Nutrition and Cancer最新文献_第6页

Calvatia Lilacina Extracts Exert Anti-Breast-Cancer Bioactivity through the Apoptosis Induction Dependent on Mitochondrial Reactive Oxygen Species and Caspase Activation. 丁香花提取物通过线粒体活性氧和半胱天冬酶激活诱导细胞凋亡发挥抗乳腺癌生物活性。

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2021-06-12 DOI: 10.1080/01635581.2021.1936576

Qinghua Zeng, Ragini Singh, Yong Ye, Shuang Cheng, Chen Fan, Qingmei Zeng

{"title":"Calvatia Lilacina Extracts Exert Anti-Breast-Cancer Bioactivity through the Apoptosis Induction Dependent on Mitochondrial Reactive Oxygen Species and Caspase Activation.","authors":"Qinghua Zeng, Ragini Singh, Yong Ye, Shuang Cheng, Chen Fan, Qingmei Zeng","doi":"10.1080/01635581.2021.1936576","DOIUrl":"https://doi.org/10.1080/01635581.2021.1936576","url":null,"abstract":"Puffballs are a class of fungi widely distributed worldwide and associated with various bioactivities. This research mainly showed the antitumor bioactivity of extracts from Calvatia lilacina (CL), which is a common variety of puffballs. NMR and high-performance liquid chromatography methods are used to characterize the extracts. Results showed that CL extracts obtained with petroleum ether, ethyl acetate, ethanol, and water elicited obvious inhibitory effects on the proliferation of A549, Caco-2, and MDA-MB-231. Among these extracts, petroleum ether extract demonstrated the highest performance. This extract was then separated into seven sub-fractions (SFs). Three of these SFs (3#, 6#, and 7#) induces a decrease in the viability of MDA-MB-231 cells in which 7# SF exhibited the highest cytotoxicity, where the major component was found to be ergosta-7,22-dien-3-one. Further tests revealed that 7# SF from petroleum ether extract could trigger severe cell death in human breast cancer cells (MDA-MB-231) by activating the apoptotic pathway dependent on mitochondrial reactive oxygen species and caspase activation. All these results in combination indicate that the mechanism of extract-potentiated apoptosis associates closely with ROS-dependent mitochondrial dysfunction events which further induces mitochondria-mediated intrinsic cytochrome C-caspase-related pathway of apoptosis.Supplemental data for this article is available online at https://doi.org/10.1080/01635581.2021.1936576.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"1058-1070"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01635581.2021.1936576","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39090015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Anticancer Effect of Inula viscosa Methanol Extract by miRNAs' Re-regulation: An in vitro Study on Human Malignant Melanoma Cells. 粘菊甲醇提取物通过mirna再调控对人恶性黑色素瘤细胞的抗癌作用

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2021-02-11 DOI: 10.1080/01635581.2020.1869791

Dilara Kamer Colak, Unal Egeli, Isil Ezgi Eryilmaz, Onder Aybastier, Hulusi Malyer, Gulsah Cecener, Berrin Tunca

{"title":"The Anticancer Effect of Inula viscosa Methanol Extract by miRNAs' Re-regulation: An in vitro Study on Human Malignant Melanoma Cells.","authors":"Dilara Kamer Colak, Unal Egeli, Isil Ezgi Eryilmaz, Onder Aybastier, Hulusi Malyer, Gulsah Cecener, Berrin Tunca","doi":"10.1080/01635581.2020.1869791","DOIUrl":"https://doi.org/10.1080/01635581.2020.1869791","url":null,"abstract":"Alternative and natural therapies are needed for malignant melanoma (MM), the most deadly skin cancer type due to chemotherapy's limited effect. In the present study, we evaluated the anticancer potentials of Inula viscosa methanol and water extracts (IVM and IVW) on MM cells, A2058 and MeWo, and normal fibroblasts. After the chromatographic and antioxidant activity analysis, their antiproliferative effects were determined with the increasing doses for 24-72 h. IVM induced more cell death in a dose and time-dependent manner in MM cells compared to IVW. This effect was probably due to the higher amount of phenolics in it. IVM significantly induced more apoptotic death in MM cells than fibroblasts (p < 0.01), which was also supported morphologically. IVM also caused cell cycle arrest at G0/G1 and G2/M phases in A2058 and MeWo, respectively, and suppressed the migration ability of MM cells (p < 0.01). Additionally, IVM was found to have significant potential in regulating MM-related miRNAs, upregulating miR-579 and miR-524, and downregulating miR-191 and miR-193, in MM cells (p < 0.05, p < 0.01). As a result, the anticancer effect of IVM via regulating miRNAs' expression has been demonstrated for the first time. Thus, IVM, with these potentials, may be a promising candidate for MM treatment.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"211-224"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01635581.2020.1869791","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25356061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Thymoquinone Potentiated the Anticancer Effect of Cisplatin on Hepatic Tumorigenesis by Modulating Tissue Oxidative Stress and Endoplasmic GRP78/CHOP Signaling. 百里醌通过调节组织氧化应激和内质GRP78/CHOP信号通路增强顺铂对肝脏肿瘤发生的抗癌作用。

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2021-02-03 DOI: 10.1080/01635581.2021.1879880

Maha Eid Farghaly, Akef Abdelhalim Khowailed, Basma Emad Aboulhoda, Laila Ahmed Rashed, Safy Salah Gaber, Hend Ashour

{"title":"Thymoquinone Potentiated the Anticancer Effect of Cisplatin on Hepatic Tumorigenesis by Modulating Tissue Oxidative Stress and Endoplasmic GRP78/CHOP Signaling.","authors":"Maha Eid Farghaly, Akef Abdelhalim Khowailed, Basma Emad Aboulhoda, Laila Ahmed Rashed, Safy Salah Gaber, Hend Ashour","doi":"10.1080/01635581.2021.1879880","DOIUrl":"https://doi.org/10.1080/01635581.2021.1879880","url":null,"abstract":"Thymoquinone (TQ) combined with Cisplatin may augment its anticancer effect on hepatocellular carcinoma (HCC), through oxidative stress mitigation and endoplasmic reticulum (ER) protein modulation. Fifty adult male Wistar albino rats were assigned into five equal experimental groups (n = 10); 1) Control, 2) diethylnitrosamine/carbon tetrachloride-induced liver tumorigenesis model (HCC), 3) Cisplatin (2 mg.kg-1ip) treated rats, 4) Thymoquinone treated group (20 mg.kg-1oral), and 5) group treated with both drugs as in Groups 3 and 4. Treatment regimens started following model confirmation and continued for 4 weeks. In the HCC model, we detected elevated ER chaperone glucose-regulated protein-78 (GRP78) and reduced C/EBP-homologous protein (CHOP)-mediated apoptosis that was accompanied by the elevated alpha-fetoprotein (AFP) marker and deteriorated liver functions. Our original results indicated that Thymoquinone potentiated the pro-apoptotic effect of cisplatin by modulating GRP78/CHOP signaling. Cisplatin/TQ reduced the elevated GRP78 and induced CHOP-mediated apoptosis in the diseased liver tissues compared to the HCC and Cisplatin treated groups. Cisplatin/TQ combination normalized AFP levels and improved liver functions compared to both HCC and cisplatin groups alone. In conclusion, Thymoquinone enhanced the efficacy of Cisplatin in HCC treatment by modulating the GRP78/CHOP/caspase-3 pathway. Thymoquinone is recommended to achieve greater therapeutic benefits and reduce the cisplatin hepatotoxicity in HCC management.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"278-287"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01635581.2021.1879880","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25326002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Long Noncoding RNA LINC00941 Promotes Cell Proliferation and Invasion by Interacting with hnRNPK in Oral Squamous Cell Carcinoma. 长链非编码RNA LINC00941通过与hnRNPK相互作用促进口腔鳞状细胞癌细胞增殖和侵袭

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2022-01-17 DOI: 10.1080/01635581.2022.2027473

Jie Liu, Zhenxing Li, Ting Zhang, Chunhui Wang, Wen Chen, Danfeng Zhang, Junyu Wang

{"title":"Long Noncoding RNA LINC00941 Promotes Cell Proliferation and Invasion by Interacting with hnRNPK in Oral Squamous Cell Carcinoma.","authors":"Jie Liu, Zhenxing Li, Ting Zhang, Chunhui Wang, Wen Chen, Danfeng Zhang, Junyu Wang","doi":"10.1080/01635581.2022.2027473","DOIUrl":"10.1080/01635581.2022.2027473","url":null,"abstract":"Oral squamous cell carcinoma (OSCC) is a prevalent carcinoma of the head, neck and mouth. Recently studies involving the role of long noncoding RNAs (lncRNAs) that play key regulatory roles in altering gene expression has been reported in the context of promoting tumorigenesis. However, the functions of lncRNAs in the context of oral squamous cell carcinoma have not been extensively described. In this study, we report a never identified before lncRNA, LINC00941, which was highly expressed in OSCC tissues and cells. Expression of LINC00941 promoted cell proliferation, migration, invasion, and metastasis of OSCC cells In Vitro by inducing epithelial-mesenchymal transition (EMT) and activating the Wnt/β-catenin signaling cascade. In silico analyses revealed heterogeneous nuclear ribonucleoprotein K (hnRNPK) to be a strong positive regulator of LINC00941 activity. Experimental verification of this association revealed a direct interaction of LINC00941 and hnRNPK to induce cell growth and invasion by activating EMT in OSCC cells. Therefore, our study reports that LINC00941 promotes progression of OSCC by its interaction with hnRNPK, and it may present a promising strategy for diagnosis and treatment of OSCC.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"2983-2995"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39703473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probiotics or Synbiotics for Preventing Postoperative Infection in Hepatopancreatobiliary Cancer Patients: A Meta-Analysis of Randomized Controlled Trials. 益生菌或合成制剂预防肝胆癌患者术后感染：随机对照试验的荟萃分析

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2022-06-20 DOI: 10.1080/01635581.2022.2089698

Gang Tang, Linyu Zhang, Wang Huang, Zhengqiang Wei

{"title":"Probiotics or Synbiotics for Preventing Postoperative Infection in Hepatopancreatobiliary Cancer Patients: A Meta-Analysis of Randomized Controlled Trials.","authors":"Gang Tang, Linyu Zhang, Wang Huang, Zhengqiang Wei","doi":"10.1080/01635581.2022.2089698","DOIUrl":"10.1080/01635581.2022.2089698","url":null,"abstract":"Objective: Postoperative infection of hepatopancreatobiliary cancer (HPBC) is a major cause of morbidity and mortality. Probiotics and synbiotics are potential prevention strategies, but evidence on the efficacy of probiotics or synbiotics in the prevention of postoperative infection for HPBC remains controversial. This study aimed to define the impact of probiotics or synbiotics on the incidence of postoperative infection in HPBC patients.Methods: A systematic search of the Cochrane Library, PubMed, Embase, and Web of Science databases was conducted from inception to February 2, 2021 to identify randomized controlled trials (RCTs) evaluating the efficacy of probiotics or synbiotics in HPBC. Data were pooled and expressed as the risk ratio (RR) and mean difference (MD) with 95% confidence intervals.Results: Eight RCTs involving 445 participants were included. Supplementation with probiotics or synbiotics significantly reduced the incidence of postoperative infection (RR 0.55) in HPBC patients, and both probiotics (RR 0.68) and synbiotics (RR 0.41) were effective in reducing the incidence of postoperative infection. In addition, probiotics or synbiotics can reduce duration of antibiotic use (MD -3.52) and length of hospital stay (MD -4.21).Conclusion: Probiotics or synbiotics are effective strategies for the prevention of postoperative infection in HPBC patients.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"3468-3478"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40057764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

C-Reactive Protein/Albumin Ratio on the First Day after Surgery Predicts Short-Term Complications of Gastrectomy for Gastric Cancer. 术后第一天c反应蛋白/白蛋白比值预测胃癌切除术的短期并发症。

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2022-06-28 DOI: 10.1080/01635581.2022.2083190

Zhijian Liu, Li Chen, Feng Sun, Bingxin Lv, Xiaolong Ge, Lihua Shao, Song Liu

{"title":"C-Reactive Protein/Albumin Ratio on the First Day after Surgery Predicts Short-Term Complications of Gastrectomy for Gastric Cancer.","authors":"Zhijian Liu, Li Chen, Feng Sun, Bingxin Lv, Xiaolong Ge, Lihua Shao, Song Liu","doi":"10.1080/01635581.2022.2083190","DOIUrl":"https://doi.org/10.1080/01635581.2022.2083190","url":null,"abstract":"Postoperative complications of gastrectomy for gastric cancer affect the efficacy of surgery. It is of clinical significance to identify high-risk patients with postoperative complications as early as possible. A total of 206 patients who underwent gastrectomy were enrolled in this study. Univariate and multivariate analyses were used to determine the risk factors for postoperative complications. The cutoff value and diagnostic accuracy of the C-reactive protein/albumin ratio were calculated by receiver operating characteristic curves. A total of 64 (31.1%) patients developed postoperative complications. Multivariate analysis confirmed that the C-reactive protein/albumin ratio on the first day after operation was an independent risk factor for postoperative complications (OR = 2.538, 95%CI: 1.346-4.785, P = 0.004). The cutoff value of the C-reactive protein/albumin ratio on the first day after operation was 2.105 calculated by receiver operating characteristic curves. Patients with a C-reactive protein/albumin ratio greater than 2.105 had a higher incidence of postoperative complications (43.2% vs 22.0%, P = 0.001) and longer postoperative hospital stay (15.3 ± 1.2 vs 13.0 ± 0.5, P = 0.042) than patients with less than 2.105. Patients with C-reactive protein/albumin ratio greater than 2.105 on the first day after operation are more likely to have postoperative complications.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"3574-3581"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40406363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Nutritional Support in Older Patients with Esophageal Cancer Undergoing Chemoradiotherapy. 老年食管癌放化疗患者的营养支持。

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2022-07-04 DOI: 10.1080/01635581.2022.2096245

Diğdem Doğan Akagündüz, Perim Fatma Türker

{"title":"Nutritional Support in Older Patients with Esophageal Cancer Undergoing Chemoradiotherapy.","authors":"Diğdem Doğan Akagündüz, Perim Fatma Türker","doi":"10.1080/01635581.2022.2096245","DOIUrl":"https://doi.org/10.1080/01635581.2022.2096245","url":null,"abstract":"Esophageal cancer (EC) is the eighth most prevalent malignancy and the sixth leading cause of cancer-related death worldwide. The proportion of older adults with EC has increased dramatically in recent decades due to increased life expectancy. Older patients with EC are at a highest risk of malnutrition and this predicts early death. In older patients with EC, dysphagia is a common symptom; additionally, comorbidities, polypharmacy, and physiological changes of aging such as decreased muscle mass and geriatric issues including altered cognition, mobility, and mood contribute to malnutrition. Chemoradiotherapy (CRT) is the primary treatment for unresectable locally advanced EC patients, as it successfully reduces local recurrence and distant metastases while also extending survival. In older patients with EC, nutrition is an interventional condition, unlike many other geriatric risk factors. Optimizing nutritional support may reduce treatment toxicity and facilitate the completion of definitive or neoadjuvant CRT. The relevance of nutritional status and food intake is becoming more widely acknowledged, and it now encompasses the entire spectrum of EC treatment in older patients, from diagnosis to perioperative care to long-term care. This review aims to discuss the current research on nutritional support in older patients with esophageal cancer undergoing CRT.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"3634-3639"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40559993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Hypertension Remission after Colorectal Cancer Surgery: A Single-Center Retrospective Study. 结直肠癌手术后高血压缓解:单中心回顾性研究

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2022-01-07 DOI: 10.1080/01635581.2021.2025256

Yu-Xi Cheng, Wei Tao, Xiao-Yu Liu, Chao Yuan, Bin Zhang, Zheng-Qiang Wei, Dong Peng

引用次数: 13

The Ferula Assa-foetida Essential Oil Nanoemulsion (FAEO-NE) as the Selective, Apoptotic, and Anti-Angiogenic Anticancer Compound in Human MCF-7 Breast Cancer Cells and Murine Mammary Tumor Models. 阿魏精油纳米乳(FAEO-NE)在人MCF-7乳腺癌细胞和小鼠乳腺肿瘤模型中作为选择性、凋亡和抗血管生成的抗癌化合物

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2021-10-05 DOI: 10.1080/01635581.2021.1985533

Hanieh Azani, Masoud Homayouni Tabrizi, Ali Neamati, Farzanehsadat Khadem, Niloufar Khatamian

{"title":"The Ferula Assa-foetida Essential Oil Nanoemulsion (FAEO-NE) as the Selective, Apoptotic, and Anti-Angiogenic Anticancer Compound in Human MCF-7 Breast Cancer Cells and Murine Mammary Tumor Models.","authors":"Hanieh Azani, Masoud Homayouni Tabrizi, Ali Neamati, Farzanehsadat Khadem, Niloufar Khatamian","doi":"10.1080/01635581.2021.1985533","DOIUrl":"https://doi.org/10.1080/01635581.2021.1985533","url":null,"abstract":"The Ferula assa-foetida (FA) is the healthy common-consumed anticancer beverage in Iranian folk medicine. In the current study, we aimed to produce a nanoemulsion-based drug delivery system containing FA essential oil (FAEO) and evaluate its antioxidant and anticancer activity on both MCF-7 cells and murine mammary cancer tissue. The FAEO-loaded nanoemulsion (FAEO-NE) was produced and characterized by DLS, TEM, FTIR, and Zeta potential analysis. Radical (ABTS and DPPH) scavenging activity, cytotoxic, apoptotic, and anti-angiogenic potentials of the FAEO-NE were studied by applying antioxidant (ABTS-DPPH), MTT, AO/PI cell staining, and Q-PCR analysis. Finally, its anti-tumor impact was evaluated on murine mammary tumor models. The FAEO-NE exhibited a meaningful antioxidant activity. Also, its significant cell-selective cytotoxic, apoptotic, and anti-angiogenic impacts on MCF-7 cancer cells indicated its anticancer potential. Moreover, the progressive destruction of the murine mammary glands cancer tissue confirmed their anticancer activity. Regarding the FAEO-NE cell-selective cytotoxic, apoptotic, and anti-angiogenic activity on MCF-7 breast cancer cells, it has the potential to be studied as a safe efficient anti-breast cancer agent.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"2196-2206"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39484731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Long-Term Oral Administration of Piceatannol (3,5,3',4'-Tetrahydroxystilbene) Attenuates Colon Tumor Growth Induced by Azoxymethane Plus Dextran Sulfate Sodium in C57BL/6J Mice. 长期口服皮杉醇(3,5,3'，4'-四羟基二苯乙烯)可减弱偶氮氧甲烷加葡聚糖硫酸钠诱导的C57BL/6J小鼠结肠肿瘤的生长。

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2021-10-08 DOI: 10.1080/01635581.2021.1985532

Yoshiyuki Kimura

{"title":"Long-Term Oral Administration of Piceatannol (3,5,3',4'-Tetrahydroxystilbene) Attenuates Colon Tumor Growth Induced by Azoxymethane Plus Dextran Sulfate Sodium in C57BL/6J Mice.","authors":"Yoshiyuki Kimura","doi":"10.1080/01635581.2021.1985532","DOIUrl":"https://doi.org/10.1080/01635581.2021.1985532","url":null,"abstract":"Aim: The effects of 3,5,3',4'-tetrahydroxystilbene (piceatannol) on azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced colon cancer growth and changes in IL-1β, IL-6, tumor necrosis factor-α (cytokines), MCP-1, vascular endothelial growth factor, and PD-1 colon levels were investigated herein.Methods: AOM (10 mg/kg, i.p.) on day 0 induced colorectal carcinogenesis. On day 3, mice were provided with water containing 1.5% (w/v) DSS ad libitum for 3 day, and this 3-day drinking protocol was repeated twice. Piceatannol (5 and 12.5 mg/kg, twice daily) was orally administered to mice for 7-, 7-, 7-, and 6-day and then discontinued for 14-, 15-, and 16-day. Cytokines, chemokine, and PD-1 colon levels were measured by the respective ELISA kits.Results: In mice administered piceatannol (12.5 mg/kg), the tumor number, tumor area, and Ki-67-positive cell numbers decreased by 30.1%, 57.2%, and 89.1%, respectively, colon MCP-1 and PD-1 levels showed reductions of 43.8% and 70.9%, respectively, and COX-2-positive cell numbers declined by 60.2%.Conclusions: The inhibitory effects of piceatannol on AOM/DSS-induced colon tumor growth appear to be associated with reductions in colon MCP-1 and PD-1 levels through the downregulated expression of COX-2 in the tumor microenvironment.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"2184-2195"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39521547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3