npj Biological Timing and Sleep最新文献_第2页

Optimizing timing of exercise to improve metabolic outcomes in obesity and type 2 diabetes. 优化运动时间以改善肥胖和2型糖尿病患者的代谢结果。

npj Biological Timing and Sleep Pub Date : 2026-09-01 DOI: 10.1038/s44323-026-00099-9

M Kotte, J Hoeks, P Schrauwen, T van de Weijer

引用次数: 0

A multifaceted approach for obstructive sleep apnea classification from ECG signal using deep learning. 利用深度学习从心电信号中分类阻塞性睡眠呼吸暂停的多方面方法。

npj Biological Timing and Sleep Pub Date : 2026-08-05 DOI: 10.1038/s44323-026-00101-4

Alan John Varghese, Achilles N Gatsonis, Melih Agraz, Vivek Oommen, Anshul Parulkar, Antony Chu, George Em Karniadakis

{"title":"A multifaceted approach for obstructive sleep apnea classification from ECG signal using deep learning.","authors":"Alan John Varghese, Achilles N Gatsonis, Melih Agraz, Vivek Oommen, Anshul Parulkar, Antony Chu, George Em Karniadakis","doi":"10.1038/s44323-026-00101-4","DOIUrl":"10.1038/s44323-026-00101-4","url":null,"abstract":"Obstructive sleep apnea (OSA) is a common sleep disorder associated with increased cardiovascular and neurocognitive risks. While polysomnography remains the clinical gold standard for diagnosis, it is costly and unsuitable for large-scale or real-time screening. Electrocardiogram (ECG) signals offer a non-invasive, low-cost alternative for sleep apnea detection. We present a holistic new framework for OSA detection and forecasting using ECG data on two datasets: PhysioNet Apnea-ECG dataset (healthy patients with apnea) and OSASUD dataset (patients in a stroke unit). Our framework integrates feature engineering methods rooted in dynamical systems theory and statistical analysis. These features are used across a range of models, from conventional machine learning algorithms to novel deep learning architectures. To improve generalization and personalization, we incorporate transfer learning in two ways: across datasets to adapt models trained on large cohorts to smaller clinical datasets, and at the patient level to personalize models using limited individual data, hence demonstrating the use of precision medicine.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13443621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148681835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards implementation of continuous biologically relevant light measurements at the bedside in the Neonatal Intensive Care Unit. 在新生儿重症监护病房床边实施连续生物学相关光测量。

npj Biological Timing and Sleep Pub Date : 2026-08-05 DOI: 10.1038/s44323-026-00104-1

Roos Bos, Simon Belgers, Jeroen Dudink, Yvonne de Kort, Laura Kervezee

{"title":"Towards implementation of continuous biologically relevant light measurements at the bedside in the Neonatal Intensive Care Unit.","authors":"Roos Bos, Simon Belgers, Jeroen Dudink, Yvonne de Kort, Laura Kervezee","doi":"10.1038/s44323-026-00104-1","DOIUrl":"10.1038/s44323-026-00104-1","url":null,"abstract":"Preterm infants, when admitted to the Neonatal Intensive Care Unit (NICU), are exposed to an environment that lacks a robust 24-hour light-dark cycle, potentially disrupting the input to their circadian system and developmental outcomes. Accurate quantification of biologically relevant light exposure is critical, yet no standardized frameworks of how to measure and report patient-level light exposure in the NICU are available. We used light loggers to measure continuous melanopic Equivalent Daylight Illuminance (mEDI) in the NICU of the University Medical Center Utrecht. Differences in mEDI values between the logger in the incubator and at the infant's eye-level were quantified across incubator locations and head orientations. Curtain configurations were assessed to visualize the impact of unrecorded environmental changes. Location-specific correction factors, logger adjustments, and head-orientation modifiers were derived to generate corrected infant eye-level mEDI values. This workflow enables feasible and accurate NICU eye-level light quantification, supporting biologically informed circadian care.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13443183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148681896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Timing of feeding mitigates metabolic effects of circadian disruption. 进食的时间可以减轻昼夜节律紊乱的代谢影响。

npj Biological Timing and Sleep Pub Date : 2026-07-27 DOI: 10.1038/s44323-026-00093-1

Nathan J Skinner, Victoria A Acosta-Rodríguez, Filipa Rijo-Ferreira, Alexander Tups, Joseph S Takahashi

{"title":"Timing of feeding mitigates metabolic effects of circadian disruption.","authors":"Nathan J Skinner, Victoria A Acosta-Rodríguez, Filipa Rijo-Ferreira, Alexander Tups, Joseph S Takahashi","doi":"10.1038/s44323-026-00093-1","DOIUrl":"10.1038/s44323-026-00093-1","url":null,"abstract":"Disrupted light-dark cycles and mistimed feeding are recognized metabolic stressors. In this study, we investigated the independent and combined effects of a 12:12 light:dark cycle, advanced by 6 h every 6 days (Chronic Disruption; CD), and time-restricted feeding on the metabolic health of male C57BL/6J mice. Ad libitum mice under the CD cycle gained significantly more body weight and body fat compared to animals under a control light cycle (LD), despite similar caloric intake and wheel running activity. Using specialized equipment to dissociate light cues from nutrient access, we demonstrate that light-cycle disruption induces metabolic dysfunction specifically through fragmented and misaligned eating patterns. Crucially, restricting food access to a 12-h window synchronized with the shifting dark phase abrogated the weight gain and adiposity observed in the ad libitum group. Conversely, shifting the feeding window under a stable light cycle significantly reduced food intake and weight gain, revealing that feeding regularity is a primary determinant of energy balance independent of light-cycle stability. Overall, while the light-dark cycle is the dominant zeitgeber for activity, the temporal consolidation of food intake is the primary driver of metabolic alignment, offering a potential intervention for managing metabolic risk in shift workers.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13408633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148611594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blunted light exposure amplitudes in patients with opioid use disorder. 阿片类药物使用障碍患者的钝化光暴露振幅。

npj Biological Timing and Sleep Pub Date : 2026-07-27 DOI: 10.1038/s44323-026-00102-3

Rebecca C Cox, Delainey L Wescott, Alyssa Week, Sophia Haller, Zofia Martinez-Lisowska, Abhignya Kuppa, Melissa P Knauert, Kathryn A Roecklein, Sangchoon Jeon, Declan T Barry, Dustin Scheinost, Nancy S Redeker, H Klar Yaggi, Kenneth P Wright

{"title":"Blunted light exposure amplitudes in patients with opioid use disorder.","authors":"Rebecca C Cox, Delainey L Wescott, Alyssa Week, Sophia Haller, Zofia Martinez-Lisowska, Abhignya Kuppa, Melissa P Knauert, Kathryn A Roecklein, Sangchoon Jeon, Declan T Barry, Dustin Scheinost, Nancy S Redeker, H Klar Yaggi, Kenneth P Wright","doi":"10.1038/s44323-026-00102-3","DOIUrl":"10.1038/s44323-026-00102-3","url":null,"abstract":"Accumulating evidence implicates sleep and circadian rhythm disruption in substance use disorders, including opioid use disorder (OUD). To understand whether weaker light exposure time cues are observed in patients with OUD, we compared the amplitudes of personal light exposure in patients with OUD (n = 73) and healthy controls (n = 49). Participants monitored personal light exposure and rest/activity via wrist-worn actigraphy for 1 week. We calculated light and physical activity amplitude for each day with non-orthogonal spectral analysis. Patients with OUD demonstrated significantly lower light exposure amplitudes and significantly higher physical activity amplitudes compared to healthy controls, suggesting lower light exposure amplitudes are not accounted for by sedentary behavior in patients with OUD. Blunted light exposure amplitudes, indicative of a weaker time cue to the circadian clock, characterize patients with OUD and may represent a novel target for improving sleep and circadian health in OUD.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13408350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148611596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep and light ecologies of parents with young infants: descriptive findings from the SUNSHINE project. 有年幼婴儿的父母的睡眠和光生态：来自SUNSHINE项目的描述性发现。

npj Biological Timing and Sleep Pub Date : 2026-07-27 DOI: 10.1038/s44323-026-00098-w

Vaida Verhoef, Emma Visser, Karin Smolders, Niki Antypa, Yvonne de Kort

{"title":"Sleep and light ecologies of parents with young infants: descriptive findings from the SUNSHINE project.","authors":"Vaida Verhoef, Emma Visser, Karin Smolders, Niki Antypa, Yvonne de Kort","doi":"10.1038/s44323-026-00098-w","DOIUrl":"10.1038/s44323-026-00098-w","url":null,"abstract":"The interplay between sleep, light exposure, and circadian rhythms is critical for health, yet it remains inadequately described in the everyday lives of parents with young infants. Prior work has focused mainly on mothers, the early postpartum period, and short-term assessments, leaving a limited understanding of everyday parental ecologies. To address these gaps, we conducted a 2-week observation study in both mothers and fathers of infants aged 3-9 months, simultaneously measuring sleep and light exposure using wearable actigraphy and light sensors alongside sleep diaries. Our descriptive approach aimed to characterize real-life patterns of sleep and light, quantify their variability across nights and individuals, and explore differences by infant age, parental role, and contextual factors. We found that while sleep duration was generally adequate, nights were frequently fragmented, with multiple awakenings and substantial variability across individuals and nights. Light exposure during waking hours was predominantly dim, and brief exposures to light during sleep episodes were common. Seasonal variation, infant sleep location, and caregiving roles may have shaped sleep-light patterns. These findings highlight the complexity and heterogeneity of sleep and light ecologies in early parenthood, and underscore the value of wearable monitoring and descriptive profiling for informing circadian-aware interventions.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13408594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148611562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of wearable light dosimeters for circadian lighting: spectral, spatial, photometric, melanopic, and thermal performance. 评价可穿戴昼夜照明光剂量计：光谱、空间、光度、黑视和热性能。

npj Biological Timing and Sleep Pub Date : 2026-07-21 DOI: 10.1038/s44323-026-00088-y

R S Kore, V Boyer, D A Reichenberger, J Mundinger, A M Chang, D Durmus

{"title":"Evaluation of wearable light dosimeters for circadian lighting: spectral, spatial, photometric, melanopic, and thermal performance.","authors":"R S Kore, V Boyer, D A Reichenberger, J Mundinger, A M Chang, D Durmus","doi":"10.1038/s44323-026-00088-y","DOIUrl":"10.1038/s44323-026-00088-y","url":null,"abstract":"Light is the primary stimuli for the entrainment of human circadian rhythms and holds enormous potential in aiding precision medicine. Laboratory studies highlight the roles of photic history, intensity, spectrum, and timing, but field translation gets complicated by real-world confounds. Measuring daily light exposure in realistic conditions requires an accurate, durable, and affordable wearable light dosimeter. Here, the spectral, spatial, and thermal performance of three wearable dosimeters (LYS Buttons, Blue Iris Specks, and Actiwatch Spectrum Plus) are investigated and benchmarked against a calibrated spectroradiometer under multipole lighting conditions. Light measurements taken by dosimeters under various lighting conditions are then used to calculate melanopic and photometric measures. The LYS Button was the easiest to use, albeit with reduced accuracy. The Blue Iris Speck had the highest photometric and data-logging accuracy. The Actiwatch had the poorest photometric performance, which raises caution for scientific use. The results inform device development and protocol design for chronobiology and sleep research. Future studies should evaluate and compare the performance of the dosimeters based on body-worn position.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13385892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148537531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Theoretical chronobiology of circadian timing-gold mine or minefield? 昼夜节律时间的理论时间生物学——金矿还是雷区？

npj Biological Timing and Sleep Pub Date : 2026-07-21 DOI: 10.1038/s44323-026-00090-4

Hanspeter Herzel, Solvej Lilienthal, Peter Hammerstein, Marta Del Olmo

引用次数: 0

Social jetlag predicts greater evening energy intake in a UK cohort. 一项英国研究显示，社交时差预示着晚上会摄入更多的能量。

npj Biological Timing and Sleep Pub Date : 2026-07-21 DOI: 10.1038/s44323-026-00097-x

Alan Flanagan, Barbara A Fielding, Jonathan D Johnston, Eva C Winnebeck

{"title":"Social jetlag predicts greater evening energy intake in a UK cohort.","authors":"Alan Flanagan, Barbara A Fielding, Jonathan D Johnston, Eva C Winnebeck","doi":"10.1038/s44323-026-00097-x","DOIUrl":"10.1038/s44323-026-00097-x","url":null,"abstract":"Social jetlag describes the differences in sleep timing between workdays and weekends. In a 14-day longitudinal observational study, we explored the associations between social jetlag and energy intake on workdays and weekends. Healthy male and female participants residing in the UK [n = 101] used a smartphone app to record dietary intake continuously during the study period, encompassing two working weeks and weekends. We hypothesised that higher social jetlag levels would be associated with greater evening energy intake. Using regression models with complementary social jetlag classifications, we found that increasing social jetlag levels modified temporal energy intake in both female and male participants. Overall, participants with less social jetlag exhibited earlier energy intake, while participants with more social jetlag exhibited later energy intake, although the modifying effect of social jetlag differed slightly between weekdays and weekends and the sexes. Importantly, however, the magnitude of the effect estimates was modest and, in caloric terms, unlikely to explain the higher risks of obesity and metabolic diseases previously associated with increasing social jetlag levels.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13385389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148537606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Light exposure and sleep architecture in real-world settings. 现实环境中的光照和睡眠结构。

npj Biological Timing and Sleep Pub Date : 2026-07-10 DOI: 10.1038/s44323-026-00087-z

Sena Gulsum Akgun, Burcu Gemici, Chloe Roddis, Lucien Bickerstaff, Beatriz Bano Otalora, Nina Milosavljevic, Timothy M Brown, Robert J Lucas, Altug Didikoglu

{"title":"Light exposure and sleep architecture in real-world settings.","authors":"Sena Gulsum Akgun, Burcu Gemici, Chloe Roddis, Lucien Bickerstaff, Beatriz Bano Otalora, Nina Milosavljevic, Timothy M Brown, Robert J Lucas, Altug Didikoglu","doi":"10.1038/s44323-026-00087-z","DOIUrl":"10.1038/s44323-026-00087-z","url":null,"abstract":"Light exposure can influence sleep timing, quality, and architecture, yet evidence from real-world settings remains limited. We investigated personal light exposure, quantified as melanopic equivalent daylight illuminance, and sleep parameters using consumer-grade wearables in a convenience sample of UK adults (n = 89). Participants simultaneously wore light sensors and sleep trackers for 7 days, yielding over 500 days of data, complemented by daily sleep diaries. Earlier sleep/wake timing was associated with longer-duration daytime light exposure, as well as more regular, less fragmented light patterns across the week. Higher interdaily stability and lower intradaily variability of light exposure were further linked to enhanced deep sleep intensity during the initial portion of the night. Subjective and wearable-derived measures were generally correlated, although disrupted sleep architecture was associated with greater discrepancies between subjective and wearable sleep estimates. These findings demonstrate the feasibility of naturalistic protocols and highlight the potential importance of brighter days and more stable, less fragmented light exposure patterns for sleep.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13354558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148428029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0