克服癌症治疗中的挑战:纳米光动力疗法是一种可行的解决方案

Sheeja S. Rajan, Rahul Chandran, Heidi Abrahamse
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引用次数: 0

摘要

癌症是一项艰巨的挑战,需要采用创新疗法,在最大程度发挥疗效的同时,尽量减少对健康组织的伤害。纳米技术已成为癌症治疗领域的变革力量,特别是通过纳米光动力疗法(NE-PDT),这种疗法利用精确的靶向干预。NE-PDT 利用光激活的光敏剂产生活性氧 (ROS),从而启动癌细胞的凋亡途径。纳米粒子增强技术优化了这一过程,提高了药物输送、选择性和肿瘤内 ROS 的产生。本综述剖析了 NE-PDT 的机理框架,展示了其利用细胞凋亡作为癌症治疗有效工具的潜力。此外,该综述还探讨了 NE-PDT 与化疗、免疫疗法和靶向疗法等辅助疗法之间的协同作用,强调了 NE-PDT 在扩大凋亡反应、增强对癌细胞的免疫识别和抑制抗药性机制方面的潜力。NE-PDT的临床前和临床研究进展证明了它对各种癌症类型的疗效。此外,还探讨了将 NE-PDT 转化为临床实践所面临的挑战,强调了优化纳米粒子设计、改进剂量测定和确保长期安全性的必要性。归根结底,NE-PDT 是一种很有前景的癌症治疗方法,它利用复杂的细胞凋亡机制来解决治疗障碍。这篇综述强调了了解纳米粒子、ROS 生成和凋亡途径之间相互作用的重要性,有助于加深对癌症生物学和新型治疗策略的理解。随着跨学科合作的不断发展,NE-PDT 为有效和有针对性的癌症干预带来了希望,在这种情况下,操纵细胞凋亡将成为战胜癌症的核心。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Overcoming challenges in cancer treatment: Nano-enabled photodynamic therapy as a viable solution

Overcoming challenges in cancer treatment: Nano-enabled photodynamic therapy as a viable solution
Cancer presents a formidable challenge, necessitating innovative therapies that maximize effectiveness while minimizing harm to healthy tissues. Nanotechnology has emerged as a transformative force in cancer treatment, particularly through nano-enabled photodynamic therapy (NE-PDT), which leverages precise and targeted interventions. NE-PDT capitalizes on photosensitizers activated by light to generate reactive oxygen species (ROS) that initiate apoptotic pathways in cancer cells. Nanoparticle enhancements optimize this process, improving drug delivery, selectivity, and ROS production within tumors. This review dissects NE-PDT's mechanistic framework, showcasing its potential to harness apoptosis as a potent tool in cancer therapy. Furthermore, the review explores the synergy between NE-PDT and complementary treatments like chemotherapy, immunotherapy, and targeted therapies, highlighting the potential to amplify apoptotic responses, enhance immune recognition of cancer cells, and inhibit resistance mechanisms. Preclinical and clinical advancements in NE-PDT demonstrate its efficacy across various cancer types. Challenges in translating NE-PDT into clinical practice are also addressed, emphasizing the need for optimizing nanoparticle design, refining dosimetry, and ensuring long-term safety. Ultimately, NE-PDT represents a promising approach in cancer therapy, utilizing the intricate mechanisms of apoptosis to address therapeutic hurdles. The review underscores the importance of understanding the interplay between nanoparticles, ROS generation, and apoptotic pathways, contributing to a deeper comprehension of cancer biology and novel therapeutic strategies. As interdisciplinary collaborations continue to thrive, NE-PDT offers hope for effective and targeted cancer interventions, where apoptosis manipulation becomes central to conquering cancer.
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