Sai Shashank Gudla, Siva Krishna Adithya Bhumireddy, Anil Kumar Vadaga
{"title":"Tramadol and mental health: A systematic review of case reports describing psychological side-effects.","authors":"Sai Shashank Gudla, Siva Krishna Adithya Bhumireddy, Anil Kumar Vadaga","doi":"10.1177/00912174251322356","DOIUrl":"https://doi.org/10.1177/00912174251322356","url":null,"abstract":"<p><strong>Objective: </strong>Tramadol is a synthetic opioid widely used in clinical practice to treat moderate to severe pain. While it is considered safer than traditional opioids, growing concerns have emerged regarding its adverse psychological effects. This systematic review examined tramadol-induced psychological side effects, identified risk factors, and evaluated possible underlying mechanisms that might help to guide safer clinical use.</p><p><strong>Methods: </strong>A systematic search was conducted in PubMed, Scopus, Web of Science, and Google Scholar using the related keywords of tramadol and psychological effects. This review primarily focused on case reports, which were included if they provided detailed accounts of tramadol-induced mental health side-effects. Two independent reviewers screened the studies, and data was extracted on patient demographics, details of tramadol usage, psychological outcomes, and risk factors. The quality of the case reports was assessed using the Joanna Briggs Institute (JBI) scale.</p><p><strong>Results: </strong>The review found that tramadol is associated with a range of psychological symptoms, including manic episodes, hypomania, serotonin syndrome, psychosis, and cognitive impairment. Risk factors included age, pre-existing psychiatric conditions, polydrug use, and prolonged tramadol use. Elderly individuals and those with psychiatric histories were particularly vulnerable.</p><p><strong>Conclusion: </strong>Tramadol has the potential to cause serious psychological side effects, prompting cautious prescription, especially in vulnerable populations. Clinicians should closely monitor patients for these adverse effects, and further research is needed to understand the mechanisms involved and to reduce the psychological site-effects resulting from tramadol use.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174251322356"},"PeriodicalIF":1.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Addressing severe alcohol withdrawal with bromocriptine: A case series.","authors":"Sayantan Chattopadhyay, Ayan Basak, Sukriti Mukherjee","doi":"10.1177/00912174251321962","DOIUrl":"https://doi.org/10.1177/00912174251321962","url":null,"abstract":"<p><strong>Objective: </strong>Alcohol withdrawal syndrome poses a significant health burden worldwide, with its prevalence steadily rising in countries like India due to high rates of alcohol use disorders. The treatment landscape for alcohol withdrawal syndrome is evolving with the introduction of bromocriptine offering a promising adjunctive treatment for patients resistant to standard benzodiazepine therapy.</p><p><strong>Methods: </strong>We report two cases from India of severe alcohol withdrawal syndrome successfully treated with bromocriptine.</p><p><strong>Results: </strong>There were clinically significant improvements in both patients with regard to Alcohol Withdrawal Symptoms in a relatively short time span.</p><p><strong>Conclusions: </strong>Bromocriptine represents an addition to the therapeutic options for alcohol withdrawal syndrome management, offering symptom relief, improving clinical outcomes, and addressing the neuropsychiatric burden associated with the condition.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174251321962"},"PeriodicalIF":1.1,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nevena D Randjelovic, Dragana I Ignjatovic-Ristic, Marina V Petronijevic, Kristina Z Dugalic
{"title":"Risk of suicide among oncologists in Serbia.","authors":"Nevena D Randjelovic, Dragana I Ignjatovic-Ristic, Marina V Petronijevic, Kristina Z Dugalic","doi":"10.1177/00912174251320720","DOIUrl":"https://doi.org/10.1177/00912174251320720","url":null,"abstract":"<p><strong>Objective: </strong>There is only limited research on suicidal thoughts and behaviors of oncologists. This study examined the prevalence and correlates of suicidal thoughts among oncologists in Serbia.</p><p><strong>Method: </strong>A cross-sectional study was conducted in January 2024 involving 159 oncologists from Serbia and the Republic of Srpska. Respondents completed an online questionnaire which assessed socio-demographic and work characteristics and included the Risk Assessment Suicidality Scale, Depression Anxiety Stress Scale-21, Maslach Burnout Inventory, and Brief Resilience Scale.</p><p><strong>Results: </strong>Results indicated that 21.4% of oncologists reported elevated suicidality scores. Medical oncologists had the highest average suicidality scores compared to surgical and radiation oncologists, although these differences were not statistically significant. Key associated factors with suicidality included seeing a psychiatrist, undergoing psychiatric therapy, having family history of depression, and family history of suicide attempts and/or suicide. Resilience and sense of personal accomplishment were inversely associated with suicidality.</p><p><strong>Conclusions: </strong>The finding that 1 out of 5 oncologists had elevated suicidality scores underscores the urgent need for mental health support for members of this profession, particularly those showing signs of distress. Interventions should promote resilience, enhance personal accomplishment, and ensure easy access to psychiatric care. While these results contribute to the limited data on suicidality among oncologists, they also identify gaps that future studies should address, such as the need for larger sample sizes and the exploration of other potential risk factors. Addressing oncologists' mental health challenges is critical to reducing suicide risk and fostering well-being in this high-risk profession.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174251320720"},"PeriodicalIF":1.1,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optimizing the Mental and Cognitive Health of Older Adults, Physician Well-Being, and the Mental Health of Jewish Israelis in the Global Flourishing Study.","authors":"Harold G Koenig","doi":"10.1177/00912174251321156","DOIUrl":"https://doi.org/10.1177/00912174251321156","url":null,"abstract":"","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174251321156"},"PeriodicalIF":1.1,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Quetiapine combined with escitalopram in the treatment of bipolar depression along with effects on inflammation and oxidative stress.","authors":"Pingping Zhang, Jinchang Huang, Zheng Xiong, Xueqin Liu, Haiying Peng","doi":"10.1177/00912174251316653","DOIUrl":"https://doi.org/10.1177/00912174251316653","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the efficacy of escitalopram combined with quetiapine vs quetiapine alone in the treatment of depressive episodes of bipolar disorder (BPD).</p><p><strong>Methods: </strong>88 hospitalized patients with a BPD depressive episode were recruited into the study. All patients were randomized to a control group (n = 44) or the intervention group (n = 44). Members of the control group received quetiapine fumarate alone, with an initial dose 50 mg/time twice/day; the dose was increased by 50-100 mg daily until 300-600 mg/d was reached. The treatment group received quetiapine at the same doses plus escitalopram, with the initial dose of escitalopram 10 mg/d, adjusting the dose to 20 mg/d after 1 week. Both groups were treated for 8 weeks. The scores on the Hamilton Depression Scale (HAMD) and Young Mania Rating Scale (YMRS), along with levels of IL-6, IL-1β, MIF, SOD, CAT, MDA and GSH-Px, were compared between groups.</p><p><strong>Results: </strong>Among those in the intervention group, 88.6% of participants experienced a 50% or greater reduction in HAMD score compared to 70.5% in the control group (<i>P</i> < .05). Participants in the intervention group also experienced a significantly greater reduction in IL-6, IL-1β, MIF and MDA levels (<i>P</i> < .05), and a significant increase in SOD, CAT and GSH-Px levels compared to the control group (<i>P</i> < .05).</p><p><strong>Conclusion: </strong>Escitalopram oxalate combined with quetiapine is more effective than quetiapine alone in the treatment of patients with bipolar depressive episodes, which can effectively improve the symptoms of depression, inhibit the body's inflammatory response, regulate the state of oxidative stress, and does not increase the risk of mania.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174251316653"},"PeriodicalIF":1.1,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mayuresh Chaudhari, Luis Mendez, Rene L Olvera, Sudha Seshadri, Antonio L Teixeira
{"title":"Cardiovascular disease and bipolar disorder: A review of pathophysiology and treatment implications.","authors":"Mayuresh Chaudhari, Luis Mendez, Rene L Olvera, Sudha Seshadri, Antonio L Teixeira","doi":"10.1177/00912174251316947","DOIUrl":"https://doi.org/10.1177/00912174251316947","url":null,"abstract":"<p><strong>Objective: </strong>Despite the well-established increased risk of cardiovascular mortality in individuals with bipolar disorder (BD), prevention and treatment of cardiovascular risk factors and diseases have been largely overlooked in this population. This manuscript reviews the pathophysiological basis of the connection between BD and cardiovascular diseases, highlighting their shared mechanisms, reciprocal interactions, and relevant prevention and treatment strategies.</p><p><strong>Methods: </strong>For this narrative review, a search was carried out on PubMed using the keywords bipolar disorder, cardiovascular diseases, and cardiovascular risk factors.</p><p><strong>Results: </strong>The increased frequency of cardiovascular morbidity in BD can be attributed to overlapping biological and psychosocial mechanisms. These mechanisms are complex and involve both direct effects of BD and indirect effects mediated by lifestyle and pharmacological factors. Cardiovascular diseases also significantly exacerbate the clinical course of BD and increase morbidity and healthcare costs; thus, their effective management can improve psychiatric outcomes and vice versa. However, patients with BD frequently encounter healthcare barriers.</p><p><strong>Conclusion: </strong>Awareness initiatives and research on integrated care are needed to determine the best strategies for improving cardiovascular and psychiatric outcomes in individuals with BD.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174251316947"},"PeriodicalIF":1.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Religion and mental health seeking behaviors in war-tone zones of the Democratic Republic of the Congo.","authors":"Bives Mutume Nzanzu Vivalya, Martial Mumbere Vagheni, Astride Lina Piripiri, Jean-Bosco Kahindo Mbeva","doi":"10.1177/00912174251316784","DOIUrl":"https://doi.org/10.1177/00912174251316784","url":null,"abstract":"<p><strong>Objective: </strong>Although religious leaders play an important role in providing informal mental health care to individuals struggling to seek religious and spiritual care, existing studies have not explored the magnitude of psychiatric symptoms and motivators to seek mental health services from religious leaders in religious listening centers and mental hospitals. This paper presents preliminary data from a survey aimed at assessing psychiatric symptoms and factors associated with access to spiritual services among 151 individuals at a religious listening center, as well as to determine the pathways of care among 150 patients attending a mental health clinic in conflict zones of the Eastern Democratic Republic of the Congo.</p><p><strong>Method: </strong>Three hundred and one participants were screened for psychiatric symptoms and factors motivating access to religious leaders using a semi-structured questionnaire. Descriptive analyses were performed to determine information on psychiatric symptoms and factors affecting access to spiritual and mental health services.</p><p><strong>Results: </strong>Nearly 6 in 10 individuals seeking spiritual help in the religious center had psychiatric symptoms. Furthermore, 7 in 10 patients seek help for mental health needs from religious leaders and healers before seeking conventional mental health services; among such individuals, there was a high prevalence of bipolar disorder and schizophrenia spectrum disorder, recurrent admissions, and poor adherence to psychotropic medication.</p><p><strong>Conclusion: </strong>These results highlight the need for greater integration of mental health services with care provided by religious organizations within conflict zones such as the Congo. They also emphasize the need for greater promotion of person-centered care that considers and integrates patients' religious beliefs in their treatment.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174251316784"},"PeriodicalIF":1.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Randi H Libbon, Meagan Watson, Sunita Ramocan, Abbie Pennetti, Laura Strom, Zachary Giano
{"title":"Associations between violent and sexual childhood trauma and maladaptive coping in patients with functional seizures.","authors":"Randi H Libbon, Meagan Watson, Sunita Ramocan, Abbie Pennetti, Laura Strom, Zachary Giano","doi":"10.1177/00912174251314216","DOIUrl":"https://doi.org/10.1177/00912174251314216","url":null,"abstract":"<p><strong>Objective: </strong>Functional seizures (FS) are a highly debilitating symptom of functional neurological disorder (FND). FS requires a multi-disciplinary approach to treatment because the patient's initial presentation is to neurology, emergency medicine, or primary care and treatment consists of psychotherapy. People with FS commonly experience severe childhood trauma, particularly sexual trauma. The authors aimed to investigate associations between reported trauma and maladaptive coping mechanisms in the FS population.</p><p><strong>Methods: </strong>This retrospective, observational study reports on 137 patients enrolled in the FS Clinic at the University of Colorado between March 2020 - March 2021. Multiple linear regression was used to reveal associations between self-reported childhood sexual and violent trauma and maladaptive coping mechanisms of self-blame and disengagement on the Brief COPE. A quantile regression was generated for each of these outcomes.</p><p><strong>Results: </strong>Results showed that violent and sexual trauma were experienced by 47.5% and 61.6% of the population sample, respectively. Of those exposed to violent trauma, 27.2% perceived it as extremely severe while 43.4% of those exposed to sexual trauma perceived it as extremely severe. Quantile regressions for self-blame and disengagement showed significance for the 25<sup>th</sup> percentile of those who experienced violent trauma. Self-blame was significantly associated with the 50<sup>th</sup> and 75<sup>th</sup> percentile of those exposed to sexual trauma.</p><p><strong>Conclusions: </strong>This evidence supports the value of identifying trauma experienced by individuals with FS as it is associated with specific coping mechanisms that may affect treatment. Identifying prior trauma and resulting coping mechanisms can potentially assist in individualizing care for people with FS.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"912174251314216"},"PeriodicalIF":1.1,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Psychiatric problems in medical patients relevant to primary care physicians and mental health providers.","authors":"Harold G Koenig","doi":"10.1177/00912174241297503","DOIUrl":"10.1177/00912174241297503","url":null,"abstract":"","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"3-6"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdi Mahamed Muhummed, Meka Kedir Jibril, Ahmed Adem Yimam, Seid Yimam Ali
{"title":"Prevalence and correlates of post-traumatic stress disorder among internal displaced people in Qoloji Camps, Somali regional state, Eastern Ethiopia.","authors":"Abdi Mahamed Muhummed, Meka Kedir Jibril, Ahmed Adem Yimam, Seid Yimam Ali","doi":"10.1177/00912174241232001","DOIUrl":"10.1177/00912174241232001","url":null,"abstract":"<p><strong>Objectives: </strong>This study assessed the prevalence and correlates of post-traumatic stress disorder (PTSD) among internally displaced people (IDP) in the Qoloji Camp, Somali Regional State, Eastern Ethiopia.</p><p><strong>Methods: </strong>A community-based cross-sectional study was conducted from October 20 to November 5, 2021. The study utilized systematic random sampling to identify 410 IDP participants from the Qoloji Camp. PTSD was measured using the PTSD Check-list for DSM-5 (PCL-5). Bivariate analysis was performed to determine the crude odds ratio, and multivariate analysis was used to calculate adjusted odds ratios for associations between PTSD and independent variables.</p><p><strong>Results: </strong>A total of 404 participants were interviewed (98.5% response rate). The estimated prevalence of PTSD symptoms was 41.1%. In the multivariate logistic regression analysis, several factors were significantly associated with PTSD: being female (AOR = 2.5, 95% CI = 1.39-4.44), lack of food and water (AOR = 2.2, 95% CI = 1.17, 4.23), destruction of personal property (AOR = 3.1, 95% CI = 1.62-6.09), and experiencing torture or beatings (AOR = 1.8, 95% CI = 1.01-3.28).</p><p><strong>Conclusion: </strong>This study found a high prevalence of PTSD symptoms among IDPs, with factors such as female sex, property destruction, deprivation of essential goods and services, and experiences of torture or beatings significantly associated with those symptoms. To address these findings, prioritizing the well-being of IDPs with a specific focus on women, on-site screening, and the establishment of a referral system to facilitate access to specialized care are essential to enhance the overall mental health of such persons.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"17-32"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139730898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}