Impact of Nutritional Status on Survival in Head and Neck Cancer Patients After Total Laryngectomy.

Nutrition and Cancer Pub Date : 2022-01-01 Epub Date: 2021-07-19 DOI:10.1080/01635581.2021.1952446

Adriana Santos, Izabella Costa Santos, Patrícia Fonseca Dos Reis, Viviane Dias Rodrigues, Wilza Arantes Ferreira Peres

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引用次数: 7

Abstract

Malnutrition is an important prognostic indicator of laryngeal squamous cell carcinoma. Retrospective study with head and neck cancer patients who underwent total laryngectomy. 243 patients of both sex were evaluated. The univariate analyses demonstrated an increased risk of death for the patients with greater weight loss, hypoalbuminemia, radiotherapy as an initial treatment, salvage surgery, and radical neck dissection. In a Multivariate Cox regression, older age (p = 0.03, 95% confidence interval [CI] 1.003-1.06, hazard ratio [HR] 1.029), Nutritional Risk Index ≤100 (p = 0.008, 95% CI 1.18-3.12, HR 1.921) and adjuvant radiotherapy (p = 0.029, 95% CI 0.31-3.12, HR 0.544) demonstrated prognostic significance in survival. Nutritional status is a modifiable variable and these findings highlight the need to adoption of simple nutritional assessment methods routinely during the treatment of head and neck cancer patients, in order to help improve prognosis after surgery.

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营养状况对全喉切除术后头颈癌患者生存的影响。

营养不良是喉鳞癌的重要预后指标。接受全喉切除术的头颈癌患者的回顾性研究。对243例男女患者进行了评估。单因素分析表明，体重减轻、低白蛋白血症、以放疗作为初始治疗、补救性手术和根治性颈部清扫的患者死亡风险增加。在多因素Cox回归中，年龄(p = 0.03, 95%可信区间[CI] 1.003-1.06，风险比[HR] 1.029)、营养风险指数≤100 (p = 0.008, 95% CI 1.18-3.12, HR 1.921)和辅助放疗(p = 0.029, 95% CI 0.31-3.12, HR 0.544)对生存率有预后意义。营养状况是一个可改变的变量，这些发现强调在头颈癌患者治疗过程中需要常规采用简单的营养评估方法，以帮助改善术后预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Nutrition and Cancer

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