npj Biological Timing and Sleep最新文献

Constructing melanopic light exposure profiles from sparse daily-route measurements. 从稀疏的每日路线测量中构建黑视光暴露剖面。

npj Biological Timing and Sleep Pub Date : 2026-10-16 DOI: 10.1038/s44323-026-00108-x

Niloufar Tabandeh, Jennifer A Veitch, Manuel Spitschan

{"title":"Constructing melanopic light exposure profiles from sparse daily-route measurements.","authors":"Niloufar Tabandeh, Jennifer A Veitch, Manuel Spitschan","doi":"10.1038/s44323-026-00108-x","DOIUrl":"10.1038/s44323-026-00108-x","url":null,"abstract":"Daily light exposure is temporally structured, yet calibrated spectral measurements are usually available only at selected locations and times. Turning such a sparse library into a schedule-resolved profile requires an assignment rule: a decision about which measurements may represent each unmeasured part of the day. We examined how much that decision matters. Sixty-three eye-level spectral irradiance measurements, collected across home, commute, office and lunch settings on three June days in Ottawa, were mapped onto a schedule of 22 half-hour slots. For each of six assignment rules we generated 100,000 profiles and computed melanopic dose and time above thresholds of 250, 1,000 and 10,000 melanopic lx. Indoor-only and outdoor-only assignments gave contrasting bounds, with median doses of 16,536 and 119,995 lx ⋅ h. Among the four rules that combined indoor and outdoor measurements, median dose varied only from 44,257 to 48,337 lx ⋅ h, whereas the central 95% of the generated dose distributions spanned ranges differing by nearly a factor of two. Central estimates were set largely by the composition of the eligible measurement pools rather than by the structure a rule preserved; the rule mainly determined spread. Targeted substitutions, in which only commute and lunch conditions were changed, raised median dose by 28,600 lx ⋅ h, with outdoor lunch contributing more cumulative dose and outdoor commuting more time above 10,000 lx. The framework supports sensitivity and scenario analysis rather than reconstruction of continuous personal exposure, and shows why the assignment step must be reported explicitly for a constructed profile to be interpretable.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149207934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attractive and repulsive couplings between circadian pacemaker neurons promote entrainment to light-dark cycles with after-effect. 昼夜节律起搏器神经元之间的吸引力和排斥性耦合促进了光-暗循环的尾随和后效。

npj Biological Timing and Sleep Pub Date : 2026-10-07 DOI: 10.1038/s44323-026-00112-1

Yuta Kitaguchi, Satoru Komori, Hajime Tei, Koichiro Uriu

{"title":"Attractive and repulsive couplings between circadian pacemaker neurons promote entrainment to light-dark cycles with after-effect.","authors":"Yuta Kitaguchi, Satoru Komori, Hajime Tei, Koichiro Uriu","doi":"10.1038/s44323-026-00112-1","DOIUrl":"10.1038/s44323-026-00112-1","url":null,"abstract":"The mammalian circadian pacemaker, the suprachiasmatic nucleus (SCN), comprises a core region that receives light signals from the retina and a shell region that outputs pacemaking rhythms to peripheral tissues. The free-running period (FRP) of animals in constant darkness (DD) correlates with the period of the preceding LD cycle, a phenomenon known as after-effect. To elucidate the mechanisms underlying robust entrainment and after-effect, we analyzed phase oscillator models incorporating attractive and repulsive couplings that respectively decrease or increase phase differences between oscillators. Attractive coupling from the core to shell regions accounts for experimentally observed phase relationships between these regions under LD cycles. Remarkably, repulsive coupling from the shell to core regions promotes SCN entrainability to LD cycles. Furthermore, after transfer to DD, the FRP slowly returns to the intrinsic SCN period, reflecting the after-effect. Our analysis identifies an SCN coupling architecture that underlies stable daily activity rhythms.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13645733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149129784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Considerations and guidelines for photic measurement in field studies of the physiological effects of light. 光生理效应野外研究中光测量的注意事项和指南。

npj Biological Timing and Sleep Pub Date : 2026-10-07 DOI: 10.1038/s44323-026-00110-3

Sara C Bessman, Elizabeth M Harrison, Andrea Wilkerson, Michael Herf, Morgan Pattison, Celine Vetter, Gena L Glickman

{"title":"Considerations and guidelines for photic measurement in field studies of the physiological effects of light.","authors":"Sara C Bessman, Elizabeth M Harrison, Andrea Wilkerson, Michael Herf, Morgan Pattison, Celine Vetter, Gena L Glickman","doi":"10.1038/s44323-026-00110-3","DOIUrl":"10.1038/s44323-026-00110-3","url":null,"abstract":"Guidelines for light measurement in laboratory studies of the non-visual effects of light have recently been put forward. Yet, outside of controlled environments, unique challenges necessitate additional consideration and modifications to those recommendations. The purpose of this paper is to build on prior work by outlining pre-ocular, ocular, and post-ocular factors and associated considerations that influence photic exposure and the physiological effects of light in the field. Practical constraints of applying laboratory measurement guidelines and tools and strategies for light measurement in field-based work are discussed in detail, including the trade-offs of different approaches. A standard operating procedure for measuring light in field studies is provided, with particular attention to managing sources of variability, along with an example that applies the procedure to a recent study. Finally, future directions and remaining challenges of photic measurement during field studies of sleep, circadian rhythms, and other non-visual effects of light are identified.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149129827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sympathetic activation links light exposure and rest-activity rhythm to liver injury and bile acid dysregulation. 交感神经激活将光照和休息-活动节律与肝损伤和胆汁酸失调联系起来。

npj Biological Timing and Sleep Pub Date : 2026-09-29 DOI: 10.1038/s44323-026-00103-2

Min Yan, Jian-Wei Li, Jing-Hong Yuan, Meng Nie, Yue-Jun Lin, Chuang Li, Jing Lyu, Qin Luo, Xu-Wei Wang, Xin-Jing Zheng, Qian Wang, Jing-Ru Huo, Hong-Bin Yu, Xiao-Qing Guo, Teng Sun, Ji-Min Cao, Lan Zhou, Lin Wang

{"title":"Sympathetic activation links light exposure and rest-activity rhythm to liver injury and bile acid dysregulation.","authors":"Min Yan, Jian-Wei Li, Jing-Hong Yuan, Meng Nie, Yue-Jun Lin, Chuang Li, Jing Lyu, Qin Luo, Xu-Wei Wang, Xin-Jing Zheng, Qian Wang, Jing-Ru Huo, Hong-Bin Yu, Xiao-Qing Guo, Teng Sun, Ji-Min Cao, Lan Zhou, Lin Wang","doi":"10.1038/s44323-026-00103-2","DOIUrl":"10.1038/s44323-026-00103-2","url":null,"abstract":"Prolonged light exposure and rest-activity alteration are increasingly prevalent in modern society, yet their health consequence and the underlying mechanism remain poorly characterized. The liver is an organ central to metabolic and circadian regulation. We hypothesized that extended wakefulness, which was modeled as long photoperiod in humans and short photoperiod in nocturnal mice, would affect liver integrity and function. Actigraphic watch, wheel running, morphological, biochemical, transcriptomic, and chromatographic techniques were employed to examine the impact of light exposure alteration. To reverse the circadian disorders mediated by the sympathetic nervous system (SNS) activation, SNS inhibitor or time-restricted feeding was applied. In both humans and mice, extended wakefulness increased daily activity and reduced rest, as well as inducing tissue injury exclusively in the liver and predominantly affecting bile acid metabolism. Mechanistically, short photoperiod enhanced hepatic sympathetic innervation and activity in mice, activating a norepinephrine-β2-adrenergic receptor-protein kinase A signaling axis that reprogrammed the hepatic circadian clock and bile acid metabolism. Chemical sympathectomy not time-restricted feeding restored bile acid rhythmicity and alleviated liver injury. These findings identified the liver as a primary target of circadian disruption and established elevated sympathetic tone as a key mediator linking extended light exposure to metabolic dysfunction.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The nutritional and metabolic impact of night shift work in a real-world setting. 在现实世界中夜班工作对营养和代谢的影响。

npj Biological Timing and Sleep Pub Date : 2026-09-29 DOI: 10.1038/s44323-026-00107-y

Friedrich C Jassil, Nicholas E Phillips, Alexandra Hemmer, Céline Joris, Andrew D Biancolin, Steffen L Hartmeyer, Victor Dorribo, Stephen Perrig, Laurence Genton, Virginie Sterpenich, Marcel Salathé, Jacques A Pralong, Marilyne Andersen, Claude Pichard, Charna Dibner, Tinh-Hai Collet

{"title":"The nutritional and metabolic impact of night shift work in a real-world setting.","authors":"Friedrich C Jassil, Nicholas E Phillips, Alexandra Hemmer, Céline Joris, Andrew D Biancolin, Steffen L Hartmeyer, Victor Dorribo, Stephen Perrig, Laurence Genton, Virginie Sterpenich, Marcel Salathé, Jacques A Pralong, Marilyne Andersen, Claude Pichard, Charna Dibner, Tinh-Hai Collet","doi":"10.1038/s44323-026-00107-y","DOIUrl":"10.1038/s44323-026-00107-y","url":null,"abstract":"Growing evidence from epidemiological and lab-controlled studies links night shift work to adverse health outcomes, but evidence from real-world occupational environments remains limited. Using multiple wearable devices and mobile health apps, alongside other objective and subjective assessment tools, we assess nutritional intake and cardiometabolic parameters among 72 shift workers recruited from a single-center Swiss hospital (82% female; median age 31 years; body mass index 22.7 kg/m2) during three consecutive night shifts and three consecutive day shifts. While intake of calories, protein, and fat is reduced during night shifts, glycemic variability and postprandial glucose spikes are increased compared to day shifts. After three consecutive night shifts, plasma cortisol is reduced, and the 24-h heart rate and heart rate variability are altered. Exploratory analysis reveals higher protein intake correlates with lower glycemic variability, whereas nighttime eating is associated with increased glycemic variability. Future interventional studies should explore whether adjusting meal composition and timing could improve glycemic variability in night shift workers.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From phenomenon to mechanism in the circadian clock of Synechococcus elongatus. 长聚球菌的生理时钟从现象到机制。

npj Biological Timing and Sleep Pub Date : 2026-09-29 DOI: 10.1038/s44323-026-00109-w

Susan S Golden

引用次数: 0

Required components of a sleep-wake online daily diary for accurate and efficient human research. 需要的组件睡眠-觉醒在线日记准确和有效的人类研究。

npj Biological Timing and Sleep Pub Date : 2026-09-29 DOI: 10.1038/s44323-026-00106-z

Andrew W McHill, Melissa A St Hilaire, Akane Sano, Jason P Sullivan, Salim Qadri, Sara Taylor, Laura K Barger, Andrew J K Phillips, Erin E Flynn-Evans, Conor O'Brien, Steven W Lockley, Charles A Czeisler, Elizabeth B Klerman

引用次数: 0

Electronic self-monitored morning depression scores are related to sleep timing and sleep length in depressed patients. 电子自我监测的早晨抑郁评分与抑郁症患者的睡眠时间和睡眠时间有关。

npj Biological Timing and Sleep Pub Date : 2026-09-01 DOI: 10.1038/s44323-026-00100-5

Anne Sofie Aggestrup, Signe Dunker Svendsen, Lasse Nørregaard, Philip Løventoft, Ulla Knorr, Erik Frøkjær, Ida Hageman, Maria Faurholt-Jepsen, Lars Vedel Kessing, Lene Theil Skovgaard, Klaus Martiny

{"title":"Electronic self-monitored morning depression scores are related to sleep timing and sleep length in depressed patients.","authors":"Anne Sofie Aggestrup, Signe Dunker Svendsen, Lasse Nørregaard, Philip Løventoft, Ulla Knorr, Erik Frøkjær, Ida Hageman, Maria Faurholt-Jepsen, Lars Vedel Kessing, Lene Theil Skovgaard, Klaus Martiny","doi":"10.1038/s44323-026-00100-5","DOIUrl":"10.1038/s44323-026-00100-5","url":null,"abstract":"The relationship between depression symptoms and sleep in major depressive episodes (MDE) is complex. In this trial, 103 patients with a MDE entered morning and evening depression scores (0-10; 10 = no depression) and sleep parameters in an electronic system for 28 days after discharge from inpatient wards. Mean diurnal variation (difference between evening and morning depression scores) was 0.33 (SE = 0.10; p = 0.0009) with very large day-to-day variations. Morning depression symptoms were associated with length of sleep period in a non-linear association, with least depression symptoms at 8 h of sleep increasing for longer and shorter sleep time (p = 0.04). Morning depression symptoms were also found to increase with a later sleep midpoint (p < 0.001), a delay in sleep onset (p = 0.0001) and wakeups (p < 0.0001). In conclusion, a long and short sleep duration, late sleep-timing, sleep onset delays and wakeups, were associated with more morning depression symptoms. These explorative results should be investigated in Randomized Clinical Trials (RCTs), to test the casual relation and if confirmed, be used clinically in depression treatment to qualify the use of methods working on sleep timing and sleep maintenance like Cognitive Behavioural Therapy for insomnia (CBT-I). Trial Registration ClinicalTrials.gov NCT02679768; https://clinicaltrials.gov/study/NCT02679768 .","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13534645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148877084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tilia Tomentosa promotes sleep, preserving sleep structure. 紫椴促进睡眠，保持睡眠结构。

npj Biological Timing and Sleep Pub Date : 2026-09-01 DOI: 10.1038/s44323-026-00105-0

Antonio Di Soccio, Martina Canova, Nicola Rizzo, Claudia Lodovichi

{"title":"Tilia Tomentosa promotes sleep, preserving sleep structure.","authors":"Antonio Di Soccio, Martina Canova, Nicola Rizzo, Claudia Lodovichi","doi":"10.1038/s44323-026-00105-0","DOIUrl":"10.1038/s44323-026-00105-0","url":null,"abstract":"Tilia extracts have been used for centuries for their relaxing and hypnotic properties; however, their impact on the sleep-wake cycle and sleep architecture remained elusive. In this study, we investigated the effects of a chronic treatment with Tilia tomentosa extracts on the sleep-wake cycle and the associated neuronal activity, using chronic electrophysiological recordings in freely moving mice. We found that Tilia treatment induced a significant increase in NREM sleep and a concomitant reduction of wakefulness during the nocturnal (active) hours, in treated mice compared to controls. Furthermore, the treatment significantly reduced brief awakenings during light (resting) hours. Tilia did not cause alterations of the essential electrophysiological features of the EEG signal. Moreover, Tilia administration did not impair either the homeostasis or the structure of the sleep-wake cycle. Spectral analysis reported mild changes in high gamma and theta bands in Tilia-treated mice compared to controls. Altogether, our data provide preliminary evidence that Tilia favours sleep and reduces sleep fragmentation, without interfering with the physiological structure of sleep and the associated neuronal activity.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13534599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148877069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of real-world eye level light exposure through spectacle lens. 通过眼镜透镜的真实眼平水平光暴露分析。

npj Biological Timing and Sleep Pub Date : 2026-09-01 DOI: 10.1038/s44323-026-00095-z

Emmanuel Kobia-Acquah, Camille Prince, Eléonore Pic, Des Coughlan, Joshua Hazle, Coralie Barrau

{"title":"Analysis of real-world eye level light exposure through spectacle lens.","authors":"Emmanuel Kobia-Acquah, Camille Prince, Eléonore Pic, Des Coughlan, Joshua Hazle, Coralie Barrau","doi":"10.1038/s44323-026-00095-z","DOIUrl":"10.1038/s44323-026-00095-z","url":null,"abstract":"This study presents a simulation-based methodology for evaluating lens-modulated light exposure across diverse real-world environmental conditions. A total of 987 outdoor light conditions were captured using calibrated spectroradiometers in 12 countries, recording spectral irradiance (280-780 nm, 1-nm resolution) and illuminance without lenses. Conditions varied by geographic region, weather, head inclination, and solar orientation. A lens transmittance model assigned transmittance values based on ambient illuminance and temperature to simulate the illuminance reaching the eye through clear, sun, and light-adaptive lenses. Melanopic equivalent daylight illuminance (EDI) was also computed to assess biologically relevant light exposure. Mean ambient illuminance was 42,561 ± 45,480 lux (range: 266-288,178) and 5934 ± 6738 lux (243-6738 lux) after light-adaptive lens simulation, with significant variations across environmental conditions. High-illuminance exposure (>10,000 lux) decreased from 68% (clear) to 6% (light-adaptive lens), while exposure between 1000 and 10,000 lux increased from 30% to 90%, and low-illuminance (<1000 lux) remained low (1.7% vs 3.1%). Melanopic analysis showed largely preserved melanopic EDI, with only 6% of conditions falling below 250 melanopic EDI. Light-adaptive lens reduced high-intensity light while maintaining moderate daylight levels and melanopic EDI. This methodology provides a more ecologically valid evaluation of lens performance than conventional lab-based testing.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13534726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148877091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0