Journal of Infection最新文献

{"title":"Impact of distribution of facemasks on community incidence and outcomes of COVID-19: A cluster randomised trial in India","authors":"Poppy A.C. Mallinson ,&nbsp;Teena Dasi ,&nbsp;Santosh Kumar Banjara ,&nbsp;Judith Lieber ,&nbsp;Santhi Bhogadi ,&nbsp;Srivalli Addanki ,&nbsp;Prasad Undrajavarapu ,&nbsp;Subhash Masapeta ,&nbsp;Hemant Mahajan ,&nbsp;Bharati Kulkarni ,&nbsp;Sanjay Kinra","doi":"10.1016/j.jinf.2025.106557","DOIUrl":"10.1016/j.jinf.2025.106557","url":null,"abstract":"<div><h3>Background</h3><div>Randomised evidence on the effectiveness of delivering facemasks for reducing the health impact of COVID-19 remains limited.</div></div><div><h3>Methods</h3><div>We conducted a cluster randomised trial in Telangana, India, in August–November 2020 to investigate whether distribution and promotion of facemasks in villages reduces the incidence and adverse outcomes of COVID-19. We randomised 20 villages from the ongoing APCAPS surveillance study (1:1 ratio) to village-wide distribution of 3-layer cloth facemasks along with promotional messaging, or no intervention. Outcomes were incidence of notified COVID-19 (primary), hospitalised COVID-19 and all-cause mortality (secondary), collected through household surveillance by village health workers. Mask wearing was assessed through standardised observations in village centres. Data were analysed by multilevel Poisson regression.</div></div><div><h3>Findings</h3><div>Use of the study facemasks and any face coverings in public spaces was higher in intervention villages (19% and 59%, respectively) than control villages (0% and 38%). In the 10 intervention (N=16,741 adults) and 10 control villages (N=15,278 adults), respectively, the crude incidence per thousand person months (number of events) of notified COVID-19 was 2.15 (n=144) and 2.45 (n=150), of hospitalised COVID-19 was 0.07 (n=5) and 0.21 (n=13), and of all-cause mortality was 0.91 (n=61) and 1.10 (n=67). In models accounting for age, sex and pre-intervention COVID-19 rate, rate ratios in intervention versus control villages were 0.96 (95% confidence interval 0.57–1.63) for COVID-19 cases, 0.36 (0.12–1.05) for COVID-19 hospitalisations, and 0.84 (0.55–1.29) for all-cause mortality. No adverse effects were reported.</div></div><div><h3>Interpretation</h3><div>We are unable to draw firm conclusions about the effect of village-wide distribution and promotion of facemasks on COVID-19 incidence from these data due to a low number of events leading to imprecise effect estimates. Nonetheless, our findings are consistent with the modest protective effect on incident cases seen in previous randomised trials, extending these to adverse outcomes for the first time.</div></div><div><h3>Registration</h3><div>The trial was pre-registered on the Clinical Trials Registry of India on 25/07/2020 (CTRI/2020/07/026796).</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 2","pages":"Article 106557"},"PeriodicalIF":11.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative infectivity, virulence and molecular epidemiology of MDR and XDR Acinetobacter baumannii isolates emerging from war-related injuries in Ukraine","authors":"Jale Boral ,&nbsp;Chaitanya Tellapragada ,&nbsp;Oskar Thofte ,&nbsp;Valdemar Öhnström ,&nbsp;Michal Magda ,&nbsp;Erika Matuschek ,&nbsp;Oleksandr Nazarchuk ,&nbsp;Christian Giske ,&nbsp;Anna M. Blom ,&nbsp;Kristian Riesbeck","doi":"10.1016/j.jinf.2025.106561","DOIUrl":"10.1016/j.jinf.2025.106561","url":null,"abstract":"<div><h3>Background</h3><div>Multidrug resistant <em>Acinetobacter baumannii</em> remains a global concern with its ability to adhere, disperse and sustain in areas involving suboptimal infection control measures, particularly in war areas. In this study we aimed to evaluate the susceptibility profiles, molecular epidemiology and pathogenesis of <em>A. baumannii</em> isolates from conflict zones in Ukraine.</div></div><div><h3>Methods</h3><div><em>A. baumannii</em> wound isolates (<em>n</em>=46) were tested to comparatively assess antimicrobial resistance, molecular epidemiology, pathogenesis and infectivity. Briefly, antimicrobial susceptibility testing, whole genome sequencing, biofilm and capsule formation, as well as serum survival and bacterial viability in <em>G. mellonella</em> and a mouse infection model were performed.</div></div><div><h3>Results</h3><div>Dominating sequence types were ST2, ST19, ST78 and ST400 while 65.21% of isolates were from international clones. All isolates were multidrug resistant (MDR), and 7 isolates were extensively drug resistant (XDR). ST19 isolates had higher encapsulation, lower serum survival and missing T6SS, <em>omp33–36</em> and biofilm production associated genes. However, bacteria expressed higher virulence and lethality during early infection compared to later stages <em>in vivo</em>.</div></div><div><h3>Conclusion</h3><div>We report the first results characterizing the pathogenesis and infectivity of the emerging <em>A. baumannii</em> ST19. High MDR and XDR rates alongside clonally related isolates are concerning and highlight the importance of infection prevention and control measures in conflict zones.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 2","pages":"Article 106561"},"PeriodicalIF":11.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Umrah- and travel-associated meningococcal disease due to multiple serogroup W ST-11 sub-strains pre-Hajj 2024","authors":"Jay Lucidarme ,&nbsp;Ala-Eddine Deghmane ,&nbsp;Shalabh Sharma ,&nbsp;Courtney Meilleur ,&nbsp;Lorraine Eriksson ,&nbsp;Paula Mölling ,&nbsp;Heike Claus ,&nbsp;Nina M. van Sorge ,&nbsp;Célia Bettencourt ,&nbsp;Paula Bajanca-Lavado ,&nbsp;Raymond S.W. Tsang ,&nbsp;Dominique A. Caugant ,&nbsp;Paola Stefanelli ,&nbsp;Arianna Neri ,&nbsp;Georgina Tzanakaki ,&nbsp;Aiswarya Lekshmi ,&nbsp;Helen Campbell ,&nbsp;Stephen A. Clark ,&nbsp;Emma J. Heymer ,&nbsp;Sonia Ribeiro ,&nbsp;Ray Borrow","doi":"10.1016/j.jinf.2025.106558","DOIUrl":"10.1016/j.jinf.2025.106558","url":null,"abstract":"<div><h3>Objectives</h3><div>Collectively, the Hajj and Umrah pilgrimages draw &gt;30 million pilgrims to the Kingdom of Saudi Arabia (KSA) each year. Before Hajj 2024 (14 to 19 June), the meningococcal serogroup W ST-11 complex (W:cc11) Hajj-strain sublineage caused multiple international cases of invasive meningococcal disease (IMD) associated with travel to the Middle East and Asia. Here we identify and characterise the strains responsible.</div></div><div><h3>Methods</h3><div>All Hajj strain sublineage genomes on PubMLST.org underwent core genome MLST comparisons (PubMLST.org).</div></div><div><h3>Results</h3><div>Isolates from 30 cases, across seven countries, formed five phylogenetic clusters within two distinct strains. Travel histories included KSA, other Middle Eastern countries, India, Mauritius, Kenya via Turkey, and no known associated travel. The prevalent strain, representing four clusters, had no African, and limited Middle Eastern, representation. The geo-temporal distribution of available genomes indicated Eastern Europe as a possible source.</div></div><div><h3>Conclusions</h3><div>The rapid expansion of Umrah/travel-related W:cc11 IMD cases in early 2024 was due to multiple strains/sublineages. Despite the involvement of non-KSA travel-destinations, the coincidence of cases with the busy month of Ramadan, and the abrupt cessation during Hajj (when vaccine compliance is maximal), suggest that Umrah was a key driver and highlight the need to reinforce mandatory vaccination whilst maintaining global vigilance.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 4","pages":"Article 106558"},"PeriodicalIF":11.9,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of polymerase acidic subunit (PA) substitutions on fever and symptoms in pediatric influenza A patients treated with baloxavir: A pooled four-season analysis","authors":"Reiko Saito ,&nbsp;Irina Chon ,&nbsp;Isamu Sato ,&nbsp;Takashi Kawashima ,&nbsp;Fujio Kakuya ,&nbsp;Tadashi Saito ,&nbsp;Michiyoshi Minato ,&nbsp;Naoki Kodo ,&nbsp;Eitaro Suzuki ,&nbsp;Yasuhiko Ono ,&nbsp;Hironori Masaki ,&nbsp;Norichika Asou ,&nbsp;Yoshiko Tsuchihashi ,&nbsp;Yutaka Shirahige ,&nbsp;Akito Kitano ,&nbsp;Yasushi Shimada ,&nbsp;Hirotsune Hamabata ,&nbsp;Jiaming Li ,&nbsp;Yuyang Sun ,&nbsp;Nanjun Lee ,&nbsp;Hisami Watanabe","doi":"10.1016/j.jinf.2025.106555","DOIUrl":"10.1016/j.jinf.2025.106555","url":null,"abstract":"<div><h3>Background</h3><div>Baloxavir marboxil is used for influenza treatment in Japan. However, the clinical and virologic significance of baloxavir-associated PA variants in children remains unclear.</div></div><div><h3>Methods</h3><div>We conducted a four-season, multicenter study from 2018–2019 to 2023–2024 in pediatric patients under 19 years old with influenza A who were treated with baloxavir. Clinical data were collected at the first visit; diary cards were maintained for up to 8 days. Clinical specimens were collected twice, with a median interval of 4 days. PA substitutions were screened by real-time RT-PCR and confirmed by next-generation sequencing and Sanger methods.</div></div><div><h3>Results</h3><div>Among 247 patients, 24 (9.7%) harbored PA variants, one pre-treatment and 23 post-treatment. PA/I38T was the most common substitution. A(H3N2) patients had a higher frequency of PA variants than A(H1N1)pdm09 (13.8% vs. 5.1%). Although PA variants were associated with slower viral RNA decline, no significant differences were observed in fever duration (median 22.6 vs. 15.6 h) or symptom duration (median 105.0 vs. 113.3 h) compared to wild-type virus infections.</div></div><div><h3>Conclusion</h3><div>PA variants, especially PA/I38T, emerged more frequently in A(H3N2) infections but had minimal clinical impact. The rarity of pre-treatment variants supports limited community transmission. Continued surveillance is warranted, particularly in younger children.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 2","pages":"Article 106555"},"PeriodicalIF":14.3,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards real-time in vitro Enterobacteriaceae beta-lactamase quantification using iridium oxide-based biosensors","authors":"Jennifer Lawrence ,&nbsp;Danny O’Hare ,&nbsp;Joseph van Batenburg-Sherwood ,&nbsp;Stephanie d'Arc ,&nbsp;Frances Davies ,&nbsp;Lucy Bock ,&nbsp;J. Mark Sutton ,&nbsp;Alison Holmes ,&nbsp;Timothy Miles Rawson","doi":"10.1016/j.jinf.2025.106554","DOIUrl":"10.1016/j.jinf.2025.106554","url":null,"abstract":"<div><div>The increasing prevalence of beta-lactamase-producing <em>Enterobacteriaceae</em> presents a critical challenge in clinical microbiology, complicating infection management due to resistance to most first- and second-line beta-lactam antibiotics. Current antimicrobial susceptibility testing (AST) approaches may not reliably detect and rapidly characterise beta-lactamase production, potentially leading to suboptimal treatment. In this study, we introduce a novel iridium oxide-based biosensor that detects in vitro beta-lactamase production in <em>Escherichia coli</em> (<em>E.coli</em>) type strains and genetically modified <em>E.coli</em> isolates within 10 min. The biosensor demonstrated high reproducibility (6.88% coefficient of variation). Clinical validation using 26 <em>E. coli</em> isolates from urinary tract infection patients showed a sensitivity of 100%, specificity of 57%, and accuracy of 88%. This biosensor-based method offers a rapid, reproducible, and cost-effective method for phenotypic detection of antimicrobial resistance, with the potential to significantly reduce diagnostic turnaround times and support individualised AST strategies.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 2","pages":"Article 106554"},"PeriodicalIF":11.9,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An 11-year multicentre clinical and genomic surveillance of listeriosis across Japan","authors":"Koh Shinohara,&nbsp;Yusuke Tsuda,&nbsp;Yasuhiro Tsuchido,&nbsp;Masaki Yamamoto,&nbsp;Yasufumi Matsumura,&nbsp;Miki Nagao","doi":"10.1016/j.jinf.2025.106552","DOIUrl":"10.1016/j.jinf.2025.106552","url":null,"abstract":"<div><h3>Objectives</h3><div>We conducted a multicenter retrospective study to characterize the clinical features of listeriosis and the genomic characteristics of causative <em>Listeria monocytogenes</em> isolates across Japan.</div></div><div><h3>Methods</h3><div>In this retrospective observational cohort study, we enrolled all microbiologically confirmed listeriosis cases between Jan 1, 2011, and Dec 31, 2021. We collected the causative isolates and performed whole genome sequencing. The isolates were compared using Multi-locus Sequence Typing (MLST), core-genome MLST, and single-nucleotide polymorphism (SNP)-based phylogeny.</div></div><div><h3>Results</h3><div>A total of 195 listeriosis cases from 22 hospitals were enrolled, including 134 cases of bacteremia, 43 cases of neurolisteriosis, 11 cases of perinatal infection, and 7 cases of other infections. Of the neurolisteriosis cases in patients aged one month to under 50 years, five out of six (83%) occurred in immunocompetent individuals. Nosocomial-onset cases accounted for 31 (17%) of the non-perinatal listeriosis cases, including four cases that presented with febrile neutropenia. Ninety-five <em>L. monocytogene</em>s isolates from 16 hospitals were collected, and cgMLST analysis revealed multiple previously unnoticed disease clusters. In MLST analysis, clonal complex (CC) 1 was the most predominant, followed by CC3, CC87, CC155, and CC2. International transmission events in the late 20th century contributed to the emergence of CC87 isolates in Eastern Asian countries.</div></div><div><h3>Conclusion</h3><div>This study highlighted concerns regarding neurolisteriosis occurring in immunocompetent children and young adults, as well as the significance of non-clustered nosocomial onset listeriosis. Genomic analysis using whole-genome sequencing revealed previously unnoticed disease clusters and the unique population structure of <em>L. monocytogenes</em> in Japan.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 2","pages":"Article 106552"},"PeriodicalIF":14.3,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reassessing acquired antimicrobial resistance genes in Helicobacter pylori: the role of recombinant, isogenic, and contaminated genomes","authors":"João Pedro Rueda Furlan,&nbsp;Yawen Yu,&nbsp;Qian Tong,&nbsp;Fábio Parra Sellera,&nbsp;Yingying Zhang,&nbsp;Zhi Ruan","doi":"10.1016/j.jinf.2025.106553","DOIUrl":"10.1016/j.jinf.2025.106553","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 2","pages":"Article 106553"},"PeriodicalIF":14.3,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The epidemiology of haemolytic uraemic syndrome in England, 2009-2023: An analysis of national surveillance data","authors":"Luke J. McGeoch ,&nbsp;Orlagh Quinn ,&nbsp;Amy Douglas ,&nbsp;Clare Sawyer ,&nbsp;Claire Jenkins ,&nbsp;Sooria Balasegaram","doi":"10.1016/j.jinf.2025.106551","DOIUrl":"10.1016/j.jinf.2025.106551","url":null,"abstract":"<div><h3>Objectives</h3><div>Haemolytic uraemic syndrome (HUS) is a serious multi-system disorder, predominantly caused by Shiga toxin-producing <em>Escherichia coli</em> (STEC). We aimed to describe the epidemiology of HUS in England, including characteristics associated with HUS among STEC cases.</div></div><div><h3>Methods</h3><div>Enhanced surveillance questionnaire (ESQ) and microbiological data were extracted for HUS and laboratory-confirmed STEC cases reported through national surveillance between 2009–2023. HUS incidence rates were computed. Trends in demographic, clinical, microbiological and exposure characteristics were described for STEC cases with (STEC-HUS) and without (non-HUS STEC) HUS, with complete ESQs. Associations with HUS were assessed using multivariable logistic regression.</div></div><div><h3>Results</h3><div>There were 991 HUS cases, 601 STEC-HUS cases and 12,916 non-HUS STEC cases. Between 2009–2023, serogroup O26 positivity increased from 3.3% to 48.6% among STEC-HUS cases, and 0.0% to 16.0% among non-HUS STEC cases. Characteristics associated with HUS included serogroup O26 (OR 2.30, 95% CI 1.68–3.11), <em>stx2a</em> (2.66, 2.10–3.37), <em>stx2d</em> (5.48, 2.41–11.66), <em>eae</em> (OR 3.00, 1.60–5.80), vomiting (4.78, 3.83–5.99), younger age, bloody diarrhoea, unpasteurised dairy consumption, and antibiotic use.</div></div><div><h3>Conclusions</h3><div>STEC O26 is the most common serogroup detected in HUS in England. We recommend efforts to improve surveillance of non-O157 serogroups and investigate drivers of STEC O26 infection and its relationship with HUS.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 2","pages":"Article 106551"},"PeriodicalIF":14.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bordetella pertussis infection and antibody dynamics in household cohorts in two South African communities, 2016 – 2018: findings from the PHIRST study","authors":"Fahima Moosa ,&nbsp;Jackie Kleynhans ,&nbsp;Lillian Makhathini ,&nbsp;Mignon du Plessis ,&nbsp;Stefano Tempia ,&nbsp;Meredith L. McMorrow ,&nbsp;Jocelyn Moyes ,&nbsp;Amelia Buys ,&nbsp;Lorens Maake ,&nbsp;Sheilagh Smit ,&nbsp;Neil A. Martinson ,&nbsp;Kathleen Kahn ,&nbsp;Limakatso Lebina ,&nbsp;Cheryl Cohen ,&nbsp;Anne von Gottberg ,&nbsp;Nicole Wolter","doi":"10.1016/j.jinf.2025.106550","DOIUrl":"10.1016/j.jinf.2025.106550","url":null,"abstract":"<div><h3>Introduction and methods</h3><div>In a cohort study, enrolling new households annually during 2016–2018, we estimated the <em>B. pertussis</em> attack rate using serology and PCR, identified factors associated with seroconversion, and described antibody changes over time. Nasopharyngeal swabs were collected biweekly for 6–10 months annually, with cases defined as individuals testing PCR-positive at least once. Seroconversion was defined as a ≥4-fold increase in anti-pertussis toxin IgG concentration between consecutive blood draws. Logistic regression was used to identify factors associated with seroconversion among PCR-positive individuals.</div></div><div><h3>Results</h3><div>Among 1509 participants, the serology attack rate was 5.8% (87/1509), 6.2% (94/1509) by PCR, and 9.6% (145/1509) combining both methods. Among PCR-positive cases, 38.3% (36/94) seroconverted, with a mean time to seroconversion of 2.9 months (range: 3 weeks–5.9 months). Younger participants (5–18 years) (adjusted odds ratio (aOR) 6.8, 95% confidence interval (CI) 1.3–35.1) and those with episode durations of ≥7 days (aOR 13.3, 95% CI 3.4–51.1) were more likely to seroconvert. Among the seroconverted, 75.0% (27/36) maintained antibody concentrations &gt;40 IU/ml for at least 12 months post-infection.</div></div><div><h3>Discussion</h3><div>Almost 10% of participants had <em>B. pertussis</em> infection during follow-up. Less than half of individuals with PCR-confirmed infection seroconverted but maintained elevated antibodies for at least one-year post-infection.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 2","pages":"Article 106550"},"PeriodicalIF":14.3,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between caspofungin treatment and mortality in non-HIV Pneumocystis jirovecii pneumonia: A multicenter, retrospective study","authors":"Jun Xu,&nbsp;Baoyue Lin,&nbsp;Guojun He,&nbsp;Chunfeng He,&nbsp;Kangchen Li,&nbsp;Yuanxiu Huang,&nbsp;Lingtong Huang,&nbsp;Hongliu Cai","doi":"10.1016/j.jinf.2025.106548","DOIUrl":"10.1016/j.jinf.2025.106548","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 2","pages":"Article 106548"},"PeriodicalIF":14.3,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}