npj Biological Timing and Sleep最新文献

Harnessing the circadian nature of the choroid plexus and cerebrospinal fluid. 利用脉络膜丛和脑脊液的昼夜节律特性。

npj Biological Timing and Sleep Pub Date : 2025-01-01 Epub Date: 2025-05-26 DOI: 10.1038/s44323-025-00033-5

Ryann M Fame

引用次数: 0

Chronic circadian disruption alters cardiac function and glucose regulation in mice. 慢性昼夜节律紊乱会改变小鼠的心功能和葡萄糖调节。

npj Biological Timing and Sleep Pub Date : 2025-01-01 Epub Date: 2025-05-13 DOI: 10.1038/s44323-025-00032-6

Jenna E J Gearey, Melinda Wang, Michael C Antle

{"title":"Chronic circadian disruption alters cardiac function and glucose regulation in mice.","authors":"Jenna E J Gearey, Melinda Wang, Michael C Antle","doi":"10.1038/s44323-025-00032-6","DOIUrl":"https://doi.org/10.1038/s44323-025-00032-6","url":null,"abstract":"Cardiometabolic disease is a leading cause of death worldwide. One factor that may contribute to the risk, onset, and severity of symptoms is disrupted circadian rhythms. Our study uses two strains of mice to further elucidate this relationship: healthy controls, and a mouse model of insulin resistance with short freerunning periods (~ 22.75 h) and enlarged hearts, raised in either a 24-h or 22.75-h LD cycle. Through glucose and insulin tolerance tests, routine electrocardiograms from one to four months old, and histology, we reveal worse cardiometabolic health outcomes for mice gestated and housed in a mismatched LD cycle compared to those in an LD cycle that matches their endogenous rhythm. This was characterized by heightened blood glucose levels following a glucose or insulin bolus, altered electrophysiological parameters of the cardiac waveform, and increased cardiomyocyte size. Circadian disruption due to work/social schedules or circadian-related disorders in people is often confounded with other unhealthy lifestyles. The present study demonstrates that circadian disruption on its own can lead to adverse health states.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"2 1","pages":"18"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges and opportunities for statistical power and biomarker identification arising from rhythmic variation in proteomics. 蛋白质组学中节律性变异对统计能力和生物标志物鉴定的挑战和机遇。

npj Biological Timing and Sleep Pub Date : 2025-01-01 Epub Date: 2025-01-25 DOI: 10.1038/s44323-024-00020-2

Matt Spick, Cheryl M Isherwood, Lee A Gethings, Christopher J Hughes, Matthew E Daly, Hana Hassanin, Daan R van der Veen, Debra J Skene, Jonathan D Johnston

{"title":"Challenges and opportunities for statistical power and biomarker identification arising from rhythmic variation in proteomics.","authors":"Matt Spick, Cheryl M Isherwood, Lee A Gethings, Christopher J Hughes, Matthew E Daly, Hana Hassanin, Daan R van der Veen, Debra J Skene, Jonathan D Johnston","doi":"10.1038/s44323-024-00020-2","DOIUrl":"10.1038/s44323-024-00020-2","url":null,"abstract":"Time-of-day variation in the molecular profile of biofluids and tissues is a well-described phenomenon, but-especially for proteomics-is rarely considered in terms of the challenges this presents to reproducible biomarker identification. We provide a case study analysis of human circadian and ultradian rhythmicity in proteins, including in the complement and coagulation cascades and apolipoproteins, with PLG, CFAH, ZA2G and ITIH2 demonstrated as rhythmic for the first time. We also show that rhythmicity increases the risk of Type II errors due to the reduction in statistical power from increased variance, and that controlling for rhythmic time-of-day variation improves statistical power and reduces the chances of Type II errors. We recommend that best practice in proteomics study design should account for temporal variation and that time of sampling be reported as part of study metadata. These simple steps can mitigate against both false and missed discoveries, as well as improving reproducibility.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"2 1","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shifted levels of sleep and activity during the night as mechanisms underlying ectoparasite resistance. 夜间睡眠和活动水平的变化是抵抗外寄生虫的机制。

npj Biological Timing and Sleep Pub Date : 2025-01-01 Epub Date: 2025-04-02 DOI: 10.1038/s44323-025-00031-7

Joshua B Benoit, Joy Bose, Oluwaseun M Ajayi, Ashley Webster, Karl Grieshop, David Lewis, Hailie Talbott, Michal Polak

{"title":"Shifted levels of sleep and activity during the night as mechanisms underlying ectoparasite resistance.","authors":"Joshua B Benoit, Joy Bose, Oluwaseun M Ajayi, Ashley Webster, Karl Grieshop, David Lewis, Hailie Talbott, Michal Polak","doi":"10.1038/s44323-025-00031-7","DOIUrl":"10.1038/s44323-025-00031-7","url":null,"abstract":"Parasites harm host fitness and are pervasive agents of natural selection capable of driving the evolution of host resistance traits. Previously we demonstrated evolutionary responses to artificial selection for increasing behavioral immunity to Gamasodes queenslandicus mites for Drosophila melanogaster. Here, we report transcriptional shifts in metabolic processes due to selection for mite resistance. We also show decreased starvation resistance and increased use of nutrient reserves in flies from mite-resistant lines. Resistant lines exhibited increased activity, reduced sleep, and elevated oxygen consumption during the night. Using a panel of D. melanogaster lines exhibiting variable sleep durations, we found a positive correlation between mite resistance and reduced sleep. Restraining the activity of artificially selected mite-resistant flies during exposure to parasites reduced their resistance advantage relative to control flies. The results suggest that ectoparasite resistance in this system involves increased activity during the scotophase and metabolic gene expression at the expense of starvation resistance.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"2 1","pages":"15"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11964914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual orexin receptor antagonists as promising therapeutics for Alzheimer's disease. 双重食欲素受体拮抗剂有望治疗阿尔茨海默病。

npj Biological Timing and Sleep Pub Date : 2025-01-01 Epub Date: 2025-03-08 DOI: 10.1038/s44323-025-00025-5

S M Ragsdale, J M Radovich, I I Coiduras, W V McCall, S C Grant, C Lee, A Wilber

引用次数: 0

Beyond vision: effects of light on the circadian clock and mood-related behaviours. 超越视觉：光对生物钟和情绪相关行为的影响。

npj Biological Timing and Sleep Pub Date : 2025-01-01 Epub Date: 2025-03-13 DOI: 10.1038/s44323-025-00029-1

Dean Stewart, Urs Albrecht

引用次数: 0

Nature's Master of Ceremony: The Populus Circadian Clock as Orchestratot of Tree Growth and Phenology. 大自然的司仪：杨树的生物钟作为树木生长和物候的管弦乐。

npj Biological Timing and Sleep Pub Date : 2025-01-01 Epub Date: 2025-04-07 DOI: 10.1038/s44323-025-00034-4

Bertold Mariën, Kathryn M Robinson, Manuela Jurca, Ingrid H Michelson, Naoki Takata, Iwanka Kozarewa, Pierre A Pin, Pär K Ingvarsson, Thomas Moritz, Cristian Ibáñez, Ove Nilsson, Stefan Jansson, Steve Penfield, Jun Yu, Maria E Eriksson

{"title":"Nature's Master of Ceremony: The Populus Circadian Clock as Orchestratot of Tree Growth and Phenology.","authors":"Bertold Mariën, Kathryn M Robinson, Manuela Jurca, Ingrid H Michelson, Naoki Takata, Iwanka Kozarewa, Pierre A Pin, Pär K Ingvarsson, Thomas Moritz, Cristian Ibáñez, Ove Nilsson, Stefan Jansson, Steve Penfield, Jun Yu, Maria E Eriksson","doi":"10.1038/s44323-025-00034-4","DOIUrl":"https://doi.org/10.1038/s44323-025-00034-4","url":null,"abstract":"Understanding the timely regulation of plant growth and phenology is crucial for assessing a terrestrial ecosystem's productivity and carbon budget. The circadian clock, a system of genetic oscillators, acts as 'Master of Ceremony' during plant physiological processes. The mechanism is particularly elusive in trees despite its relevance. The primary and secondary tree growth, leaf senescence, bud set, and bud burst timing were investigated in 68 constructs transformed into Populus hybrids and compared with untransformed or transformed controls grown in natural or controlled conditions. The results were analyzed using generalized additive models with ordered-factor-smooth interaction smoothers. This meta-analysis shows that several genetic components are associated with the clock. Especially core clock-regulated genes affected tree growth and phenology in both controlled and field conditions. Our results highlight the importance of field trials and the potential of using the clock to generate trees with improved characteristics for sustainable silviculture (e.g., reprogrammed to new photoperiodic regimes and increased growth).","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"2 1","pages":"16"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11976295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reassessing the involvement of the CREB pathway in the circadian clock of Drosophila melanogaster 重新评估CREB通路在黑腹果蝇生物钟中的作用

npj Biological Timing and Sleep Pub Date : 2024-12-04 DOI: 10.1038/s44323-024-00015-z

Anna Katharina Eick, Maite Ogueta, Ralf Stanewsky

{"title":"Reassessing the involvement of the CREB pathway in the circadian clock of Drosophila melanogaster","authors":"Anna Katharina Eick, Maite Ogueta, Ralf Stanewsky","doi":"10.1038/s44323-024-00015-z","DOIUrl":"10.1038/s44323-024-00015-z","url":null,"abstract":"Circadian clocks are ubiquitous in almost all organisms on Earth and many key genes are highly conserved among species. In the mammalian suprachiasmatic nucleus, the cAMP response element binding protein (CREB) pathway is known to play a crucial role in conveying light-input to the transcription of clock genes. The fruit fly Drosophila melanogaster also expresses two Creb proteins, CrebA and CrebB, which have been associated with the circadian clock. For example, Drosophila Creb has been suggested to constitute a molecular link between neuronal excitability and clock gene transcription. In this study we subjected flies with clock cell specific CrebA or CrebB mutations to circadian behavioral and bioluminescence assays. Surprisingly, we found that neither loss of CrebA or CrebB did affect free-running locomotor behavior, rhythmic period oscillations in clock neurons, or light-dependent synchronization. In conclusion our findings question the conserved circadian role of the Creb pathway in Drosophila and encourage further studies to elucidate its potential function within insect circadian clocks.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":" ","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44323-024-00015-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Light exposure differs by sex in the US, with females receiving less bright light 在美国，不同性别的人接受的光照不同，女性接受的光照较少

npj Biological Timing and Sleep Pub Date : 2024-12-04 DOI: 10.1038/s44323-024-00016-y

Danielle A. Wallace

引用次数: 0

Sleep and diurnal alternative polyadenylation sites associated with human APA-linked brain disorders 与人类 APA 相关脑部疾病有关的睡眠和昼夜替代多聚腺苷酸位点

npj Biological Timing and Sleep Pub Date : 2024-11-01 DOI: 10.1038/s44323-024-00012-2

Carlos C. Flores, Nickolas A. Pasetto, Hongyang Wang, Alexander G. Dimitrov, Jon F. Davis, Zhihua Jiang, Christopher J. Davis, Jason R. Gerstner

{"title":"Sleep and diurnal alternative polyadenylation sites associated with human APA-linked brain disorders","authors":"Carlos C. Flores, Nickolas A. Pasetto, Hongyang Wang, Alexander G. Dimitrov, Jon F. Davis, Zhihua Jiang, Christopher J. Davis, Jason R. Gerstner","doi":"10.1038/s44323-024-00012-2","DOIUrl":"10.1038/s44323-024-00012-2","url":null,"abstract":"Disruption of sleep and circadian rhythms are a comorbid feature of many pathologies, and can negatively influence many health conditions, including neurodegenerative disease, metabolic illness, cancer, and various neurological disorders. Genetic association studies linking sleep and circadian disturbances with disease susceptibility have mainly focused on changes in gene expression due to mutations, such as single-nucleotide polymorphisms. The interaction between sleep and/or circadian rhythms with the use of Alternative Polyadenylation (APA) has been largely undescribed, particularly in the context of other disorders. APA generates transcript isoforms by utilizing various polyadenylation sites (PASs) from the same gene affecting its mRNA translation, stability, localization, and subsequent function. Here we identified unique APAs expressed in rat brain over time-of-day, immediately following sleep deprivation, and the subsequent recovery period. From these data, we performed a secondary analysis of these sleep- or time-of-day associated PASs with recently described APA-linked human brain disorder susceptibility genes.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":" ","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44323-024-00012-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0