Nutrition and Cancer最新文献_第5页

Low Food Consumption Interferes with the Nutritional Status of Surgical Patients with Neoplasia of the Gastrointestinal Tract. 低食物消耗干扰胃肠道肿瘤手术患者的营养状况。

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2021-07-19 DOI: 10.1080/01635581.2021.1952452

Anieli Golin, Caroline Zucchetto Freitas, Mairin Schott, Bruna Pessoa Alves, Juliana Ebling Brondani, Silvia Cercal Bender, Juliana Fleck, Edson Irineu Müller, Clandio Timm Marques, Elisângela Colpo

{"title":"Low Food Consumption Interferes with the Nutritional Status of Surgical Patients with Neoplasia of the Gastrointestinal Tract.","authors":"Anieli Golin, Caroline Zucchetto Freitas, Mairin Schott, Bruna Pessoa Alves, Juliana Ebling Brondani, Silvia Cercal Bender, Juliana Fleck, Edson Irineu Müller, Clandio Timm Marques, Elisângela Colpo","doi":"10.1080/01635581.2021.1952452","DOIUrl":"https://doi.org/10.1080/01635581.2021.1952452","url":null,"abstract":"Nutritional support strongly influence the nutritional status of the surgical neoplastic patients. This study aimed to evaluate the influence of food consumption on the perioperative nutritional status of hospitalized patients with neoplasia of the upper (UGIT) and lower (LGIT) gastrointestinal tract.Method: Observational, longitudinal, and prospective study. Data collected: food consumption, Subjective Global Assessment, anthropometry, laboratory tests.Results: Eighty patients were followed up: 43 (54%) in the UGIT and 37 (46%) in the LGIT. The consumption in the perioperative period was lower than the usual consumption in the UGIT and LGIT groups, respectively, of energy (14.2 ± 6.5; 22.8 ± 11.2 Kcal/kg/d, p < 0.001; 13.6 ± 1.2; 19.0 ± 2.0 Kcal/kg/d; p = 0.014), protein (1.1 ± 0.7; 0.6 ± 0.3 g/kg/d, p < 0.001; 0.8 ± 0.1; 0.5 ± 0.1 g/kg/d; p = 0.058), selenium, zinc and copper. Most patients presented in the UGIT and LGIT groups, respectively, worsening malnutrition and muscle depletion according to the Subjective Global Assessment (61.9%; 51.4%) and hypoalbuminemia, mainly in the UGIT in the postoperative.Conclusion: Low food consumption during the perioperative period associated with prolongation of the postoperative fasting period worsens the nutritional status of patients undergoing surgery of the gastrointestinal tract for neoplasia, especially in the UGIT group.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"1279-1290"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01635581.2021.1952452","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39198194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucosinolate-Enriched Fractions from Maca (Lepidium meyenii) Exert Myrosinase-Dependent Cytotoxic Effects against HepG2/C3A and HT29 Tumor Cell Lines. 玛卡(Lepidium meyenii)富含硫代葡萄糖苷的组分对HepG2/C3A和HT29肿瘤细胞具有黑芥子酶依赖的细胞毒作用。

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2021-07-20 DOI: 10.1080/01635581.2021.1952444

Raquely M Lenzi, Luciano H Campestrini, Simone C Semprebon, Jonas A R Paschoal, Monique A G Silva, Selma F Zawadzki-Baggio, Mário S Mantovani, Carmen L O Petkowicz, Juliana B B Maurer

{"title":"Glucosinolate-Enriched Fractions from Maca (Lepidium meyenii) Exert Myrosinase-Dependent Cytotoxic Effects against HepG2/C3A and HT29 Tumor Cell Lines.","authors":"Raquely M Lenzi, Luciano H Campestrini, Simone C Semprebon, Jonas A R Paschoal, Monique A G Silva, Selma F Zawadzki-Baggio, Mário S Mantovani, Carmen L O Petkowicz, Juliana B B Maurer","doi":"10.1080/01635581.2021.1952444","DOIUrl":"https://doi.org/10.1080/01635581.2021.1952444","url":null,"abstract":"The consumption of glucosinolate (GL)-rich foods, including Brassica vegetables, such as mustard, broccoli, and maca, is associated with decreased risk of developing cancer. The GL content in maca, which is recognized as a \"superfood\", is approximately 100-times higher than that in other brassicas. Although maca is a potential dietary source of GLs, limited studies have examined the bioactivity of maca GLs using the combination of chemical characterization and bioassays. In this study, the fractions (Lm-II and Lm-III) rich in intact GLs (glucotropaeolin and glucolimnanthin) were isolated and characterized from maca ethanolic extracts using chromatography and mass spectrometry. Additionally, the growth-inhibitory effects of Lm-II and Lm-II fractions against hepatocellular carcinoma (HepG2/C3A) and colon adenocarcinoma (HT29) cell lines were examined in the absence or presence of myrosinase (MYR). Fractions lacking low molecular weight sugars dose-dependently exerted cytotoxic effects in the presence of MYR. The half-maximal inhibitory concentration values of Lm-II and Lm-III against HepG2/C3A were 118.8 and 69.9 µg/mL, respectively, while those against HT29 were 102.6 and 71.5 µg/mL, respectively. These results suggest that the anticancer properties of maca can be attributed to GLs and corroborate the categorization of maca as a \"superfood.\"Supplemental data for this article is available online at https://doi.org/10.1080/01635581.2021.1952444.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"1322-1337"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01635581.2021.1952444","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39200797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Association of Controlling Nutritional Status (CONUT) Score with Survival in Patients with Surgically Treated Renal Cell Carcinoma and Upper Tract Urothelial Carcinoma: A Systematic Review and Meta-Analysis. 控制营养状况(CONUT)评分与手术治疗肾细胞癌和上尿路上皮癌患者生存的关系:一项系统回顾和荟萃分析。

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2021-09-07 DOI: 10.1080/01635581.2021.1974894

Wenrui Xue, Xiaopeng Hu, Yu Zhang

{"title":"The Association of Controlling Nutritional Status (CONUT) Score with Survival in Patients with Surgically Treated Renal Cell Carcinoma and Upper Tract Urothelial Carcinoma: A Systematic Review and Meta-Analysis.","authors":"Wenrui Xue, Xiaopeng Hu, Yu Zhang","doi":"10.1080/01635581.2021.1974894","DOIUrl":"https://doi.org/10.1080/01635581.2021.1974894","url":null,"abstract":"In recent years, Controlling Nutritional Status (CONUT) Score has become widely recognized as a novel index to evaluate the survival in urological neoplasms patients, especially with renal cell carcinoma (RCC) and upper tract urothelial carcinoma (UTUC). The aim of this meta-analysis is to evaluate the prognostic value of CONUT score in patients with RCC and UTUC. PubMed, Web of Science and Embase were searched for data on the association between CONUT score and RCC/UTUC prognosis up to July 29, 2021. Duplicates were excluded, and inclusion/exclusion criteria were applied to all abstracts. We sorted out relevant studies and extracted the risk ratios (RRs) and its 95% confidence interval (CI) for recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS). The relationship between gender and survival outcomes was analyzed using univariate cox regression. We analyzed seven studies including 5410 patients in the meta-analysis. A high CONUT score was associated with poor 5-year RFS (RR = 1.27, 95% CI = 1.13-1.43, P = 0.0001), CSS (RR = 1.22, 95% CI = 1.07-1.39, P = 0.003) and OS (RR = 1.24, 95% CI = 1.10-1.41, P = 0.0005). As a result, the association between CONUT score and survival was statistically significant. In addition, gender was not related to survival outcomes. Our results show that the CONUT score is associated with RCC and UTUC outcomes and can serve as a readily available biomarker for managing this disease.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"1907-1916"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39393442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Impact of a Simplified Scoring System on Long-Term Survival Outcomes in Patients with Gastric Cancer Undergoing Gastrectomy. 简化评分系统对胃癌切除术患者长期生存结果的影响。

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2021-11-22 DOI: 10.1080/01635581.2021.2005807

Xianfu Lu, Man Zhang, Cuina Wei, Zan Wang, Qiang Zheng, Changjun Yu

{"title":"The Impact of a Simplified Scoring System on Long-Term Survival Outcomes in Patients with Gastric Cancer Undergoing Gastrectomy.","authors":"Xianfu Lu, Man Zhang, Cuina Wei, Zan Wang, Qiang Zheng, Changjun Yu","doi":"10.1080/01635581.2021.2005807","DOIUrl":"https://doi.org/10.1080/01635581.2021.2005807","url":null,"abstract":"Gastric cancer (GC) is a worldwide public health concern. We aimed to investigate the association between preoperative prognostic scoring system based on the combination of age, American Society of Anesthesiologists physical status (ASA-PS), and prognostic nutritional index (PNI) and long-term survival outcomes in patients with (GC). Data from 513 patients were analyzed using Cox proportional hazards regression models to evaluate the association between this prognostic score system and risks of all-cause mortality. This simple prognostic score system (0-3 points) was an independent predictor of long-term survival outcomes in patients with GC after radical gastrectomy based on multivariate analyses. Prognostic 1-point score, 2-point score, and 3-point score significantly increased 50% (95% CI, 14%-98%; P = 0.004), 75% (95% CI, 22%-151%; P = 0.003), and 116% (95% CI, 26%-271%; P = 0.005) hazards of 5-year all-cause mortality, respectively, compared to prognostic 0-point score. Five-year overall survival rates were significantly decreased as prognostic scores increased, (0 point, 57.3%; 1-point, 41.3%; 2-ponint, 36.6%; 3-point, 25.9%; P < 0.01; area under the curve [AUC] = 0.62). A prognostic scoring method based on combination of age, ASA-PS, and PNI may serve as an independent risk stratification metric for long-term survival in patients with GC.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"2365-2372"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39648734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica). 醋栗预防癌症的分子机制。

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2021-11-28 DOI: 10.1080/01635581.2021.2008988

Gaurav Kumar, Venkateshwar Madka, Gopal Pathuri, Vishal Ganta, Chinthalapally V Rao

{"title":"Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica).","authors":"Gaurav Kumar, Venkateshwar Madka, Gopal Pathuri, Vishal Ganta, Chinthalapally V Rao","doi":"10.1080/01635581.2021.2008988","DOIUrl":"https://doi.org/10.1080/01635581.2021.2008988","url":null,"abstract":"Indian gooseberry (Emblica officinalis Gaertn or Phyllanthus emblica Linn; family Phyllanthaceae) has a recognized history in Indian traditional medicine (Ayurveda). Various therapeutic properties have been attributed to gooseberry as a dietary supplement. Many parts of the plant (fruits, seed, leaves, root, bark, and flowers) possess various activities and are used to treat a range of diseases. This review focuses on the evidence for the cancer-preventive properties of gooseberry, its extracts, and its principal phytochemicals based on studies In Vitro and In Vivo. Most importantly, in multiple rodent models of cancer, treatment with P. emblica was found to prevent tumor incidence, number, and volume at various organ sites. The mechanism(s) implicated in gooseberry-mediated cancer inhibition are diverse and include antioxidants, Phase I and II enzyme modifications, anti-inflammatory action, regulation of the cell cycle, and modulation of oncogenic signaling genes. Studies in humans also indicate that P. emblica can offer various health benefits and synergize with other treatments. This review provides detailed information on the potential use of gooseberry extract as an anticarcinogenic in humans, illuminates the therapeutic applications, and discusses clinical trials.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"2291-2302"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9341453/pdf/nihms-1808885.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39673050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Individual Differences in Chemosensory Perception Amongst Cancer Patients Undergoing Chemotherapy: A Narrative Review. 化疗患者化学感觉知觉的个体差异:一个叙述性的回顾。

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2022-02-01 DOI: 10.1080/01635581.2021.2000625

Alba Ruiz-Ceamanos, Charles Spence, Jordi Navarra

{"title":"Individual Differences in Chemosensory Perception Amongst Cancer Patients Undergoing Chemotherapy: A Narrative Review.","authors":"Alba Ruiz-Ceamanos, Charles Spence, Jordi Navarra","doi":"10.1080/01635581.2021.2000625","DOIUrl":"https://doi.org/10.1080/01635581.2021.2000625","url":null,"abstract":"Chemotherapy is an aggressive form of treatment for cancer and its toxicity directly affects the eating behavior of many patients, usually by adversely affecting their sense of smell and/or taste. These sensory alterations often lead to serious nutritional deficiencies that can jeopardize the patient's recovery, and even continue to affect their lives once treatment has terminated. Importantly, however, not all patients suffer from such alterations to their chemical senses; and those who do, do not necessarily describe the side effects in quite the same way, nor suffer from them with equal intensity. The origin of these individual differences between cancer patients undergoing chemotherapy treatment has not, as yet, been studied in detail. This review is therefore designed to encourage future research that can help to address the perceptual/sensory problems (and the consequent malnutrition) identified amongst this group of patients in a more customized/personalized manner. In particular, by providing an overview of the possible causes of these large individual differences that have been reported in the literature. For this reason, in addition to the narrative bibliographic review, several possible strategies that could help to improve the chemosensory perception of food are proposed.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"1927-1941"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39739200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Novel Compound Plumercine from Plumeria alba Exhibits Promising Anti-Leukemic Efficacies against B Cell Acute Lymphoblastic Leukemia. 一种新型化合物鸡鸡素对B细胞急性淋巴母细胞白血病具有良好的抗白血病作用。

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2022-02-01 DOI: 10.1080/01635581.2021.2010777

Aaheli Chatterjee, Amrita Pal, Santanu Paul

{"title":"A Novel Compound Plumercine from Plumeria alba Exhibits Promising Anti-Leukemic Efficacies against B Cell Acute Lymphoblastic Leukemia.","authors":"Aaheli Chatterjee, Amrita Pal, Santanu Paul","doi":"10.1080/01635581.2021.2010777","DOIUrl":"https://doi.org/10.1080/01635581.2021.2010777","url":null,"abstract":"The current study was focused to evaluate the antioxidant and the anti-cancerous properties of Plumeria alba. Plumeria alba was chosen due to its existing medicinal values. Antioxidant assays like Superoxide radical scavenging assay, Nitrous Oxide radical scavenging assay, were performed, on the methanolic and ethyl acetate extracts of the plant, that depicts the pro-oxidant nature of the extract. Further, they were tested to check cell viability on B cell Acute Lymphoblastic Leukemia (ALL) Cell line (NALM 6), human lung cancer cell line (A549), T cell Acute Lymphoblastic Leukemia cell line (MOLT4), and PBMC isolated from normal donors utilizing MTT assay. Robust anti-proliferative activity was observed in the case of NALM 6 followed by A549, MOLT4, whereas negligible activity was observed in the case of PBMC. Intrigued by this finding, in silico docking was performed using three bioactive compounds namely Plumericine, Isoplumericine, and 13-O-p-Coumaroylplumieride, unique to Plumeria sp. They were docked against five different cyclins and Cdk proteins responsible for ALL. The compounds have shown satisfactory results and their druggability and ADMET properties were checked further. Plumercine turned out to be the most competent compound and hence can be considered as a potential leukemic drug candidate in the future.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"2565-2580"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39739202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Potential for Natural Products to Overcome Cancer Drug Resistance by Modulation of Epithelial-Mesenchymal Transition. 天然产物通过调节上皮-间质转化来克服癌症耐药的潜力。

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2022-01-07 DOI: 10.1080/01635581.2021.2022169

Asefeh Dahmardeh Ghalehno, Arad Boustan, Hakimeh Abdi, Zahra Aganj, Fatemeh Mosaffa, Khadijeh Jamialahmadi

{"title":"The Potential for Natural Products to Overcome Cancer Drug Resistance by Modulation of Epithelial-Mesenchymal Transition.","authors":"Asefeh Dahmardeh Ghalehno, Arad Boustan, Hakimeh Abdi, Zahra Aganj, Fatemeh Mosaffa, Khadijeh Jamialahmadi","doi":"10.1080/01635581.2021.2022169","DOIUrl":"https://doi.org/10.1080/01635581.2021.2022169","url":null,"abstract":"The acquisition of resistance and ultimately disease relapse after initial response to chemotherapy put obstacles in the way of cancer therapy. Epithelial-mesenchymal transition (EMT) is a biologic process that epithelial cells alter to mesenchymal cells and acquire fibroblast-like properties. EMT plays a significant role in cancer metastasis, motility, and survival. Recently, emerging evidence suggested that EMT pathways are very important in making drug-resistant involved in cancer. Natural products are gradually emerging as a valuable source of safe and effective anticancer compounds. Natural products could interfere with the different processes implicated in cancer drug resistance by reversing the EMT process. In this review, we illustrate the molecular mechanisms of EMT in the emergence of cancer metastasis. We then present the role of natural compounds in the suppression of EMT pathways in different cancers to overcome cancer cell drug resistance and improve tumor chemotherapy. HighlightsDrug-resistance is one of the obstacles to cancer treatment.EMT signaling pathways have been correlated to tumor invasion, metastasis, and drug-resistance.Various studies on the relationship between EMT and resistance to chemotherapy agents were reviewed.Different anticancer natural products with EMT inhibitory properties and drug resistance reversal effects were compared.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"2686-2712"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39792942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Natural Lignans Honokiol and Magnolol as Potential Anticarcinogenic and Anticancer Agents. A Comprehensive Mechanistic Review. 天然木脂素、厚朴酚和厚朴酚作为潜在的抗癌和抗癌剂。综合机制综述。

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2021-05-28 DOI: 10.1080/01635581.2021.1931364

Sayeh Mottaghi, Hassan Abbaszadeh

{"title":"Natural Lignans Honokiol and Magnolol as Potential Anticarcinogenic and Anticancer Agents. A Comprehensive Mechanistic Review.","authors":"Sayeh Mottaghi, Hassan Abbaszadeh","doi":"10.1080/01635581.2021.1931364","DOIUrl":"https://doi.org/10.1080/01635581.2021.1931364","url":null,"abstract":"Plant lignans constitute an important group of polyphenols, which have been demonstrated to significantly induce cancer cell death and suppress cancer cell proliferation with minimal toxicity against non-transformed cells. Numerous epidemiological studies have shown that the intake of lignans is associated with lower risk of several cancers. These natural compounds have the potential to inhibit carcinogenesis, tumor growth, and metastasis by targeting various signaling molecules and pathways. Growing evidence indicates that honokiol and magnolol as natural lignans possess potent anticancer activities against various types of human cancer. The aim of present review is to provide the reader with the newest findings in understanding the cellular and molecular mechanisms mediating anticancer effects of honokiol and magnolol. This review comprehensively elucidates the effects of honokiol and magnolol on the molecular targets and signal transduction pathways implicated in cancer cell proliferation and metastasis. The findings of current review indicate that honokiol and magnolol can be considered as promising carcinopreventive and anticancer agents.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"761-778"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01635581.2021.1931364","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39041907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Effects of Fasting on Chemotherapy Treatment Response: A Systematic Review of Current Evidence and Suggestions for the Design of Future Clinical Trials. 禁食对化疗治疗反应的影响:对现有证据的系统回顾和对未来临床试验设计的建议。

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2021-06-14 DOI: 10.1080/01635581.2021.1938147

Esther Heyde Selke Costa, Jenifer Faria Krüger, Carolina Q Camargo, Vinícius Basso Preti, Elaine Hillesheim, Estela I Rabito

{"title":"Effects of Fasting on Chemotherapy Treatment Response: A Systematic Review of Current Evidence and Suggestions for the Design of Future Clinical Trials.","authors":"Esther Heyde Selke Costa, Jenifer Faria Krüger, Carolina Q Camargo, Vinícius Basso Preti, Elaine Hillesheim, Estela I Rabito","doi":"10.1080/01635581.2021.1938147","DOIUrl":"https://doi.org/10.1080/01635581.2021.1938147","url":null,"abstract":"Fasting associated with chemotherapy could improve the efficacy of anticancer treatments without increasing their adverse effects. We conducted a systematic review following the PRISMA Statement to summarize the evidence on the effects of fasting on treatment response of adults undergoing chemotherapy and make suggestions for the design of future clinical trials The search was performed on CENTRAL, PubMed/MEDLINE, LILACS and Embase. Randomized and non-randomized clinical trials evaluating the effects of fasting (above 12 h, at anytime) on treatment response of adult cancer patients undergoing chemotherapy were included. The risk of bias assessment was conducted in accordance with the Cochrane Handbook. Literature search retrieved 1393 citations and three studies were included in the review. All studies had as an intervention fasting of at least 24 h, before chemotherapy. Two studies showed that immediately after chemotherapy, damage to healthy cells was increased, however after 48 and 72 h, of fasting there was a decrease on damage magnitude. There was no difference in chemotherapy-related adverse events between intervention and control groups. All studies presented two or more criteria with a high risk of bias. Fasting of at least 24 h, appears to be safe and showed some beneficial effects on chemotherapy toxicity, that could be further investigated, however studies presented heterogeneous samples and protocols. We highlight the need and provide recommendations for well-designed randomized clinical trials that evaluate the effect of fasting on chemotherapy-related adverse events. This systematic review was registered on PROSPERO as CRD42019120071.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"1213-1221"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01635581.2021.1938147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39087644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2