Rethinking HLA-B27 Testing: What HLA-B27 Can- and Cannot-Tell Us.

Abstract

HLA-B27: a cornerstone in spondyloarthritis Nearly 50 years after its discovery as a major genetic risk factor for spondyloarthritis (SpA),1 the precise contribution of HLA-B27 to disease development and progression remains only partially understood. Proposed mechanisms include aberrant antigen presentation, misfolding-induced endoplasmic reticulum stress and modulation of innate immune responses.2.