The Journal of Rheumatology最新文献

{"title":"Rethinking HLA-B27 Testing: What HLA-B27 Can- and Cannot-Tell Us.","authors":"Marie Beaufrère,Bilade Cherqaoui,Félicie Costantino","doi":"10.3899/jrheum.2025-0809","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0809","url":null,"abstract":"HLA-B27: a cornerstone in spondyloarthritis Nearly 50 years after its discovery as a major genetic risk factor for spondyloarthritis (SpA),1 the precise contribution of HLA-B27 to disease development and progression remains only partially understood. Proposed mechanisms include aberrant antigen presentation, misfolding-induced endoplasmic reticulum stress and modulation of innate immune responses.2.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144960295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sabbatical in a Pediatric Rheumatology Unit in India.","authors":"Yosef Uziel","doi":"10.3899/jrheum.2025-0230","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0230","url":null,"abstract":"","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Usual Suspects: Established and Emerging Predictor Variables for Remission in Rheumatoid Arthritis.","authors":"Elle Sauve,Cheryl Barnabe","doi":"10.3899/jrheum.2025-0476","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0476","url":null,"abstract":"There are several potential factors that predict the outcome of remission in rheumatoid arthritis (RA). These reflect various domains including personal characteristics, health status, disease characteristics and treatment exposures. While some predictors are consistently identified across a variety of settings, others have limited or conflicting data, and new potential predictors are emerging. In this review, we summarize the available evidence to highlight predictors that should be incorporated into all rheumatology prognostic research, namely age, sex, smoking status, body mass index, function, disease duration, rheumatoid factor status, disease activity at treatment start, inflammatory markers, and treatment strategy. We identify opportunities for improving the measurement and characterization of these factors for improved precision in determining prognosis. We propose new predictors that could expand our understanding of factors influencing the attainment of remission, but that require further investigation.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"294 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levamisole-Adulterated Cocaine-Induced Vasculitis Mimicking Acute Limb Ischemia.","authors":"Shahriar Amin,Deepak Nagra,Devika Dua,Ganesh Kasavkar","doi":"10.3899/jrheum.2025-0526","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0526","url":null,"abstract":"","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing Centers of Excellence for Psoriatic Disease in Latin America: Consensus Recommendations from the REAL-PANLAR Group.","authors":"Rodrigo Garcia-Salinas,Alexis Ogdie,Fernando Sommerfleck,Enrique R Soriano,Andre L Ribeiro,Verónica Avellanal,Javier Badilla,Antonio Cachafeiro,Juan Raul Castro Ayarza,Nelly Colman,Boris Garro,Sebastián Ibañez Vodnizza,Angela Londoño-Garcia,John Londoño,Daniel Palleiro,Cesar Pacheco-Tena,Carlos Rios,Jossiel Then,Manuel F Ugarte-Gil,Carlo Vinicio Caballero,Paula A Beltran,Pedro Santos-Moreno","doi":"10.3899/jrheum.2025-0405","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0405","url":null,"abstract":"OBJECTIVEPsoriatic Disease (PsD) is a chronic, multisystem inflammatory condition characterized by heterogeneous manifestations, including peripheral arthritis, axial involvement, enthesitis, and cutaneous and nail psoriasis. The condition has significant physical, emotional, and psychosocial impacts on patients. In Latin America, healthcare disparities exacerbate delays in diagnosis and treatment, increasing the burden of PsD and associated comorbidities. This study aimed to establish regionally adapted criteria for Centers of Excellence (CoE) to optimize PsD care.METHODSA panel of 18 experts in rheumatology and dermatology from 12 Latin American countries developed CoE criteria using the Delphi methodology. A narrative literature review informed the process, and criteria were evaluated using a Likert scale. Consensus was defined as ≥70% agreement. An in-person meeting refined unresolved items. The criteria were categorized into structure, process, and outcomes, based on Donabedian's quality evaluation model.RESULTSTwo types of CoE were defined: Optimal and Model. Optimal CoEs require a multidisciplinary team including rheumatologists, dermatologists, nurses, and psychologists. Model CoEs expand this team to include gastroenterologists, ophthalmologists, physiatrists, among other specialists. Structural criteria emphasized infrastructure and electronic systems for data management. Process criteria included patient-centered education, multidisciplinary consultations, and psychosocial support. Outcomes focused on standardized clinimetric tools (e.g., PASI, DAPSA) and the \"treat-to-target\" strategy. Approval ratings ranged from 80% to 100%.CONCLUSIONThe consensus establishes a framework for CoE in PsD care in Latin America, addressing structural, process, and outcome criteria to improve clinical outcomes, patient satisfaction, and healthcare system sustainability. These standards provide a roadmap for enhancing PsD management in resource-limited settings.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"184 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical Lymphadenitis in a Patient Receiving Tumor Necrosis Factor Inhibitor Therapy.","authors":"Matthew Anacleto-Dabarno,Dafna D Gladman,Denis Poddubnyy","doi":"10.3899/jrheum.2025-0173","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0173","url":null,"abstract":"","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization of Rehabilitation Services After Idiopathic Inflammatory Myopathy (IIM) Diagnosis: A US Retrospective Cohort Assessment.","authors":"Astia Allenzara,Katherine Jicha,Carolina Álvarez,Brian Kanapkey,Jamie Regan,Amanda E Nelson,Galen Foulke,Louise Thoma","doi":"10.3899/jrheum.2025-0097","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0097","url":null,"abstract":"OBJECTIVEInvestigate use and timing of rehabilitation services for patients with Idiopathic Inflammatory Myopathies (IIM).METHODSThis was a retrospective analysis of US patients in the TriNetX dataset. Patients were defined by at least two IIM International Classification of Disease (ICD) codes between 1-12 months apart with at least a year of preceding data (from prior non-IIM ICD codes or Common Procedural Terminology (CPT) codes). Recurrent event modeling was performed from first IIM ICD code to the event of a CPT code for Physical therapy (PT), Occupational therapy (OT), and Speech language pathology (SLP). Analysis was adjusted for the following potential confounders: age at first IIM ICD code, sex, IIM diagnosis subtype, stroke, hospitalization, orthopedic procedure, hip fracture and glucocorticoid use.RESULTSA total of 22,434 patients with IIM and available data were identified, of whom 29.4% were male. After the first IIM ICD code, 20.1%, 5.3%, and 3.7% of patients had at least one PT, OT, and/or SLP evaluation over an average of 10 years follow up. Mean time to rehabilitation services utilization was just under 2 years after first IIM code. Older age and prior use of the respective rehabilitation service was associated with higher rehabilitation service use across all categories. The dermatomyositis ICD group had significantly lower PT and OT use compared to the polymyositis ICD group.CONCLUSIONRehabilitation use was infrequent overall, occurring nearly two years after the initial IIM ICD code. This may indicate barriers to appropriate integration of rehabilitation services for patients with IIM.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"107 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parvovirus B19-Associated Large-Vessel Vasculitis in an Immunocompromised Patient.","authors":"Michael Aw,Todd C Lee,Arielle Mendel,Inés Colmegna","doi":"10.3899/jrheum.2025-0514","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0514","url":null,"abstract":"","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"107 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Clinicians Need to Know About Glucagon-like Peptide 1 Agonists.","authors":"Dimitri Luz Felipe da Silva,Shikha Singla,Philip J Mease","doi":"10.3899/jrheum.2025-0531","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0531","url":null,"abstract":"The interplay between metabolic health and autoimmune diseases such as psoriasis (PsO) and psoriatic arthritis (PsA) has garnered increasing attention. Obesity, a key feature of metabolic syndrome, exacerbates disease severity in these conditions, prompting the exploration of treatments addressing both the immune system and metabolism. Glucagon-like peptide 1 receptor agonists (GLP-1RAs), primarily used for type 2 diabetes mellitus, have demonstrated benefits beyond glycemic control, including promoting weight loss, improving metabolic health, and potentially modulating immune responses. There is also a dual GLP-1 and glucose-dependent insulinotropic polypeptide receptor agonist with similar and potentially superior capabilities; throughout this manuscript these will be collectively known as GLP-1RA. Recent studies also suggest that GLP-1RAs may help manage PsO and PsA in patients with obesity. These medications may offer dual benefits by reducing inflammation and addressing metabolic abnormalities like insulin resistance and hyperlipidemia. This article reports on a presentation given at the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) 2024 annual meeting underscoring the potential of GLP-1RAs as a therapeutic option, particularly for obese patients with PsO and PsA. Although promising, the evidence supporting GLP-1RAs for treating PsO and PsA remains limited, necessitating further clinical research to evaluate their safety and efficacy.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Diagnostic Challenge: Palatal Nodules as the First Sign of IgG4-Related Disease.","authors":"Shuangshuang Wu,Zhimin Yan","doi":"10.3899/jrheum.2025-0569","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0569","url":null,"abstract":"","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}