G6PD缺乏与动脉粥样硬化性心血管疾病的临床关联和潜在细胞机制

npj Metabolic Health and Disease Pub Date : 2025-01-01 Epub Date: 2025-04-24 DOI:10.1038/s44324-025-00061-6
Patrick H Andrews, James C Zimring, Coleen A McNamara
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引用次数: 0

摘要

葡萄糖6-磷酸脱氢酶缺乏症(G6PD-d)是世界上最常见的酶病,发生在全球人口的5-8%(5亿人)。最近的流行病学证据表明,G6PD-d可能与心血管疾病(CVD)的增加有关。动脉粥样硬化是心血管疾病的主要原因,包括心肌梗死、心力衰竭、中风和外周动脉疾病。反过来,动脉粥样硬化是一种慢性炎症性疾病,由氧化脂质推动,并受到多种免疫和非免疫细胞的影响,包括血管内皮细胞和平滑肌细胞、单核细胞和巨噬细胞、T细胞、B细胞和红细胞。在这里,我们回顾了支持G6PD-d在人类CVD中的作用的现有流行病学证据,并探索了G6PD-d可能加剧动脉粥样硬化的潜在细胞机制的数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical associations and potential cellular mechanisms linking G6PD deficiency and atherosclerotic cardiovascular disease.

Glucose 6-phosphate dehydrogenase deficiency (G6PD-d) is the most common enzymopathy in the world, occurring in 5-8% of the global population (half a billion people). Recent epidemiological evidence suggests that G6PD-d may be associated with increased cardiovascular disease (CVD). Atherosclerosis is the dominant cause of CVD, including myocardial infarction, heart failure, stroke, and peripheral artery disease. Atherosclerosis, in turn, is a chronic inflammatory disease, fueled by oxidized lipids and influenced by various immune and nonimmune cells including vascular endothelial and smooth muscle cells, monocytes and macrophages, T cells, B cells, and red blood cells. Here, we review the existing epidemiological evidence supporting a role for G6PD-d in CVD in humans and explore the data on potential cellular mechanisms by which G6PD-d may exacerbate atherosclerosis.

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