npj Metabolic Health and Disease最新文献_第4页

An IL6 variant -174 G-C alters cardiac hypertrophy but not cardiometabolic responses to HFD in mice. il - 6变体-174 G-C改变小鼠心脏肥厚，但不改变HFD对心脏代谢的反应。

npj Metabolic Health and Disease Pub Date : 2026-03-23 DOI: 10.1038/s44324-026-00107-3

L E Watson, M Annandale, C L MacRae, J Bai, J Dayaram, N Burgess, C Puliuvea, P Kallingappa, C P Hedges, R F D'Souza, K L Weeks, N Fleming, T L Merry, K M Mellor

{"title":"An IL6 variant -174 G-C alters cardiac hypertrophy but not cardiometabolic responses to HFD in mice.","authors":"L E Watson, M Annandale, C L MacRae, J Bai, J Dayaram, N Burgess, C Puliuvea, P Kallingappa, C P Hedges, R F D'Souza, K L Weeks, N Fleming, T L Merry, K M Mellor","doi":"10.1038/s44324-026-00107-3","DOIUrl":"10.1038/s44324-026-00107-3","url":null,"abstract":"Chronic elevations in interleukin-6 (IL6) signaling have been shown to exacerbate features of cardiometabolic disease. A common variant in the IL6 promoter (location -174 G/C, identifier rs1800795) is associated with increased circulating IL6, and increased cardiometabolic disease incidence in some populations. This study's objective was to isolate the impact of this gene variant on cardiometabolic responses to metabolic stress, using knock-in mice with a GG wildtype or variant CC genotype for the murine homolog of rs1800795. Male and female IL6 variant CC mice on a high fat diet exhibited enhanced systemic IL6 levels but similar weight gain, energy expenditure, adipose tissue inflammation, glucose homeostasis, and cardiac function relative to control GG mice. Sex differences in the effect of the IL6 variant on cardiomyocyte dimensions were observed, with male variant mice exhibiting smaller cardiomyocyte volume, and female variant mice exhibiting larger cardiomyocyte volume with smaller raw heart mass relative to control GG mice. These findings suggest that, in a controlled experimental setting, the IL6 promoter variant (-174 G/C) does not increase susceptibility to cardiometabolic disease. Further work is required to understand the mechanistic link between this IL6 variant and associated increased cardiometabolic risk observed in population studies.","PeriodicalId":501710,"journal":{"name":"npj Metabolic Health and Disease","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13009176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enteric nervous system in exercise physiology: a microbiota-neural interface. 运动生理学中的肠神经系统：微生物群-神经界面。

npj Metabolic Health and Disease Pub Date : 2026-03-12 DOI: 10.1038/s44324-026-00106-4

Hui-Ling Chen, Jia-Ting Huang, Jian-Jun Guo, Li-Shun Wang

引用次数: 0

A multi-omic approach reveals iron availability influences cell fate fidelity. 多组学方法揭示铁的可用性影响细胞命运的保真度。

npj Metabolic Health and Disease Pub Date : 2026-03-06 DOI: 10.1038/s44324-026-00102-8

Athena Jessica S Ong, Tara A Tigani, Adele J Gomes, Jordyn M Reinecke, Andrew G Cox, Kristin K Brown

引用次数: 0

Lifestyle strategies and mechanistic implications for slowing neurodegeneration. 生活方式策略和减缓神经退行性变的机制含义。

npj Metabolic Health and Disease Pub Date : 2026-03-02 DOI: 10.1038/s44324-026-00101-9

Jordan A Gunning, Mario I Hernandez, Behzad Gudarzi, Hana M Roushdy, Yonas E Geda, Susan B Racette

引用次数: 0

ZOMES: expanding roles of the PCI complexes from protein metabolism to drug discovery. 扩展PCI复合物的作用，从蛋白质代谢到药物发现。

npj Metabolic Health and Disease Pub Date : 2026-02-27 DOI: 10.1038/s44324-026-00100-w

Lu Zhou, Hai Rao, Feng Rao

引用次数: 0

Adipose tissue-derived MFG-E8 promotes hepatic inflammation and fibrosis through macrophage activation in a mouse MASH model. 在小鼠MASH模型中，脂肪组织来源的MFG-E8通过巨噬细胞激活促进肝脏炎症和纤维化。

npj Metabolic Health and Disease Pub Date : 2026-02-20 DOI: 10.1038/s44324-026-00099-0

Masashi Kuroda, Kazuhiro Nomura, Azumi Wada, Yui Hatano, Miki Ogawa, Saya Okamoto, Etsuko Ishikawa, Yuna Izumi-Mishima, Sonoko Yasui-Yamada, Yasuo M Tsutsumi, Nagakatsu Harada, Rie Tsutsumi, Hiroshi Sakaue

{"title":"Adipose tissue-derived MFG-E8 promotes hepatic inflammation and fibrosis through macrophage activation in a mouse MASH model.","authors":"Masashi Kuroda, Kazuhiro Nomura, Azumi Wada, Yui Hatano, Miki Ogawa, Saya Okamoto, Etsuko Ishikawa, Yuna Izumi-Mishima, Sonoko Yasui-Yamada, Yasuo M Tsutsumi, Nagakatsu Harada, Rie Tsutsumi, Hiroshi Sakaue","doi":"10.1038/s44324-026-00099-0","DOIUrl":"10.1038/s44324-026-00099-0","url":null,"abstract":"Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by hepatocellular injury, macrophage activation, and severe fibrosis, and often progresses to liver cirrhosis and hepatocellular carcinoma. Excessive accumulation of visceral fat exacerbates hepatic inflammation and fibrosis independently of fatty liver, but the underlying molecular mechanisms have remained unclear. We here identify MFG-E8 (milk fat globule-EGF8) as a secreted protein that is overexpressed in adipose tissue of obese mice and contributes to such exacerbation. MFG-E8 deficiency in MASH model (STAM-MASH) mice was associated with reduced hepatic expression of inflammation- and fibrosis-related genes without attenuation of steatosis. Conversely, MFG-E8 supplementation in MFG-E8 knockout mice intensified hepatic inflammation and promoted the formation of hepatic crownlike structures. Coculture of macrophages with apoptotic hepatocytes induced expression of inflammatory cytokine genes, and this effect was enhanced by the presence of exogenous MFG-E8 in the culture medium. Our findings suggest that adipose tissue-derived MFG-E8 infiltrates the liver and promotes macrophage-hepatocyte interaction, thereby contributing to hepatic inflammation and fibrosis in MASH.","PeriodicalId":501710,"journal":{"name":"npj Metabolic Health and Disease","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12923611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146260606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatiotemporal metabolic mapping reveals diet-independent remodeling of the postnatal mouse brain. 时空代谢图谱揭示了出生后小鼠大脑的饮食独立重塑。

npj Metabolic Health and Disease Pub Date : 2026-02-10 DOI: 10.1038/s44324-025-00098-7

Elisa M York, Anne Miller, Sylwia A Stopka, Nathalie Y R Agar, Gary Yellen

{"title":"Spatiotemporal metabolic mapping reveals diet-independent remodeling of the postnatal mouse brain.","authors":"Elisa M York, Anne Miller, Sylwia A Stopka, Nathalie Y R Agar, Gary Yellen","doi":"10.1038/s44324-025-00098-7","DOIUrl":"10.1038/s44324-025-00098-7","url":null,"abstract":"Developing cells undergo extensive metabolic adaptations to support growth and differentiation. Here, using spatially resolved mass spectrometry imaging and stable isotope tracing, we systematically investigate metabolic remodeling in mouse brains at postnatal day 14 and day 28, a period coinciding with the transition from a maternal milk diet to solid food. Untargeted metabolomics reveals global shifts in lipid composition, and region-specific remodeling of central energy metabolism, including increased glycolytic intermediates in grey matter-enriched regions and a global decrease in tricarboxylic acid (TCA) cycle metabolites after weaning. Despite these marked changes in metabolite levels, the glucose incorporation rate remains constant across these developmental stages. Notably, weaning mice onto a milk-replacement diet demonstrates that the observed metabolic adaptations are largely diet-independent. Together, our data suggest that postnatal brain metabolic remodeling is an intrinsically programmed feature of maturation providing region-specific metabolic reorganization to support developmental demands.","PeriodicalId":501710,"journal":{"name":"npj Metabolic Health and Disease","volume":"4 1","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12891541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146160083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hallmarks of nuclear metabolism: implications for genome integrity, nuclear signaling, and therapeutic targeting. 核代谢的标志：对基因组完整性、核信号和治疗靶向的影响。

npj Metabolic Health and Disease Pub Date : 2026-02-02 DOI: 10.1038/s44324-025-00097-8

Alisa Schmidt, Matilda Pfeiffer, Sara Sdelci

引用次数: 0

Muscle mass as a resilence factor for endothelial health in obesity. 肌肉质量是肥胖患者内皮健康的弹性因素。

npj Metabolic Health and Disease Pub Date : 2026-02-02 DOI: 10.1038/s44324-025-00096-9

David W Stepp, David J R Fulton

引用次数: 0

Sepsis and the immunometabolic inflammatory response. 脓毒症与免疫代谢炎症反应。

npj Metabolic Health and Disease Pub Date : 2026-02-02 DOI: 10.1038/s44324-025-00095-w

Samuel N Paul, Isabell Nessel, Zudin Puthucheary, Siân M Henson

引用次数: 0