Nutrition and Cancer最新文献

{"title":"The Protective Role of <i>Urtica dioica</i> Seed Extract Against Azoxymethane-Induced Colon Carcinogenesis in Rats.","authors":"Ahmet Uyar,&nbsp;Abdulahad Doğan,&nbsp;Turan Yaman,&nbsp;Ömer Faruk Keleş,&nbsp;Zabit Yener,&nbsp;İsmail Çelik,&nbsp;Elif Ebru Alkan","doi":"10.1080/01635581.2021.1881568","DOIUrl":"https://doi.org/10.1080/01635581.2021.1881568","url":null,"abstract":"<p><p>The aim of this study was to investigate the protective role of <i>Urtica dioica</i> seed (UDS) extract against azoxymethane (AOM)-induced colon carcinogenesis in rats. Thirty-two male Wistar albino rats were divided into four groups: Control, AOM, AOM + UDS, and UDS. The AOM and AOM + UDS groups were induced by AOM (15 mg/kg body weight) subcutaneously once a week for 10 weeks. AOM + UDS and UDS groups additionally received fed with pellets included 30 ml/kg UDS extract. At the end of the trial, blood and colon tissue samples were taken from the rats following necropsy. The gross and histopathological findings revealed that the administration of UDS extract significantly decreased lesions including aberrant cript foci, adenoma, and adenocarcinoma formation both numerically and dimensionally. Immunohistochemically, slight CEA and COX-2, strong Caspase-3 immune-expressions were detected in the group AOM + UDS compared to AOM group. Biochemical examinations indicated that a markedly increase in the malondialdehyde and fluctuated antioxidant defense system constituents levels such as reduced glutathione, glutathione <i>s</i>-transferase, glutathione peroxidase, superoxide dismutase were restored in AOM + UDS group. These results reveal that the UDS may act as a chemopreventive dietary agent, inducing apoptosis, resulting in a significant reduction of colon carcinogenesis.</p>","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"306-319"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01635581.2021.1881568","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25347743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional Risk and Assessment for Patients with Cancer Pain.","authors":"Yajun Chen,&nbsp;Qi Xiang,&nbsp;Chunlei Li,&nbsp;Yaqi Zeng,&nbsp;Jie Dong,&nbsp;Ping Zhang,&nbsp;Yueying Li,&nbsp;Yujie Wang,&nbsp;Kun Wang","doi":"10.1080/01635581.2021.1882510","DOIUrl":"https://doi.org/10.1080/01635581.2021.1882510","url":null,"abstract":"<p><strong>Background: </strong>The incidence of nutritional risk and malnutrition are high in patients with cancer pain. It is very important to choose an effective tool to identify these patients promptly. However, few studies have discussed this issue. The primary objective of this study is to clarify the similarities and differences between the two nutritional screening and assessment tools, and to estimate the anthropometry and biochemical indicators of the patients with cancer pain, with a view to provide help for treatment of these patients.</p><p><strong>Method: </strong>Data of 146 patients with cancer pain were collected from August 2018 to May 2019 in the Pain Therapy Department of Tianjin Cancer Hospital. The information of numerical rating scale (NRS), nutritional risk screening-2002 (NRS-2002), patient-generated subjective global assessment (PG-SGA), anthropometry and biochemical indicators were collected for pain assessment, nutritional risk screening, and nutritional status assessment.</p><p><strong>Results: </strong>NRS scores had a positive correlation with NRS-2002 (<i>R</i> = 0.273, <i>P</i> = 0.001) and PG-SGA (<i>R</i> = 0.341, <i>P</i> = 0.000) separately. NRS-2002 and PG-SGA had a significant positive correlation with each other (<i>R</i> = 0.468, <i>P</i> = 0.000). NRS-2002 was finished in a shorter time period (4.2 ± 0.8 min vs. 12.8 ± 0.8 min, <i>P</i> = 0.001), while PG-SGA had a higher detection rate of malnutrition (86.3% vs. 65.8%). In the stepwise multiple regression analysis, NRS (0.258, <i>P</i> = 0.001), PA (-0.297, <i>P</i> = 0.000), TP (0.178, <i>P</i> = 0.030) are the indicators of NRS-2002; and NRS (0.317, <i>P</i> = 0.000), PA (<i>β</i> = 0.288, <i>P</i> = 0.000) and BMI (-0.281, <i>P</i> = 0.000) are the related variables of PG-SGA. The kappa coefficient was lower than 0.4 (kappa value = 0.396) when choosing the score of NRS-2002 ≥ 3 and PG-SGA ≥ 9 as the diagnostic criteria. If choosing the score of NRS-2002 ≥ 2 and PG-SGA ≥ 9, both the correlation coefficient (<i>R</i> = 0.699, <i>P</i> = 0.000) and the kappa coefficient (kappa value = 0.698, <i>P</i> = 0.000) became more coefficient.</p><p><strong>Conclusions: </strong>Both NRS-2002 and PG-SGA could identify patients with nutritional risk and malnutrition accurately. NRS-2002 is simpler and takes less time to finish, while PG-SGA is more cumbersome with a higher detection rate of malnutrition. NRS, PA, TP and BMI are the most important reference indicators predicting on nutritional risk index and malnutrition status. We recommend NRS-2002 ≥ 2 as the diagnostic criteria in order to avoid missing the patients with nutritional risk.</p>","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"168-174"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01635581.2021.1882510","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25356064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omega-3 Polyunsaturated Fatty Acids Can Reduce C-Reactive Protein in Patients with Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Lei Pan,&nbsp;Yun Zhou,&nbsp;Haitao Yin,&nbsp;Hui Hui,&nbsp;Yongzhong Guo,&nbsp;Xiaomei Xie","doi":"10.1080/01635581.2021.1931365","DOIUrl":"https://doi.org/10.1080/01635581.2021.1931365","url":null,"abstract":"ABSTRACTS Omega-3 polyunsaturated fatty acids (PUFAs) possess anti-inflammatory properties. There is a lack of consensus regarding the effects of omega-3 PUFAs on C-reactive protein (CRP), a marker of systemic inflammation, in cancer patients. Herein, a meta-analysis of randomized controlled trials was conducted to evaluate the effects of omega-3 PUFAs on CRP levels in patients with cancer. PubMed and EMBASE were searched until May 2020 to identify randomized controlled trials that examined the effects of omega-3 PUFA administration on CRP levels in cancer patients. Standardized mean differences (SMDs) with their 95% confidence intervals (CIs) were calculated to determine the differences in omega-3 PUFA administration and control conditions. Seventeen eligible studies involving 916 cancer patients were included in this meta-analysis. Significant heterogeneity was present among individual studies (Pheterogeneity = 0.000; I 2 = 74.5%). The overall SMDs of CRP levels between omega-3 PUFA administration and control conditions were 0.628 (95% CI: 0.342-0.914) and 0.456 (95% CI: 0.322-0.590) by the random-effect and fixed-effect models, respectively. Sources of heterogeneity were not found through subgroup and meta-regression analyses. Existing publication bias contributed slightly to the effect size. Omega-3 PUFAs can reduce systemic inflammation, as indicated by CRP levels in cancer patients. The use of omega-3 PUFAs is recommended for cancer patients due to their anti-inflammatory properties.","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"840-851"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01635581.2021.1931365","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39036622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Synbiotic Supplementation on Serum Anti-Inflammatory Factors in the Survivors of Breast Cancer with Lymphedema following a Low Calorie Diet: A Randomized, Double-Blind, Clinical Trial.","authors":"Ali Saneei Totmaj,&nbsp;Shahpar Haghighat,&nbsp;Shapour Jaberzadeh,&nbsp;Mehraban Navaei,&nbsp;Saeideh Vafa,&nbsp;Leila Janani,&nbsp;Hadi Emamat,&nbsp;Zahra Salehi,&nbsp;Maryam Izad,&nbsp;Mitra Zarrati","doi":"10.1080/01635581.2021.1933096","DOIUrl":"https://doi.org/10.1080/01635581.2021.1933096","url":null,"abstract":"<p><strong>Background and aim: </strong>Breast cancer-related lymphedema (BCRL) is a treatment-related inflammatory complication in breast cancer survivors (BCSs). This study was aimed to evaluate the effect of synbiotic supplementation on serum concentrations of IL-10, TGF-β, VEGF, adiponectin, and edema volume among overweight or obese BCSs with lymphedema following a low-calorie diet (LCD).</p><p><strong>Method: </strong>In a randomized double-blind, controlled clinical trial, 88 obese and overweight BCSs women were randomized to synbiotic supplement (<i>n</i> = 44) or placebo (<i>n</i> = 44) groups and both groups followed an LCD for 10 weeks. Pre- and post-intervention comparisons were made regarding the anti-inflammatory markers which included IL-10, TGF-β, VEGF, adiponectin, edema volume, and anthropometric measurements. Also, the same factors were analyzed to find inter-group disparities.</p><p><strong>Results: </strong>There were no significant differences among participants in the baseline, except for IL-10 and adiponectin. Post-intervention, no significant differences were observed regarding the anti-inflammatory markers, including IL-10, VEGF, adiponectin, and TGF-β between the groups. After 10 weeks of intervention edema volume significantly decreased in the synbiotic group; additionally, anthropometric measurements (body weight, BMI, body fat percent, and WC) decreased in both groups significantly (<i>P</i> < 0.001 and <i>P</i> < 0.005; respectively).</p><p><strong>Conclusion: </strong>Synbiotic supplementation coupled with an LCD in a 10-week intervention had beneficial effects on increasing the serum TGF-β, IL-10, and adiponectin levels in women with BCRL. It also reduced arm lymphedema volume. Therefore, synbiotic supplementation can be effective in improving health status in BCRL patients.</p>","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"869-881"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01635581.2021.1933096","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39059208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of Nutrient Intake in Relation to Gastric Cancer: A Case Control Study.","authors":"Saba Narmcheshm,&nbsp;Bahareh Sasanfar,&nbsp;Maryam Hadji,&nbsp;Kazem Zendehdel,&nbsp;Fatemeh Toorang,&nbsp;Leila Azadbakht","doi":"10.1080/01635581.2021.1931697","DOIUrl":"https://doi.org/10.1080/01635581.2021.1931697","url":null,"abstract":"<p><p>Gastric Cancer (GC) is the most common cancer among Iranian men. We conducted a case-control study to investigate the association between patterns of nutrient intake and the risk of GC in Iran. We enrolled 178 GC patients and 271 controls matched for age and sex. We collected dietary intakes using a validated diet history questionnaire. We performed factor analysis on 28 nutrients using multivariate logistic regression models on tertiles of factor scores and estimated odds ratios (OR) and 95% confidence intervals (95% CI). We identified three nutrient patterns. The first pattern included pantothenic acid, riboflavin, zinc, animal protein, and calcium. Selenium, thiamin, carbohydrate, vegetable protein, niacin and low intake of vitamin E loaded the second pattern, and the third pattern was abundant in fiber, carotene, vitamin C and A. We found no significant association between GC and any of the dietary patterns. However, in the first patterns, men in the highest tertile had significantly higher odds of GC than the lowest (OR = 2.15, 95% CI: 1.13-4.09, p trend = 0.02). A dietary pattern loaded by animal products may increase the risk of GC among Iranian men. Larger studies are required to approve these findings in overall and in different subgroups.Supplemental data for this article is available online at https://doi.org/10.1080/01635581.2021.1931697.</p>","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"830-839"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01635581.2021.1931697","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39059187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Performance of SGA, PG-SGA and MUST for Malnutrition Assessment in Adult Cancer Patients: A Systematic Literature Review and Hierarchical Bayesian Meta-Analysis.","authors":"Rena Nakyeyune,&nbsp;Xiaoli Ruan,&nbsp;Yi Shen,&nbsp;Yi Shao,&nbsp;Chen Niu,&nbsp;Zhaoping Zang,&nbsp;Fen Liu","doi":"10.1080/01635581.2021.1942080","DOIUrl":"https://doi.org/10.1080/01635581.2021.1942080","url":null,"abstract":"<p><p>Because cancer-associated malnutrition is a major health complication, timely nutritional screening is of utmost importance. The aim of this study was to conduct a systematic literature review and meta-analysis of three tools in order to identify the method with the best diagnostic performance. PubMed, EMBASE and Cochrane central register of controlled trials were searched for articles published from database inception to January 2021. Studies that assessed the diagnostic accuracy of the SGA, PG-SGA or MUST in adult cancer patients were included. In order to evaluate the quality of each included study, the QUADAS-2 tool was used after which a meta-analysis was conducted using the hierarchical bivariate model. This model accounts for both within and between study variability. 16 studies (18 datasets) were included to evaluate these tools. The overall sensitivity and specificity for SGA was 0.69 and 0.80, 0.95 and 0.81 for PG-SGA, along with 0.83 and 0.83 for MUST respectively. An assessment of the likelihood ratios showed that PG-SGA had the highest LR + and the lowest LR-, it therefore has the best diagnostic performance to confirm malnutrition in adult cancer patients.</p>","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"903-915"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01635581.2021.1942080","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39121299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lycopene Does Not Affect Prostate-Specific Antigen in Men with Non-Metastatic Prostate Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Elham Sharifi Zahabi,&nbsp;Sepideh Soltani,&nbsp;Farzad Shidfar","doi":"10.1080/01635581.2021.2022724","DOIUrl":"https://doi.org/10.1080/01635581.2021.2022724","url":null,"abstract":"Dear Editor We have read the study by Sadeghian et al. titled “Lycopene Does Not Affect Prostate-Specific Antigen in Men with Non-Metastatic Prostate Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials” (1). This meta-analysis was conducted on six randomized controlled trials (2–7) and the pooled results indicated that lycopene supplementation had no significant effect on PSA level (WMD: −0.60, 95% CI: −2.01, 0.81 mg/L). However, subgroup analysis conducted on three studies (2–4) revealed a significant reduction effect of lycopene on PSA level in patients with higher levels of baseline PSA. Unfortunately, we found several problems in this systematic review that seriously affect the validity and interpretation of the study findings. First, it is important to note that two of the six included studies were conducted on the same overlapping population (2, 3) and authors did not consider this issue in their study. Most concerning, is the inclusion of these two studies in subgroup one analysis that was confined to studies conducted on patients with higher baseline levels of PSA (≥6.5 μg/L). Since these two studies account for the major weight of the included studies in subgroup 1 (18.23% vs. 19.13% for subtotal weight), the results of the subgroup may not be correct and need more evaluation. Therefore, it is worth noting that when multiple reports from the same underlying RCT are available, inclusion of the RCT only once in the meta-analysis is crucial, to avoid duplication of findings (8) Second the included studies were subgrouped based on mean value of serum PSA of participants at the beginning of the study, but not based on the inclusion criteria. This may lead to misclassification of subgroups. Since, there may have been a combination of patients with serum levels of PSA higher or lower than 6.5 μg/L, the mean value of serum PSA is not a correct estimation of the whole population. Third, to assess pairwise comparisons, data on three different doses of lycopene supplementation from the original RCT were included (6) and comparisons were done vs. one placebo group (three different dose of lycopene supplementation vs. one placebo group). In this case, the placebo group may have been considered 3 times in the overall analysis. Therefore, overestimation of the effect size may have led to misleading results, according to the Cochrane handbook (9). Fourth, in the inclusion criteria section, authors mentioned that they included studies that used other treatment in both intervention and control groups. However, in the exclusion criteria, it was reported that those studies that administered lycopene in combination with other bioactive components were excluded. This led to a controversy in the study methodology, as we realized that the study by Bunker et al (5) in which the comparison groups were “lycopene + multivitamin” and “multivitamin” were included in this meta-analysis and the study by Lane et al. (10) which had a factorial d","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"806-807"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40313565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Nutritional and Functional Status on Postoperative Outcomes following Esophageal Cancer Surgery.","authors":"Irene Lidoriki,&nbsp;Konstantinos S Mylonas,&nbsp;Athanasios Syllaios,&nbsp;Chrysovalantis Vergadis,&nbsp;Panagiota Stratigopoulou,&nbsp;Georgios Marinos,&nbsp;Aikaterini Mastoraki,&nbsp;Ioannis Karavokyros,&nbsp;Dimitrios Schizas","doi":"10.1080/01635581.2022.2036769","DOIUrl":"https://doi.org/10.1080/01635581.2022.2036769","url":null,"abstract":"<p><p>Malnourished patients undergoing esophagectomy have increased risk of postoperative complications. The aim of the current study was to identify nutritional and functional risk factors for postoperative complications in patients with esophageal and gastroesophageal junction cancer who underwent esophagectomy. Seventy patients who were admitted at the First Department of Surgery, Laikon General Hospital, Athens, Greece, were included in this study. Laboratory data and data regarding nutritional and functional status were recorded preoperatively. Postoperative complications were graded according to Clavien-Dindo classification. Thirty-seven patients (52.9%) developed postoperative complications. Albumin and Geriatric Nutritional Risk Index (GNRI) levels were lower in patients who developed major complications compared to patients who did not develop postoperative complications (3.90 ± 0.44 vs 4.18 ± 0.37 g/dL, <i>p</i> = 0.014 and 107.40 ± 15.76 vs 114.98 ± 12.26, <i>p</i> = 0.050 respectively). Major complications were associated with higher percentage of weight loss (12.1 ± 11.1 vs 6.2 ± 7.5%, <i>p</i> = 0.019) and with low handgrip strength (80 vs 16.9%, <i>p</i> = 0.006). Albumin (3.93 ± 0.18 vs 4.15 ± 0.41 g/dL, <i>p</i> = 0.019) and low muscle mass (22.6 vs 2.8%, <i>p</i> = 0.016) were significantly associated with anastomotic leakage occurence. The incorporation of patients' nutritional and functional status in the preoperative risk assessment might increase prognostic ability concerning postoperative complications of patients undergoing esophagectomy.</p>","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"2846-2858"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39896174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hot Tea Drinking and the Risk of Esophageal Cancer: A Systematic Review and Meta-Analysis.","authors":"Yulian Zhong,&nbsp;Chao Yang,&nbsp;Niannian Wang,&nbsp;Da Pan,&nbsp;Shaokang Wang,&nbsp;Guiju Sun","doi":"10.1080/01635581.2021.2007963","DOIUrl":"https://doi.org/10.1080/01635581.2021.2007963","url":null,"abstract":"<p><p>This study aimed to explore the association between hot tea drinking and the risk of esophageal cancer. PubMed, Web of Science, Embase, Scopus and Cochrane library were searched for relevant studies from inception to October 29, 2020 by using (Tea OR \"Green Tea\" OR \"Black Tea\") AND (\"Esophageal Neoplasms\" OR \"Esophageal Cancer\" OR \"Esophagus Cancer\") as key words. The Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of the literatures. The meta-analysis was performed using the Revman 5.3 and Stata 13.0 software. The subgroup analyses were conducted on publication year, population regions, tea type, tea temperature, and type of esophageal cancer, and the publication bias was calculated using the funnel plot and Begg's regression. A total of 12 case-control studies with 5253 cases and 8273 controls were included. The meta-analysis displayed that hot tea drinking was significantly associated with the risk of esophageal cancer (pooled odds ratio, 2.04; 95% CI, 1.78-2.31). However, the research evidence is still limited, therefore, it needs further discussion.</p>","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"2384-2391"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39908406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Vitamin E in Selected Malignant Neoplasms in Women.","authors":"Anna Markowska,&nbsp;Michał Antoszczak,&nbsp;Janina Markowska,&nbsp;Adam Huczyński","doi":"10.1080/01635581.2021.1952626","DOIUrl":"https://doi.org/10.1080/01635581.2021.1952626","url":null,"abstract":"<p><p>Vitamin E, which is actually a mixture of eight isoforms (four tocopherols and four tocotrienols), is a powerful antioxidant that protects polyunsaturated fatty acids against oxidation and has the ability to break the chain lipid peroxidation, which is used in the treatment of heart disease, atherosclerosis, muscle disorders or infertility among men. Studies in-vitro show that one of the effects of tocopherol is the reduction of cancer stem cell activity which is connected to poor clinical course. In the scientific literature, reports on the participation of vitamin E not only in protection against the mutagenic effects of reactive oxygen species, but also in its anti-angiogenic activity and the ability to inhibit the invasion and metastasis of neoplastic cells are increasingly common. In this context, the role of vitamin E in preventing the neoplastic process and selected malignant neoplasms among women seems to be of particular interest. In this article, we present the results of research on the potential anticancer effects of vitamin E in the fight against breast, cervical, endometrial and ovarian cancer.</p>","PeriodicalId":501691,"journal":{"name":"Nutrition and Cancer","volume":" ","pages":"1163-1170"},"PeriodicalIF":2.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01635581.2021.1952626","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39197835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}