WIREs Nanomedicine and Nanobiotechnology最新文献_第2页

Water-based technologies for improving water quality at the point of use: A review 在使用点改善水质的水基技术：综述

WIREs Nanomedicine and Nanobiotechnology Pub Date : 2024-01-24 DOI: 10.1002/wnan.1940

Godfrey M. Shayo, Elianaso Elimbinzi, Godlisten N. Shao

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引用次数: 0

Nanotechnology-mediated photodynamic therapy: Focus on overcoming tumor hypoxia 纳米技术介导的光动力疗法：关注克服肿瘤缺氧

WIREs Nanomedicine and Nanobiotechnology Pub Date : 2023-12-10 DOI: 10.1002/wnan.1937

Kave Moloudi, Heidi Abrahamse, Blassan P. George

{"title":"Nanotechnology-mediated photodynamic therapy: Focus on overcoming tumor hypoxia","authors":"Kave Moloudi, Heidi Abrahamse, Blassan P. George","doi":"10.1002/wnan.1937","DOIUrl":"https://doi.org/10.1002/wnan.1937","url":null,"abstract":"The oxygen level in the tumor is a critical marker that determines response to different treatments. Cancerous cells can adapt to hypoxia and low pH conditions within the tumor microenvironment (TME) to regulate tumor metabolism, proliferation, and promote tumor metastasis as well as angiogenesis, consequently leading to treatment failure and recurrence. In recent years, widespread attempts have been made to overcome tumor hypoxia through different methods, such as hyperbaric oxygen therapy (HBOT), hyperthermia, O2 carriers, artificial hemoglobin, oxygen generator hydrogels, and peroxide materials. While oxygen is found to be an essential agent to improve the treatment response of photodynamic therapy (PDT) and other cancer treatment modalities, the development of hypoxia within the tumor is highly associated with PDT failure. Recently, the use of nanoparticles has been a hot topic for researchers and exploited to overcome hypoxia through Oxygen-generating hydrogels, O2 nanocarriers, and O2-generating nanoparticles. This review aimed to discuss the role of nanotechnology in tumor oxygenation and highlight the challenges, prospective, and recent advances in this area to improve PDT outcomes.","PeriodicalId":501345,"journal":{"name":"WIREs Nanomedicine and Nanobiotechnology","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138560473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cover Image, Volume 15, Issue 6 封面图片，第15卷，第6期

WIREs Nanomedicine and Nanobiotechnology Pub Date : 2023-11-10 DOI: 10.1002/wnan.1936

引用次数: 0

Cover Image, Volume 15, Issue 2 封面图片，第15卷，第2期

WIREs Nanomedicine and Nanobiotechnology Pub Date : 2023-03-13 DOI: 10.1002/wnan.1883

引用次数: 0

Cover Image, Volume 15, Issue 1 封面图片，第15卷，第1期

WIREs Nanomedicine and Nanobiotechnology Pub Date : 2023-01-13 DOI: 10.1002/wnan.1878

引用次数: 0