妊娠期 COVID-19 再感染:英格兰的严重程度和妊娠结局评估。

IF 14.3 1区 医学 Q1 INFECTIOUS DISEASES
Anna A. Mensah , Julia Stowe , Kevin Brown , Jamie LopezBernal , Shamez Ladhani , Nick Andrews , Helen Campbell
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引用次数: 0

摘要

背景:妊娠期SARS-CoV-2再感染后的疾病严重程度和妊娠结局尚不清楚。方法:我们将2021年4月至2022年3月期间社区COVID-19检测呈阳性的18至50岁女性与医院、疫苗和孕产妇服务数据库联系起来。我们比较了孕妇和非孕妇感染和再感染后的住院率和重症监护病房(ICU)住院率,以及妊娠期感染和再感染妇女的低出生体重、早产和死胎率。结果:我们确定了68,842名孕妇和3,915,069名感染的非孕妇。SARS-CoV-2再感染后住院在妊娠期更为常见,尤其是在妊娠晚期(aOR= 18.56;95% CI: 9.46 ~ 36.42),妊娠期再感染或原发感染后相似(aOR= 0.82;95% ci: 0.50 - 1.33)。所有妊娠期ICU住院病例(n=49)均发生在原发性感染delta后。妊娠期首次感染和再次感染SARS-CoV-2后的不良妊娠结局无显著差异。结论:与未怀孕妇女相比,孕妇在再感染期间仍有更高的严重疾病风险;住院和ICU入院风险低。需要评估流行变体的毒力,以指导孕产妇预防COVID-19疫苗接种规划。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
COVID-19 reinfection in pregnancy: Assessment of severity and pregnancy outcomes in England

Background

Disease severity and pregnancy outcomes following SARS-CoV-2 reinfections in pregnancy are not well understood.

Methods

We linked women aged 18 to 50 years testing positive in the community for COVID-19 between April 2021 and March 2022 to hospital, vaccine and maternal services databases. We compared hospital and intensive care unit (ICU) admission rates following infection and reinfection in pregnant and non-pregnant women, and low birthweight, prematurity and stillbirth in women infected and reinfected during pregnancy.

Results

We identified 68,842 pregnant and 3,915,069 infected non-pregnant women. Hospital admission after SARS-CoV-2 reinfection was more common in pregnancy, especially during the third trimester (aOR= 18.56; 95% CI: 9.46 - 36.42) and was similar following reinfection or primary infection in pregnancy (aOR= 0.82; 95% CI: 0.50 - 1.33). All ICU admissions (n=49) in pregnancy occurred after primary infection with delta. There was no notable difference in adverse pregnancy outcomes after primary infection or reinfection with SARS-CoV-2 during pregnancy.

Conclusion

Pregnant women remain at higher risk of more severe disease during reinfection compared to non-pregnant women yet; hospitalisation and ICU admissions risk were low during the omicron period. The virulence of circulating variants needs to be assessed to guide maternal COVID-19 vaccination programmes against.
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来源期刊
Journal of Infection
Journal of Infection 医学-传染病学
CiteScore
45.90
自引率
3.20%
发文量
475
审稿时长
16 days
期刊介绍: The Journal of Infection publishes original papers on all aspects of infection - clinical, microbiological and epidemiological. The Journal seeks to bring together knowledge from all specialties involved in infection research and clinical practice, and present the best work in the ever-changing field of infection. Each issue brings you Editorials that describe current or controversial topics of interest, high quality Reviews to keep you in touch with the latest developments in specific fields of interest, an Epidemiology section reporting studies in the hospital and the general community, and a lively correspondence section.
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