Engineered shapes using electrohydrodynamic atomization for an improved drug delivery

Deng-Guang Yu, Wenjian Gong, Jianfeng Zhou, Yanan Liu, Yunajie Zhu, Xuhua Lu
{"title":"Engineered shapes using electrohydrodynamic atomization for an improved drug delivery","authors":"Deng-Guang Yu, Wenjian Gong, Jianfeng Zhou, Yanan Liu, Yunajie Zhu, Xuhua Lu","doi":"10.1002/wnan.1964","DOIUrl":null,"url":null,"abstract":"The shapes of micro- and nano-products have profound influences on their functional performances, which has not received sufficient attention during the past several decades. Electrohydrodynamic atomization (EHDA) techniques, mainly include electrospinning and electrospraying, are facile in manipulate their products' shapes. In this review, the shapes generated using EHDA for modifying drug release profiles are reviewed. These shapes include linear nanofibers, round micro-/nano-particles, and beads-on-a-string hybrids. They can be further divided into different kinds of sub-shapes, and can be explored for providing the desired pulsatile release, sustained release, biphasic release, delayed release, and pH-sensitive release. Additionally, the shapes resulted from the organizations of electrospun nanofibers are discussed for drug delivery, and the shapes and inner structures can be considered together for developing novel drug delivery systems. In future, the shapes and the related shape–performance relationships at nanoscale, besides the size, inner structure and the related structure–performance relationships, would further play their important roles in promoting the further developments of drug delivery field.","PeriodicalId":501345,"journal":{"name":"WIREs Nanomedicine and Nanobiotechnology","volume":"96 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"WIREs Nanomedicine and Nanobiotechnology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/wnan.1964","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

The shapes of micro- and nano-products have profound influences on their functional performances, which has not received sufficient attention during the past several decades. Electrohydrodynamic atomization (EHDA) techniques, mainly include electrospinning and electrospraying, are facile in manipulate their products' shapes. In this review, the shapes generated using EHDA for modifying drug release profiles are reviewed. These shapes include linear nanofibers, round micro-/nano-particles, and beads-on-a-string hybrids. They can be further divided into different kinds of sub-shapes, and can be explored for providing the desired pulsatile release, sustained release, biphasic release, delayed release, and pH-sensitive release. Additionally, the shapes resulted from the organizations of electrospun nanofibers are discussed for drug delivery, and the shapes and inner structures can be considered together for developing novel drug delivery systems. In future, the shapes and the related shape–performance relationships at nanoscale, besides the size, inner structure and the related structure–performance relationships, would further play their important roles in promoting the further developments of drug delivery field.

Abstract Image

利用电流体动力雾化技术设计形状,改善药物输送效果
微米和纳米产品的形状对其功能性能有着深远的影响,而在过去的几十年中,这一问题一直没有得到足够的重视。电流体动力雾化(EHDA)技术,主要包括电纺丝和电喷雾,可以方便地操纵其产品的形状。本综述对利用 EHDA 生成的用于改变药物释放曲线的形状进行了综述。这些形状包括线性纳米纤维、圆形微/纳米颗粒和串珠混合体。它们还可进一步分为不同的子形状,并可用于提供所需的脉冲释放、持续释放、双相释放、延迟释放和 pH 值敏感释放。此外,还讨论了电纺纳米纤维组织所产生的形状在给药方面的应用,这些形状和内部结构可用于开发新型给药系统。今后,除了尺寸、内部结构和相关的结构性能关系外,纳米尺度的形状和相关的形状性能关系也将进一步发挥其重要作用,促进给药领域的进一步发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信