ISME Journal最新文献

{"title":"Ruminosignatures associated with methane emissions and feed efficiency across geographies and cattle breeds.","authors":"Ioanna-Theoni Vourlaki, Ori Furman, Ilma Tapio, Le Luo Guan, Sinéad M Waters, David Kenny, Paul Smith, Stuart F Kirwan, David Kelly, Ross Evans, Raquel Quintanilla, Miriam Piles, Antonio Reverter, Pâmela A Alexandre, Fuyong Li, Philip C Garnsworthy, Paolo Bani, Phillip B Pope, Diego P Morgavi, Itzhak Mizrahi, Yuliaxis Ramayo-Caldas","doi":"10.1093/ismejo/wrag185","DOIUrl":"10.1093/ismejo/wrag185","url":null,"abstract":"<p><p>The cattle rumen microbiota represents a complex and dynamic ecosystem whose organization and relationship to host phenotypes are important for food security and environmental sustainability. We analyzed rumen microbiota profiles from 2496 cattle representing five breeds and production systems across five countries, identifying microbial co-abundance groups termed Ruminosignatures. We detected 14 distinct Ruminosignatures, including 2 observed across all populations dominated by Prevotella and UBA2810. Additional Ruminosignatures showed breed- and diet-specific patterns and collectively explained 96%-99% of variance in rumen microbial composition. Integrative cross-country analysis confirmed 10 out of 14 Ruminosignatures identified in cohort-specific analyses. Several Ruminosignatures were associated with methane emissions and feed efficiency traits and were partially under host genetic control, with heritability estimates ranging from 0.09 to 0.58. Structural equation modeling revealed consistent negative genetic and phenotypic correlations between the UBA2810-dominated Ruminosignature (RS_UBA2) and methane emissions across cohorts (rg = -0.40 to -0.65), with structural coefficients concordant in sign across all populations, supporting the expected direction of phenotypic response to selection on RS_UBA2. Meta-analysis confirmed positive associations of RS_UBA2 with average daily gain and negative associations with methane-related traits and feed conversion ratio. Functional genome-based predictions suggested RS_UBA2 may reduce methanogenesis through alternative hydrogen utilization pathways competing with methanogenic archaea. Production system type influenced both Ruminosignature occurrence and relationships with host phenotypes, emphasizing the relevance of context-specific strategies for microbiome modulation. Our findings highlight the potential of the Ruminosignatures framework for microbiome-informed breeding programs aimed at improving feed efficiency while reducing the environmental impact of cattle production.</p>","PeriodicalId":50271,"journal":{"name":"ISME Journal","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13573583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148425956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterologous expression in E. coli reveals that bicarbonate transporter BicA2 mediates carbon uptake in marine Prochlorococcus spp.","authors":"Loraine M Rourke, Caitlin S Byrt, G Dean Price, Benedict M Long","doi":"10.1093/ismejo/wrag222","DOIUrl":"10.1093/ismejo/wrag222","url":null,"abstract":"<p><p>The widespread oceanic cyanobacterial Prochlorococcus genus is a major contributor to global carbon fixation, yet mechanisms enabling this lineage to elevate intracellular inorganic carbon as a substrate for photosynthesis remain unresolved. Cyanobacterial CO2-concentrating mechanisms typically rely on membrane-bound bicarbonate (HCO3-) transporters SbtA1, SbtA2, BicA and BCT1, and CO2-to-HCO3- conversion uptake systems (CO2 pumps; NDH-I3 and NDH-I4), to elevate a cellular HCO3- pool for use by Rubisco-containing carboxysomes. Evidence suggests Prochlorococcus harbours carboxysomes with a low-CO2-specificity Rubisco, implying a functional CCM dependent on active HCO3- uptake. However, canonical CO2 pumps are absent, leaving distant HCO3- transporter homologues, BicA2 and SbtA2, as prime candidates for HCO3- transport in this group. Yet these have not been functionally characterized. Here we demonstrate that BicA2 from P. marinus CCMP1375 mediates Na+-dependent HCO3- uptake in Escherichia coli, whereas BicA2 from P. marinus CCMP1986 is inactive in its native form but acquired transport function through a single amino acid substitution during adaptive laboratory evolution. These findings confirm BicA2 as a low-affinity, Na+-dependent bicarbonate transporter with variable flux, revealing a previously uncharacterized CCM component in Prochlorococcus. This mechanistic insight reshapes our understanding of carbon acquisition strategies in the most abundant photosynthetic organism on Earth and highlights evolutionary plasticity in transporter function with implications for global biogeochemical cycles.</p>","PeriodicalId":50271,"journal":{"name":"ISME Journal","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13588710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration and regulation of stolen organelles in a marine protist.","authors":"Julian M Jacobs, Zachary L Reitz, Erica Lasek-Nesselquist, Amelie L'Etoile-Goga, Brittany N Sprecher, Matthew D Johnson, Holly V Moeller","doi":"10.1093/ismejo/wrag204","DOIUrl":"10.1093/ismejo/wrag204","url":null,"abstract":"<p><p>Chloroplast-stealing (a.k.a., \"kleptoplastidic\") plankton transiently obtain and integrate prey metabolic machinery into their own cells. To do so, they must address a series of challenges, including physical localization of acquired machinery, metabolic integration of organelles and their products, and maintenance of machinery. Here, we study this transient integration in the marine ciliate Mesodinium chamaeleon by pulse feeding the ciliate with cryptophyte algal prey (Storeatula major) and then tracking changes in ciliate cellular ultrastructure, physiology (growth and photosynthesis), and gene expression over time. We demonstrate a predictable series of changes, from the reconfiguration of metabolic activity fueled by recent ingestion, to a period of rapid growth, to a reduction in physiological performance as prey organelle number and functionality become limiting. Because M. chamaeleon also steals transcriptionally active prey nuclei, gene expression is a complex milieu of host and cryptophyte expression, with much of prey metabolism apparently intact in the new host, albeit at low levels. Collectively, our results highlight the holistic orchestration of stolen organelles to produce rapid-yet transient-growth in a new host.</p>","PeriodicalId":50271,"journal":{"name":"ISME Journal","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13592161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue-specific experimental evolution reveals adaptive trade-offs in the plant vascular pathogen Clavibacter michiganensis.","authors":"Raj Kumar Verma, Veronica Roman-Reyna, Nathan Benmoche, Evanson Ngugi, Eduard Belausov, Noa Sela, Maya Bar, Jonathan M Jacobs, Doron Teper","doi":"10.1093/ismejo/wrag110","DOIUrl":"10.1093/ismejo/wrag110","url":null,"abstract":"<p><p>The plant pathogenic bacterium Clavibacter michiganensis (Cm) is a systemic vascular pathogen that colonizes both xylem vessels and the intracellular apoplast during different stages of infection. To identify traits and loci associated with adaptation to these distinct host microenvironments, we conducted tissue-specific experimental evolution. Twenty independent Cm lineages were repeatedly passaged in either tomato stems or leaves to promote adaptation to vascular or apoplastic lifestyles, respectively. After fifteen passages, adapted clones were characterized for virulence and virulence-related traits. These characterizations demonstrated clear differential associations of virulence-associated traits with the adapted tissue. The majority of vascular-adapted clones displayed enhanced surface attachment, reduced cellulase activity, reduced exopolysaccharide (EPS) production, and attenuated virulence on tomato compared to the parent clone. In contrast, apoplast-adapted clones displayed reduced biofilm formation and enhanced EPS production and retained their virulence on tomato. Whole-genome sequencing of all adapted clones revealed candidate loci linked to tissue adaptation. Six of ten vascular-adapted clones carried two independent mutations in CMM_1284, a putative HipB/XRE-type transcriptional regulator. A CMM_1284 marker exchange mutant displayed phenotypes similar to vascular-adapted clones, suggesting a role for this regulator in vascular colonization. Together, these findings highlight the role of phenotypic plasticity in tissue adaptation of plant pathogens, showing that tissue-specific adaptation involves modulation of surface attachment, EPS production, and cell wall-degrading enzymes and suggest a trade-off between vascular persistence, supported by strong surface attachment, and systemic virulence, which depends on bacterial dispersal and migration.</p>","PeriodicalId":50271,"journal":{"name":"ISME Journal","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13298646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Olsenella scatoligenes-derived skatole promotes smooth muscle cell proliferation and migration to aggravate atherosclerosis.","authors":"","doi":"10.1093/ismejo/wrag240","DOIUrl":"10.1093/ismejo/wrag240","url":null,"abstract":"","PeriodicalId":50271,"journal":{"name":"ISME Journal","volume":"20 1","pages":""},"PeriodicalIF":10.2,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149185639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of maternal, infant, and household factors on early-life gut microbiome development in a rural setting.","authors":"Mona Parizadeh, Isabelle Laforest-Lapointe, Angélica Serrano-Vázquez, Patricia Morán-Silva, Liliana Rojas-Velázquez, Javier Torres, Cecilia Ximénez-García, Marie-Claire Arrieta","doi":"10.1093/ismejo/wrag124","DOIUrl":"10.1093/ismejo/wrag124","url":null,"abstract":"<p><p>Early-life gut microbiome development is influenced by host, microbial, environmental, and social factors. Rural infants typically exhibit greater microbial diversity than their urban counterparts, yet microbiome maturation patterns in less industrialized settings remain underexplored. Additionally, though microbial eukaryotes are integral to gut ecology, most studies to date have focused predominantly on bacterial communities. Using shallow shotgun metagenomics and 18S ribosomal RNA gene sequencing, we characterized bacterial and eukaryotic gut microbiomes in an intensively sampled longitudinal cohort of 10 infants from a rural community in Morelos, Mexico, each followed monthly from the first to the 18th month, providing a detailed view of early-life microbiome development in a low-resource setting. Although both bacterial and eukaryotic alpha diversity increased over time, they showed distinct colonization trajectories. Age, delivery mode, and environmental exposures, such as animal contact and household factors, influenced bacterial and eukaryotic community compositions, and bacterial metabolic composition. Inter-kingdom microbial networks varied with age, with a reduction in taxonomic diversity after the first year of life. Age and birth mode also influenced changes in the overall community structure and connectivity of microbial co-occurrence patterns, but did not impact the associations among specific microbial taxa. Functional profiling revealed that bacterial metabolic potential diversified with age, whereas the mode of birth had a minimal impact on functional variation. These findings highlight the dynamic nature of bacterial and eukaryotic microbiota in early life and underscore the need to explore how rural environmental exposures shape microbial maturation, with potential implications for immune development and long-term health.</p>","PeriodicalId":50271,"journal":{"name":"ISME Journal","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13317942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147935101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predator avoidance promotes interbacterial symbiosis with myxobacteria in polymicrobial communities.","authors":"Shailaja Khanal Pokharel, Sheila Walsh, Nawal Shehata, Andrew Ahearne, Daniel Belin, Britney Larson, Benjamin Tabor, Daniel Wall, David Cole Stevens","doi":"10.1093/ismejo/wrag140","DOIUrl":"10.1093/ismejo/wrag140","url":null,"abstract":"<p><p>Myxobacteria are predatory soil bacteria with the largest known bacterial genomes, rich in biosynthetic gene clusters for specialized metabolites. Despite their ecological importance as potential keystone taxa in soil food webs, there is a disconnect between laboratory-isolated myxobacteria and abundant Myxococcota detected in environmental metagenomic studies. Here, we report the isolation and characterization of stable myxobacterial swarm consortia from rhizospheric soil, consisting of myxobacteria associated with novel Microvirga species. Using metagenomic sequencing, we assembled metagenome-assembled genomes for four consortia, revealing phylogenetically distinct yet stably associated bacterial partnerships. Comparative genomics identified evidence of horizontal gene transfer, including acyl-homoserine lactone synthases and ankyrin repeat (ANKYR) proteins shared between consortium members, and genome-scale metabolic modeling predicted complementary auxotrophies. Time-lapse microscopy revealed that Archangium exhibited reduced predation toward its Microvirga companion (0.7% predation rate) compared to nonsymbiotic Myxococcus xanthus (14.9% predation rate) but maintained robust predatory capacity against Escherichia coli prey. These findings indicate that predation avoidance and metabolic complementarity can drive stable interbacterial symbiosis in predatory myxobacterial communities, providing foundational insights into previously overlooked myxobacterial partnerships that may be prevalent in natural soil ecosystems.</p>","PeriodicalId":50271,"journal":{"name":"ISME Journal","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13293253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148139701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary niches drive microbial community assembly, network reorganization, and symbiont evolution in freshwater fish gut microbiomes.","authors":"Hongye Shen, Jinhui Song, Jinshan Li, Yongmei Hu, Nan Peng, Shumiao Zhao","doi":"10.1093/ismejo/wrag125","DOIUrl":"10.1093/ismejo/wrag125","url":null,"abstract":"<p><p>Host diet is a fundamental ecological factor shaping the assembly and evolution of host-associated microbiomes, yet how dietary niches influence the structure of microbial associations and functional adaptation in freshwater fish remains poorly understood. This study selected five dominant farmed freshwater fish species in China with distinct feeding habits (herbivory, omnivory, filter-feeding, and carnivory) and systematically investigated the adaptive mechanisms of their gut microbiomes by integrating metagenomics, targeted cultivation, comparative genomics, and in vitro assays. We show that dietary niches exert a strong deterministic effect on microbial community assembly, leading to pronounced differences in ecological network topology, including connectivity, modularity, and keystone taxa. Cetobacterium was detected in all five fish species but exhibited a higher relative abundance in omnivorous (16.0%) compared to carnivorous fish (5.4%), suggesting that it may be a core genus within the gut microbiota of freshwater fish. Comparative genomics further revealed that Cetobacterium symbionts exhibit streamlined genome architectures and conserved core metabolic functions, indicative of adaptive evolution toward stable host-associated lifestyles. Guided by metagenomic insights, we isolated multiple Cetobacterium strains displaying host-adapted functional traits, linking community-level ecological patterns to cultivable symbiont resources. In summary, our findings demonstrate that freshwater fish guts function as ecological niches that deterministically structure microbial community assembly and drive symbiont evolution, providing a conceptual framework for understanding host-microbiome co-adaptation in aquatic ecosystems.</p>","PeriodicalId":50271,"journal":{"name":"ISME Journal","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13249080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147949841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early transcription factor activation distinguishes symbiotic from non-symbiotic bacteria during microbiome processing in a sponge.","authors":"Bin Yang, Benedict Yuen-Simović, Huifang Yuan, Bernard M Degnan, Sandie M Degnan","doi":"10.1093/ismejo/wrag150","DOIUrl":"10.1093/ismejo/wrag150","url":null,"abstract":"<p><p>Animals that filter-feed on environmental microbes must rapidly discriminate among captured bacteria to maintain beneficial associations while avoiding inappropriate immune activation. In innate immunity, this discrimination is executed through transcription factors (TFs), whose activation and nuclear translocation initiate effector gene expression and shape the nature of the host response. In sponges, bacteria are first physically captured by choanocytes, but the timing and cellular context in which TF-mediated immune discrimination becomes evident remain unclear. Here, we investigate the earliest detectable regulatory responses associated with discrimination between symbiotic and non-symbiotic bacteria in the marine sponge Amphimedon queenslandica. Using a feeding-based design to model post-metamorphic microbiome restructuring, we exposed juvenile sponges that already harbour vertically inherited symbionts to native (symbiont) or foreign (non-symbiont) bacterial communities and assessed early cellular processing and transcriptional responses to bacterial uptake. Symbiotic bacteria were rapidly transported across the epithelium and induced a strong, transient activation of conserved innate immune TFs, including interferon regulatory factor (IRF), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and signal transducer and activator of transcription, together with associated signalling pathways. IRF and NF-κB translocated to the nuclei of amoebocytes that had engulfed symbionts, indicating that discrimination becomes evident shortly after uptake and precedes downstream effector responses. In contrast, foreign bacteria were internalized more slowly, failed to induce coordinated immune TF activation or nuclear translocation, and instead elicited a xenobiotic-dominated transcriptional program. Together, these findings identify TF activation as an early regulatory checkpoint in sponge-microbe interactions and reveal key mechanisms that underpin the initial stages of symbiont discrimination.</p>","PeriodicalId":50271,"journal":{"name":"ISME Journal","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13372038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148220503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxylipin-mediated metabolic signatures of symbiosis homeostasis and thermal stress in a model sea anemone.","authors":"Marina T Botana, Robert E Lewis, Kevin Mitchell, Olivier Salamin, Johanna Revol-Cavalier, Evan Heit, Andrea Gamba, Shaun P Wilkinson, Sabrina L Rosset, Clinton A Oakley, Matthew R Nitschke, Mats Hamberg, Arthur R Grossman, David J Suggett, Virginia M Weis, Craig E Wheelock, Simon K Davy","doi":"10.1093/ismejo/wrag143","DOIUrl":"10.1093/ismejo/wrag143","url":null,"abstract":"<p><p>Oxylipins are oxygenated products of fatty acids proposed to exert a regulatory role in cnidarian-dinoflagellate symbiosis; however, this has not been investigated in detail. We integrated physiological measurements and molecular phenotyping with comparative transcriptome mining to examine how the symbiotic cnidarian model, the sea anemone Aiptasia (i.e. Exaiptasia diaphana), and its dinoflagellate symbiont Breviolum minutum respond to symbiosis and thermal stress. We performed lipidomics in combination with the quantification of oxylipins, including octadecanoids, eicosanoids, and docosanoids derived from C18, C20, and C22 fatty acids, respectively, and reconstructed their putative biosynthetic routes through cross-phylogenetic protein sequence homology. Relative to aposymbiotic, symbiotic anemones were enriched with omega-3 fatty acids and downstream octadecanoids of symbiont origin, consistent with inter-partner metabolite flux. Cytochrome P450-derived eicosanoids and docosanoids increased up to 300-fold in symbiotic versus aposymbiotic anemones. Under elevated temperature, anemones showed minor changes in their physiology and lipid profiles; however, the symbiont fraction displayed multiple signatures of stress. In comparison, aposymbiotic anemones showed a 50% reduction in protein abundance as well as structural and storage lipids, while simultaneously accumulating oxylipins linked to inflammation and oxidative stress. Our findings report novel oxylipins that have not been previously observed in dinoflagellates. We identified regulatory pathways that are conserved across cnidarians and higher metazoans, advancing our understanding of cnidarian-dinoflagellate symbiosis and its response to warming climate. We are targeting specific oxylipins and signalling pathways for further research that may aid molecular intervention strategies for selective breeding and assisted evolution to enhance coral resilience in warming oceans.</p>","PeriodicalId":50271,"journal":{"name":"ISME Journal","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13440314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148200776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}