Journal of Clinical Hypertension最新文献_第2页

Temporal Patterns in Blood Pressure Management Before and After Recent Clinical Trials and Guideline Recommendations

IF 2.7 3区医学

Journal of Clinical Hypertension Pub Date : 2025-03-18 DOI: 10.1111/jch.70030

Eric J. Brandt, Craig J. Beavers, Zhuxuan Fu, Erica S. Spatz, Philip G. Jones, Suzanne V. Arnold, Nihar R. Desai

引用次数: 0

Cluster-Based Analysis of Lipid Profiles and Inflammation in Association With Cardiovascular Disease Incidence and Mortality: A 17.5-Year Longitudinal Study

IF 2.7 3区医学

Journal of Clinical Hypertension Pub Date : 2025-03-18 DOI: 10.1111/jch.70035

A-Ra Cho, Seok-Jae Heo, Taehwa Han, Yu-Jin Kwon

{"title":"Cluster-Based Analysis of Lipid Profiles and Inflammation in Association With Cardiovascular Disease Incidence and Mortality: A 17.5-Year Longitudinal Study","authors":"A-Ra Cho, Seok-Jae Heo, Taehwa Han, Yu-Jin Kwon","doi":"10.1111/jch.70035","DOIUrl":"https://doi.org/10.1111/jch.70035","url":null,"abstract":"Cardiovascular mortality is a leading cause of global deaths, with aging, dyslipidemia, and inflammation recognized as key risk factors. This study aimed to identify distinct cardiovascular risk profiles using cluster analysis based on lipid profiles and inflammatory markers in a large cohort of middle-aged Korean adults. Our analysis included 8115 participants without cardiovascular disease (CVD) at baseline from the Korean Genome and Epidemiology Study. We applied the K-means clustering algorithm to conduct a cluster analysis of six normalized variables: age, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), non-HDL-C, and CRP. Multivariable Cox proportional-hazard regression analysis was performed to assess the hazard ratio with 95% confidence interval for CVD incidence, CVD mortality, major adverse cardiac event (MACE) mortality, and all-cause mortality. Four clusters were identified based on age, lipids (TC, TG, HDL-C, non-HDL-C), and CRP. Cluster 1 (older age, high CRP) and cluster 2 (high TC, non-HDL-C, insulin resistance) had the highest risks for new-onset CVD, while cluster 1 had the highest risks for all-cause and cardiovascular mortality. Cluster 3 (high HDL-C) showed a lower CVD risk, while cluster 4 (younger age, favorable lipid profile) had the lowest risk across all outcomes. This study highlighted the combined impact of aging, dyslipidemia, and inflammation on CVD risk. The clusters with older age and high inflammation or dyslipidemia had the highest cardiovascular risks, emphasizing the importance of managing these factors in high-risk populations.","PeriodicalId":50237,"journal":{"name":"Journal of Clinical Hypertension","volume":"27 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jch.70035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Abdominal Obesity, Body Mass Index, and Hypertension in India: Evidence From a Large Nationally Representative Data

IF 2.7 3区医学

Journal of Clinical Hypertension Pub Date : 2025-03-18 DOI: 10.1111/jch.70034

Rajat Das Gupta, Mohammad Rifat Haider, Simanta Roy, Mohammad Rashidul Hashan, Amrit Baral, Nowrin Tamanna, Ananna Mazumder, Shams Shabab Haider, Biplab Datta

{"title":"Association Between Abdominal Obesity, Body Mass Index, and Hypertension in India: Evidence From a Large Nationally Representative Data","authors":"Rajat Das Gupta, Mohammad Rifat Haider, Simanta Roy, Mohammad Rashidul Hashan, Amrit Baral, Nowrin Tamanna, Ananna Mazumder, Shams Shabab Haider, Biplab Datta","doi":"10.1111/jch.70034","DOIUrl":"https://doi.org/10.1111/jch.70034","url":null,"abstract":"Hypertension prevalence is rising among individuals with abdominal obesity in Southeast Asia, including India, but the relationship between abdominal obesity, body mass index (BMI), and hypertension remains underexplored. This study examines the association between these factors in a nationally representative Indian population aged 20–54 years (males: N = 78 832; females: N = 559 059). We analyzed data from the National Family Health Survey 2019–21 (NFHS-5). Hypertension was defined as a systolic blood pressure (SBP) ≥ 140 mm Hg, diastolic blood pressure (DBP) ≥ 90 mm Hg, or use of blood pressure-lowering medication. Abdominal obesity was defined by waist–hip ratio (>0.90 for men, >0.85 for women). BMI categories were underweight (<18.5 kg/m2), normal (18.5–<25.0 kg/m2), overweight (25.0–<30.0 kg/m2), and obese (≥30.0 kg/m2). Multivariable logistic regression adjusted for demographic and lifestyle factors was used to assess the link between BMI, abdominal obesity, and hypertension. Individuals with both obesity and abdominal obesity had significantly higher odds of hypertension, with males having 3.3 times (95% confidence interval [CI]: 2.9–3.7) and females 2.8 times (95% CI: 2.6–2.9) odds compared to those with normal BMI and no abdominal obesity. Both genders showed increased SBP and DBP by 3.0–5.0 mm Hg when abdominal obesity was present, regardless of BMI. Indian health programs should emphasize the risks of high BMI and abdominal obesity to reduce hypertension.","PeriodicalId":50237,"journal":{"name":"Journal of Clinical Hypertension","volume":"27 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jch.70034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research on Prediction model of Carotid-Femoral Pulse Wave Velocity: Based on Machine Learning Algorithm

IF 2.7 3区医学

Journal of Clinical Hypertension Pub Date : 2025-03-18 DOI: 10.1111/jch.70017

Minghui Chen, Jing Xiong, Moran Li, Tao Hu, Yi Zhang

{"title":"Research on Prediction model of Carotid-Femoral Pulse Wave Velocity: Based on Machine Learning Algorithm","authors":"Minghui Chen, Jing Xiong, Moran Li, Tao Hu, Yi Zhang","doi":"10.1111/jch.70017","DOIUrl":"https://doi.org/10.1111/jch.70017","url":null,"abstract":"Carotid-femoral pulse wave velocity (cf-PWV) is an important but difficult to obtain measure of arterial stiffness and an independent predictor of cardiovascular events and all-cause mortality. The objective of this study was to develop a predictive model for cf-PWV based on brachial-ankle pulse wave velocity (baPWV) and other the accessible clinical parameters.This model aims to allow patients to estimate their cf-PWV in advance without the need for direct measurement. We selected participants of the Northern Shanghai community from 2013 to 2022 as the study object. The Pearson correlation coefficient was employed for correlation analysis in feature selection. The linear regression models demonstrated low root mean square error (RMSE), error term (ε), and R2 values, indicating good predictive performance. A Cox proportional hazards model revealed a significant association between machine learning-predicted cf-PWV and mortality risk, supporting the validity of prediction model. Using a threshold of cf-PWV greater than 10 m/s as the criterion, a classification prediction model was developed. Shapley Additive Explanations (SHAP) analysis was then applied to the Gradient Boosting model to elucidate the predictive mechanism of the optimal model. Without precise instruments, doctors often cannot determine a patient's cf-PWV. When the cf-PWV value predicted by the machine learning algorithm is high, patients can be recommended for more precise measurements to confirm the prediction and emphasize the importance of follow-up health management and psychological support. It is feasible to use a machine learning algorithm based on baPWV and other readily available clinical parameters to predict cf-PWV.","PeriodicalId":50237,"journal":{"name":"Journal of Clinical Hypertension","volume":"27 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jch.70017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Weight-Adjusted Waist Index May Predict Hypertension Plus Hyperuricemia

IF 2.7 3区医学

Journal of Clinical Hypertension Pub Date : 2025-03-18 DOI: 10.1111/jch.70022

Huanhuan Miao, Zhanyang Zhou, Zheng Yin, Xue Li, Yuhui Zhang, Yuqing Zhang, Jian Zhang

{"title":"Weight-Adjusted Waist Index May Predict Hypertension Plus Hyperuricemia","authors":"Huanhuan Miao, Zhanyang Zhou, Zheng Yin, Xue Li, Yuhui Zhang, Yuqing Zhang, Jian Zhang","doi":"10.1111/jch.70022","DOIUrl":"https://doi.org/10.1111/jch.70022","url":null,"abstract":"The weight-adjusted waist index (WWI) is a novel indicator that could estimate body fat and muscle mass. This study aimed to investigate the relationship between WWI and hypertension plus hyperuricemia (HTN-HUA). The data were obtained from the National Health and Nutrition Examination Survey (NHANES) database from 1999 to 2018. Logistic regression analyses were used to explore the association between WWI with HTN-HUA, hypertension (HTN) alone, and hyperuricemia (HUA) alone. Restricted cubic spline (RCS) analyses were employed to examine potential nonlinear associations. Receiver operating characteristic (ROC) curves were utilized to assess the predictive ability of WWI. A total of 16 294 participants were included, among whom 2280 (12%) were diagnosed with HTN-HUA, 5148 (28%) with HTN alone, and 1252 (9%) with HUA alone. WWI was significantly associated with HTN-HUA, HTN alone, and HUA alone after adjusting for potential confounders. Compared to the lowest quartiles of WWI, the odds ratios of the highest quartiles were 2.13 (95% confidence interval [CI]: 1.59–2.83) for HTN-HUA, 1.28 (95% CI: 1.08–1.5) for HTN alone, and 1.6 (95% CI: 1.18–2.16) for HUA alone. RCS analyses demonstrated a nonlinear association between WWI and HTN-HUA. The fully adjusted model, which included WWI, exhibited a moderate predictive ability for HTN-HUA (area under the curve [AUC]: 0.804, 95% CI 0.796–0.813). The association between WWI and HTN-HUA was more prominent among young individuals and those with normal weight. The study suggested that a significant and nonlinear association between WWI and HTN-HUA. WWI had the potential to facilitate the early detection of HTN-HUA.","PeriodicalId":50237,"journal":{"name":"Journal of Clinical Hypertension","volume":"27 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jch.70022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Age on Aldosterone–Renin Ratio in Screening Primary Aldosteronism 在筛查原发性醛固酮增多症时，年龄对醛固酮-肾素比率的影响

IF 2.7 3区医学

Journal of Clinical Hypertension Pub Date : 2025-03-11 DOI: 10.1111/jch.70014

Ning Peng, Zhen Zhang, Yao Xiao, Qianwen Ye, Geru Liu, Mengling Zhen, Yanqing Zheng, Min Luo, Tiejian Jiang

{"title":"Effect of Age on Aldosterone–Renin Ratio in Screening Primary Aldosteronism","authors":"Ning Peng, Zhen Zhang, Yao Xiao, Qianwen Ye, Geru Liu, Mengling Zhen, Yanqing Zheng, Min Luo, Tiejian Jiang","doi":"10.1111/jch.70014","DOIUrl":"https://doi.org/10.1111/jch.70014","url":null,"abstract":"Primary aldosteronism (PA) is the most common endocrine cause of hypertension. The plasma aldosterone-to-renin ratio (ARR) is the most recommended screening tool for PA, but previous studies showed controversy regarding the influence of age on ARR. The aim of the study was to evaluate the impact of age on ARR measured using direct renin concentration (DRC) and its diagnostic value in patients with PA. We retrospectively collected patients with hypertension who attended Xiangya Hospital for PA screening using plasma aldosterone concentration (PAC)/DRC from January 1, 2017 to November 1, 2023. The patients were divided into the groups of PA and essential hypertension (EH) by confirmatory tests. We performed separate correlation analyses of age and DRC, PAC, and ARR, the patients were then further subdivided into four age groups: < 40, 40–49, 50–59, and ≥ 60 years old. Receiver operating characteristic curve and area under the curve (AUC) were used to determine age-specific ARR cutoff values for screening PA. We screened a total of 478 patients, comprising 255 diagnosed with PA (53.35%) and 176 with EH (36.82%). In patients with EH, PAC and DRC decreased with increasing age (p < 0.001, r = –0.34; p < 0.001, r = –0.28), whereas ARR increased with age (p = 0.002, r = 0.22). However, in patients with PA, DRC, PAC, and ARR did not show significant association with age (p = 0.40, 0.54, 0.33). The cutoff values of ARR for screening PA in four groups were 17.49, 20.79, 21.01, and 18.22. The optimal ARR cutoff was 22.52 in the all-ages, with an AUC of 0.948 (95% CI: 0.929, 0.966), sensitivity of 89.4%, and specificity of 85.2%. There was no significant correlation between age and DRC or PAC in patients with PA. Compared to the consensus-recommended cutoff of 37 (pg / mL)/(μIU/mL), a lower ARR cutoff may be more appropriate for screening PA.","PeriodicalId":50237,"journal":{"name":"Journal of Clinical Hypertension","volume":"27 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jch.70014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug-Related Hypertension: A Disproportionality Analysis Leveraging the FDA Adverse Event Reporting System

IF 2.7 3区医学

Journal of Clinical Hypertension Pub Date : 2025-03-11 DOI: 10.1111/jch.70029

Hao Zhu, Linwei Pan, Hannah Lui, Jing Zhang

{"title":"Drug-Related Hypertension: A Disproportionality Analysis Leveraging the FDA Adverse Event Reporting System","authors":"Hao Zhu, Linwei Pan, Hannah Lui, Jing Zhang","doi":"10.1111/jch.70029","DOIUrl":"https://doi.org/10.1111/jch.70029","url":null,"abstract":"Hypertension exerts a significant global disease burden, adversely affecting the well-being of billions. Alarmingly, drug-related hypertension remains an area that has not been comprehensively investigated. Therefore, this study is designed to utilize the adverse event reports (AERs) from the US Food and Drug Administration's Adverse Event Reporting System (FAERS) to more comprehensively identify drugs that may potentially lead to hypertension. Specifically, a total of 207 233 AERs were extracted from FAERS, spanning the time period from 2004 to 2024. Based on these reports, this study presented the top 40 drugs most frequently reported to be associated with post-administration hypertension in different genders. Furthermore, we employed four disproportionality analysis methods, including Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), and Empirical Bayes Geometric Mean (EBGM), to pinpoint the top three drugs with strongest signals in relation to hypertension across different age and gender subgroups. Some drugs, such as rofecoxib, lenvatinib, and celecoxib, were found to appear on both the frequency and signal strength lists. These results contribute to a more comprehensive understanding of the cardiovascular safety profiles of pharmacological agents, suggesting the necessity of blood pressure monitoring following administration.","PeriodicalId":50237,"journal":{"name":"Journal of Clinical Hypertension","volume":"27 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jch.70029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aldosterone-to-Renin Ratio Changes in Patients With Renal Artery Stenosis and Aldosteronism

IF 2.7 3区医学

Journal of Clinical Hypertension Pub Date : 2025-03-11 DOI: 10.1111/jch.70031

Qian Wang, Hui Dong, Hongwu Li, Yujie Zuo, Yubao Zou, Xiongjing Jiang

{"title":"Aldosterone-to-Renin Ratio Changes in Patients With Renal Artery Stenosis and Aldosteronism","authors":"Qian Wang, Hui Dong, Hongwu Li, Yujie Zuo, Yubao Zou, Xiongjing Jiang","doi":"10.1111/jch.70031","DOIUrl":"https://doi.org/10.1111/jch.70031","url":null,"abstract":"We conducted a retrospective cohort study to investigate changes in the aldosterone-to-renin ratio (ARR) and other influencing factors in patients with renal artery stenosis (RAS) and primary aldosteronism (PA). Patients with RAS and PA admitted to our hospital between January 2016 and December 2021 were retrospectively selected. Based on the standardized PA screening results, the patients were divided into aldosterone-to-renin ratio-positive and -negative groups. The clinical features of the patients were compared. Binary logistic regression analysis was performed to identify the factors contributing to the comorbidity of RAS with false-negative PA. A total of 78 patients (mean age: 60.2 ± 10.2 years) were selected, among whom 46 (59%) were male. Overall, 69 patients had Stage 3 hypertension (88.5%) and 57 had hypokalemia (73.1%). Additionally, 42 (53.8%) and 36 (46.2%) patients were aldosterone-to-renin ratio-positive and -negative, respectively. The aldosterone-to-renin ratio-positive group showed significant differences in malignant hypertension (2.4% vs. 27.8%; p = 0.002), Stage 3 hypertension (81.0% vs. 97.2%; p = 0.033), and RAS degree (64.3 ± 16.4% vs. 71.8 ± 14.4%; p = 0.032). Malignant hypertension (odds ratio, 15.250; 95% confidence interval, 1.787–130.132; p = 0.013) and RAS degree (odds ratio, 1.034; 95% confidence interval, 1.002–1.068; p = 0.036) influenced the comorbidity of RAS with false-negative PA. Malignant hypertension and severe RAS can contribute to false-negative PA results. Therefore, PA screening test results should be carefully analyzed and rechecked following RAS treatment to confirm the presence of PA.","PeriodicalId":50237,"journal":{"name":"Journal of Clinical Hypertension","volume":"27 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jch.70031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Undiagnosed Hypertension in Bangladesh: A Systematic Review and Meta-Analysis

IF 2.7 3区医学

Journal of Clinical Hypertension Pub Date : 2025-03-06 DOI: 10.1111/jch.70026

Nourin Sultana, Zeba Afia, Shamsuz Zoha, Md. Parvez Mosharaf, Md. Golam Hossain, Md. Kaderi Kibria

{"title":"Prevalence of Undiagnosed Hypertension in Bangladesh: A Systematic Review and Meta-Analysis","authors":"Nourin Sultana, Zeba Afia, Shamsuz Zoha, Md. Parvez Mosharaf, Md. Golam Hossain, Md. Kaderi Kibria","doi":"10.1111/jch.70026","DOIUrl":"https://doi.org/10.1111/jch.70026","url":null,"abstract":"Undiagnosed hypertension (UHTN) remains a significant public health concern in Bangladesh, leading to severe complications due to delayed diagnosis and management. This systematic review and meta-analysis examined the prevalence of UHTN among adults aged 18 years and older, using data from studies conducted in Bangladesh and published between 2010 and 2024. A comprehensive search of major databases yielded 1028 records, from which nine relevant studies, encompassing a total of 28949 participants, were selected and evaluated for quality using the Newcastle–Ottawa Scale, providing valuable insights into the prevalence of UHTN within the Bangladeshi population. The pooled prevalence of UHTN was 11% (95% CI: 6%–19%) based on a random-effects model, with substantial heterogeneity (I2 = 99.5%, p < 0.0001). Subgroup analyses revealed higher prevalence in rural areas (13%; 95% CI: 4%–35%) compared to urban areas (12%; 95% CI: 1%–54%) and elevated occupational risk among bankers (17%; 95% CI: 0%–94%). While funnel plot asymmetry was noted, Egger's test (p = 0.3113) indicated no significant publication bias. Sensitivity analyses, including Leave-One-Out Analysis, affirmed the robustness of the pooled estimate. The findings underscore notable geographic, occupational, and sociodemographic disparities in UHTN prevalence, highlighting the need for nationwide screening programs and targeted community awareness campaigns, particularly in underserved rural areas. Further research is imperative to explore causal factors and inform effective prevention and management strategies.","PeriodicalId":50237,"journal":{"name":"Journal of Clinical Hypertension","volume":"27 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jch.70026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sarcopenia and Cardiovascular Diseases in Individuals With Diabetes or Prediabetes

IF 2.7 3区医学

Journal of Clinical Hypertension Pub Date : 2025-02-28 DOI: 10.1111/jch.70024

Xia Wang, Qingyue Zeng, XiJie Yu, Shuangqing Li

{"title":"Sarcopenia and Cardiovascular Diseases in Individuals With Diabetes or Prediabetes","authors":"Xia Wang, Qingyue Zeng, XiJie Yu, Shuangqing Li","doi":"10.1111/jch.70024","DOIUrl":"https://doi.org/10.1111/jch.70024","url":null,"abstract":"Sarcopenia is a known risk factor for cardiovascular disease (CVD) in individuals with diabetes or prediabetes, but the impact of changes in sarcopenia status on CVD risk remains unclear. This study aimed to examine how changes in sarcopenia status between baseline and the second follow-up survey, conducted 2 years later, influence the risk of developing incident CVD. Incident CVD was identified based on self-reported physician diagnoses of heart disease, such as angina, myocardial infarction, heart failure, or stroke. Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusting for potential confounders. The results showed that participants who progressed from non-sarcopenia to possible sarcopenia or sarcopenia had a higher risk of developing CVD. Their risk was significantly greater compared to those who remained non-sarcopenic (HR 1.37, 95% CI 1.08–1.73). Conversely, individuals who recovered from sarcopenia to non-sarcopenia or possible sarcopenia had a lower risk of CVD. Their risk was lower than those who remained sarcopenic (HR 0.40, 95% CI 0.20–0.82). Among individuals with possible sarcopenia at baseline, those who recovered to non-sarcopenia had a reduced CVD risk. This reduction was significant compared to those who remained in possible sarcopenia (HR 0.62, 95% CI 0.46–0.84). These findings suggest that changes in sarcopenia status have a significant impact on CVD risk, with worsening sarcopenia increasing the likelihood of CVD and recovery lowering the risk in individuals with diabetes or prediabetes.","PeriodicalId":50237,"journal":{"name":"Journal of Clinical Hypertension","volume":"27 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jch.70024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143521867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0