International Journal of Neural Systems最新文献

{"title":"One-Dimensional Local Binary Pattern and Common Spatial Pattern Feature Fusion Brain Network for Central Neuropathic Pain.","authors":"Fangzhou Xu,&nbsp;Chongfeng Wang,&nbsp;Xin Yu,&nbsp;Jinzhao Zhao,&nbsp;Ming Liu,&nbsp;Jiaqi Zhao,&nbsp;Licai Gao,&nbsp;Xiuquan Jiang,&nbsp;Zhaoxin Zhu,&nbsp;Yongjian Wu,&nbsp;Dezheng Wang,&nbsp;Shanxin Feng,&nbsp;Sen Yin,&nbsp;Yang Zhang,&nbsp;Jiancai Leng","doi":"10.1142/S0129065723500302","DOIUrl":"https://doi.org/10.1142/S0129065723500302","url":null,"abstract":"<p><p>Central neuropathic pain (CNP) after spinal cord injury (SCI) is related to the plasticity of cerebral cortex. The plasticity of cortex recorded by electroencephalogram (EEG) signal can be used as a biomarker of CNP. To analyze changes in the brain network mechanism under the combined effect of injury and pain or under the effect of pain, this paper mainly studies the changes of brain network functional connectivity in patients with neuropathic pain and without neuropathic pain after SCI. This paper has recorded the EEG with the CNP group after SCI, without the CNP group after SCI, and a healthy control group. Phase-locking value has been used to construct brain network topological connectivity maps. By comparing the brain networks of the two groups of SCI with the healthy group, it has been found that in the [Formula: see text] and [Formula: see text] frequency bands, the injury increases the functional connectivity between the frontal lobe and occipital lobes, temporal, and parietal of the patients. Furthermore, the comparison of brain networks between the group with CNP and the group without CNP after SCI has found that pain has a greater effect on the increased connectivity within the patients' frontal lobes. Motor imagery (MI) data of CNP patients have been used to extract one-dimensional local binary pattern (1D-LBP) and common spatial pattern (CSP) features, the left and right hand movements of the patients' MI have been classified. The proposed LBP-CSP feature method has achieved the highest accuracy of 98.6% and the average accuracy of 91.5%. The results of this study have great clinical significance for the neural rehabilitation and brain-computer interface of CNP patients.</p>","PeriodicalId":50305,"journal":{"name":"International Journal of Neural Systems","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9544176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Efficient Multi-Objective Evolutionary Zero-Shot Neural Architecture Search Framework for Image Classification.","authors":"Jianwei Zhang,&nbsp;Lei Zhang,&nbsp;Yan Wang,&nbsp;Junyou Wang,&nbsp;Xin Wei,&nbsp;Wenjie Liu","doi":"10.1142/S0129065723500168","DOIUrl":"https://doi.org/10.1142/S0129065723500168","url":null,"abstract":"<p><p>Neural Architecture Search (NAS) has recently shown a powerful ability to engineer networks automatically on various tasks. Most current approaches navigate the search direction with the validation performance-based architecture evaluation methodology, which estimates an architecture's quality by training and validating on a specific large dataset. However, for small-scale datasets, the model's performance on the validation set cannot precisely estimate that on the test set. The imprecise architecture evaluation can mislead the search to sub-optima. To address the above problem, we propose an efficient multi-objective evolutionary zero-shot NAS framework by evaluating architectures with zero-cost metrics, which can be calculated with randomly initialized models in a training-free manner. Specifically, a general zero-cost metric design principle is proposed to unify the current metrics and help develop several new metrics. Then, we offer an efficient computational method for multi-zero-cost metrics by calculating them in one forward and backward pass. Finally, comprehensive experiments have been conducted on NAS-Bench-201 and MedMNIST. The results have shown that the proposed method can achieve sufficiently accurate, high-throughput performance on MedMNIST and 20[Formula: see text]faster than the previous best method.</p>","PeriodicalId":50305,"journal":{"name":"International Journal of Neural Systems","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9793637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved Neurophysiological Process Imaging Through Optimization of Kalman Filter Initial Conditions.","authors":"Yun Zhao,&nbsp;Felix Luong,&nbsp;Simon Teshuva,&nbsp;Andria Pelentritou,&nbsp;William Woods,&nbsp;David Liley,&nbsp;Daniel F Schmidt,&nbsp;Mario Boley,&nbsp;Levin Kuhlmann","doi":"10.1142/S0129065723500247","DOIUrl":"https://doi.org/10.1142/S0129065723500247","url":null,"abstract":"<p><p>Recent work presented a framework for space-time-resolved neurophysiological process imaging that augments existing electromagnetic source imaging techniques. In particular, a nonlinear Analytic Kalman filter (AKF) has been developed to efficiently infer the states and parameters of neural mass models believed to underlie the generation of electromagnetic source currents. Unfortunately, as the initialization determines the performance of the Kalman filter, and the ground truth is typically unavailable for initialization, this framework might produce suboptimal results unless significant effort is spent on tuning the initialization. Notably, the relation between the initialization and overall filter performance is only given implicitly and is expensive to evaluate; implying that conventional optimization techniques, e.g. gradient or sampling based, are inapplicable. To address this problem, a novel efficient framework based on blackbox optimization has been developed to find the optimal initialization by reducing the signal prediction error. Multiple state-of-the-art optimization methods were compared and distinctively, Gaussian process optimization decreased the objective function by 82.1% and parameter estimation error by 62.5% on average with the simulation data compared to no optimization applied. The framework took only 1.6[Formula: see text]h and reduced the objective function by an average of 13.2% on 3.75[Formula: see text]min 4714-source channel magnetoencephalography data. This yields an improved method of neurophysiological process imaging that can be used to uncover complex underpinnings of brain dynamics.</p>","PeriodicalId":50305,"journal":{"name":"International Journal of Neural Systems","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9443173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Longitudinal Study Using Binaural Beats on Parkinson Disease.","authors":"David González,&nbsp;Ricardo Bruña,&nbsp;Juan Carlos Martínez-Castrillo,&nbsp;Juan Manuel López,&nbsp;Guillermo de Arcas","doi":"10.1142/S0129065723500272","DOIUrl":"https://doi.org/10.1142/S0129065723500272","url":null,"abstract":"<p><p>This paper describes a longitudinal study to analyze the effects of acoustic stimulation with Binaural Beats (BBs) at 14[Formula: see text]Hz (beta band) in patients with Parkinson's Disease (PD). Participants ([Formula: see text], age [Formula: see text], stage [Formula: see text] Hoehn and Yahr scale) listened to binaural stimulation for 10[Formula: see text]min a day, 3 days a week, during six months and were assessed 3 times during this period using electroencephalography (EEG), cognitive (PD-CRS), quality of life (PDQ-39) and wearing-off (WOQ-19) tests. During each assessment (basal, and after 3 and 6 months), the relative power in theta band was analyzed before, during and after the stimulation. Focusing the analysis on the motor cortex, the results obtained have confirmed the initial hypothesis for the first session, but they have shown a habituation effect which decreases its efficiency with time. Also, different reactions have been detected among individuals, with some reacting as expected from the beginning, while others would react in an opposite way at the beginning but they have shown afterwards a tendency towards the expected outcome. Anyhow, the relative power of the theta band was reduced between the first and the last session for more than half of the participants, although with very different values. Subtle changes have also been observed in some items of the PD-CRS, PDQ-39 and WOQ-19 tests.</p>","PeriodicalId":50305,"journal":{"name":"International Journal of Neural Systems","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9914916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Pilot Study on the Functional Stability of Phonation in EEG Bands After Repetitive Transcranial Magnetic Stimulation in Parkinson's Disease.","authors":"Andrés Gómez-Rodellar,&nbsp;Jiří Mekyska,&nbsp;Pedro Gómez-Vilda,&nbsp;Luboš Brabenec,&nbsp;Patrik Šimko,&nbsp;Irena Rektorová","doi":"10.1142/S0129065723500284","DOIUrl":"https://doi.org/10.1142/S0129065723500284","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a neurodegenerative condition with constantly increasing prevalence rates, affecting strongly life quality in terms of neuromotor and cognitive performance. PD symptoms include voice and speech alterations, known as hypokinetic dysarthria (HD). Unstable phonation is one of the manifestations of HD. Repetitive transcranial magnetic stimulation (rTMS) is a rehabilitative treatment thathas been shown to improve some motor and non-motor symptoms of persons with PD (PwP). This study analyzed the phonation functional behavior of 18 participants (13 males, 5 females) with PD diagnosis before (one pre-stimulus) and after (four post-stimulus) evaluation sessions of rTMS treatment, to assess the extent of changes in their phonation stability. Participants were randomized 1:1 to receive either rTMS or sham stimulation. Voice recordings of a sustained vowel [a:] taken immediately before and after the treatment, and at follow-up evaluation sessions (immediately after, at six, ten, and fourteen weeks after the baseline assessment) were processed by inverse filtering to estimate a biomechanical correlate of vocal fold tension. This estimate was further band-pass filtered into EEG-related frequency bands. Log-likelihood ratios (LLRs) between pre- and post-stimulus amplitude distributions of each frequency band showed significant differences in five cases actively stimulated. Seven cases submitted to the sham protocol did not show relevant improvements in phonation instability. Conversely, four active cases did not show phonation improvements, whereas two sham cases did. The study provides early preliminary insights into the capability of phonation quality assessment by monitoring neuromechanical activity from acoustic signals in frequency bands aligned with EEG ones.</p>","PeriodicalId":50305,"journal":{"name":"International Journal of Neural Systems","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9914931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Explainable Artificial Intelligence in the Clock Drawing Test to Reveal the Cognitive Impairment Pattern.","authors":"Carmen Jiménez-Mesa,&nbsp;Juan E Arco,&nbsp;Meritxell Valentí-Soler,&nbsp;Belén Frades-Payo,&nbsp;María A Zea-Sevilla,&nbsp;Andrés Ortiz,&nbsp;Marina Ávila-Villanueva,&nbsp;Diego Castillo-Barnes,&nbsp;Javier Ramírez,&nbsp;Teodoro Del Ser-Quijano,&nbsp;Cristóbal Carnero-Pardo,&nbsp;Juan M Górriz","doi":"10.1142/S0129065723500156","DOIUrl":"https://doi.org/10.1142/S0129065723500156","url":null,"abstract":"<p><p>The prevalence of dementia is currently increasing worldwide. This syndrome produces a deterioration in cognitive function that cannot be reverted. However, an early diagnosis can be crucial for slowing its progress. The Clock Drawing Test (CDT) is a widely used paper-and-pencil test for cognitive assessment in which an individual has to manually draw a clock on a paper. There are a lot of scoring systems for this test and most of them depend on the subjective assessment of the expert. This study proposes a computer-aided diagnosis (CAD) system based on artificial intelligence (AI) methods to analyze the CDT and obtain an automatic diagnosis of cognitive impairment (CI). This system employs a preprocessing pipeline in which the clock is detected, centered and binarized to decrease the computational burden. Then, the resulting image is fed into a Convolutional Neural Network (CNN) to identify the informative patterns within the CDT drawings that are relevant for the assessment of the patient's cognitive status. Performance is evaluated in a real context where patients with CI and controls have been classified by clinical experts in a balanced sample size of [Formula: see text] drawings. The proposed method provides an accuracy of [Formula: see text] in the binary case-control classification task, with an AUC of [Formula: see text]. These results are indeed relevant considering the use of the classic version of the CDT. The large size of the sample suggests that the method proposed has a high reliability to be used in clinical contexts and demonstrates the suitability of CAD systems in the CDT assessment process. Explainable artificial intelligence (XAI) methods are applied to identify the most relevant regions during classification. Finding these patterns is extremely helpful to understand the brain damage caused by CI. A validation method using resubstitution with upper bound correction in a machine learning approach is also discussed.</p>","PeriodicalId":50305,"journal":{"name":"International Journal of Neural Systems","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9201397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrical Stimulation Induced Current Distribution in Peripheral Nerves Varies Significantly with the Extent of Nerve Damage: A Computational Study Utilizing Convolutional Neural Network and Realistic Nerve Models.","authors":"Jinze Du,&nbsp;Andres Morales,&nbsp;Pragya Kosta,&nbsp;Jean-Marie C Bouteiller,&nbsp;Gema Martinez-Navarrete,&nbsp;David J Warren,&nbsp;Eduardo Fernandez,&nbsp;Gianluca Lazzi","doi":"10.1142/S0129065723500223","DOIUrl":"10.1142/S0129065723500223","url":null,"abstract":"<p><p>Electrical stimulation of the peripheral nervous system is a promising therapeutic option for several conditions; however, its effects on tissue and the safety of the stimulation remain poorly understood. In order to devise stimulation protocols that enhance therapeutic efficacy without the risk of causing tissue damage, we constructed computational models of peripheral nerve and stimulation cuffs based on extremely high-resolution cross-sectional images of the nerves using the most recent advances in computing power and machine learning techniques. We developed nerve models using nonstimulated (healthy) and over-stimulated (damaged) rat sciatic nerves to explore how nerve damage affects the induced current density distribution. Using our in-house computational, quasi-static, platform, and the Admittance Method (AM), we estimated the induced current distribution within the nerves and compared it for healthy and damaged nerves. We also estimated the extent of localized cell damage in both healthy and damaged nerve samples. When the nerve is damaged, as demonstrated principally by the decreased nerve fiber packing, the current penetrates deeper into the over-stimulated nerve than in the healthy sample. As safety limits for electrical stimulation of peripheral nerves still refer to the Shannon criterion to distinguish between safe and unsafe stimulation, the capability this work demonstrated is an important step toward the development of safety criteria that are specific to peripheral nerve and make use of the latest advances in computational bioelectromagnetics and machine learning, such as Python-based AM and CNN-based nerve image segmentation.</p>","PeriodicalId":50305,"journal":{"name":"International Journal of Neural Systems","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561898/pdf/nihms-1934853.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9202305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introduction.","authors":"José Manuel Ferrández,&nbsp;Eduardo Fernandez,&nbsp;Juan Manuel Gorriz","doi":"10.1142/S0129065723030016","DOIUrl":"https://doi.org/10.1142/S0129065723030016","url":null,"abstract":"","PeriodicalId":50305,"journal":{"name":"International Journal of Neural Systems","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9556028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Functional Brain Network Dynamics in Dyslexia from fNIRS Data.","authors":"Nicolás J Gallego-Molina,&nbsp;Andrés Ortiz,&nbsp;Francisco J Martínez-Murcia,&nbsp;Ignacio Rodríguez-Rodríguez,&nbsp;Juan L Luque","doi":"10.1142/S012906572350017X","DOIUrl":"https://doi.org/10.1142/S012906572350017X","url":null,"abstract":"<p><p>Developmental dyslexia is characterized by a deficit of phonological awareness whose origin is related to atypical neural processing of speech streams. This can lead to differences in the neural networks that encode audio information for dyslexics. In this work, we investigate whether such differences exist using functional near-infrared spectroscopy (fNIRS) and complex network analysis. We have explored functional brain networks derived from low-level auditory processing of nonspeech stimuli related to speech units such as stress, syllables or phonemes of skilled and dyslexic seven-year-old readers. A complex network analysis was performed to examine the properties of functional brain networks and their temporal evolution. We characterized aspects of brain connectivity such as functional segregation, functional integration or small-worldness. These properties are used as features to extract differential patterns in controls and dyslexic subjects. The results corroborate the presence of discrepancies in the topological organizations of functional brain networks and their dynamics that differentiate between control and dyslexic subjects, reaching an Area Under ROC Curve (AUC) up to 0.89 in classification experiments.</p>","PeriodicalId":50305,"journal":{"name":"International Journal of Neural Systems","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9195763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supporting the Detection of Early Alzheimer's Disease with a Four-Channel EEG Analysis.","authors":"Eduardo Perez-Valero,&nbsp;Christian Morillas,&nbsp;Miguel A Lopez-Gordo,&nbsp;Jesus Minguillon","doi":"10.1142/S0129065723500211","DOIUrl":"https://doi.org/10.1142/S0129065723500211","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is the most prevalent form of dementia. Although there is no current cure, medical treatment can help to control its progression. Hence, early-stage diagnosis is crucial to maximize the living standards of the patients. Biochemical markers and medical imaging in combination with neuropsychological tests represent the most extended diagnosis procedure. However, these techniques require specialized personnel and long processing time. Furthermore, the access to some of these techniques is often limited in crowded healthcare systems and rural areas. In this context, electroencephalography (EEG), a non-invasive technique to obtain endogenous brain information, has been proposed for the diagnosis of early-stage AD. Despite the valuable information provided by clinical EEG and high density montages, these approaches are impractical in conditions such as those described above. Consequently, in this study, we evaluated the feasibly of using a reduced EEG montage with only four channels to detect early-stage AD. For this purpose, we involved eight clinically diagnosed AD patients and eight healthy controls. The results we obtained reveal similar accuracies ([Formula: see text]-value[Formula: see text]0.66) for the reduced montage (0.86) and a 16-channel montage (0.87). This suggests that a four-channel wearable EEG system could be an effective tool for supporting early-stage AD detection.</p>","PeriodicalId":50305,"journal":{"name":"International Journal of Neural Systems","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9195360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}