WIREs Nanomedicine and Nanobiotechnology最新文献

Extracellular vesicles-based theranostics for neurodegenerative diseases 基于细胞外囊泡的治疗神经退行性疾病的疗法

WIREs Nanomedicine and Nanobiotechnology Pub Date : 2024-09-16 DOI: 10.1002/wnan.1993

Han Zhao, Ling Zhu, Chen Wang, Yanlian Yang

{"title":"Extracellular vesicles-based theranostics for neurodegenerative diseases","authors":"Han Zhao, Ling Zhu, Chen Wang, Yanlian Yang","doi":"10.1002/wnan.1993","DOIUrl":"https://doi.org/10.1002/wnan.1993","url":null,"abstract":"With the accelerated aging of the global population, the incidence of neurodegenerative diseases (NDDs) is increasing year by year. Because of the presence of the blood–brain barrier (BBB), the low concentration of the biomarkers in peripheral blood and the low penetration rate of the drugs through BBB into brain hinders the development of diagnosis and treatment of NDDs. As an effective mediator to penetrate through BBB in both directions, extracellular vesicles (EVs) have attracted much attention in the early diagnosis and treatment of NDDs because of their superior performance as drug carriers and detection biomarkers. Brain-derived EVs in body fluids contain disease-related biomolecules can be used as early diagnostic biomarkers for NDDs. In addition, as one of the subpopulations of EVs, exosomes, especially stem cell-derived exosomes, have great potential in the treatment of NDDs. The ability to cross the BBB, together with the feasibility of versatile functionalization of EV for NDDs pathogen targeting facilitate EVs a potential tool for targeted drug delivery systems for NDDs. In this review, the important role of EVs in the diagnosis and treatment of NDDs and the current research progress will be discussed.","PeriodicalId":501345,"journal":{"name":"WIREs Nanomedicine and Nanobiotechnology","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142268569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting specific brain districts for advanced nanotherapies: A review from the perspective of precision nanomedicine 针对特定脑区的先进纳米疗法：从精准纳米医学的角度综述

WIREs Nanomedicine and Nanobiotechnology Pub Date : 2024-09-09 DOI: 10.1002/wnan.1991

Giulia Sierri, Michela Patrucco, Davide Ferrario, Antonio Renda, Susanna Comi, Matilde Ciprandi, Veronica Fontanini, Francesco Saverio Sica, Silvia Sesana, Marta Costa Verdugo, Marcelo Kravicz, Luca Salassa, Marta Busnelli, Francesca Re

{"title":"Targeting specific brain districts for advanced nanotherapies: A review from the perspective of precision nanomedicine","authors":"Giulia Sierri, Michela Patrucco, Davide Ferrario, Antonio Renda, Susanna Comi, Matilde Ciprandi, Veronica Fontanini, Francesco Saverio Sica, Silvia Sesana, Marta Costa Verdugo, Marcelo Kravicz, Luca Salassa, Marta Busnelli, Francesca Re","doi":"10.1002/wnan.1991","DOIUrl":"https://doi.org/10.1002/wnan.1991","url":null,"abstract":"Numerous studies are focused on nanoparticle penetration into the brain functionalizing them with ligands useful to cross the blood–brain barrier. However, cell targeting is also crucial, given that cerebral pathologies frequently affect specific brain cells or areas. Functionalize nanoparticles with the most appropriate targeting elements, tailor their physical parameters, and consider the brain's complex anatomy are essential aspects for precise therapy and diagnosis. In this review, we addressed the state of the art on targeted nanoparticles for drug delivery in diseased brain regions, outlining progress, limitations, and ongoing challenges. We also provide a summary and overview of general design principles that can be applied to nanotherapies, considering the areas and cell types affected by the most common brain disorders. We then emphasize lingering uncertainties that hinder the translational possibilities of nanotherapies for clinical use. Finally, we offer suggestions for continuing preclinical investigations to enhance the overall effectiveness of precision nanomedicine in addressing neurological conditions.","PeriodicalId":501345,"journal":{"name":"WIREs Nanomedicine and Nanobiotechnology","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cover Image, Volume 16, Issue 3 封面图片，第 16 卷第 3 期

WIREs Nanomedicine and Nanobiotechnology Pub Date : 2024-06-19 DOI: 10.1002/wnan.1977

引用次数: 0

Engineered shapes using electrohydrodynamic atomization for an improved drug delivery 利用电流体动力雾化技术设计形状，改善药物输送效果

WIREs Nanomedicine and Nanobiotechnology Pub Date : 2024-05-03 DOI: 10.1002/wnan.1964

Deng-Guang Yu, Wenjian Gong, Jianfeng Zhou, Yanan Liu, Yunajie Zhu, Xuhua Lu

{"title":"Engineered shapes using electrohydrodynamic atomization for an improved drug delivery","authors":"Deng-Guang Yu, Wenjian Gong, Jianfeng Zhou, Yanan Liu, Yunajie Zhu, Xuhua Lu","doi":"10.1002/wnan.1964","DOIUrl":"https://doi.org/10.1002/wnan.1964","url":null,"abstract":"The shapes of micro- and nano-products have profound influences on their functional performances, which has not received sufficient attention during the past several decades. Electrohydrodynamic atomization (EHDA) techniques, mainly include electrospinning and electrospraying, are facile in manipulate their products' shapes. In this review, the shapes generated using EHDA for modifying drug release profiles are reviewed. These shapes include linear nanofibers, round micro-/nano-particles, and beads-on-a-string hybrids. They can be further divided into different kinds of sub-shapes, and can be explored for providing the desired pulsatile release, sustained release, biphasic release, delayed release, and pH-sensitive release. Additionally, the shapes resulted from the organizations of electrospun nanofibers are discussed for drug delivery, and the shapes and inner structures can be considered together for developing novel drug delivery systems. In future, the shapes and the related shape–performance relationships at nanoscale, besides the size, inner structure and the related structure–performance relationships, would further play their important roles in promoting the further developments of drug delivery field.","PeriodicalId":501345,"journal":{"name":"WIREs Nanomedicine and Nanobiotechnology","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140832948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aggregation-enhanced photothermal therapy of organic dyes 聚合增强的有机染料光热疗法

WIREs Nanomedicine and Nanobiotechnology Pub Date : 2024-05-02 DOI: 10.1002/wnan.1960

Mengyun Yang, Chendong Ji, Meizhen Yin

引用次数: 0

Recent developments in the use of nanocrystals to improve bioavailability of APIs 利用纳米晶体提高原料药生物利用度的最新进展

WIREs Nanomedicine and Nanobiotechnology Pub Date : 2024-04-17 DOI: 10.1002/wnan.1958

Yidan Ding, Tongyi Zhao, Jianing Fang, Jiexin Song, Haobo Dong, Jiarui Liu, Sijin Li, Min Zhao

{"title":"Recent developments in the use of nanocrystals to improve bioavailability of APIs","authors":"Yidan Ding, Tongyi Zhao, Jianing Fang, Jiexin Song, Haobo Dong, Jiarui Liu, Sijin Li, Min Zhao","doi":"10.1002/wnan.1958","DOIUrl":"https://doi.org/10.1002/wnan.1958","url":null,"abstract":"Nanocrystals refer to materials with at least one dimension smaller than 100 nm, composing of atoms arranged in single crystals or polycrystals. Nanocrystals have significant research value as they offer unique advantages over conventional pharmaceutical formulations, such as high bioavailability, enhanced targeting selectivity and controlled release ability and are therefore suitable for the delivery of a wide range of drugs such as insoluble drugs, antitumor drugs and genetic drugs with broad application prospects. In recent years, research on nanocrystals has been progressively refined and new products have been launched or entered the clinical phase of studies. However, issues such as safety and stability still stand that need to be addressed for further development of nanocrystal formulations, and significant gaps do exist in research in various fields in this pharmaceutical arena. This paper presents a systematic overview of the advanced development of nanocrystals, ranging from the preparation approaches of nanocrystals with which the bioavailability of poorly water-soluble drugs is improved, critical properties of nanocrystals and associated characterization techniques, the recent development of nanocrystals with different administration routes, the advantages and associated limitations of nanocrystal formulations, the mechanisms of physical instability, and the enhanced dissolution performance, to the future perspectives, with a final view to shed more light on the future development of nanocrystals as a means of optimizing the bioavailability of drug candidates.","PeriodicalId":501345,"journal":{"name":"WIREs Nanomedicine and Nanobiotechnology","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140798886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The application strategy of liposomes in organ targeting therapy 脂质体在器官靶向治疗中的应用策略

WIREs Nanomedicine and Nanobiotechnology Pub Date : 2024-04-13 DOI: 10.1002/wnan.1955

Zengyu Xun, Tianqi Li, Xue Xue

引用次数: 0

Overcoming challenges in cancer treatment: Nano-enabled photodynamic therapy as a viable solution 克服癌症治疗中的挑战：纳米光动力疗法是一种可行的解决方案

WIREs Nanomedicine and Nanobiotechnology Pub Date : 2024-02-08 DOI: 10.1002/wnan.1942

Sheeja S. Rajan, Rahul Chandran, Heidi Abrahamse

{"title":"Overcoming challenges in cancer treatment: Nano-enabled photodynamic therapy as a viable solution","authors":"Sheeja S. Rajan, Rahul Chandran, Heidi Abrahamse","doi":"10.1002/wnan.1942","DOIUrl":"https://doi.org/10.1002/wnan.1942","url":null,"abstract":"Cancer presents a formidable challenge, necessitating innovative therapies that maximize effectiveness while minimizing harm to healthy tissues. Nanotechnology has emerged as a transformative force in cancer treatment, particularly through nano-enabled photodynamic therapy (NE-PDT), which leverages precise and targeted interventions. NE-PDT capitalizes on photosensitizers activated by light to generate reactive oxygen species (ROS) that initiate apoptotic pathways in cancer cells. Nanoparticle enhancements optimize this process, improving drug delivery, selectivity, and ROS production within tumors. This review dissects NE-PDT's mechanistic framework, showcasing its potential to harness apoptosis as a potent tool in cancer therapy. Furthermore, the review explores the synergy between NE-PDT and complementary treatments like chemotherapy, immunotherapy, and targeted therapies, highlighting the potential to amplify apoptotic responses, enhance immune recognition of cancer cells, and inhibit resistance mechanisms. Preclinical and clinical advancements in NE-PDT demonstrate its efficacy across various cancer types. Challenges in translating NE-PDT into clinical practice are also addressed, emphasizing the need for optimizing nanoparticle design, refining dosimetry, and ensuring long-term safety. Ultimately, NE-PDT represents a promising approach in cancer therapy, utilizing the intricate mechanisms of apoptosis to address therapeutic hurdles. The review underscores the importance of understanding the interplay between nanoparticles, ROS generation, and apoptotic pathways, contributing to a deeper comprehension of cancer biology and novel therapeutic strategies. As interdisciplinary collaborations continue to thrive, NE-PDT offers hope for effective and targeted cancer interventions, where apoptosis manipulation becomes central to conquering cancer.","PeriodicalId":501345,"journal":{"name":"WIREs Nanomedicine and Nanobiotechnology","volume":"174 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139764641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CRISPR/Cas gene editing and delivery systems for cancer therapy 用于癌症治疗的 CRISPR/Cas 基因编辑和传递系统

WIREs Nanomedicine and Nanobiotechnology Pub Date : 2024-01-26 DOI: 10.1002/wnan.1938

Yingjie Li, Shiyao Zhou, Qinjie Wu, Changyang Gong

引用次数: 0

Nanomedicine and nanobiotechnology in India 印度的纳米医学和纳米生物技术

WIREs Nanomedicine and Nanobiotechnology Pub Date : 2024-01-25 DOI: 10.1002/wnan.1939

Dipanjan Pan

引用次数: 0