Nutrition and Cancer最新文献_第7页

Evaluation of Anticancer Potential of Flavones from Rhamnus alaternus against B16F10 Melanoma Cells. 鼠李黄酮对B16F10黑色素瘤细胞的抗癌作用

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2021-11-16 DOI: 10.1080/01635581.2021.2004171

Ines Bouhlel Chatti, Yosr Krichen, Mouna Maatouk, Aida Lahmar, Sonia Ghoul Mazgar, Rim Kammoun, Sihem Safta Skhiri, Leila Chekir Ghedira, Mounira Krifa

{"title":"Evaluation of Anticancer Potential of Flavones from Rhamnus alaternus against B16F10 Melanoma Cells.","authors":"Ines Bouhlel Chatti, Yosr Krichen, Mouna Maatouk, Aida Lahmar, Sonia Ghoul Mazgar, Rim Kammoun, Sihem Safta Skhiri, Leila Chekir Ghedira, Mounira Krifa","doi":"10.1080/01635581.2021.2004171","DOIUrl":"https://doi.org/10.1080/01635581.2021.2004171","url":null,"abstract":"Melanoma has become an important health problem and new treatment have become an imperative medical need. Therefore, the finding and identification of natural product with less toxic effects, capable of promoting melanoma cell death have become an important goal of research in oncotherapy. In this study, we want to investigate the anticancer activity of an enriched total oligomers flavonoids (TOF) extract of R. alaternus in melanoma cells. First, TOF was exhibited to be rich in flavones. We revealed that this extract reduced proliferation and increased of sub-G1 and S phase cells built-up in B16-F10 cells in a dose-related manner. Moreover, In Vivo, TOF reduced tumor volume and weight with percentages of inhibition of 92.4% and 92.9%, respectively. R. alaternus was also found to be effective in reducing the level of pro-inflammatory cytokine IL-6 during metastasis. Level of TH1 cytokine, such as IL-2, was significantly enhanced by TOF treatment. Indeed, the histological examination of the tumor revealed the absence of mitoses and the presence of numerous melanin pigmented macrophage cells in the R. alaternus extract-treated group that could be explained by the induction of macrophage activation and by the arrest of the cell cycle in the Sub-G1 and S phases.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"2265-2275"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39881268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Chemopreventive Potential of Myrtenal against Nitrosamine-Initiated, Radiation-Promoted Rat Bladder Carcinogenesis. 桃金娘醛对亚硝胺引发、辐射促进的大鼠膀胱癌的化学预防作用。

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2021-01-29 DOI: 10.1080/01635581.2021.1879881

Mostafa A Farrag, Magda K Ezz, Nashwa K Ibrahim, Emad K Ahmed

{"title":"Chemopreventive Potential of Myrtenal against Nitrosamine-Initiated, Radiation-Promoted Rat Bladder Carcinogenesis.","authors":"Mostafa A Farrag, Magda K Ezz, Nashwa K Ibrahim, Emad K Ahmed","doi":"10.1080/01635581.2021.1879881","DOIUrl":"https://doi.org/10.1080/01635581.2021.1879881","url":null,"abstract":"The present study was undertaken to evaluate the chemopreventive activity of myrtenal, a natural monoterpene, against bladder carcinoma in rats induced with N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) and promoted with γ-ionizing radiation (γ-IRR) as well as to assess the involvement of inflammation, apoptosis and oxidative damage in tumor development. Histopathological examination of rat bladder revealed the presence of noninvasive papillary transitional cell carcinoma (Grade 2) in sections from BBN group indicating the credibility of the applied carcinogenesis model. Myrtenal treatment caused improvement in urinary bladder mucosa with cells more likely in Grade 1. Administration of myrtenal to BBN-treated rats exhibited downregulation in the expressions of COX-2, NF-kB and STAT-3 associated with suppression of inflammatory cytokines levels of TNF-α and IL-6 as well as biomarkers of oxidative damage (MDA & NO). In addition, myrtenal treatment caused a significant increase in caspase-3 activity and Bax/Bcl-2 ratio. Data obtained suggested that the anti-inflammatory effect and the induction of apoptosis contributed largely to the beneficial antitumor effects of myrtenal in rats with BBN/γ-IRR-induced bladder carcinoma. Present findings, in addition to benefits described in other pathologies, indicated myrtenal as a potential adjuvant natural compound for the prevention of tumor progression of bladder cancer.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"288-298"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01635581.2021.1879881","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38794034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Alysicarpus vaginalis Bio-Actives as ESR Signaling Pathway Inhibitor for Breast Cancer Treatment: A Network Pharmacology Approach. 作为ESR信号通路抑制剂的阴道仙人掌生物活性物用于乳腺癌治疗:网络药理学方法。

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2021-10-06 DOI: 10.1080/01635581.2021.1986080

Nikhil S Sakle, Shweta A More, Santosh N Mokale

{"title":"Alysicarpus vaginalis Bio-Actives as ESR Signaling Pathway Inhibitor for Breast Cancer Treatment: A Network Pharmacology Approach.","authors":"Nikhil S Sakle, Shweta A More, Santosh N Mokale","doi":"10.1080/01635581.2021.1986080","DOIUrl":"https://doi.org/10.1080/01635581.2021.1986080","url":null,"abstract":"In our previous study Alysicarpus vaginalis (AV) has appeared as a promising target for breast cancer hence we have screened potential targets by in silico, In Vitro and In Vivo methods. A network pharmacology (NP) approach involves prediction and validating of targets via molecular modeling, western blotting and In Vivo MNU-induced mammary cancer. The PPI network showed the 573 edges between 214 nodes (targets) that are involved in breast cancer and important one are ESR-1, ESR-2, AR, EGFR, NOS3, MAPK, KDR, SRC and MET. Compound-target-pathway network involves 04 compounds and 221 interactive protein targets associated with breast cancer. GO and KEGG enrichment analysis predicted the ERR, c-MET, PDGFR-α/β, EGFR, and VEGF as a key targets in the breast cancer treatment which are validated via molecular modeling. Expression of ER-α, AR and EGFR were significantly down regulated by AV in MCF-7 cell line. In addition, the immunoreactivity of ER-α was reduced significantly in MNU-induced mammary carcinoma, which is a key target in ER + breast cancer. Overall, this study scientifically light ups the pharmacological mechanism of AV in the treatment of breast cancer, strongly associated with the regulation of ESR signaling pathway.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"2222-2234"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39487882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Value of Pretreatment Glasgow Prognostic Score/Modified Glasgow Prognostic Score in Ovarian Cancer: A Systematic Review and Meta-Analysis. 预处理格拉斯哥预后评分/改良格拉斯哥预后评分在卵巢癌中的预后价值:系统回顾和荟萃分析。

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2021-09-22 DOI: 10.1080/01635581.2021.1980591

Siyu Xu, Lei Song, Xiaoshi Liu

{"title":"Prognostic Value of Pretreatment Glasgow Prognostic Score/Modified Glasgow Prognostic Score in Ovarian Cancer: A Systematic Review and Meta-Analysis.","authors":"Siyu Xu, Lei Song, Xiaoshi Liu","doi":"10.1080/01635581.2021.1980591","DOIUrl":"https://doi.org/10.1080/01635581.2021.1980591","url":null,"abstract":"To explore prognostic value of pretreatment Glasgow prognostic score (GPS) and modified Glasgow prognostic score (mGPS) in ovarian cancer patients.The PubMed, EMBASE (via OVID), and Web of Science databases were comprehensively searched for eligible studies. The hazard ratios (HRs) with 95% confidence intervals (CIs) were combined to evaluate the association of pretreatment GPS/mGPS with overall survival (OS) and progression-free survival (PFS) of ovarian cancer patients. STATA 12.0 version software was applied for statistical analysis.A total of eight retrospective studies involving 2260 were included into this systematic review and meta-analysis. The pooled results indicated that patients with elevated pretreatment GPS or mGPS had poorer OS (HR = 1.62, 95% CI: 1.38-1.91, P＜.001) and PFS (HR = 1.40, 95% CI: 1.02-1.93, P = .039) than patients with pretreatment GPS or mGPS 0. Subgroup analysis based on the type of score (GPS or mGPS) and tumor stage for OS were also performed and the results were consistent with above findings.Pretreatment GPS/mGPS might serve as promising prognostic indexes for ovarian cancer patients. More prospective studies with high-quality are needed to verify our findings.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"1968-1975"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39437350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Measurement of Advanced Glycation End Products Could Be Used as an Indicator of Unhealthy Nutrition for Colorectal Cancer Risk. 晚期糖基化终产物的测量可作为结直肠癌风险的不健康营养指标。

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2021-06-18 DOI: 10.1080/01635581.2021.1938148

Gulcin Sahingoz Erdal, Mustafa Yaman, Esra Yıldırım Servi, Halime Ugur, Pinar Kasapoglu, Murat Cikot, Nilgun Isiksacan

{"title":"Measurement of Advanced Glycation End Products Could Be Used as an Indicator of Unhealthy Nutrition for Colorectal Cancer Risk.","authors":"Gulcin Sahingoz Erdal, Mustafa Yaman, Esra Yıldırım Servi, Halime Ugur, Pinar Kasapoglu, Murat Cikot, Nilgun Isiksacan","doi":"10.1080/01635581.2021.1938148","DOIUrl":"https://doi.org/10.1080/01635581.2021.1938148","url":null,"abstract":"The main culprit behind most cancers is the accumulation of reactive oxygen species. Glyoxal (GO) and methylglyoxal (MGO) are reactive intermediates created by food processing and they are precursors of advanced glycation end products (AGE) that cause glycative stress. We aimed to evaluate the relationship between AGE levels of healthy volunteers and treatment-naive patients diagnosed with colorectal cancer. The study consisted of patients diagnosed with colorectal cancer and healthy volunteers who underwent routine colonoscopy. The study was conducted with a total of 42 cases, 47.6% (n = 20) female. The ages of the participants in the study ranged from 41 to 82 years, and the mean was 60.57 ± 10.78 years. The GO and MGO values of the patient group were found to be significantly higher than those of the control group (p = 0.007, p = 0.001, respectively). The risk of colorectal cancer was 22 and 57 times higher in individuals with GO and MGO values above 1.25 μg/mL and 0.0095 μg/mL, respectively. The blood AGE level is closely related to diet, and it can be decreased through the appropriate improvement of diet. Thus, the measurement of AGE can be used to predict whether a person's nutrition is healthy or unhealthy and prevent increased risk of colorectal cancer.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"896-902"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01635581.2021.1938148","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39244464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary Carbohydrate Quality and Quantity and Risk of Breast Cancer among Iranian Women. 伊朗妇女饮食碳水化合物的质量和数量与乳腺癌的风险。

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2021-06-27 DOI: 10.1080/01635581.2021.1942931

Fatemeh Hosseini, Hossein Imani, Fatemeh Sheikhhossein, Maryam Majdi, Mahtab Ghanbari, Sakineh Shab-Bidar

{"title":"Dietary Carbohydrate Quality and Quantity and Risk of Breast Cancer among Iranian Women.","authors":"Fatemeh Hosseini, Hossein Imani, Fatemeh Sheikhhossein, Maryam Majdi, Mahtab Ghanbari, Sakineh Shab-Bidar","doi":"10.1080/01635581.2021.1942931","DOIUrl":"https://doi.org/10.1080/01635581.2021.1942931","url":null,"abstract":"Objective: This study investigated the association between quality and quantity of carbohydrate by assessing low carbohydrates diet score (LCDS), carbohydrate quality score (CQI), glycemic index (GI), dietary glycemic load (GL), and dietary carbohydrate intake, and risk of breast cancer (BrCa) among Iranian women.Methods: This hospital-based case-control study was carried out in the Cancer Research Center of Imam Khomeini hospital, Iran. We included One hundred and fifty newly diagnosed BrCa cases and one hundred and fifty healthy controls in this study. Socio-demographic and dietary data and anthropometric measures were recorded.Results: We found that a higher CQI than a lower score was associated with a decrease in odds of BrCa (P = 0.04). After adjusting for potential confounders, we observed that CQI was not associated with BrCa development (P = 0.05). An increase in odds of BrCa among women in the highest tertiles of GL (P = 0.12), GI (P = 0.48), and dietary carbohydrate intake (P = 0.06) was seen, which was not statistically significant. There was also a non-significant lower chance of having BrCa with adherence to the LCDS (P = 0.09).Conclusion: Our findings suggest that CQI was not related to BrCa risk among Iranian women. This relation deserves to be investigated in prospective studies.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"916-926"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01635581.2021.1942931","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39114496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Dietary Antioxidant Capacity and Serum Inflammatory Biomarkers Levels in Cancer Survivors. 癌症幸存者饮食抗氧化能力和血清炎症生物标志物水平

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2021-07-19 DOI: 10.1080/01635581.2021.1952443

Şenay Burçin Alkan, Mehmet Artaç, Neslişah Rakıcıoğlu

{"title":"Dietary Antioxidant Capacity and Serum Inflammatory Biomarkers Levels in Cancer Survivors.","authors":"Şenay Burçin Alkan, Mehmet Artaç, Neslişah Rakıcıoğlu","doi":"10.1080/01635581.2021.1952443","DOIUrl":"https://doi.org/10.1080/01635581.2021.1952443","url":null,"abstract":"This study aimed to compare the dietary intake of carotenoids, tocopherols, ascorbic acid, flavonoids, and dietary total antioxidant capacity (dTAC) and to evaluate relationship of dTAC with serum inflammatory biomarkers in patients with gastrointestinal system (GIS) and non-GIS cancer. In total, 104 adult cancer survivors (52 GIS and 52 non-GIS cancer cases) were included. 24-hour dietary recalls were obtained and dTAC was calculated on the basis of oxygen radical absorption capacity (ORAC), Trolox equivalent antioxidant capacity (TEAC), total radical-trapping antioxidant parameter (TRAP), ferric reducing antioxidant potential (FRAP), and vitamin C equivalents (VCE). Serum C-reactive protein (CRP) level, neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) were used as inflammatory biomarkers. Routinely analyzed serum CRP, neutrophil, lymphocyte, and platelet levels every day in hospital biochemistry laboratory were obtained from patients' file. There was no significant difference between patients with GIS and non-GIS cancer in terms of dietary intake of carotenoids, tocopherols, and flavonoids. While there was no significant difference between groups in terms of the mean dietary ORAC, TEAC, and FRAP, the mean TRAP of patients with GIS cancer was significantly higher than patients with non-GIS cancer. Serum inflammatory markers (CRP and NLR) were found to have an inverse relationship with dTAC.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"1243-1251"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01635581.2021.1952443","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39198229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Impact of Nutritional Status on Survival in Head and Neck Cancer Patients After Total Laryngectomy. 营养状况对全喉切除术后头颈癌患者生存的影响。

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2021-07-19 DOI: 10.1080/01635581.2021.1952446

Adriana Santos, Izabella Costa Santos, Patrícia Fonseca Dos Reis, Viviane Dias Rodrigues, Wilza Arantes Ferreira Peres

{"title":"Impact of Nutritional Status on Survival in Head and Neck Cancer Patients After Total Laryngectomy.","authors":"Adriana Santos, Izabella Costa Santos, Patrícia Fonseca Dos Reis, Viviane Dias Rodrigues, Wilza Arantes Ferreira Peres","doi":"10.1080/01635581.2021.1952446","DOIUrl":"https://doi.org/10.1080/01635581.2021.1952446","url":null,"abstract":"Malnutrition is an important prognostic indicator of laryngeal squamous cell carcinoma. Retrospective study with head and neck cancer patients who underwent total laryngectomy. 243 patients of both sex were evaluated. The univariate analyses demonstrated an increased risk of death for the patients with greater weight loss, hypoalbuminemia, radiotherapy as an initial treatment, salvage surgery, and radical neck dissection. In a Multivariate Cox regression, older age (p = 0.03, 95% confidence interval [CI] 1.003-1.06, hazard ratio [HR] 1.029), Nutritional Risk Index ≤100 (p = 0.008, 95% CI 1.18-3.12, HR 1.921) and adjuvant radiotherapy (p = 0.029, 95% CI 0.31-3.12, HR 0.544) demonstrated prognostic significance in survival. Nutritional status is a modifiable variable and these findings highlight the need to adoption of simple nutritional assessment methods routinely during the treatment of head and neck cancer patients, in order to help improve prognosis after surgery.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"1252-1260"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01635581.2021.1952446","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39198233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Thymus Vulgaris Inhibit Lung Fibrosis Progression and Oxidative Stress Induced by Bleomycin in Wistar Rats. 寻常胸腺对博来霉素诱导Wistar大鼠肺纤维化进展及氧化应激的抑制作用。

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2021-07-19 DOI: 10.1080/01635581.2021.1952451

Sana Bahri, Mona Mlika, Afef Nahdi, Ridha Ben Ali, Saloua Jameleddine

{"title":"Thymus Vulgaris Inhibit Lung Fibrosis Progression and Oxidative Stress Induced by Bleomycin in Wistar Rats.","authors":"Sana Bahri, Mona Mlika, Afef Nahdi, Ridha Ben Ali, Saloua Jameleddine","doi":"10.1080/01635581.2021.1952451","DOIUrl":"https://doi.org/10.1080/01635581.2021.1952451","url":null,"abstract":"Idiopathic pulmonary fibrosis (IPF) is a chronic, devastating and fatal disease characterized by aberrant fibroblasts proliferation, oxidative stress and collagen accumulation in the interstitial tissue. We aimed to evaluate in the present study the efficacy of Thymus vulagris extract (TVE) on an experimental model of pulmonary fibrosis induced by bleomycin (BLM). Wistar rats were given a single dose of BLM (4 mg/kg, intratracheal), while TVE (50, 100 and 200 mg/kg, intraperitoneal) was administered 3 days later and continued for 4 weeks. We reveled by HPLC analysis an important amount of phenolic bioactive compounds such as rosmarinic and vanillic acids. Our results showed a significant decrease of catalase and superoxide dismutase activities and an increase in lipid peroxidation compared to control group after BLM injection. Treatment with TVE (200 mg/kg) was able to normalize the level of these oxidative markers and to decrease collagen accumulation compared to BLM group. Moreover, this high dose of TVE have no renal or hepatic cytotoxic effects. This study allowed us to conclude that thyme extract has a strong antioxidant and antifibrotic activities due to its high content of polyphenols.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"1420-1430"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01635581.2021.1952451","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39199082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Efficacy of Nutrients in Reducing the Symptoms of Radiation Induced Oral Mucositis in a Hamster Model. 营养素对减轻仓鼠放射性口腔黏膜炎症状的作用。

IF 2.9

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2021-07-20 DOI: 10.1080/01635581.2021.1952440

Svyatoslav Dvoretskiy, Suzette L Pereira, Tapas Das

{"title":"Efficacy of Nutrients in Reducing the Symptoms of Radiation Induced Oral Mucositis in a Hamster Model.","authors":"Svyatoslav Dvoretskiy, Suzette L Pereira, Tapas Das","doi":"10.1080/01635581.2021.1952440","DOIUrl":"https://doi.org/10.1080/01635581.2021.1952440","url":null,"abstract":"Radiation-induced oral mucositis (RIOM) is a painful, dose-limiting toxicity in cancer therapy. RIOM was induced by radiation on the left buccal pouch mucosa of Golden Syrian hamsters (n = 8/group). Animals were treated topically with polyphenols (Curcumin or Quercetin) or amino acids/metabolite mixtures (Alanyl-Glutamine or Arginine + Glutamine + β-Hydroxy β-methylbutyric acid (Arg/Gln/HMB)) for over 20 day. Progression of RIOM was assessed using a standard visual scoring six-point scale, for differences in severity of mucositis (score ≥3) (Chi-square analysis) and in the daily group scores (Mann-Whitney rank sum test). Compared to the controls, there was a significant reduction in number of days with severe RIOM (score ≥3) in the treatment groups: Curcumin (50 μg/ml) = 17%; Control = 38.5%, p < 0.001; Quercetin (50 μg/ml) = 27.6% and Quercetin (100 μg/ml) = 25%; Control = 41.3%, p = 0.007 and p = 0.001, respectively; Arg/Gln/HMB (50 mg/ml) = 31.9%; Control = 50.0%, p = 0.040. In addition, Curcumin (50 μg/ml), Quercetin (100 μg/ml) and Arg/Gln/HMB (100 mg/ml) groups had lower mucositis scores (≥3) on at least two consecutive time points over the course of the study than their respective controls. There were no significant group differences in deaths or body weight. This study demonstrates the potential benefits of topical application of either plant polyphenols or amino acid/metabolite mixtures in addressing severity and progression of RIOM.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"1079-1089"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01635581.2021.1952440","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39200796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1