The Journal of Rheumatology最新文献_第8页

Real-World Persistence on Tofacitinib in Psoriatic Arthritis Patients With Enthesitis: Comments on Recent Findings. 托法替尼在银屑病关节炎伴炎患者中的持续应用：对近期发现的评论。

The Journal of Rheumatology Pub Date : 2025-08-15 DOI: 10.3899/jrheum.2025-0722

Joaquín Borrás-Blasco,Alejandro Valcuende-Rosique,Silvia Cornejo-Uixeda

引用次数: 0

Crystalline Deposition in a Nose With a Sinus Tract. 有鼻窦道的鼻子里的结晶沉积。

The Journal of Rheumatology Pub Date : 2025-08-15 DOI: 10.3899/jrheum.2025-0439

Peter Xie,Michael Oliffe,Geraldine Hassett,David Massasso

引用次数: 0

A New Mouse Model of Psoriatic Arthritis. 银屑病关节炎小鼠模型的建立。

The Journal of Rheumatology Pub Date : 2025-08-15 DOI: 10.3899/jrheum.2025-0528

Bahram Razani,Vinod Chandran,Kurt de Vlam,Wilson Liao,Barbara A Malynn,Averil Ma

{"title":"A New Mouse Model of Psoriatic Arthritis.","authors":"Bahram Razani,Vinod Chandran,Kurt de Vlam,Wilson Liao,Barbara A Malynn,Averil Ma","doi":"10.3899/jrheum.2025-0528","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0528","url":null,"abstract":"Polymorphisms in the TNFAIP3 locus encoding the A20 protein are strongly associated with psoriatic skin and joint disease. Reduced A20 expression, driven by both genetic and epigenetic factors, underscores its critical role as a negative regulator of psoriatic disease (PsD). Our recent study using a germline knockin mouse model harboring a mutation in A20's seventh zinc finger, which impairs A20 binding to linear (M1) ubiquitin, revealed a spontaneous phenotype resembling psoriatic arthritis. These mice demonstrated sustained nuclear factor-κB signaling in response to transient tumor necrosis factor stimulation, leading to inappropriate transcription of mid- and late-response inflammatory genes. These findings highlight the role of dysregulated innate immune-signaling kinetics as a potential driver of PsD pathogenesis. These findings, together with distinct inflammatory mouse models resulting from temporally extended inflammatory gene activation, highlight the role of dysregulated innate immune-signaling kinetics as a potential driver of tissue inflammation with relevance to psoriatic skin and joint disease. This newly developed mouse model of PsD was presented at the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) 2024 annual meeting.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"294 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GRAPPA 2024: Innovations in Education Workshop. GRAPPA 2024：教育创新研讨会。

The Journal of Rheumatology Pub Date : 2025-08-15 DOI: 10.3899/jrheum.2025-0240

Gizem Ayan,M Elaine Husni,Ashish J Mathew,Iain B McInnes,Philip J Mease

引用次数: 0

Young-GRAPPA 2024: Progress, Achievements, and Strategic Developments. Young-GRAPPA 2024：进展、成就和战略发展。

The Journal of Rheumatology Pub Date : 2025-08-15 DOI: 10.3899/jrheum.2025-0263

Andre L Ribeiro,Gizem Ayan,Hanna J Johnsson,Roxana Coras,Michelle Mulder,Daniela B Tovar-Bastidas,Dimitri L F Silva,Arani Vivekanantham,Fabian Proft

{"title":"Young-GRAPPA 2024: Progress, Achievements, and Strategic Developments.","authors":"Andre L Ribeiro,Gizem Ayan,Hanna J Johnsson,Roxana Coras,Michelle Mulder,Daniela B Tovar-Bastidas,Dimitri L F Silva,Arani Vivekanantham,Fabian Proft","doi":"10.3899/jrheum.2025-0263","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0263","url":null,"abstract":"The Young Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (Y-GRAPPA) was established in 2021. As of July 2024, the group consists of 152 members, featuring a balanced gender distribution and a 70/30 split between rheumatology and dermatology specialties. In the last year, Y-GRAPPA updated its major project-the GRAPPA slide library-to include translations in 5 new languages, continued to publish the \"Do Not Miss\" newsletters, and presented \"Virtual Highlights\" for major international conferences (American Academy of Dermatology [AAD] annual meeting, European Alliance of Associations for Rheumatology [EULAR] annual congress, European Academy of Dermatology and Venereology [EADV] congress, and American College of Rheumatology [ACR] Convergence). Presently, Y-GRAPPA is boosting social media presence and refining its organizational structure and activities. This includes restructuring committees with new leaders to each focus on specific objectives, streamlined leadership, and proactive member recruitment and engagement. The key objective of Y-GRAPPA remains to ensure active participation in all GRAPPA activities through collaboration and communication between Y-GRAPPA and senior GRAPPA members.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How to Identify and Monitor Axial and Peripheral Psoriatic Arthritis by Magnetic Resonance Imaging. 如何用磁共振成像识别和监测轴型和外周型银屑病关节炎。

The Journal of Rheumatology Pub Date : 2025-08-05 DOI: 10.3899/jrheum.2025-0433

Pamela Díaz,Walter P Maksymowych,Mikkel Østergaard

引用次数: 0

Composite Outcome Measures for Psoriatic Arthritis: Project Updates 2024. 银屑病关节炎的综合疗效测量：项目更新2024。

The Journal of Rheumatology Pub Date : 2025-08-05 DOI: 10.3899/jrheum.2025-0268

Andre L Ribeiro,Tommy Kok Annfeldt,Dafna D Gladman,William Tillett,Ana-Maria Orbai,Ying Ying Leung

{"title":"Composite Outcome Measures for Psoriatic Arthritis: Project Updates 2024.","authors":"Andre L Ribeiro,Tommy Kok Annfeldt,Dafna D Gladman,William Tillett,Ana-Maria Orbai,Ying Ying Leung","doi":"10.3899/jrheum.2025-0268","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0268","url":null,"abstract":"The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA)-Outcome Measures in Rheumatology (OMERACT) psoriatic arthritis (PsA) working group provided updates at the GRAPPA 2024 annual meeting on their assessment of composite outcome measures for PsA. The group presented the progress of a systematic literature review on the psychometric properties of the following candidate composite outcome measures using the OMERACT filter 2.2: (1) minimal disease activity (MDA), (2) Disease Activity for Psoriatic Arthritis (DAPSA), (3) American College of Rheumatology (ACR) response criteria, (4) Psoriatic Arthritis Disease Activity Score (PASDAS), (5) Composite Psoriatic Disease Activity Index (CPDAI), (6) 3-item visual analog scale (3VAS), and (7) 4VAS. A Delphi exercise for patient research partners (PRPs) on domain match and feasibility is ongoing. Following analysis and endorsement of domain match and feasibility by PRPs, the working group will seek endorsement from the GRAPPA community. In addition, the group illustrated a new research proposal for using network metaanalysis to quantitatively compare the responsiveness of these various composite outcome measures.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"728 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges and Opportunities in Psoriatic Disease: An Integrated View of the Future. 银屑病的挑战和机遇：未来的综合观点。

The Journal of Rheumatology Pub Date : 2025-08-05 DOI: 10.3899/jrheum.2025-0264

Lyn Chinchay,Kaiyang Song,Jeffrey Stark,Nicole L Ward,Iain B McInnes

{"title":"Challenges and Opportunities in Psoriatic Disease: An Integrated View of the Future.","authors":"Lyn Chinchay,Kaiyang Song,Jeffrey Stark,Nicole L Ward,Iain B McInnes","doi":"10.3899/jrheum.2025-0264","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0264","url":null,"abstract":"Psoriatic disease (PsD), which includes cutaneous psoriasis (PsO) and psoriatic arthritis (PsA), affects 2% of the global population, and results in the development of comorbidities that adversely affect quality of life (QOL) and physical function. Recent advances in the field have allowed for earlier diagnosis of PsD and improved clinical strategies for care, including the use of innovative pathway-specific immune-targeted therapies. Despite these advances, there is no cure for PsD. Ongoing challenges in disease management include the need for adequate treatment response, precision-based care for individual patients, and a better understanding of the interrelationship between the pathogenesis of cutaneous PsO and PsO comorbidities, including PsA. Future progress may arise from integrating clinical disciplines, harnessing artificial intelligence, using molecular dissection to map out the disease pathogenesis of PsA to identify more effective treatment strategies, and exploring the interplay between PsD and comorbidities including cardiovascular disease, obesity, and depression. These developments could lead to personalized treatment approaches and increase the efficacy of therapeutics for PsD, ultimately improving patient outcomes and QOL. This article highlights the presentation of this topic at the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) 2024 annual meeting.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hot Topics: Exploring Artificial Intelligence and Inflammatory Memory in the Management of Psoriatic Diseases. 热点议题：探索人工智能和炎症记忆在银屑病管理中的作用。

The Journal of Rheumatology Pub Date : 2025-08-05 DOI: 10.3899/jrheum.2025-0241

Huidi Shucheng,April W Armstrong,Liv Eidsmo,Denis Poddubnyy

{"title":"Hot Topics: Exploring Artificial Intelligence and Inflammatory Memory in the Management of Psoriatic Diseases.","authors":"Huidi Shucheng,April W Armstrong,Liv Eidsmo,Denis Poddubnyy","doi":"10.3899/jrheum.2025-0241","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0241","url":null,"abstract":"The \"hot topics\" session of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) 2024 annual meeting and trainee symposium explored the integration of artificial intelligence (AI) in managing psoriatic diseases (PsD) and the underlying mechanisms of inflammatory memory that drive recurrence in psoriasis and psoriatic arthritis. Drs. April Armstrong and Denis Poddubnyy discussed the transformative role of AI in enhancing diagnostic accuracy, assessing disease severity, and predicting treatment responses, particularly through deep learning models such as convolutional neural networks. AI systems have shown promise in providing objective, standardized assessments for psoriasis, with applications expanding across dermatology and rheumatology. Dr. Liv Eidsmo presented insights into inflammatory memory, a phenomenon sustained by both immune and nonimmune cells, including tissue-resident memory cells and epigenetically altered keratinocytes. Eidsmo emphasized the importance of understanding the cellular and molecular pathways that contribute to disease persistence. Both AI and inflammatory memory highlight key challenges and opportunities in PsD management; future research is needed to integrate technological advancements, with a deeper understanding of the biological processes affecting treatment outcomes.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MHC-I-opathy: A Unified Concept for the Etiology of Several Major Histocompatibility Complex-Associated Conditions Including Psoriasis and Psoriatic Arthritis. mhc - 1病变：银屑病和银屑病关节炎等几种主要组织相容性复合物相关疾病病因学的统一概念

The Journal of Rheumatology Pub Date : 2025-08-05 DOI: 10.3899/jrheum.2025-0235

Andrea Leung,Kerem Abacar,Georgia Marquez-Grap,Allison Kranyak,Wilson Liao,Dennis McGonagle

{"title":"MHC-I-opathy: A Unified Concept for the Etiology of Several Major Histocompatibility Complex-Associated Conditions Including Psoriasis and Psoriatic Arthritis.","authors":"Andrea Leung,Kerem Abacar,Georgia Marquez-Grap,Allison Kranyak,Wilson Liao,Dennis McGonagle","doi":"10.3899/jrheum.2025-0235","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0235","url":null,"abstract":"At the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) 2024 annual meeting, Drs. Dennis McGonagle and Wilson Liao discussed \"MHC-I-opathies,\" a class of immune-mediated diseases genetically associated with major histocompatibility complex class I (MHC-I) and class I peptide processing. MHC-I-opathies demonstrate epistatic interactions, genetic associations, and immunopathology that are distinct from classic B cell and autoantibody-driven autoimmune diseases. Investigations into the pathomechanisms of MHC-I-opathies have revealed a blend of tissue-specific innate immunity and CD8 T cell responses. Several functional pathomechanisms by which MHC-I molecules increase psoriasis (PsO) susceptibility were presented by McGonagle and Liao, and there were multiple associations within the HLA-C locus. Antigen presentation to T cells, HLA regulation of natural killer cells and CD8 T cells through killer immunoglobulin-like receptors, and HLA regulation of dendritic cells through leukocyte immunoglobulin-like receptors were discussed. Interestingly, MHC-I associations are not only linked to excessive inflammation in MHC-I-opathies but also to the spontaneous suppression of infection (eg, HIV-1 elite controllers). This striking prominence of MHC-I in PsO and antiviral immunity provides insight into why autoimmune alleles are maintained in the human genome and how protective antiviral pathways may be linked to aberrant activation of MHC-I-opathies. Outside of spinal inflammation in HLA-B27-positive axial psoriatic arthritis (PsA), the basis for MHC-I genetics in PsA remains less clear and is at least partly linked to greater PsA heterogeneity. Understanding the contribution of MHC-I in PsO and PsA may have important implications for therapy development.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0