npj Biological Timing and Sleep最新文献_第3页

Additive framework of hormonal waves accounts for species and age differences in circadian intraocular pressure rhythm. 激素波的加性框架解释了昼夜眼压节律的物种和年龄差异。

npj Biological Timing and Sleep Pub Date : 2026-07-06 DOI: 10.1038/s44323-026-00096-y

Keisuke Ikegami, Ryo Fujie, Fumito Mori, Shinobu Yasuo

{"title":"Additive framework of hormonal waves accounts for species and age differences in circadian intraocular pressure rhythm.","authors":"Keisuke Ikegami, Ryo Fujie, Fumito Mori, Shinobu Yasuo","doi":"10.1038/s44323-026-00096-y","DOIUrl":"10.1038/s44323-026-00096-y","url":null,"abstract":"Elevated intraocular pressure (IOP) is the primary risk factor for glaucoma, yet IOP demonstrates significant circadian rhythms whose underlying mechanisms remain incompletely understood, and disruption of this rhythm heightens disease susceptibility. A paradox exists in that both diurnal and nocturnal animals experience nocturnal IOP elevation despite their contrasting behavioral chronotypes. Here, we developed a minimal mathematical framework in which IOP rhythms arise from the linear superposition of two sinusoidal signals: adrenal glucocorticoids (GC) and norepinephrine (NE) from the superior cervical ganglion. In both diurnal and nocturnal species, NE levels increase at night, while GC levels peak oppositely in the morning and evening. A meta-analysis of published datasets showed that IOP peaks in the early night for nocturnal animals and in the late night for diurnal animals, aligning with the predicted maxima of the combined GC and NE sine waves. In aged mice and following superior cervical ganglionectomy, IOP rhythms shifted phase and decreased amplitude; these changes were accounted for by selectively reducing the NE amplitude in the model. In diurnal humans, aging delayed IOP phase, which is replicated by diminishing NE amplitude. Thus, species differences, age-related changes, and the effects of sympathetic ablation on IOP could be largely accounted for within this simplified qualitative framework. This framework provides a unifying conceptual basis for the circadian regulation of IOP across species and may inform novel diagnostic algorithms and chronotherapeutic strategies for glaucoma.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13338408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148400335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The importance of meal timing for maintenance of daily rhythms in the gut transcriptome and microbiota. 进餐时间对维持肠道转录组和微生物群日常节律的重要性。

npj Biological Timing and Sleep Pub Date : 2026-06-22 DOI: 10.1038/s44323-026-00089-x

Felicity K Hunter, Polly Downton, Andrea Luengas-Martinez, Suzanna H Dickson, Jafar Cain, Kathryn J Else, Matthew R Hepworth, Julie E Gibbs

{"title":"The importance of meal timing for maintenance of daily rhythms in the gut transcriptome and microbiota.","authors":"Felicity K Hunter, Polly Downton, Andrea Luengas-Martinez, Suzanna H Dickson, Jafar Cain, Kathryn J Else, Matthew R Hepworth, Julie E Gibbs","doi":"10.1038/s44323-026-00089-x","DOIUrl":"10.1038/s44323-026-00089-x","url":null,"abstract":"Gut function exhibits 24 h (circadian) rhythmicity, in part driven by intrinsic clocks within intestinal epithelial cells (IECs). The gut microbiome also demonstrates circadian rhythms in composition and function, important for maintenance of metabolic, immune and gut health. Here, we determined the influence of feeding behaviour on the 24 h colonic landscape using an interval feeding paradigm, whereby food intake was partitioned equally across the 24 h day. RNAseq analysis revealed that the IEC intrinsic clock persists in the absence of diurnal feeding rhythms; however, a subset of key transcripts loses rhythmicity, demonstrating that cell extrinsic temporal cues contribute significantly to the maintenance of the rhythmic gut transcriptome. Furthermore, interval-fed mice demonstrated a striking loss of rhythms in secretory IgA, a critical regulator of the temporal landscape of the gut microbiome. In keeping, rhythmicity within the microbiota and microbial-derived short chain fatty acids was significantly diminished. This work highlights the importance of daily rhythms in feeding behaviour for the maintenance of rhythmic processes within the gut, with implications for metabolic and immune health.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13287471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148304493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nightmare disorder shows reduced slow oscillation-dominant spindle coupling in NREM sleep. 噩梦障碍显示非快速眼动睡眠中慢振荡-主导纺锤体耦合减少。

npj Biological Timing and Sleep Pub Date : 2026-06-22 DOI: 10.1038/s44323-026-00094-0

Istvan Papp, Zoran Cvetkovic, Nazanin Biabani, Jan Rosenzweig, Camilla Speicher, Alessio Delogu, Alexander D Nesbitt, Panagis Drakatos, Ines R Violante, Dijana Vilic, Clive Ballard, David O'Regan, Peter J Goadsby, Ivana Rosenzweig

{"title":"Nightmare disorder shows reduced slow oscillation-dominant spindle coupling in NREM sleep.","authors":"Istvan Papp, Zoran Cvetkovic, Nazanin Biabani, Jan Rosenzweig, Camilla Speicher, Alessio Delogu, Alexander D Nesbitt, Panagis Drakatos, Ines R Violante, Dijana Vilic, Clive Ballard, David O'Regan, Peter J Goadsby, Ivana Rosenzweig","doi":"10.1038/s44323-026-00094-0","DOIUrl":"10.1038/s44323-026-00094-0","url":null,"abstract":"Nightmare disorder is historically conceptualised as a rapid eye movement (REM) sleep parasomnia, but evidence also points to altered non-rapid eye movement (NREM) sleep physiology. Here, in a retrospective case-control study, we analysed overnight polysomnography from 26 adults with nightmare disorder and 32 controls using a harmonised event-based EEG pipeline. Nightmare disorder showed reduced frontal slow-oscillation-spindle coupling, whereas delta-spindle coupling was preserved, yielding lower coupling dominance than in controls (0.137 ± 0.083 versus 0.238 ± 0.096; p = 6.8 × 10-5). Stage-adjusted K-complex density across the first 6 h from sleep onset was also lower in nightmare disorder (0.463 ± 0.345 versus 0.723 ± 0.475 events per minute of available N2/N3 sleep; p = 0.019), whereas peak-timing differences were not robust. These findings suggest altered NREM sleep microarchitecture in nightmare disorder rather than a phenotype confined to REM sleep, and warrant prospective confirmation in harmonised, clinically phenotyped cohorts.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13287732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148304423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human data at odds and in confirmation of the two-process model of sleep regulation-a perspective. 人类数据不一致，证实了睡眠调节的双过程模型——一个视角。

npj Biological Timing and Sleep Pub Date : 2026-06-22 DOI: 10.1038/s44323-026-00083-3

Derk-Jan Dijk

引用次数: 0

Variation in sleep duration across latitudes and countries: a Bayesian hierarchical analysis of wearable data. 不同纬度和国家的睡眠时间差异：可穿戴数据的贝叶斯层次分析。

npj Biological Timing and Sleep Pub Date : 2026-06-22 DOI: 10.1038/s44323-026-00092-2

Faraaz Akhtar, Alistair Brownlee, Cameron Crawford

{"title":"Variation in sleep duration across latitudes and countries: a Bayesian hierarchical analysis of wearable data.","authors":"Faraaz Akhtar, Alistair Brownlee, Cameron Crawford","doi":"10.1038/s44323-026-00092-2","DOIUrl":"10.1038/s44323-026-00092-2","url":null,"abstract":"Seasonal effects on sleep have been documented but remain poorly characterised at a global scale. Using wearable-derived data from 697 individuals contributing 185,143 nights across 49 countries, we examined how sleep duration varies with season, day length, latitude, and country using Bayesian hierarchical models. Across the dataset, sleep duration decreased with increasing day length, with a reduction of roughly 4.4 minutes per additional hour of daylight. In contrast, categorical season indicators contributed little explanatory power once individual- and country-level differences were modelled, suggesting that coarse season labels do not capture consistent structure in globally distributed samples. We found limited evidence that photoperiod sensitivity scales with latitude, despite large differences in seasonal light amplitude. At the same time, country-level variability emerged in both baseline sleep duration and estimated photoperiod responses. These findings indicate that global variation in sleep duration is shaped more strongly by individual and national differences than by calendar season.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13287479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148304485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in circadian rhythms research in fungi since the millenium. 千年以来真菌昼夜节律研究的趋势。

npj Biological Timing and Sleep Pub Date : 2026-06-22 DOI: 10.1038/s44323-026-00086-0

Jay C Dunlap

引用次数: 0

Humidity as a potential zeitgeber for circadian entrainment of insect systems. 湿度作为昆虫系统昼夜节律干扰的潜在授时因子。

npj Biological Timing and Sleep Pub Date : 2026-06-22 DOI: 10.1038/s44323-026-00082-4

Shyh-Chi Chen, Grace Goodhart, Daniel Eaton, Nathan Catlett, Tabitha Cady, Hannah Tran, Luke E Lutz, Lyn Wang, Ella Girard, Jaida Savino, Jodi Perry, Libby Coen, Leo Walker, Amena Bidiwala, Emma Tarter, Joshua Tompkin, Nina Greene, Aiden Yang, Joshua B Benoit

{"title":"Humidity as a potential zeitgeber for circadian entrainment of insect systems.","authors":"Shyh-Chi Chen, Grace Goodhart, Daniel Eaton, Nathan Catlett, Tabitha Cady, Hannah Tran, Luke E Lutz, Lyn Wang, Ella Girard, Jaida Savino, Jodi Perry, Libby Coen, Leo Walker, Amena Bidiwala, Emma Tarter, Joshua Tompkin, Nina Greene, Aiden Yang, Joshua B Benoit","doi":"10.1038/s44323-026-00082-4","DOIUrl":"10.1038/s44323-026-00082-4","url":null,"abstract":"Humidity levels, like light and temperature, fluctuate daily yet are less predictable; however, whether humidity can entrain circadian clocks and synchronize animal behaviors with environmental variations remains unknown. Here, we investigate the circadian humidity entrainment in various insects across multiple orders. Insect species respond to humidity cycles with distinct patterns, some active during either wet/dry periods or at the arid-humid transition. When the humidity cue is removed, most species continue to show rhythmic activity associated with the previous arid-humid (AH) cycles. Fruit flies shift their activity accordingly when humidity cycles are altered and remain in the new rhythms under the following free-running conditions (FRC; constant humidity, HH). Moreover, Drosophila clock and hygrosensation mutants have lower rhythmic activity during AH and a significant reduction in rhythms after humidity entrainment (FRC with HH), indicating that core clock components and hygrosensors are essential for humidity-dependent circadian entrainment. Our findings provide strong evidence that humidity is likely to serve as a potential zeitgeber for circadian entrainment in most, but not all, insect systems and should have broad applicability and importance across animal systems. While light and temperature act as the primary zeitgebers, understanding the mechanisms of humidity entrainment will help us better interpret the behavioral patterns of terrestrial animals, particularly small insects susceptible to dehydration.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13287731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148304445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time to listen: harnessing podcasts for stakeholder engagement in circadian and sleep science. 时间一到：利用播客让利益相关者参与昼夜节律和睡眠科学。

npj Biological Timing and Sleep Pub Date : 2026-06-03 DOI: 10.1038/s44323-026-00077-1

Carolina Guidolin, Manuel Spitschan

引用次数: 0

Perivascular space, brain functional connectivity and sleep: a healthy aging population study. 血管周围空间、脑功能连通性与睡眠：一项健康老龄化人群的研究。

npj Biological Timing and Sleep Pub Date : 2026-06-03 DOI: 10.1038/s44323-026-00081-5

Nien-Chu Shih, Joey A Contreras, Wendy J Mack, Jeiran Choupan

{"title":"Perivascular space, brain functional connectivity and sleep: a healthy aging population study.","authors":"Nien-Chu Shih, Joey A Contreras, Wendy J Mack, Jeiran Choupan","doi":"10.1038/s44323-026-00081-5","DOIUrl":"10.1038/s44323-026-00081-5","url":null,"abstract":"Perivascular space (PVS) surrounds cortical perforating vessels as part of the brain clearance system. Sleep affects both brain clearance and functional connectivity (FC), but impacts of PVS on FC remains unclear. We utilized T1-W and resting state-fMRI data, Pittsburgh Sleep Quality Index, and NIH cognitive tests from 512 health aging (HCP-Aging). Basal ganglia (BG)-PVS was positively correlated with FC in the right anterior medial temporal gyrus (aMTG) and right temporal regions, while centrum-semiovale (CSO)-PVS was positively correlated with FC in the left hippocampus and right frontal regions. In early middle-aged, increased CSO-PVS showed higher hippocampal FC and better cognition. Individuals with longer time spent in bed had larger BG-PVS linked to higher FC in the right aMTG. Additionally, older adults with better sleep quality had larger BG-PVS linked to higher FC in the right aMTG. This suggests that PVS morphology may reflect changes in neural connections involved in memory-related regions. This study is based on the same cohort as our previous work; however, it extends the investigation by incorporating functional connectivity analyses to provide novel insights beyond regional activity.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13233977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modelling the effect of V1a receptor antagonism and its potential therapeutic effect in circadian disorders. 模拟V1a受体拮抗剂的作用及其在昼夜节律紊乱中的潜在治疗作用。

npj Biological Timing and Sleep Pub Date : 2026-06-03 DOI: 10.1038/s44323-026-00085-1

Marcelo Boareto, Jorge Mendoza, Sebastian C Holst, Andries Kalsbeek, Eric Prinssen, Christophe Grundschober

{"title":"Modelling the effect of V1a receptor antagonism and its potential therapeutic effect in circadian disorders.","authors":"Marcelo Boareto, Jorge Mendoza, Sebastian C Holst, Andries Kalsbeek, Eric Prinssen, Christophe Grundschober","doi":"10.1038/s44323-026-00085-1","DOIUrl":"10.1038/s44323-026-00085-1","url":null,"abstract":"The suprachiasmatic nucleus (SCN) is the central circadian clock in mammals, and its dysregulation is linked to various circadian disorders. Vasopressin signaling is a primary regulator of SCN synchronicity and functional output. We investigated the effect of the V1a receptor (V1aR) antagonist, balovaptan (30 mg/kg), on locomotor activity rhythms in mice following a 6-hour phase advance of the light-dark cycle. We found that a single administration significantly accelerated resynchronization of locomotor rhythms. To investigate the underlying mechanism, we developed a mathematical framework simulating the SCN and its control of biomarkers, including melatonin and core body temperature. Our model successfully captures the accelerated synchronization observed under V1aR antagonism and replicates well-established SCN behaviors, such as the phase response curve and forced desynchronization. Mechanistically, the model suggests that weakening vasopressin signaling strengthens the SCN's resistance to internal desynchronization. Furthermore, we show a strong link between the endogenous period and the phase of circadian biomarkers. The model predicts that V1aR antagonism induces a phase advance proportional to the endogenous period, suggesting that individuals with longer endogenous periods may experience more substantial therapeutic benefits. This framework establishes a computational foundation for designing clinical trials evaluating V1aR antagonism for circadian rhythm disorders.","PeriodicalId":501704,"journal":{"name":"npj Biological Timing and Sleep","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13234031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0