International Journal of Biostatistics最新文献

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A multivariate Bayesian learning approach for improved detection of doping in athletes using urinary steroid profiles. 一种多变量贝叶斯学习方法,用于使用尿类固醇谱改善运动员兴奋剂检测。
IF 1.2 4区 数学
International Journal of Biostatistics Pub Date : 2025-03-28 DOI: 10.1515/ijb-2024-0019
Dimitra Eleftheriou, Thomas Piper, Mario Thevis, Tereza Neocleous
{"title":"A multivariate Bayesian learning approach for improved detection of doping in athletes using urinary steroid profiles.","authors":"Dimitra Eleftheriou, Thomas Piper, Mario Thevis, Tereza Neocleous","doi":"10.1515/ijb-2024-0019","DOIUrl":"https://doi.org/10.1515/ijb-2024-0019","url":null,"abstract":"<p><p>Biomarker analysis of athletes' urinary steroid profiles is crucial for the success of anti-doping efforts. Current statistical analysis methods generate personalised limits for each athlete based on univariate modelling of longitudinal biomarker values from the urinary steroid profile. However, simultaneous modelling of multiple biomarkers has the potential to further enhance abnormality detection. In this study, we propose a multivariate Bayesian adaptive model for longitudinal data analysis, which extends the established single-biomarker model in forensic toxicology. The proposed approach employs Markov chain Monte Carlo sampling methods and addresses the scarcity of confirmed abnormal values through a one-class classification algorithm. By adapting decision boundaries as new measurements are obtained, the model provides robust and personalised detection thresholds for each athlete. We tested the proposed approach on a database of 229 athletes, which includes longitudinal steroid profiles containing samples classified as normal, atypical, or confirmed abnormal. Our results demonstrate improved detection performance, highlighting the potential value of a multivariate approach in doping detection.</p>","PeriodicalId":50333,"journal":{"name":"International Journal of Biostatistics","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regression analysis of clustered current status data with informative cluster size under a transformed survival model. 转换生存模型下具有信息聚类大小的聚类现状数据的回归分析。
IF 1.2 4区 数学
International Journal of Biostatistics Pub Date : 2025-03-24 DOI: 10.1515/ijb-2023-0130
Yanqin Feng, Shijiao Yin, Jieli Ding
{"title":"Regression analysis of clustered current status data with informative cluster size under a transformed survival model.","authors":"Yanqin Feng, Shijiao Yin, Jieli Ding","doi":"10.1515/ijb-2023-0130","DOIUrl":"https://doi.org/10.1515/ijb-2023-0130","url":null,"abstract":"<p><p>In this paper, we study inference methods for regression analysis of clustered current status data with informative cluster sizes. When the correlated failure times of interest arise from a general class of semiparametric transformation frailty models, we develop a nonparametric maximum likelihood estimation based method for regression analysis and conduct an expectation-maximization algorithm to implement it. The asymptotic properties including consistency and asymptotic normality of the proposed estimators are established. Extensive simulation studies are conducted and indicate that the proposed method works well. The developed approach is applied to analyze a real-life data set from a tumorigenicity study.</p>","PeriodicalId":50333,"journal":{"name":"International Journal of Biostatistics","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic adjustment with efficient estimators to unbiasedly leverage historical data in randomized trials. 随机试验中使用有效估计器进行预后调整,以无偏倚地利用历史数据。
IF 1.2 4区 数学
International Journal of Biostatistics Pub Date : 2025-03-11 DOI: 10.1515/ijb-2024-0018
Lauren D Liao, Emilie Højbjerre-Frandsen, Alan E Hubbard, Alejandro Schuler
{"title":"Prognostic adjustment with efficient estimators to unbiasedly leverage historical data in randomized trials.","authors":"Lauren D Liao, Emilie Højbjerre-Frandsen, Alan E Hubbard, Alejandro Schuler","doi":"10.1515/ijb-2024-0018","DOIUrl":"https://doi.org/10.1515/ijb-2024-0018","url":null,"abstract":"<p><p>Although randomized controlled trials (RCTs) are a cornerstone of comparative effectiveness, they typically have much smaller sample size than observational studies due to financial and ethical considerations. Therefore there is interest in using plentiful historical data (either observational data or prior trials) to reduce trial sizes. Previous estimators developed for this purpose rely on unrealistic assumptions, without which the added data can bias the treatment effect estimate. Recent work proposed an alternative method (prognostic covariate adjustment) that imposes no additional assumptions and increases efficiency in trial analyses. The idea is to use historical data to learn a prognostic model: a regression of the outcome onto the covariates. The predictions from this model, generated from the RCT subjects' baseline variables, are then used as a covariate in a linear regression analysis of the trial data. In this work, we extend prognostic adjustment to trial analyses with nonparametric efficient estimators, which are more powerful than linear regression. We provide theory that explains why prognostic adjustment improves small-sample point estimation and inference without any possibility of bias. Simulations corroborate the theory: efficient estimators using prognostic adjustment compared to without provides greater power (i.e., smaller standard errors) when the trial is small. Population shifts between historical and trial data attenuate benefits but do not introduce bias. We showcase our estimator using clinical trial data provided by Novo Nordisk A/S that evaluates insulin therapy for individuals with type 2 diabetes.</p>","PeriodicalId":50333,"journal":{"name":"International Journal of Biostatistics","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bayesian covariance regression in functional data analysis with applications to functional brain imaging. 贝叶斯协方差回归在功能数据分析中的应用,以及在脑功能成像中的应用。
IF 1.2 4区 数学
International Journal of Biostatistics Pub Date : 2025-02-05 DOI: 10.1515/ijb-2023-0029
John Shamshoian, Nicholas Marco, Damla Şentürk, Shafali Jeste, Donatello Telesca
{"title":"Bayesian covariance regression in functional data analysis with applications to functional brain imaging.","authors":"John Shamshoian, Nicholas Marco, Damla Şentürk, Shafali Jeste, Donatello Telesca","doi":"10.1515/ijb-2023-0029","DOIUrl":"https://doi.org/10.1515/ijb-2023-0029","url":null,"abstract":"<p><p>Function on scalar regression models relate functional outcomes to scalar predictors through the conditional mean function. With few and limited exceptions, many functional regression frameworks operate under the assumption that covariate information does not affect patterns of covariation. In this manuscript, we address this disparity by developing a Bayesian functional regression model, providing joint inference for both the conditional mean and covariance functions. Our work hinges on basis expansions of both the functional evaluation domain and covariate space, to define flexible non-parametric forms of dependence. To aid interpretation, we develop novel low-dimensional summaries, which indicate the degree of covariate-dependent heteroskedasticity. The proposed modeling framework is motivated and applied to a case study in functional brain imaging through electroencephalography, aiming to elucidate potential differentiation in the neural development of children with autism spectrum disorder.</p>","PeriodicalId":50333,"journal":{"name":"International Journal of Biostatistics","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DsubCox: a fast subsampling algorithm for Cox model with distributed and massive survival data. DsubCox:一种针对分布式海量生存数据的Cox模型的快速子采样算法。
IF 1.2 4区 数学
International Journal of Biostatistics Pub Date : 2025-02-04 DOI: 10.1515/ijb-2024-0042
Haixiang Zhang, Yang Li, HaiYing Wang
{"title":"<b>DsubCox</b>: a fast subsampling algorithm for Cox model with distributed and massive survival data.","authors":"Haixiang Zhang, Yang Li, HaiYing Wang","doi":"10.1515/ijb-2024-0042","DOIUrl":"https://doi.org/10.1515/ijb-2024-0042","url":null,"abstract":"<p><p>To ensure privacy protection and alleviate computational burden, we propose a fast subsmaling procedure for the Cox model with massive survival datasets from multi-centered, decentralized sources. The proposed estimator is computed based on optimal subsampling probabilities that we derived and enables transmission of subsample-based summary level statistics between different storage sites with only one round of communication. For inference, the asymptotic properties of the proposed estimator were rigorously established. An extensive simulation study demonstrated that the proposed approach is effective. The methodology was applied to analyze a large dataset from the U.S. airlines.</p>","PeriodicalId":50333,"journal":{"name":"International Journal of Biostatistics","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypothesis testing for detecting outlier evaluators. 检测离群评估员的假设检验。
IF 1.2 4区 数学
International Journal of Biostatistics Pub Date : 2024-11-04 eCollection Date: 2024-11-01 DOI: 10.1515/ijb-2023-0004
Li Xu, David M Zucker, Molin Wang
{"title":"Hypothesis testing for detecting outlier evaluators.","authors":"Li Xu, David M Zucker, Molin Wang","doi":"10.1515/ijb-2023-0004","DOIUrl":"10.1515/ijb-2023-0004","url":null,"abstract":"<p><p>In epidemiological studies, the measurements of disease outcomes are carried out by different evaluators. In this paper, we propose a two-stage procedure for detecting outlier evaluators. In the first stage, a regression model is fitted to obtain the evaluators' effects. Outlier evaluators have different effects than normal evaluators. In the second stage, stepwise hypothesis tests are performed to detect outlier evaluators. The true positive rate and true negative rate of the proposed procedure are assessed in a simulation study. We apply the proposed method to detect potential outlier audiologists among the audiologists who measured hearing threshold levels of the participants in the Audiology Assessment Arm of the Conservation of Hearing Study, which is an epidemiological study for examining risk factors of hearing loss.</p>","PeriodicalId":50333,"journal":{"name":"International Journal of Biostatistics","volume":" ","pages":"419-431"},"PeriodicalIF":1.2,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimizing personalized treatments for targeted patient populations across multiple domains. 跨领域优化针对目标患者群体的个性化治疗。
IF 1.2 4区 数学
International Journal of Biostatistics Pub Date : 2024-09-26 eCollection Date: 2024-11-01 DOI: 10.1515/ijb-2024-0068
Yuan Chen, Donglin Zeng, Yuanjia Wang
{"title":"Optimizing personalized treatments for targeted patient populations across multiple domains.","authors":"Yuan Chen, Donglin Zeng, Yuanjia Wang","doi":"10.1515/ijb-2024-0068","DOIUrl":"10.1515/ijb-2024-0068","url":null,"abstract":"<p><p>Learning individualized treatment rules (ITRs) for a target patient population with mental disorders is confronted with many challenges. First, the target population may be different from the training population that provided data for learning ITRs. Ignoring differences between the training patient data and the target population can result in sub-optimal treatment strategies for the target population. Second, for mental disorders, a patient's underlying mental state is not observed but can be inferred from measures of high-dimensional combinations of symptomatology. Treatment mechanisms are unknown and can be complex, and thus treatment effect moderation can take complicated forms. To address these challenges, we propose a novel method that connects measurement models, efficient weighting schemes, and flexible neural network architecture through latent variables to tailor treatments for a target population. Patients' underlying mental states are represented by a compact set of latent state variables while preserving interpretability. Weighting schemes are designed based on lower-dimensional latent variables to efficiently balance population differences so that biases in learning the latent structure and treatment effects are mitigated. Extensive simulation studies demonstrated consistent superiority of the proposed method and the weighting approach. Applications to two real-world studies of patients with major depressive disorder have shown a broad utility of the proposed method in improving treatment outcomes in the target population.</p>","PeriodicalId":50333,"journal":{"name":"International Journal of Biostatistics","volume":" ","pages":"437-453"},"PeriodicalIF":1.2,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
History-restricted marginal structural model and latent class growth analysis of treatment trajectories for a time-dependent outcome. 针对随时间变化的结果,对治疗轨迹进行历史限制边际结构模型和潜类增长分析。
IF 1.2 4区 数学
International Journal of Biostatistics Pub Date : 2024-08-12 eCollection Date: 2024-11-01 DOI: 10.1515/ijb-2023-0116
Awa Diop, Caroline Sirois, Jason R Guertin, Mireille E Schnitzer, James M Brophy, Claudia Blais, Denis Talbot
{"title":"History-restricted marginal structural model and latent class growth analysis of treatment trajectories for a time-dependent outcome.","authors":"Awa Diop, Caroline Sirois, Jason R Guertin, Mireille E Schnitzer, James M Brophy, Claudia Blais, Denis Talbot","doi":"10.1515/ijb-2023-0116","DOIUrl":"10.1515/ijb-2023-0116","url":null,"abstract":"<p><p>In previous work, we introduced a framework that combines latent class growth analysis (LCGA) with marginal structural models (LCGA-MSM). LCGA-MSM first summarizes the numerous time-varying treatment patterns into a few trajectory groups and then allows for a population-level causal interpretation of the group differences. However, the LCGA-MSM framework is not suitable when the outcome is time-dependent. In this study, we propose combining a nonparametric history-restricted marginal structural model (HRMSM) with LCGA. HRMSMs can be seen as an application of standard MSMs on multiple time intervals. To the best of our knowledge, we also present the first application of HRMSMs with a time-to-event outcome. It was previously noted that HRMSMs could pose interpretation problems in survival analysis when either targeting a hazard ratio or a survival curve. We propose a causal parameter that bypasses these interpretation challenges. We consider three different estimators of the parameters: inverse probability of treatment weighting (IPTW), g-computation, and a pooled longitudinal targeted maximum likelihood estimator (pooled LTMLE). We conduct simulation studies to measure the performance of the proposed LCGA-HRMSM. For all scenarios, we obtain unbiased estimates when using either g-computation or pooled LTMLE. IPTW produced estimates with slightly larger bias in some scenarios. Overall, all approaches have good coverage of the 95 % confidence interval. We applied our approach to a population of older Quebecers composed of 57,211 statin initiators and found that a greater adherence to statins was associated with a lower combined risk of cardiovascular disease or all-cause mortality.</p>","PeriodicalId":50333,"journal":{"name":"International Journal of Biostatistics","volume":" ","pages":"467-490"},"PeriodicalIF":1.2,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141972255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hybrid classical-Bayesian approach to sample size determination for two-arm superiority clinical trials. 经典-贝叶斯混合法确定双臂优势临床试验的样本量。
IF 1.2 4区 数学
International Journal of Biostatistics Pub Date : 2024-07-01 eCollection Date: 2024-11-01 DOI: 10.1515/ijb-2023-0050
Valeria Sambucini
{"title":"Hybrid classical-Bayesian approach to sample size determination for two-arm superiority clinical trials.","authors":"Valeria Sambucini","doi":"10.1515/ijb-2023-0050","DOIUrl":"10.1515/ijb-2023-0050","url":null,"abstract":"<p><p>Traditional methods for Sample Size Determination (SSD) based on power analysis exploit relevant fixed values or preliminary estimates for the unknown parameters. A hybrid classical-Bayesian approach can be used to formally incorporate information or model uncertainty on unknown quantities by using prior distributions according to the Bayesian approach, while still analysing the data in a frequentist framework. In this paper, we propose a hybrid procedure for SSD in two-arm superiority trials, that takes into account the different role played by the unknown parameters involved in the statistical power. Thus, different prior distributions are used to formalize design expectations and to model information or uncertainty on preliminary estimates involved at the analysis stage. To illustrate the method, we consider binary data and derive the proposed hybrid criteria using three possible parameters of interest, i.e. the difference between proportions of successes, the logarithm of the relative risk and the logarithm of the odds ratio. Numerical examples taken from the literature are presented to show how to implement the proposed procedure.</p>","PeriodicalId":50333,"journal":{"name":"International Journal of Biostatistics","volume":" ","pages":"553-570"},"PeriodicalIF":1.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An interpretable cluster-based logistic regression model, with application to the characterization of response to therapy in severe eosinophilic asthma. 基于聚类的可解释逻辑回归模型,应用于描述严重嗜酸性粒细胞性哮喘的治疗反应。
IF 1.2 4区 数学
International Journal of Biostatistics Pub Date : 2024-06-25 eCollection Date: 2024-11-01 DOI: 10.1515/ijb-2023-0061
Massimo Bilancia, Andrea Nigri, Barbara Cafarelli, Danilo Di Bona
{"title":"An interpretable cluster-based logistic regression model, with application to the characterization of response to therapy in severe eosinophilic asthma.","authors":"Massimo Bilancia, Andrea Nigri, Barbara Cafarelli, Danilo Di Bona","doi":"10.1515/ijb-2023-0061","DOIUrl":"10.1515/ijb-2023-0061","url":null,"abstract":"<p><p>Asthma is a disease characterized by chronic airway hyperresponsiveness and inflammation, with signs of variable airflow limitation and impaired lung function leading to respiratory symptoms such as shortness of breath, chest tightness and cough. Eosinophilic asthma is a distinct phenotype that affects more than half of patients diagnosed with severe asthma. It can be effectively treated with monoclonal antibodies targeting specific immunological signaling pathways that fuel the inflammation underlying the disease, particularly Interleukin-5 (IL-5), a cytokine that plays a crucial role in asthma. In this study, we propose a data analysis pipeline aimed at identifying subphenotypes of severe eosinophilic asthma in relation to response to therapy at follow-up, which could have great potential for use in routine clinical practice. Once an optimal partition of patients into subphenotypes has been determined, the labels indicating the group to which each patient has been assigned are used in a novel way. For each input variable in a specialized logistic regression model, a clusterwise effect on response to therapy is determined by an appropriate interaction term between the input variable under consideration and the cluster label. We show that the clusterwise odds ratios can be meaningfully interpreted conditional on the cluster label. In this way, we can define an effect measure for the response variable for each input variable in each of the groups identified by the clustering algorithm, which is not possible in standard logistic regression because the effect of the reference class is aliased with the overall intercept. The interpretability of the model is enforced by promoting sparsity, a goal achieved by learning interactions in a hierarchical manner using a special group-Lasso technique. In addition, valid expressions are provided for computing odds ratios in the unusual parameterization used by the sparsity-promoting algorithm. We show how to apply the proposed data analysis pipeline to the problem of sub-phenotyping asthma patients also in terms of quality of response to therapy with monoclonal antibodies.</p>","PeriodicalId":50333,"journal":{"name":"International Journal of Biostatistics","volume":" ","pages":"361-388"},"PeriodicalIF":1.2,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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