Ilaria Ippoliti, Silvia Di Giacomo, Gabriela Mazzanti, Marco Silano, Francesca Menniti-Ippolito
{"title":"Analysis of suspected adverse reactions to food supplements containing beehive products: an update from the Italian Phytovigilance System.","authors":"Ilaria Ippoliti, Silvia Di Giacomo, Gabriela Mazzanti, Marco Silano, Francesca Menniti-Ippolito","doi":"10.4415/ANN_24_03_08","DOIUrl":"https://doi.org/10.4415/ANN_24_03_08","url":null,"abstract":"<p><strong>Introduction: </strong>Beehive products are widely used in food supplements; however, their composition variability and allergenic components have raised some concerns. This work aims to provide information about the beehive products safety profile by evaluating the suspected adverse reactions (ARs).</p><p><strong>Methods: </strong>The suspected report of ARs collected within the Italian Phytovigilance System (IPS) were evaluated. The clinical and demographic characteristics of the cases were described, and the causality assessment performed.</p><p><strong>Results: </strong>61 reports were analysed, mainly concerned women. Serious events were reported in 17 forms (28%). The ARs (n=116) referred to respiratory (25.0%), skin (24.1%), and gastrointestinal disorders (21.5%). Label warnings for atopic subjects were present only in 7 food supplements. The causality assessment was mostly probable (54.1%).</p><p><strong>Conclusions: </strong>Present findings outline relevant information about the safety issues of beehive product consumption, especially in atopic or allergic subjects, and strengthen the importance of IPS to point out safety signals.</p>","PeriodicalId":502090,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"60 3","pages":"225-233"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giorgio Di Leone, Luigi Bertinato, Gianfranco Brambilla, Valerio Manno, Flavio Napolano, Simona Savi, Gaetano Settimo, Domenico Lagravinese
{"title":"COVID-19 in meat plants: a survey framed within a Target Prevention Plan, in Italy.","authors":"Giorgio Di Leone, Luigi Bertinato, Gianfranco Brambilla, Valerio Manno, Flavio Napolano, Simona Savi, Gaetano Settimo, Domenico Lagravinese","doi":"10.4415/ANN_24_03_01","DOIUrl":"https://doi.org/10.4415/ANN_24_03_01","url":null,"abstract":"<p><strong>Background: </strong>During the COVID-19 pandemic, several outbreaks have been recorded worldwide in industrial slaughterhouses and meat-processing plants. Competent Italian health authorities at regional and provincial levels agreed on a risk-oriented control plan.</p><p><strong>Methods: </strong>Advocacy actions were activated, targeting meat plant managers and related food business operators. A questionnaire focused on the inventoried risk factors from literature was developed and administered voluntarily to interested stakeholders. In addition, an outbreak questionnaire was proposed to the prevention department of local health units.</p><p><strong>Results: </strong>From 2021 to 2022, 333 advocacy and 24 outbreak questionnaires on 4,765 inventoried plants were collected. The lack of awareness in updating the Risk Assessment Document for COVID-19, non-instrumental body temperature checks at the entrance, working force from different subcontractors, poor hygiene in shared places, and insufficient ventilation were the main critical points recorded.</p><p><strong>Conclusions: </strong>Results provide a post hoc review with an eye toward future zoonotic pandemics.</p>","PeriodicalId":502090,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"60 3","pages":"171-178"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giuseppe Marano, Romano Arcieri, Rosalba Elisabetta Rocchi, Arianna Annunziata, Maria Cutillo, Giampaolo Bucaneve, Roberto Da Cas, Mariangela Rossi
{"title":"Use of antidepressant and antipsychotic drugs in subjects with hemophilia of the Umbria Region in the period 2011-2022.","authors":"Giuseppe Marano, Romano Arcieri, Rosalba Elisabetta Rocchi, Arianna Annunziata, Maria Cutillo, Giampaolo Bucaneve, Roberto Da Cas, Mariangela Rossi","doi":"10.4415/ANN_24_03_06","DOIUrl":"https://doi.org/10.4415/ANN_24_03_06","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic diseases, such as hemophilia, can evoke psychological sequelae and be associated with a higher risk of mental health disorders. The utilization of antidepressant and antipsychotic drugs in subjects with hemophilia is not completely understood and few data are available.</p><p><strong>Objectives: </strong>The aim of this analysis is to describe use of antidepressant and antipsychotic drugs in subjects with hemophilia of the Umbria Region in the period 2011-2022.</p><p><strong>Methods: </strong>A descriptive, cross-sectional, and retrospective analysis based on data on filled prescriptions for antidepressants and antipsychotics has been carried out. The overall and annual prevalence of drugs use and consumption were calculated based on pharmaceutical prescriptions charged to the National Health Service in subjects with hemophilia and matched controls from general population.</p><p><strong>Results: </strong>In the study period 170 subjects with hemophilia were identified; about 80% were male. About 20% and 8.2% received antidepressants and antipsychotics, respectively. A higher percentage of users and consumption were found in subjects with hemophilia compared to matched controls, although no statistically significant differences were observed.</p><p><strong>Conclusions: </strong>Our analysis suggests that depression and psychosis are important comorbidities in subjects with hemophilia. Further larger studies are needed in order to confirm these data and better define the burden of mental health disorders in subjects with hemophilia.</p>","PeriodicalId":502090,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"60 3","pages":"208-215"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anna Carannante, Marco Giustini, Emanuele Caredda, Simona Gaudi
{"title":"Precision prevention network: new pathway for supporting women victims of violence.","authors":"Anna Carannante, Marco Giustini, Emanuele Caredda, Simona Gaudi","doi":"10.4415/ANN_24_03_09","DOIUrl":"https://doi.org/10.4415/ANN_24_03_09","url":null,"abstract":"<p><strong>Introduction: </strong>Violence against women (VAW) is a persistent global public health problem that runs across all social classes and ethnicities with a considerable negative influence on women's health and behaviour. Early detection, appropriate interventions and multidisciplinary cooperation are crucial factors in tackling gender violence.</p><p><strong>Objectives: </strong>This note describes \"The Violence against women: long-term health effects for precision prevention\" transdisciplinary and multicenter project that aims to implement the National Guidelines with two sets of questions: the European Injury Database (EU-IDB) violence module and the Post-Traumatic Stress Disorder (PTSD) questionnaire for improving innovative approaches to limit the long-term health effect of VAW. Furthermore, the analysis of epigenetic profile in women's DNA may contribute to the knowledge of molecular mechanisms underlying PTSD and other non-communicable diseases. Epigenomic research in parallel with rigourous guidelines and social, educational, clinical and community interventions could accomplish innovative precision prevention protocols.</p><p><strong>Conclusions: </strong>Public health plays essential role in identifying risk factors and strengthening the support for women victims of violence.</p>","PeriodicalId":502090,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"60 3","pages":"234-238"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alice Valdesalici, Diego Saccon, Elena Boatto, Amalia Manzan, Roberto Manera, Alessandro Pani, Valentina Pavani, Giancarlo Zecchinato, Vito Sava, Giovanni Greco, Sally Paganin, Marco Solmi
{"title":"Clinical medical practice and stigma towards patients with substance use disorder in an Italian sample of healthcare workers.","authors":"Alice Valdesalici, Diego Saccon, Elena Boatto, Amalia Manzan, Roberto Manera, Alessandro Pani, Valentina Pavani, Giancarlo Zecchinato, Vito Sava, Giovanni Greco, Sally Paganin, Marco Solmi","doi":"10.4415/ANN_24_03_05","DOIUrl":"https://doi.org/10.4415/ANN_24_03_05","url":null,"abstract":"<p><strong>Introduction: </strong>People with substance use disorder (SUD) face challenges like stigma and discrimination, impacting their healthcare experiences.</p><p><strong>Aim: </strong>This study aims to: (i) assess physicians' clinical practices and stigma toward SUD patients among healthcare personnel and (ii) explore the relationship among stigma, psychological well-being, and burnout.</p><p><strong>Methods: </strong>A survey covering sociodemographic data, physicians' clinical practices, stigmatizing attitudes, psychological well-being, and burnout was completed by 1,796 employees of the Veneto's Local Health Units (Italy).</p><p><strong>Results: </strong>Healthcare professionals reported increased stigma towards SUDs (p-values<0.05). Stigma consistently correlated with variables such as sex, profession, department, and levels of burnout (p-values<0.05). Notably, high burnout levels were associated with increased stigma. Staff in addiction departments displayed lower stigma levels compared to other departments. No significant differences were found in physicians' clinical practices.</p><p><strong>Conclusions: </strong>Targeted training for healthcare professionals is crucial to reduce stigma, enhance attitudes toward SUDs, and broaden overall knowledge of the condition.</p>","PeriodicalId":502090,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"60 3","pages":"197-207"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Margherita Zeduri, Cosimo Campagni, Giulia Carreras, Silvano Gallus, Alessandra Lugo, Chiara Stival, Luisa Mastrobattista, Claudia Mortali, Anna Odone, Andrea Amerio, Giuseppe Gorini
{"title":"Changes in the use of nicotine-containing products during and after the COVID-19 pandemic in a representative sample of the Italian adult population.","authors":"Margherita Zeduri, Cosimo Campagni, Giulia Carreras, Silvano Gallus, Alessandra Lugo, Chiara Stival, Luisa Mastrobattista, Claudia Mortali, Anna Odone, Andrea Amerio, Giuseppe Gorini","doi":"10.4415/ANN_24_03_03","DOIUrl":"https://doi.org/10.4415/ANN_24_03_03","url":null,"abstract":"<p><strong>Introduction: </strong>To assess nicotine-containing products (NCPs; heated tobacco products and/or electronic cigarettes) use in relation to conventional smoking.</p><p><strong>Methods: </strong>\"LOST IN ITALY\" (\"LOckdown and Lifestyles IN ITALY\") and \"LOST IN TOSCANA\" cross-sectional surveys estimated lifestyles changes before, during, and after the lockdown in a representative sample of the Italian population. A Poisson regression model was used to estimate prevalence ratios of NCP use according to socio-demographic, mental distress, and smoking variables.</p><p><strong>Results: </strong>The prevalence of conventional cigarette smokers did not decrease, remaining stable at 23%. Exclusive conventional cigarette smokers decreased from 21% before the lockdown in 2020 to 15% in 2023 but dual users, representing the large majority of NCP users, increased by 4 times, and exclusive NCP users decreased from 7% in 2020 to 5% in 2023.</p><p><strong>Conclusions: </strong>NCPs are mostly accompanying instead of replacing conventional cigarettes. A targeted campaign should be developed in Italy to raise awareness on that.</p>","PeriodicalId":502090,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"60 3","pages":"184-190"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Irene Rutigliano, Morena Luce Mansueto, Rossella Canestrale, Rossella Giorgio, Michele Sacco, Maria Rosa Pastore
{"title":"Children's diet assessed with the Mediterranean Diet Index: the finding of new eating habits and their impact on a cohort of Italian children.","authors":"Irene Rutigliano, Morena Luce Mansueto, Rossella Canestrale, Rossella Giorgio, Michele Sacco, Maria Rosa Pastore","doi":"10.4415/ANN_24_03_02","DOIUrl":"https://doi.org/10.4415/ANN_24_03_02","url":null,"abstract":"<p><strong>Objectives: </strong>Mediterranean Diet (MD) has been inversely associated with many diseases: it reduces total mortality and lowers cardiovascular risk. Despite the known benefits of MD, variations of dietary habits have occurred in recent years especially in young people. The aim of our study is to evaluate MD adherence in a cohort of Italian children and adolescents living in Southern Italy.</p><p><strong>Methods and results: </strong>Adherence to MD was evaluated with the Mediterranean Diet Index (KIDMED). Sex, age, and anthropometric measures were recorded on a population of 132 children; of those 71.2% showed poor adherence to MD, 26.5% average adherence and only 2.3% good adherence. Higher prevalence of poor adherence was recorded in obese children and there was statistically significant inverse correlation between age and adherence score.</p><p><strong>Conclusions: </strong>Our results highlight low adherence to MD in a cohort of Italian children. These findings support the importance of monitoring dietary habits, especially in adolescents.</p>","PeriodicalId":502090,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"60 3","pages":"179-183"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Claudio Giovannini, Leuconoe Grazia Sisti, Paola Gabbrielli, Cesare Marino, Claudio Pacillo, Angelo Farina, Maria Angela Falà, Walter Malorni
{"title":"Responding to healthcare needs of different religious communities: implications for the Italian National Health Service.","authors":"Claudio Giovannini, Leuconoe Grazia Sisti, Paola Gabbrielli, Cesare Marino, Claudio Pacillo, Angelo Farina, Maria Angela Falà, Walter Malorni","doi":"10.4415/ANN_24_03_07","DOIUrl":"https://doi.org/10.4415/ANN_24_03_07","url":null,"abstract":"<p><strong>Background: </strong>One of the challenges that our Italian National Health Service is facing is the structural change of society, regarding the migratory flows recorded in the last thirty years with the consequent increase in faithful who follow religions other than the Catholic one.</p><p><strong>Aim of the study: </strong>This study highlights the critical issues due to religious indications of different faiths which can have implications for our healthcare system. The study analyses the different concept of health, illness, well-being and pain, life and death, gender issues, rules regarding diet, fasting and drugs that can be taken by the patients. Religious norms regarding procreation, termination of pregnancy, and the use of contraceptive methods are also considered; as well as euthanasia, organ donation and the specific needs for end-of-life rites in different religious faiths, as they are presented in the literature and as they emerged in the dialogue with the national representatives of the religious faiths that make up the Interreligious Table of Rome. Conclusions and future perspective. The complexity of this relatively recent Italian reality necessarily leads to an in-depth analysis of religious and cultural diversity. The National Health Service must face a series of changes which concern both the adaptation of health structures and the adequate preparation of health workers, who are called upon to know how to communicate and offer care and assistance to all.</p>","PeriodicalId":502090,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"60 3","pages":"216-224"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lucrezia Lanciotti, Felice Giordano, Rosanna Maria Fidente, Carolina Ferranti, Roberta Lavalle, Marco Famele, Denise Pires Marafon, Rosa Draisci
{"title":"Dangerous exposures to chemicals managed by Poison Centers all around the world during the COVID-19 pandemic: a systematic review and proportional meta-analysis.","authors":"Lucrezia Lanciotti, Felice Giordano, Rosanna Maria Fidente, Carolina Ferranti, Roberta Lavalle, Marco Famele, Denise Pires Marafon, Rosa Draisci","doi":"10.4415/ANN_24_02_08","DOIUrl":"10.4415/ANN_24_02_08","url":null,"abstract":"<p><strong>Introduction: </strong>During COVID-19 pandemic, cleaning/disinfection activities were highly recommended. This study summarizes the state of art and estimates the prevalence of dangerous exposures to specific chemicals managed by Poison Centers (PCs) from all over the world during 2020 vs 2019, trying to overcome the critical aspects of the product categorization systems used by PCs.</p><p><strong>Materials and methods: </strong>A systematic research was conducted in 3 major databases and 2 websites of PCs associations. Proportional meta-analyses were performed to estimate the prevalence of exposures to disinfectants, household products and hand sanitizers in 2020 vs 2019.</p><p><strong>Results: </strong>The pooled prevalence of exposures to disinfectants, household products and hand sanitizers were respectively 5.9% (95% CI 4.9-7.0) (2019: 4.4% vs 2020: 7.8%; p=0.22), 25.9% (95% CI 24.0-27.7) (2019: 25.0% vs 2020: 28.6%; p=0.71) and 1.6% (95% CI 1.3-1.9) (2019: 0.6% vs 2020: 2.8%; p<0.001).</p><p><strong>Conclusions: </strong>This study detected overall increases of exposures to specific chemicals in 2020, suggesting that the awareness on topics related to the safe use of these products should be improved, especially during health emergencies, highlighting the need to develop standardized systems to better compare data coming from PCs all over the world.</p>","PeriodicalId":502090,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"60 2","pages":"134-144"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roberta Vittoria Cicero, Francesca Zambri, Michele Grandolfo, Federica Varone, Margaret Smith, Sofia Colaceci
{"title":"Characteristics of out-of-hospital births and perinatal outcomes: data from the Lazio Region, Italy, cross-sectional study from 2019 to 2021.","authors":"Roberta Vittoria Cicero, Francesca Zambri, Michele Grandolfo, Federica Varone, Margaret Smith, Sofia Colaceci","doi":"10.4415/ANN_24_02_03","DOIUrl":"https://doi.org/10.4415/ANN_24_02_03","url":null,"abstract":"<p><strong>Introduction: </strong>In Italy, the primary place of birth is typically a hospital, with only a small number of women opting for an out-of-hospital setting. This study details the characteristics of midwifery care and perinatal and maternal outcomes of women who gave birth in an out-of-hospital setting in the Lazio Region, Italy, from 2019 to 2021.</p><p><strong>Methods: </strong>A cross-sectional study was carried out. The study population included 542 healthy low-risk women who completed the process of planning an out-of-hospital birth, and excluding transfers, this resulted in a total sample of 478 women who gave birth out-of-hospital. Descriptive and inferential analyses and also a logistic regression model were performed.</p><p><strong>Results: </strong>The main outcomes of the out-of-hospital deliveries were: intact perineum in 38.9% of cases, two cases of 3rd degree laceration (0.4%) and in one case (0.2%) episiotomy. Intrapartum emergencies occurred in 85 out of 478 women (17.8%) but only 10 women required a transfer to hospital after delivery. The one minute Apgar score was equal to or greater than 7 in 99.2% of cases. Exclusive breastfeeding of 96% one week after birth and 94.6% one month. Furthermore, having a previous vaginal hospital birth (adjOR 9.7; CI 95% 4.33-21.68 P<0.001) and a previous out-of-hospital birth (adjOR 24.2; CI 95% 3.23-181.48 P=0.002) was associated with the continuation of out-of-hospital birth.</p><p><strong>Conclusions: </strong>For low-risk pregnant women who have planned an out-of-hospital birth, it has been shown to be a safe, adequate, appropriate, and effective alternative.</p>","PeriodicalId":502090,"journal":{"name":"Annali dell'Istituto superiore di sanita","volume":"60 2","pages":"98-106"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}