The Journal of Rheumatology最新文献

{"title":"Herpes Zoster Vaccine and Rheumatoid Arthritis.","authors":"Shih-Wei Lai","doi":"10.3899/jrheum.2025-0272","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0272","url":null,"abstract":"","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Residual Disease Activity and Burden of Disease in Canadian Patients with Axial Spondyloarthritis: Results from a Multi-registry Analysis (UNISON-Axial SpA).","authors":"Denis Choquette,Dafna D Gladman,Robert D Inman,Proton Rahman,Marie-Claude Laliberté,Pierre-André Fournier,Tanya Girard,Stephanie Wichuk,Louis Coupal,Vinod Chandran,Sherry Rohekar,Tristan Boyd,Michel Zummer,Nicolas Richard,Carter Thorne,Dianne Mosher,Olga Ziouzina,Alexander Tsoukas,Michael Starr,Jonathan Chan,Sibel Zehra Aydin,Walter P Maksymowych","doi":"10.3899/jrheum.2024-1303","DOIUrl":"https://doi.org/10.3899/jrheum.2024-1303","url":null,"abstract":"OBJECTIVEThere is a key knowledge gap in quantifying residual disease activity in Canadian patients with axial spondyloarthritis (axSpA). The objective of this study was to evaluate and describe residual disease activity and burden of disease in Canadian patients with axSpA.METHODSThis was an observational, retrospective analysis of data extracted from the Rhumadata™ (Québec), SPondyloArthritis Research Consortium of Canada (SPARCC, East/Atlantic and West regions, and Ontario), and FOllow-up Research Cohort of Ankylosing SpondyliTis (FORCAST, Alberta) registries. The primary endpoint was proportion of patients who failed to achieve sustained low disease activity (LDA) at 12 months; LDA was defined as a Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score <3 and sustained LDA defined as achieving LDA at both 6 and 12 months after the most recent change in treatment. Analyses included outcomes by treatment class (nonsteroidal anti-inflammatory drugs [NSAIDs], tumor necrosis factor inhibitor, or interleukin-17 inhibitor).RESULTSA total of 980 patients (Rhumadata™, N=488; SPARCC, N=239; FORCAST, N=253) were included. Nearly half of patients with axSpA from Rhumadata™/Québec (49.5%) and FORCAST/Alberta (55.3%) and 65.8% of those from SPARCC/Ontario failed to achieve LDA (BASDAI <3) at 6 months after treatment initiation. At 12 months, failure to achieve sustained LDA rose to 62.0% in Rhumadata™/Québec, 65.1% in FORCAST/Alberta, and 81.0% in SPARCC/Ontario. Pain persisted in nearly half of all patients.CONCLUSIONThis analysis demonstrated that most Canadians with axSpA failed to achieve sustained LDA after 12 months of initiating their latest therapy and confirms a high unmet need for additional treatments.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endothelial Cell and Neutrophil Activation in Untreated Intercritical Patients With Gout.","authors":"Michael Toprover,Binita Shah,Kamelia Drenkova,Ana Leonard,Michael H Pillinger,Michael Garshick","doi":"10.3899/jrheum.2025-0255","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0255","url":null,"abstract":"","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"154 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, Risk Factors, and Outcomes of Chronic Kidney Disease in Systemic Lupus Erythematosus Patients with and without Lupus Nephritis.","authors":"Keren Cohen-Hagai,Mor Saban,Sydney Benchetrit,Dorin Bar-Ziv,Naomi Nacasch,Moshe Shashar,Yael Pri-Paz Basson,Ori Wand,Ayelet Grupper,Shaye Kivity,Oshrat E Tayer-Shifman","doi":"10.3899/jrheum.2024-1087","DOIUrl":"https://doi.org/10.3899/jrheum.2024-1087","url":null,"abstract":"OBJECTIVEChronic kidney disease (CKD) has significant clinical and therapeutic implications. This study assesses CKD prevalence, risk factors, and long-term outcomes in systemic lupus erythematosus (SLE) with and without lupus nephritis (LN).METHODSThis single-center, retrospective medical records review study (2014-2023) included adult SLE patients. CKD was defined as estimated glomerular filtration rate (eGFR) <60 ml/min/1.73m2 or albuminuria ≥30 mg/24h in at least two consecutive tests, spaced ≥ 3 months apart. Statistical analyses included chi-squared tests, t-tests, multivariable regression, and Cox proportional hazards models.RESULTS175 SLE patients were included with a mean follow-up of 18.3±14.7 years; 12 required kidney replacement therapy. CKD was diagnosed in 54.6% (89/163) of patients, including 15.7% with reduced eGFR only, 52.8% with albuminuria only, and 31.5% with both. LN was associated with a higher hazard ratio (HR=5.4) for CKD. Nevertheless, 46.1% of CKD patients had no history of LN. CKD was associated with increased cardiovascular morbidity, hospitalization rates for SLE exacerbations and infections. Cox analyses identified LN as the strongest predictor of CKD; other predictors were age and lower eGFR at diagnosis. CKD was an important predictor of mortality among patients with lupus, both in univariate and multivariable analyses (19.1% vs. 1.4%, p<0.001).CONCLUSIONCKD is highly prevalent in SLE, including in patients without prior LN. CKD is associated with increased morbidity and mortality. This study emphasizes the clinical relevance of CKD diagnosis and management in SLE patients.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Damage Accrual in Lupus Nephritis Stratified by Biological Sex.","authors":"Fadi Kharouf,Pankti Mehta,Ali Alhadri,Qixuan Li,Laura P Whittall Garcia,Dafna D Gladman,Zahi Touma","doi":"10.3899/jrheum.2025-0302","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0302","url":null,"abstract":"OBJECTIVESeveral studies in systemic lupus erythematosus (SLE) have suggested that male individuals may experience a higher risk of damage compared to female individuals. However, this has not been adequately explored in cohorts focused specifically on lupus nephritis (LN). We aimed to investigate sex-based differences in the accrual of both extrarenal and renal damage in a cohort of patients with LN.METHODSThis retrospective study included patients with SLE from an observational cohort who developed LN at or after clinic entry. Outcomes of extrarenal and renal damage were assessed using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) and kidney function measures. Statistical analyses included Fine-Gray subdistribution hazard models and Kaplan-Meier survival analysis.RESULTSThe cohort included 460 patients, with a predominance of female individuals (83.5%) and a median age of 33 years. Over a median follow-up of 8.6 years, 45.3% of patients accrued extrarenal damage, defined as an increase in nonrenal SDI by ≥ 1, whereas 32.2% experienced renal damage, defined as a composite of either a sustained ≥ 30% decline in estimated glomerular filtration rate or progression to end-stage kidney disease. No significant differences in the accrual of damage were observed between male and female individuals, and the time to outcomes was not statistically different between both sexes. Multivariable analysis revealed that male sex was not associated with higher damage accrual, either extrarenal (hazard ratio [HR] 1.13, 95% CI 0.76-1.70) or renal (HR 1.26, 95% CI 0.67-2.36).CONCLUSIONExtrarenal and renal damage accrual are frequent in patients with LN and do not appear to be higher in male individuals.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"648 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of Hand Blood Flow by 82Rubidium Positron Emission Tomography.","authors":"Attila Feher,Ilayda Gunes,Ibolya Csecs,Dana C Peters,Albert J Sinusas,Edward J Miller,Monique Hinchcliff","doi":"10.3899/jrheum.2025-0415","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0415","url":null,"abstract":"","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Risk and Time Course for Autoimmune Rheumatic Disease Development in Patients With Raynaud Phenomenon.","authors":"Shannon Teaw,Abbas Shojaee,Miruna Carnaru,Monique Hinchcliff","doi":"10.3899/jrheum.2024-0954","DOIUrl":"https://doi.org/10.3899/jrheum.2024-0954","url":null,"abstract":"","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying the State of Mental Health Care in Canadian Adults with Systemic Lupus Erythematosus.","authors":"Justin David Smith,Bo Pan,Stephanie Keeling","doi":"10.3899/jrheum.2025-0089","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0089","url":null,"abstract":"OBJECTIVETo identify barriers to accessing mental health care among adult patients with systemic lupus erythematosus (SLE) in Canada, exploring physician- and patient-reported barriers and evaluating possible interventions.METHODSWe surveyed Canadian rheumatologists and adult patients with SLE. Physicians reported current practices, barriers, and interventions for mental health care. Patients reported their mental health experiences, barriers to access, and preferences for interventions. Surveys were distributed through professional networks, clinics, and social media, with analyses conducted using descriptive statistics and Cohen's kappa for agreement.RESULTSA total of 25 rheumatologists and 235 patients participated. Physicians cited limited availability of mental health providers (88%) and insufficient time (84%) as top barriers. Few used standardized screening tools like PHQ-9 (16%) or GAD-7 (12%). Patients reported anxiety (41.7%) and depression (39.9%) as common concerns, with many facing challenges accessing care due to long wait times and affordability. Patients favored integrated mental health services within rheumatology clinics (58.6%), whereas physicians preferred external referrals. Agreement between groups on interventions ranged from moderate (κ=0.64) for primary care screening to low (κ=0.25) for integration of services into the rheumatology clinic.CONCLUSIONMental health care in SLE management remains underdeveloped, hindered by systemic barriers and discordance between patient and provider preferences. Standardized screening, interprofessional collaboration, and alignment of perspectives would likely improve mental health outcomes and overall patient quality of life. These findings highlight opportunities for targeted interventions and guideline development in mental health care for SLE.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refractory Sclerosing Mesenteritis/Mesenteric Panniculitis Presenting With Macrophage Activation Syndrome Treated With Rituximab.","authors":"Anjali Nidhaan,Gauri Pethe,Shannon Iriza","doi":"10.3899/jrheum.2025-0111","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0111","url":null,"abstract":"","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"189 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multivariable models to predict a diagnosis of Giant Cell Arteritis: systematic review and meta-analysis.","authors":"Mats L Junek,Iva Okaj,Sagar Patel,Angela Hu,Matthew A Jessome,Deborah Koh,Seungwon Choi,Sukhreet Atwal,John Koussiouris,Johan Pushani,Colin Stark,Farid Foroutan,Stephanie Garner,Nader Khalidi","doi":"10.3899/jrheum.2022-1204","DOIUrl":"https://doi.org/10.3899/jrheum.2022-1204","url":null,"abstract":"OBJECTIVEMultiple models to predict a diagnosis of Giant cell arteritis (GCA) have been developed to assist clinicians. We conducted a systematic review and meta-analysis of model variables and model performance.METHODSWe searched Pubmed, Embase, and the Cochrane Library from January 1990 to April 2024 for studies that used multivariable models to diagnose GCA. Study characteristics, patient characteristics, method of and criteria for diagnosis, and model details were extracted. Metaanalysis of individual signs and symptoms was performed using generic inverse variance. The Prediction model Risk of Bias Assessment tool was used to assess individual model risk of bias. Certainty of the effect estimate for each predictor was assessed using Grading of Recommendations, Assessment, Development and Evaluations framework.RESULTSWe screened 2 254 abstracts and included 44 studies. A total of 15 409 patients and 4 340 diagnoses of GCA were included. Predictors with high certainty of effect and large effect size included jaw claudication, C-reactive protein elevation above 24.5 mg/dL, platelets above 400x109/L, positive temporal artery ultrasound, and presence of synovitis (predictive of a non-GCA diagnosis). Other factors classically associated with GCA including vision loss, symptoms of polymyalgia rheumatica, and headache were found to be predictive with lower certainty of effect. Models included were predominantly found to be at high risk of bias.CONCLUSIONPredictors of GCA were consistent across models, however, models were of poor methodologic quality. Future models to predict a diagnosis of GCA should be constructed with improved methodologic rigor.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}