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Toward Increasing Precision in the Early Diagnosis of Psoriatic Arthritis. 提高银屑病关节炎早期诊断的准确性。
The Journal of Rheumatology Pub Date : 2025-08-05 DOI: 10.3899/jrheum.2025-0363
Andre L Ribeiro,Lihi Eder,Sibel Z Aydin,Gurjit S Kaeley
{"title":"Toward Increasing Precision in the Early Diagnosis of Psoriatic Arthritis.","authors":"Andre L Ribeiro,Lihi Eder,Sibel Z Aydin,Gurjit S Kaeley","doi":"10.3899/jrheum.2025-0363","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0363","url":null,"abstract":"The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) ultrasound (US) group continued its focus on developing an early diagnostic tool for psoriatic arthritis (PsA). During the annual US workshop at the GRAPPA 2024 annual meeting in Seattle, Washington, participants reviewed preliminary analyses from the Diagnostic Ultrasound Enthesitis Tool (DUET) study and discussed the initial results of a DUET substudy aimed at defining enthesitis at the single enthesis level. Participants also previewed the ongoing systematic review of articular and periarticular manifestations of PsA, with particular attention to smaller joints. A summary of the 2024 US workshop is given herein.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Update on the Axial Involvement in Psoriatic Arthritis (AXIS) Project. 银屑病关节炎轴向受累（AXIS）项目进展。
The Journal of Rheumatology Pub Date : 2025-08-05 DOI: 10.3899/jrheum.2025-0234
Murat Torgutalp,Denis Poddubnyy,Dafna D Gladman
{"title":"Update on the Axial Involvement in Psoriatic Arthritis (AXIS) Project.","authors":"Murat Torgutalp,Denis Poddubnyy,Dafna D Gladman","doi":"10.3899/jrheum.2025-0234","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0234","url":null,"abstract":"Psoriatic arthritis (PsA) is an inflammatory disease associated with psoriasis, often affecting both peripheral and axial skeletal structures. Axial symptoms affect a significant portion of individuals with PsA. The Axial Involvement in Psoriatic Arthritis (AXIS) study, a multinational, multicenter cross-sectional study conducted under the umbrella of the Group for Research on Psoriasis and Psoriatic Arthritis (GRAPPA) and Assessment of SpondyloArthritis international Society (ASAS), aimed to establish a unified definition and classification criteria for axial involvement in PsA. The study enrolled 409 patients from 41 centers across 19 countries. Comprehensive clinical and imaging assessments were conducted for each patient including radiographs and magnetic resonance imaging of the sacroiliac joints and spine. Imaging data were reviewed by both local investigators and a central imaging committee. Final judgment on the presence or absence of axial involvement was made by investigators following evaluation of all data by the investigators and the central expert imaging team. Axial involvement was assessed to be present in 112/409 patients (27.4%). Data analysis is ongoing and the full study results are expected shortly. This update was presented at the GRAPPA 2024 annual meeting.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Scientific Method and Advancing Omic Technologies: Breakthroughs in Psoriatic Disease. 科学的方法和先进的组学技术：银屑病的突破。
The Journal of Rheumatology Pub Date : 2025-08-05 DOI: 10.3899/jrheum.2025-0267
Hanna J Johnsson,Stephen R Pennington,Nicole L Ward
{"title":"The Scientific Method and Advancing Omic Technologies: Breakthroughs in Psoriatic Disease.","authors":"Hanna J Johnsson,Stephen R Pennington,Nicole L Ward","doi":"10.3899/jrheum.2025-0267","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0267","url":null,"abstract":"A morning workshop addressing the topic of \"What You Always Wanted to Know About Science but Were Afraid to Ask\" was held at the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) 2024 annual meeting. In brief, Profs. Stephen Pennington and Nicole Ward covered the effect of recent multiomics and artificial intelligence technologies on psoriatic disease research by introducing these revolutionary advances in the context of the traditional scientific method. The workshop presented the fundamentals of genomics, transcriptomics, proteomics, and metabolomics; the limitations and challenges of these technologies; and current methods to present and interpret big data.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quality of Life in Adult SAPHO and Chronic Nonbacterial Osteomyelitis and Comparison to Chronic Rheumatic and Inflammatory Diseases. 成人SAPHO和慢性非细菌性骨髓炎的生活质量及与慢性风湿病和炎症性疾病的比较。
The Journal of Rheumatology Pub Date : 2025-08-01 DOI: 10.3899/jrheum.2025-0414
Aleksander Lenert,Jenna Thomason,Melanie H Smith,Helena Abodeely,Sandy D Hong,Courtney E Kremer,Petar S Lenert,T Shawn Sato,Sandra Hansmann,Melissa Oliver,Yongdong Dan Zhao,Jonathan Templin,Mary Vaughan-Sarrazin,Robyn Domsic,Daniel H Solomon,Polly J Ferguson
{"title":"Quality of Life in Adult SAPHO and Chronic Nonbacterial Osteomyelitis and Comparison to Chronic Rheumatic and Inflammatory Diseases.","authors":"Aleksander Lenert,Jenna Thomason,Melanie H Smith,Helena Abodeely,Sandy D Hong,Courtney E Kremer,Petar S Lenert,T Shawn Sato,Sandra Hansmann,Melissa Oliver,Yongdong Dan Zhao,Jonathan Templin,Mary Vaughan-Sarrazin,Robyn Domsic,Daniel H Solomon,Polly J Ferguson","doi":"10.3899/jrheum.2025-0414","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0414","url":null,"abstract":"OBJECTIVEThe health effects of SAPHO syndrome and chronic nonbacterial osteomyelitis (CNO) have not been well studied. We assessed health-related quality life (HRQOL) in adults with SAPHO-CNO and performed a review of EQ-5D outcomes amongst similar chronic rheumatic and inflammatory diseases.METHODSWe enrolled patients in the first US-based SAPHO-CNO prospective registry and assessed their HRQOL using the EQ-5D index and EQ-5D VAS. A focused scoping review was performed of EQ-5D related outcomes amongst disease cohorts with phenotypic similarities to SAPHO-CNO.RESULTSIn the 138 SAPHO-CNO participants, mean age (standard deviation) was 37.7 (15.0) years with a mean disease duration of 6.4 (6.2) years. All subjects had musculoskeletal involvement (44% having spine involvement) and 48% had skin involvement. Mean EQ-5D-5L index value was 0.75 (0.16) and mean EQ-VAS was 63.0 (21.0). Most patients were impacted by pain/discomfort (86%), difficulty in carrying out usual activities (65%) and anxiety/depression (54%); over one-third reported problems in all five EQ-5D domains. These SAPHO-CNO adults had similarly reduced EQ-5D and VAS values, and similar high proportion of perceived problems, as other inflammatory disease cohorts.CONCLUSIONThe HRQOL among adults with SAPHO-CNO is low, with more than half of patients experiencing an impact in perceived pain, performing usual activities, and feelings of anxiety or depression. Future therapies should target the multi-dimensional nature of SAPHO-CNO, targeting HRQOL as a major outcome.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144763176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Stars Align: The Incredible Discovery Story of VEXAS. 星星排成一行：令人难以置信的发现VEXAS的故事。
The Journal of Rheumatology Pub Date : 2025-08-01 DOI: 10.3899/jrheum.2025-0644
Jason E Liebowitz
{"title":"The Stars Align: The Incredible Discovery Story of VEXAS.","authors":"Jason E Liebowitz","doi":"10.3899/jrheum.2025-0644","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0644","url":null,"abstract":"","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144763235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developing Rheumatology in Sub-Saharan Africa: Addressing the Challenges. 在撒哈拉以南非洲发展风湿病学：应对挑战。
The Journal of Rheumatology Pub Date : 2025-08-01 DOI: 10.3899/jrheum.2025-0725
Robert J Moots
{"title":"Developing Rheumatology in Sub-Saharan Africa: Addressing the Challenges.","authors":"Robert J Moots","doi":"10.3899/jrheum.2025-0725","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0725","url":null,"abstract":"","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"160 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144763245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVID-19 vaccine booster uptake and effectiveness among persons with systemic autoimmune and rheumatic diseases. COVID-19疫苗增强剂在系统性自身免疫性疾病和风湿病患者中的吸收和有效性
The Journal of Rheumatology Pub Date : 2025-08-01 DOI: 10.3899/jrheum.2025-0535
Yonah C Ziemba,Eric P Elkin,Elham Kazemian,Brigid M Wilson,Hinnah Siddiqui,Cheryl B Schleicher,Crystal A Hsiao,David A Zidar,Lawrence H Kushi,Jane C Figueiredo,Jacek Skarbinski,James M Crawford
{"title":"COVID-19 vaccine booster uptake and effectiveness among persons with systemic autoimmune and rheumatic diseases.","authors":"Yonah C Ziemba,Eric P Elkin,Elham Kazemian,Brigid M Wilson,Hinnah Siddiqui,Cheryl B Schleicher,Crystal A Hsiao,David A Zidar,Lawrence H Kushi,Jane C Figueiredo,Jacek Skarbinski,James M Crawford","doi":"10.3899/jrheum.2025-0535","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0535","url":null,"abstract":"OBJECTIVETo assess COVID-19 booster uptake and vaccine effectiveness (VE) in reducing COVID-19 hospitalization in persons with systemic autoimmune and rheumatic diseases (SARDs).METHODSAdult patients with SARDs receiving disease modifying anti-rheumatic drugs at four health systems in the United States were identified retrospectively. Exposures were: 1) receipt of an additional dose of monovalent COVID-19 vaccine prior to January 1, 2022, with follow-up to August 31, 2022; and (2) receipt of bivalent COVID-19 vaccine between September 1, 2022 to August 31, 2023.RESULTSAmong 201,165 patients with SARDs, 126,756 (63%) had received one monovalent booster as of January 1, 2022. During 94,842 person-years of follow-up, the COVID-19 hospitalization rate was 15.6 per 1000 person-years among those who had received a monovalent booster versus 20.1 per 1000 person-years among those who had not, with an adjusted VE of 38% (95% confidence interval [CI] 31% - 44%) and a number needed to vaccinate of 267 (CI 230-325). Among 246,991 patients with SARDs with 233,622 person-years of follow-up in the bivalent study period, the COVID-19 hospitalization rate was 7.9 per 1000 person-years for the 87,906 (36%) patients who received the bivalent vaccine, versus 10.2 per 1000 person-years for the patients who did not. The adjusted VE of the bivalent vaccine was 32% (CI 24% - 39%) with a number needed to vaccinate of 617 (CI 500-838).CONCLUSIONCOVID-19 booster vaccinations provided significant protection against severe COVID-19 in persons with autoimmune disease. Thus, increasing vaccine uptake should be prioritized in this high-risk immunocompromised population.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144763306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Towards Harmonized Recommendations for Psoriatic Arthritis: A Comparative Viewpoint on Global Guidelines. 银屑病关节炎的统一建议：全球指南的比较观点。
The Journal of Rheumatology Pub Date : 2025-08-01 DOI: 10.3899/jrheum.2025-0491
Andre L Ribeiro,Mohamad Bittar,Wafa Hamdi,Ashish J Mathew,Fabian Proft,Nelly Ziade,Rodrigo Garcia-Salinas
{"title":"Towards Harmonized Recommendations for Psoriatic Arthritis: A Comparative Viewpoint on Global Guidelines.","authors":"Andre L Ribeiro,Mohamad Bittar,Wafa Hamdi,Ashish J Mathew,Fabian Proft,Nelly Ziade,Rodrigo Garcia-Salinas","doi":"10.3899/jrheum.2025-0491","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0491","url":null,"abstract":"Psoriatic arthritis (PsA) treatment guidelines aim to deliver consistent, evidence-based care across clinical settings. However, the development of multiple regional guidelines often leads to methodological overlap, variability in implementation, and resource redundancy. This Viewpoint compares recent recommendations from ACR, GRAPPA, EULAR, PANLAR exploring their similarities and differences in methodology, structure, and stakeholder composition. We discuss the challenges in maintaining updated recommendations in a rapidly evolving therapeutic landscape and propose a collaborative framework centered on core global recommendations with regional adaptations. Emerging tools, such as living systematic reviews and artificial intelligence, may support more efficient updates, but stakeholder engagement remains essential. Ultimately, a hybrid approach balancing global harmonization with local relevance may enhance the utility and sustainability of PsA guidance.","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144763247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engaging Arabic-Speaking Patients With Rheumatic Diseases Through Social Media: A Multinational Infodemiology Analysis. 通过社交媒体接触讲阿拉伯语的风湿病患者：一项跨国信息流行病学分析。
The Journal of Rheumatology Pub Date : 2025-08-01 DOI: 10.3899/jrheum.2025-0455
Ihsane Hmamouchi,Jean W Liew,Nelly Ziade,Nizar Abdullateef,Fatemah Abutiban,Manal Elrakawi,Mounir Ghogho,Elizabeth R Graef,Najia Hajjaj-Hassouni,Basel Masri,Ahmed Hussein Subki,Noelle A Rolle,Hussein Halabi,Lina El Kibbi
{"title":"Engaging Arabic-Speaking Patients With Rheumatic Diseases Through Social Media: A Multinational Infodemiology Analysis.","authors":"Ihsane Hmamouchi,Jean W Liew,Nelly Ziade,Nizar Abdullateef,Fatemah Abutiban,Manal Elrakawi,Mounir Ghogho,Elizabeth R Graef,Najia Hajjaj-Hassouni,Basel Masri,Ahmed Hussein Subki,Noelle A Rolle,Hussein Halabi,Lina El Kibbi","doi":"10.3899/jrheum.2025-0455","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0455","url":null,"abstract":"","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144763243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recurrent Monoarthritis in a 40-Year-Old Woman. 复发性单关节炎1例40岁女性。
The Journal of Rheumatology Pub Date : 2025-08-01 DOI: 10.3899/jrheum.2025-0381
Brennan S Mao,Pierre A Brown,Kawan S Rakhra,Susan Humphrey-Murto
{"title":"Recurrent Monoarthritis in a 40-Year-Old Woman.","authors":"Brennan S Mao,Pierre A Brown,Kawan S Rakhra,Susan Humphrey-Murto","doi":"10.3899/jrheum.2025-0381","DOIUrl":"https://doi.org/10.3899/jrheum.2025-0381","url":null,"abstract":"","PeriodicalId":501812,"journal":{"name":"The Journal of Rheumatology","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144763236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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