Daniela Pilunni, Maria Erica Blandino, Pierluigi Navarra
{"title":"Compassionate drug uses in Italy. Analysis at single-center level.","authors":"Daniela Pilunni, Maria Erica Blandino, Pierluigi Navarra","doi":"10.4415/ANN_24_02_04","DOIUrl":"https://doi.org/10.4415/ANN_24_02_04","url":null,"abstract":"<p><strong>Aims: </strong>Using a database from two pharmaceutical companies that managed several compassionate use programs in the last few years in Italy, we have previously analyzed the data by the number of patients and centers in each region and province, showing that the use of compassionate drugs is largely diffused in the country, in a manner directly related to the size of population of each region. In the present study we used the same database to expand the analysis to single-center level, aiming to test the hypothesis whether, despite a good diffusion of compassionate drug uses in each region, the majority of them concentrates within a relatively low number of centers.</p><p><strong>Methods: </strong>Data from different programs were grouped per center, and the centers were ordered per the number of compassionate uses dispensed, and per region. Two cutoff levels, at 75% and 90%, were drawn to look at the number of centers accounting for such percentages of compassionate uses in each region.</p><p><strong>Results: </strong>Out of 343 centers throughout Italy, 93 and 156 centers (i.e., 27.11% and 45.48% of the total) account for about 75% and 90% of all compassionate drugs dispensed in Italy. In 6 regions out of 20 (Valle d'Aosta, Liguria, Umbria, Lazio, Molise and Campania) the centers accounting for 75% of all compassionate drugs dispensed are located in a single town. Forty and 20 out of the 93 centers dispensing 75% of all compassionate drugs are academic hospitals and research hospitals (Istituti di Ricovero e Cura a Carattere Scientifico, IRCCS), respectively.</p><p><strong>Conclusions: </strong>In this study we have demonstrated that, in spite of widespread diffusion of compassionate drug uses in all Italian regions, their management is restricted to a relatively low number of dispensing centers in each region.</p>","PeriodicalId":502090,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"60 2","pages":"107-110"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fabio Caputo, Lisa Lungaro, Giorgia Palamara, Raimondo Maria Pavarin, Samantha Sanchini, Anna Costanzini, Giacomo Caio, Roberto De Giorgio, Gianni Testino, Emanuele Scafato
{"title":"Driving under the influence of alcohol and alcohol use disorder: the relevance of early identification from an Italian retrospective outpatient study.","authors":"Fabio Caputo, Lisa Lungaro, Giorgia Palamara, Raimondo Maria Pavarin, Samantha Sanchini, Anna Costanzini, Giacomo Caio, Roberto De Giorgio, Gianni Testino, Emanuele Scafato","doi":"10.4415/ANN_24_02_05","DOIUrl":"https://doi.org/10.4415/ANN_24_02_05","url":null,"abstract":"<p><strong>Introduction: </strong>Worldwide, almost 1.2 million people drive under the influence of alcohol. However, early identification of alcohol use disorder (AUD) in subjects driving under the influence (DUI) of alcohol is seldom achieved.</p><p><strong>Aim: </strong>The aim of our retrospective study is to investigate the presence of AUD in a population of DUI subjects who had their driving license suspended, and if they were following a specific rehabilitation program.</p><p><strong>Methods and results: </strong>750 subjects were retrospectively enrolled from 2018 to 2021. DSM-V to assess AUD was used. Forty-eight (6.4%) subjects presented a diagnosis of AUD, after one month they showed a statistically significant reduction of carbohydrate-deficient transferrin (CDT) (p<0.0001); however, none were following a program for the treatment of AUD.</p><p><strong>Conclusions: </strong>This outpatient setting may be considered a place of primary and secondary prevention where DUI subjects with a diagnosis of AUD may be entrusted to a Centre in order to follow rehabilitation treatment.</p>","PeriodicalId":502090,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"60 2","pages":"111-117"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Martina Giusti, Cosimo Nardi, Guglielmo Bonaccorsi, Chiara Lorini, Niccolò Persiani
{"title":"Organizational Health Literacy as a supportive tool for the effective implementation of the 2013/59/EURATOM Directive in Italy.","authors":"Martina Giusti, Cosimo Nardi, Guglielmo Bonaccorsi, Chiara Lorini, Niccolò Persiani","doi":"10.4415/ANN_24_02_09","DOIUrl":"https://doi.org/10.4415/ANN_24_02_09","url":null,"abstract":"<p><strong>Introduction: </strong>Since 2013, European countries have transposed the 2013/59/EURATOM Directive that lays down basic safety standards for protection against dangers arising from exposure to ionising radiation. In the years between the issuance of the European Directive and its formal transposition, Italian researchers investigated solutions to renew the technological, educational, and organizational culture in radiology departments.</p><p><strong>Scope: </strong>This article proposed a reflection on the contribution of Organizational Health Literacy (OHL) to implement Legislative Decree 101/2020 in the practice of Italian radiology departments.</p><p><strong>Results: </strong>By implementing OHL principles, examinations with exposure to ionizing radiation and related informative processes could be personalized based on patients' knowledge, abilities, and competencies, as well as on the services' provision. These principles can be in fact integrated with the organizational, training, and management requirements set by the Directive.</p><p><strong>Conclusions: </strong>According with the state-of-the-art, decision-makers and health managers could support the application of OHL principles in Italian radiology departments.</p>","PeriodicalId":502090,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"60 2","pages":"145-153"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rosilde Di Pirchio, Silvia Ghirini, Marta De Santis, Antonella Sanseverino, Claudia Mortali, Monica Vichi, Eloise Longo, Massimiliano Orri, Alberto Forte, Antonella Faieta, Luisa Mastrobattista
{"title":"ViolHelp: results of a pilot study to identify potential warning signs and risk factors for self- and hetero-directed violence in the calls received by the Helplines of the Italian National Institute of Health.","authors":"Rosilde Di Pirchio, Silvia Ghirini, Marta De Santis, Antonella Sanseverino, Claudia Mortali, Monica Vichi, Eloise Longo, Massimiliano Orri, Alberto Forte, Antonella Faieta, Luisa Mastrobattista","doi":"10.4415/ANN_24_02_10","DOIUrl":"https://doi.org/10.4415/ANN_24_02_10","url":null,"abstract":"<p><strong>Background: </strong>Self- and hetero-directed violence (SHDV) is a serious public health problem and a complex phenomenon, influenced by individual and environmental factors. SHDV may occur particularly in moments of personal, economic and/or social crisis. During the COVID-19 pandemic, the ISS-Helplines operators have perceived an increase in psychological distress and self-isolation among callers. The ViolHelp project aimed at identifying potential warning signs and risk factors of SHDV emerging in the activity of the ISS-Helplines (Istituto Superiore di Sanità, ISS, Italian National Institute of Health).</p><p><strong>Materials and methods: </strong>A dashboard collecting warning signs and risk factors of SHDV was developed to be used during the ISS-Helplines activity.</p><p><strong>Results: </strong>In one year of data collection, 135 calls were compiled. In 106 calls, callers referred experienced violence: 72 self-directed violence (SDV), 20 hetero-directed violence (HDV), 14 both. The most frequent warning signs and risk factors for SDV were desire to die (68.6%), previous suicide attempts (31.4%) and threat of self-harm (25.6%); for HDV were depressed mood (32.4%), diagnosis of pathology and/or psychiatric disorders, desire to die, use of psychotropic drugs, and alcohol abuse (29.4%).</p><p><strong>Conclusions: </strong>The results of this pilot project show the importance of being able to read the warning signs and to create a network that can improve information, prevention and support activities for people at risk of violence and their families.</p>","PeriodicalId":502090,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"60 2","pages":"154-165"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Italian National Institute of Health helpline to quit tobacco and nicotine dependence: 20 years of activity.","authors":"Luisa Mastrobattista, Renata Solimini, Guido Mortali, Rosilde Di Pirchio, Graziella Lanzillotta, Piergiorgio Massaccesi, Claudia Mortali, Simona Pichini, Ilaria Palmi","doi":"10.4415/ANN_24_02_07","DOIUrl":"https://doi.org/10.4415/ANN_24_02_07","url":null,"abstract":"<p><strong>Introduction: </strong>Tobacco use is one of the world's leading preventable causes of death and is a major preventable risk factor of non-communicable diseases. Although smokers are aware of the health risks, their attempts to quit often fail, primarily due to the strong nicotine and/or tobacco dependence. Antismoking helplines have become an integral part of tobacco control efforts in many countries. In Italy, the ISS Antismoking Helpine is active since 2000.</p><p><strong>Material and methods: </strong>The professional staff of the ISS Antismoking Helpline have gathered socio-demographic and smoking-related data via an electronic form, related to the received calls. The collected data have been processed in a dedicated database and analyzed to monitor the use and the quality of the service. In this study, a descriptive statistical analysis was conducted to inform about the activity of the helpline over the years.</p><p><strong>Results: </strong>From May 2003 to June 2023 the helpline received 99,423 calls. Most smokers called to receive \"support to quit\" (82.6%). Counselling was provided in 11.4% of cases, and in the last two years has been strongly increased (40.0% of cases). The percentage of users requesting information on emerging tobacco and nicotine products is 1.2%, even if in 2023 this percentage has risen significantly (6.0%). Two legislative measures (in 2012 and in 2016) required to add the helpline number to all packets of tobacco cigarettes. Accordingly, the offer of counselling increased from 2.6% to 12.2%.</p><p><strong>Conclusions: </strong>The available resources in tobacco control, including the helpline, are still not sufficient to meet all the users needs. Adequate policies and stable funding to fight tobacco and nicotine dependence need increased commitment from government institutions to ensure equal access to treatments for all Italian citizens.</p>","PeriodicalId":502090,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"60 2","pages":"126-133"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amerigo Zona, Caterina Bruno, Achille Cernigliaro, Marco De Santis, Salvatore Scondotto, Lucia Fazzo
{"title":"Mortality in an Italian cohort of former asbestos cement workers.","authors":"Amerigo Zona, Caterina Bruno, Achille Cernigliaro, Marco De Santis, Salvatore Scondotto, Lucia Fazzo","doi":"10.4415/ANN_24_02_06","DOIUrl":"https://doi.org/10.4415/ANN_24_02_06","url":null,"abstract":"<p><strong>Background: </strong>A pooled study on Italian asbestos cement plant cohorts observed mortality risk for asbestos-related diseases. This study analysed the mortality of workers cohort of an asbestos cement plant in Syracuse, Italy.</p><p><strong>Methods: </strong>Workers' vital status and causes of death, during 1970-2018, were identified in regional health databases. Standardized mortality ratios (SMRs) by sex and temporal variables were calculated.</p><p><strong>Results: </strong>Of the 900 cohort's subjects (636 men, 259 women, 5 unknown sex), for 867 the vital ascertainment was possible: 505 died during study period. All-cause mortality is similarly to the expected among men and lower among women. Pleural and lung malignant neoplasms (MN) exceeded in men (SMR=27.1, SMR=1.95), retroperitoneal and peritoneal MN in both sexes, no cases of larynx MN were observed. Mortality excess for ovarian MN (SMR=1.5) and asbestosis in both sexes (men: SMR=431.9, women: SMR=116.6) were found.</p><p><strong>Conclusions: </strong>Exceeding mortality from asbestos-related diseases, particularly in men was highlighted.</p>","PeriodicalId":502090,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"60 2","pages":"118-125"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The \"Investigating and translating genomic evidence for public health response to SARS-CoV-2 (INSIDE SARS-CoV-2)\" project - Network of excellence. Commentary.","authors":"Angela Di Martino, Sankar Bhattacharyya, Flavia Riccardo, Rajesh Pandey, Matteo Chiara, Shailendra Mani, Patrizio Pezzotti, Alessandra Lo Presti, Luigina Ambrosio, Valentina Marziano, Piero Poletti, Graziano Pesole, Jitendra Narayan, Megha Brijwal, Aashish Choudhary, Fabio Tramuto, Walter Mazzucco, Anurag Agrawal, Anant Mohan, Paola Stefanelli","doi":"10.4415/ANN_24_02_01","DOIUrl":"https://doi.org/10.4415/ANN_24_02_01","url":null,"abstract":"<p><p>The \"Investigating and translating genomic evidence for public health response to SARS-CoV-2 (INSIDE SARS-CoV-2)\" project is part of the initiative \"Joint science and technology cooperation call for joint project proposals for the years 2021-2023\" promoted by the Italian Ministry of Foreign Affairs and International Cooperation (MAECI) and the Republic of India. To start the project activities, the pandemic response and the epidemiological situation in Italy and in India, together with the genomic surveillance strategies for SARS-CoV-2 virus in the two countries, are here described.</p>","PeriodicalId":502090,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"60 2","pages":"85-88"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Drieda Zaçe, Emanuele La Gatta, Luigi Petrella, Alessia Orfino, Anna Maria Viteritti, Maria Luisa Di Pietro
{"title":"Diet and lifestyles of young women of childbearing age: an Italian survey.","authors":"Drieda Zaçe, Emanuele La Gatta, Luigi Petrella, Alessia Orfino, Anna Maria Viteritti, Maria Luisa Di Pietro","doi":"10.4415/ANN_24_02_02","DOIUrl":"https://doi.org/10.4415/ANN_24_02_02","url":null,"abstract":"<p><strong>Background: </strong>Daily lifestyles play a pivotal role in influencing the preconception health of women in their childbearing years. The aim of this cross-sectional study is to delineate, within the Italian context, the lifestyles of young women of childbearing age, that may have repercussions on their preconception health.</p><p><strong>Methods: </strong>From July 2020 until April 2021, an anonymous online questionnaire was administered to a sample of 340 women aged 18-25 years attending secondary grade schools and universities in Italy.</p><p><strong>Results: </strong>Over the course of the preceding three days, 90.29% of women had meat, 45.59% had fish. 28.24%, 38.82% and 18.53% of women reported tobacco, alcohol and drugs consumption, respectively. The mean amount of folic acid taken through foods consumed was 341 µg/day. Only 53.53% of women did sports. Smokers were more frequently consuming alcohol and drugs. Women who never did sports, were more likely to use drugs.</p><p><strong>Conclusions: </strong>Young women in our sample had suboptimal dietary habits. It is imperative to advocate for policies and interventions that endorse healthy dietary patterns and physical activity, improve knowledge and discourage young women from smoking, alcohol consumption and drug use.</p>","PeriodicalId":502090,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"60 2","pages":"89-97"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sabina Gainotti, Paola Torreri, Chiara Mannelli, Celeste Cagnazzo, Bruno Ficara, Carlo Petrini
{"title":"Registries or non-pharmacological observational studies? An operational attempt to draw the line and to provide some suggestions for the ethical evaluation of rare disease registries.","authors":"Sabina Gainotti, Paola Torreri, Chiara Mannelli, Celeste Cagnazzo, Bruno Ficara, Carlo Petrini","doi":"10.4415/ANN_24_01_05","DOIUrl":"https://doi.org/10.4415/ANN_24_01_05","url":null,"abstract":"<p><p>Originally established to evaluate the ethical aspects of clinical trials, Ethics Committees (ECs) are now requested to review different types of projects, including, among others, observational studies and disease registries. In Italy, clinical trials on medicinal products for human use and on medical devices are regulated by EU Regulation 536/2014, EU Regulation 2017/745, and 2017/746 while pharmacological observational studies are regulated by the Italian Medicines Agency guidelines of 2008 and by Ministerial Decree of November 30th, 2021. The other types of studies are not strictly regulated, causing discrepancies in their definition and assessment by the ECs, and slowdowns in the start of projects. The present contribution aims to propose definitions and distinctions between non-pharmacological observational studies and disease registries, which constitute different entities but are often assimilated by ECs, and to formulate suggestions for the evaluation of rare disease registries, which are an expanding research area of interest.</p>","PeriodicalId":502090,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"60 1","pages":"29-36"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141452574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Benedetta Armocida, Beatrice Formenti, Marco Silano, Albert Aszalos, Hector Bueno, Mounia Elyamani, Ane Fullaondo Zabala, Matilde Leonardi, Jaana Lindström, Karolina Michalak, Bernardino Morillo, Michal Nowicki, Denis Oprešnik, Luigi Palmieri, Roberta Papa, Markku Peltonen, Helena Safadi, Hanna Shchetynina, Natalia Skogberg, Hanna Tolonen, Edwin Wouters, Jelka Zaletel, Graziano Onder
{"title":"Tackling the challenge of cardiovascular diseases and diabetes across Europe: a joint action by more than 300 public health professionals. Commentary.","authors":"Benedetta Armocida, Beatrice Formenti, Marco Silano, Albert Aszalos, Hector Bueno, Mounia Elyamani, Ane Fullaondo Zabala, Matilde Leonardi, Jaana Lindström, Karolina Michalak, Bernardino Morillo, Michal Nowicki, Denis Oprešnik, Luigi Palmieri, Roberta Papa, Markku Peltonen, Helena Safadi, Hanna Shchetynina, Natalia Skogberg, Hanna Tolonen, Edwin Wouters, Jelka Zaletel, Graziano Onder","doi":"10.4415/ANN_24_01_02","DOIUrl":"https://doi.org/10.4415/ANN_24_01_02","url":null,"abstract":"<p><p>Cardiovascular diseases (CVD) and diabetes pose significant health challenges in Europe, affecting millions and burdening healthcare systems. The recent EU4Health Programme places reducing the burden of non-communicable diseases (NCD) at the forefront, through a Joint Action focused on CVD and diabetes (JACARDI, Joint Action on CARdiovascular diseases and DIabetes). This initiative unites 21 European countries, including Ukraine, and over 300 experts. Employing an innovative approach and standardised methodology, JACARDI implements 142 pilot projects covering the entire \"patient\" journey. Particular focus will be given to improvement of data availability and quality. Additionally, JACARDI will emphasise transversal and intersectional aspects, such as health equity, determinants of health, and social, cultural, and ethnic diversity, while pioneering gender-transformative leadership. Committed to evidence-based interventions, JACARDI aims to harmonise strategies and disseminate knowledge for enhanced CVD and diabetes prevention and management. The goal is to identify effective strategies for wider implementation, fostering cross-national collaboration and fortifying Europe's health resilience.</p>","PeriodicalId":502090,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"60 1","pages":"4-7"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141452578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}