharmacology Pub Date : 2023-12-26 DOI: 10.12737/2409-3750-2023-9-3-2-5
M. Rapcun
{"title":"A clinical case of iron deficiency anemia in an elderly patient with a complicated cardiovascular history","authors":"M. Rapcun","doi":"10.12737/2409-3750-2023-9-3-2-5","DOIUrl":"https://doi.org/10.12737/2409-3750-2023-9-3-2-5","url":null,"abstract":"A clinical case of iron deficiency anemia in a patient with chronic heart failure, coronary artery disease after myocardial infarction and coronary artery stenting, which aggravated the course of the underlying disease and worsened the quality of life, is presented. The important role of correction of iron deficiency anemia in patients with pathologies of the cardiovascular system is shown.","PeriodicalId":503376,"journal":{"name":"Clinical Medicine and Pharmacology","volume":"40 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139155151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GENETICALLY ENGINEERED BIOLOGICAL THERAPY IN ONCOLOGY (literature review) 基因工程生物疗法在肿瘤学中的应用（文献综述）
Clinical Medicine and Pharmacology Pub Date : 2023-12-26 DOI: 10.12737/2409-3750-2023-9-3-26-32
S. Mamedova
{"title":"GENETICALLY ENGINEERED BIOLOGICAL THERAPY IN ONCOLOGY (literature review)","authors":"S. Mamedova","doi":"10.12737/2409-3750-2023-9-3-26-32","DOIUrl":"https://doi.org/10.12737/2409-3750-2023-9-3-26-32","url":null,"abstract":"The main advantage of targeted therapy for cancer is the unique ability to mobilize the body's own immune system. Stimulation of the immune response leads to activation of internal protective functions that prevent angiogenesis and apoptosis of cancer cells. In addition, drugs that modify the biological reaction accelerate the process of tissue regeneration and the replacement of pathogenic cells with genetically normal ones.","PeriodicalId":503376,"journal":{"name":"Clinical Medicine and Pharmacology","volume":"20 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139155363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Difficulties of differential diagnosis of sarcoidosis and lymphoproliferative disease 肉样瘤病和淋巴增生性疾病的鉴别诊断难题
Clinical Medicine and Pharmacology Pub Date : 2023-12-26 DOI: 10.12737/2409-3750-2023-9-3-6-12
M. Rapcun, E. Belyaeva
{"title":"Difficulties of differential diagnosis of sarcoidosis and lymphoproliferative disease","authors":"M. Rapcun, E. Belyaeva","doi":"10.12737/2409-3750-2023-9-3-6-12","DOIUrl":"https://doi.org/10.12737/2409-3750-2023-9-3-6-12","url":null,"abstract":"Sarcoidosis is a systemic inflammatory disease of unknown origin. It belongs to the group of interstitial lung diseases, difficult to diagnose pathologies that require a multidisciplinary approach. A clinical case of the complexity of differential diagnosis of sarcoidosis and lymphoproliferative disease in a young patient is presented. The role of morphological verification in establishing the final diagnosis is shown.","PeriodicalId":503376,"journal":{"name":"Clinical Medicine and Pharmacology","volume":"24 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139157093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信