npj Biological Timing and Sleep最新文献_第2页

Dual orexin receptor antagonists as promising therapeutics for Alzheimer's disease. 双重食欲素受体拮抗剂有望治疗阿尔茨海默病。

npj Biological Timing and Sleep Pub Date : 2025-01-01 Epub Date: 2025-03-08 DOI: 10.1038/s44323-025-00025-5

S M Ragsdale, J M Radovich, I I Coiduras, W V McCall, S C Grant, C Lee, A Wilber

引用次数: 0

The cyanobacterial circadian clock. 蓝藻的生物钟。

npj Biological Timing and Sleep Pub Date : 2025-01-01 Epub Date: 2025-06-30 DOI: 10.1038/s44323-025-00042-4

Yong-Gang Chang, Andy LiWang

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Light does not phase shift the circadian clock of subcutaneous adipose tissue in vitro. 光不相移的生物钟皮下脂肪组织在体外。

npj Biological Timing and Sleep Pub Date : 2025-01-01 Epub Date: 2025-09-04 DOI: 10.1038/s44323-025-00048-y

Anna Edmondson, Charley Beresford, Jan-Frieder Harmsen

引用次数: 0

Insect circadian plasticity as a proposed target for the expression of parasite extended phenotypes. 昆虫昼夜节律可塑性作为寄生虫扩展表型表达的拟议目标。

npj Biological Timing and Sleep Pub Date : 2025-01-01 Epub Date: 2025-08-01 DOI: 10.1038/s44323-025-00046-0

Joana Dopp, Charissa de Bekker

引用次数: 0

Beyond vision: effects of light on the circadian clock and mood-related behaviours. 超越视觉：光对生物钟和情绪相关行为的影响。

npj Biological Timing and Sleep Pub Date : 2025-01-01 Epub Date: 2025-03-13 DOI: 10.1038/s44323-025-00029-1

Dean Stewart, Urs Albrecht

引用次数: 0

Associations between sleep and circadian rhythm disruption and perinatal anxiety. 睡眠和昼夜节律紊乱与围产期焦虑之间的关系。

npj Biological Timing and Sleep Pub Date : 2025-01-01 Epub Date: 2025-09-16 DOI: 10.1038/s44323-025-00051-3

Rebecca C Cox

引用次数: 0

Nature's Master of Ceremony: The Populus Circadian Clock as Orchestratot of Tree Growth and Phenology. 大自然的司仪：杨树的生物钟作为树木生长和物候的管弦乐。

npj Biological Timing and Sleep Pub Date : 2025-01-01 Epub Date: 2025-04-07 DOI: 10.1038/s44323-025-00034-4

Bertold Mariën, Kathryn M Robinson, Manuela Jurca, Ingrid H Michelson, Naoki Takata, Iwanka Kozarewa, Pierre A Pin, Pär K Ingvarsson, Thomas Moritz, Cristian Ibáñez, Ove Nilsson, Stefan Jansson, Steve Penfield, Jun Yu, Maria E Eriksson

{"title":"Nature's Master of Ceremony: The Populus Circadian Clock as Orchestratot of Tree Growth and Phenology.","authors":"Bertold Mariën, Kathryn M Robinson, Manuela Jurca, Ingrid H Michelson, Naoki Takata, Iwanka Kozarewa, Pierre A Pin, Pär K Ingvarsson, Thomas Moritz, Cristian Ibáñez, Ove Nilsson, Stefan Jansson, Steve Penfield, Jun Yu, Maria E Eriksson","doi":"10.1038/s44323-025-00034-4","DOIUrl":"https://doi.org/10.1038/s44323-025-00034-4","url":null,"abstract":"Understanding the timely regulation of plant growth and phenology is crucial for assessing a terrestrial ecosystem's productivity and carbon budget. The circadian clock, a system of genetic oscillators, acts as 'Master of Ceremony' during plant physiological processes. The mechanism is particularly elusive in trees despite its relevance. The primary and secondary tree growth, leaf senescence, bud set, and bud burst timing were investigated in 68 constructs transformed into Populus hybrids and compared with untransformed or transformed controls grown in natural or controlled conditions. The results were analyzed using generalized additive models with ordered-factor-smooth interaction smoothers. This meta-analysis shows that several genetic components are associated with the clock. Especially core clock-regulated genes affected tree growth and phenology in both controlled and field conditions. Our results highlight the importance of field trials and the potential of using the clock to generate trees with improved characteristics for sustainable silviculture (e.g., reprogrammed to new photoperiodic regimes and increased growth).","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"2 1","pages":"16"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11976295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum: Publisher Correction: Crosstalk between salicylic acid signalling and the circadian clock promotes an effective immune response in plants. 勘误：出版者更正：水杨酸信号和生物钟之间的串扰促进了植物有效的免疫反应。

npj Biological Timing and Sleep Pub Date : 2025-01-01 Epub Date: 2025-03-07 DOI: 10.1038/s44323-025-00026-4

Olivia J P Fraser, Samantha J Cargill, Steven H Spoel, Gerben van Ooijen

引用次数: 0

Social jetlag alters markers of exercise-induced mitochondrial adaptations in the heart. 社交时差改变了心脏中运动诱导的线粒体适应的标记。

npj Biological Timing and Sleep Pub Date : 2025-01-01 Epub Date: 2025-01-25 DOI: 10.1038/s44323-024-00019-9

Michael B Dial, Elias M Malek, Austin R Cooper, Greco A Neblina, Nikoleta I Vasileva, Graham R McGinnis

{"title":"Social jetlag alters markers of exercise-induced mitochondrial adaptations in the heart.","authors":"Michael B Dial, Elias M Malek, Austin R Cooper, Greco A Neblina, Nikoleta I Vasileva, Graham R McGinnis","doi":"10.1038/s44323-024-00019-9","DOIUrl":"https://doi.org/10.1038/s44323-024-00019-9","url":null,"abstract":"Social jetlag (SJL) represents the behavioral misalignment of sleep and wake times on work days and free days, and potently disrupts the circadian rhythm. SJL affects up to 70% of the population worldwide and is associated with increased risk for many cardiometabolic diseases. Animal models of acute SJL have shown disruption in locomotor activity and expression of clock genes in select tissues, its impact on the heart remains unclear. The purpose of this study was to investigate the effects of prolonged SJL (6 weeks), on activity rhythms, and the impact on exercise-induced adaptations in the heart. Male mice (n = 40, C57BL6) were assigned to a control light:dark (LD) cycle or SJL schedule (4-hour shift on weekends) for 6 weeks. Mice in each condition were further divided into voluntary exercise (EX) or sedentary (SED) groups. SJL resulted in significant shifts in the onset of physical activity in both sedentary (SJL-SED) and exercised (SJL-EX) mice on weekends, and exercise accelerated the speed of re-entrainment to the weekday schedule. Exercise induced myocardial hypertrophy in both CON-EX and SJL-EX groups. While there were no changes in mitochondrial content, SJL decreased expression of mitochondrial fusion proteins MFN1 and OPA1, and inhibited exercise-induced increases in MFN2. Taken together, these findings suggest that exercise hastens re-entrainment to the weekday schedule under SJL, but that SJL disrupts exercise-induced alterations to mitochondrial fusion/fission dynamics in the heart. Further investigation of cardiovascular function is warranted and will enable the development of strategies to prevent the effects of SJL on the heart.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144985209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reassessing the involvement of the CREB pathway in the circadian clock of Drosophila melanogaster 重新评估CREB通路在黑腹果蝇生物钟中的作用

npj Biological Timing and Sleep Pub Date : 2024-12-04 DOI: 10.1038/s44323-024-00015-z

Anna Katharina Eick, Maite Ogueta, Ralf Stanewsky

{"title":"Reassessing the involvement of the CREB pathway in the circadian clock of Drosophila melanogaster","authors":"Anna Katharina Eick, Maite Ogueta, Ralf Stanewsky","doi":"10.1038/s44323-024-00015-z","DOIUrl":"10.1038/s44323-024-00015-z","url":null,"abstract":"Circadian clocks are ubiquitous in almost all organisms on Earth and many key genes are highly conserved among species. In the mammalian suprachiasmatic nucleus, the cAMP response element binding protein (CREB) pathway is known to play a crucial role in conveying light-input to the transcription of clock genes. The fruit fly Drosophila melanogaster also expresses two Creb proteins, CrebA and CrebB, which have been associated with the circadian clock. For example, Drosophila Creb has been suggested to constitute a molecular link between neuronal excitability and clock gene transcription. In this study we subjected flies with clock cell specific CrebA or CrebB mutations to circadian behavioral and bioluminescence assays. Surprisingly, we found that neither loss of CrebA or CrebB did affect free-running locomotor behavior, rhythmic period oscillations in clock neurons, or light-dependent synchronization. In conclusion our findings question the conserved circadian role of the Creb pathway in Drosophila and encourage further studies to elucidate its potential function within insect circadian clocks.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":" ","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44323-024-00015-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0