Journal of Neuroscience最新文献

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Phonological Representations of Auditory and Visual Speech in the Occipito-temporal Cortex and Beyond. 枕颞皮层及其他部位听觉和视觉言语的语音表征。
IF 4.4 2区 医学
Journal of Neuroscience Pub Date : 2025-06-25 DOI: 10.1523/JNEUROSCI.1415-24.2025
Alice Van Audenhaege, Stefania Mattioni, Filippo Cerpelloni, Remi Gau, Arnaud Szmalec, Olivier Collignon
{"title":"Phonological Representations of Auditory and Visual Speech in the Occipito-temporal Cortex and Beyond.","authors":"Alice Van Audenhaege, Stefania Mattioni, Filippo Cerpelloni, Remi Gau, Arnaud Szmalec, Olivier Collignon","doi":"10.1523/JNEUROSCI.1415-24.2025","DOIUrl":"10.1523/JNEUROSCI.1415-24.2025","url":null,"abstract":"<p><p>Speech is a multisensory signal that can be extracted from the voice and the lips. Previous studies suggested that occipital and temporal regions encode both auditory and visual speech features but their location and nature remain unclear. We characterized brain activity using fMRI (13 males and 11 females) to functionally and individually define bilateral fusiform face areas (FFA), the left word-selective ventral occipito-temporal cortex (word-VOTC), an audiovisual speech region in the left superior temporal sulcus (lSTS); and control regions in bilateral scene-selective parahippocampal place areas (PPA). In these regions, we performed multivariate pattern classification of corresponding phonemes (speech sounds) and visemes (lip movements). We observed that the word-VOTC and lSTS represent phonological information from both vision and sounds. The multisensory nature of phonological representations appeared selective to the word-VOTC, as we found viseme but not phoneme representation in adjacent FFA, while PPA did not encode phonology in any modality. Interestingly, cross-modal decoding revealed aligned phonological representations across the senses in lSTS, but not in word-VOTC. A whole-brain cross-modal searchlight analysis additionally revealed aligned audiovisual phonological representations in bilateral pSTS and left somato-motor cortex overlapping with oro-facial articulators. Altogether, our results demonstrate that auditory and visual phonology are represented in the word-VOTC, extending its functional coding beyond orthography. The geometries of auditory and visual representations do not align in the word-VOTC as they do in the STS and left somato-motor cortex, suggesting distinct representations across a distributed multisensory phonological network.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12199548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abrupt and Gradual Changes in Neuronal Processing upon Falling Asleep and Awakening. 睡眠和觉醒时神经元处理的突然和逐渐的变化
IF 4.4 2区 医学
Journal of Neuroscience Pub Date : 2025-06-25 DOI: 10.1523/JNEUROSCI.1288-24.2025
Amit Marmelshtein, Barak Lavy, Barak Hadad, Yuval Nir
{"title":"Abrupt and Gradual Changes in Neuronal Processing upon Falling Asleep and Awakening.","authors":"Amit Marmelshtein, Barak Lavy, Barak Hadad, Yuval Nir","doi":"10.1523/JNEUROSCI.1288-24.2025","DOIUrl":"10.1523/JNEUROSCI.1288-24.2025","url":null,"abstract":"<p><p>The neural processes that change when falling asleep are only partially understood. At the cortical level, features of both spontaneous neural activity and sensory responses change between wakefulness and sleep. For example, in the early auditory cortex, sleep increases the occurrence of postonset silent (OFF) periods and elevates population synchrony. However, it remains unknown whether such changes occur abruptly or gradually around sleep onset and awakening. Here, we recorded spontaneous and sound-evoked neuronal spiking activity in the early auditory cortex along with polysomnography during thousands of episodes when male rats fell asleep or woke up. We found that when falling asleep, stimulus-induced neuronal silent periods (OFF periods), characteristic of nonrapid eye movement sleep, increased within a few seconds around sleep onset. In contrast, a gradual increase in neuronal population synchrony built up over tens of seconds until reaching maximal levels. EEG auditory-evoked potentials likely representing stimulus-triggered \"K-complexes\" changed along with postonset neuronal firing, whereas ongoing EEG slow-wave activity was associated with neuronal population synchrony. Similar effects, but with opposite direction, were observed around awakenings. The results highlight late stimulus-induced neuronal silence as a key feature changing abruptly around transitions between vigilance states, likely reflecting neuronal bistability and manifesting also in EEG-evoked potentials. More generally, these findings emphasize the added value of going beyond monitoring ongoing activity and perturbing the nervous system to reveal its state-an insight that could also help guide the development of more sensitive noninvasive monitors of falling asleep in humans.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12199541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Purkinje cell spatial correlation dynamics are key to cerebellar cortical contributions to behavior. 浦肯野细胞空间相关动力学是小脑皮层对行为贡献的关键。
IF 5.3 2区 医学
Journal of Neuroscience Pub Date : 2025-06-24 DOI: 10.1523/jneurosci.1915-24.2025
Martha L Streng,Russell E Carter,Benjamin W Kottke,Kayla Togneri,Emma Wasserman,Vijay Rajendran,Suhasa B Kodandaramaiah,Esther Krook-Magnuson,Timothy J Ebner
{"title":"Purkinje cell spatial correlation dynamics are key to cerebellar cortical contributions to behavior.","authors":"Martha L Streng,Russell E Carter,Benjamin W Kottke,Kayla Togneri,Emma Wasserman,Vijay Rajendran,Suhasa B Kodandaramaiah,Esther Krook-Magnuson,Timothy J Ebner","doi":"10.1523/jneurosci.1915-24.2025","DOIUrl":"https://doi.org/10.1523/jneurosci.1915-24.2025","url":null,"abstract":"A major challenge in cerebellar physiology is determining how the stereotypic, conserved circuitry of the cerebellar cortex, with its dominant parasagittal and transverse architectures, underlies its fundamental computations and contributions to behavior. Recent advances have allowed for the resolution of Purkinje cell dendritic activity at large scales, but the full roles of these Purkinje cell dynamics during behavior remain undetermined. To interrogate Purkinje cell dynamics at the population level during behavior, we implemented a novel approach for awake, chronic, wide-field Ca2+ imaging of the cerebellar cortex. We performed wide-field cerebellar recordings in mice of both sexes exhibiting sparse expression of the Ca2+ indicator GCaMP6s, which importantly allowed for the resolution of both dendritic and somatic Purkinje cell activity. Blind source separation of wide-field dynamics using spatial independent component analysis (sICA) extracts components consisting of either Purkinje cell dendrites or somata, with distinct activity and spatial properties. These independent components (ICs) tend to be either parasagittally organized and likely reflective of dendritic activity, or more spatially distributed populations of Purkinje cell somata. We observe broad, bilateral activation of both these dendritic and somatic ICs during behavior, but they exhibit distinct and divergent patterns of spatial correlations occurring primarily along the parasagittal and transverse directions, consistent with the main geometry of the cerebellar cortex. Somatic correlation dynamics are robustly modulated by prediction errors and reflect ultimate behavioral outcomes. These results provide a novel link between cerebellar structure and function, with the correlation dynamics of Purkinje cell activity a key feature during behavior.Significance statement The cerebellar cortex exhibits highly conserved, elegant cytoarchitecture, but a full understanding of how this organization contributes to cerebellar processing is limited. We performed wide-field Ca2+ recordings of the primary output neurons of the cerebellar cortex, Purkinje cells, and find that they are organized into distinct networks, which are either parasagittally organized or distributed populations of somatic activity. While both networks are highly engaged during behavior, they exhibit distinct spatial correlation dynamics consistent with the main geometry of the cerebellar cortex, with somatic correlation dynamics conveying information about prediction error and behavioral outcomes. Together, these results provide new insights into the functional organization of Purkinje cells and implicate somatic network correlation dynamics as a key feature of cerebellar processing.","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":"639 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging adulthood is marked by a cortical dendritic arborization phase depending on the actin nucleator Cobl. 成年初期的特征是皮层树突树突化阶段,这取决于肌动蛋白成核子Cobl。
IF 5.3 2区 医学
Journal of Neuroscience Pub Date : 2025-06-24 DOI: 10.1523/jneurosci.2062-24.2025
Jule González Delgado,Katrin Pickrodt,Yuanyuan Ji,Sarah Krüger,Jana-Fabienne Rieß,Natja Haag,Britta Qualmann,Michael Manfred Kessels
{"title":"Emerging adulthood is marked by a cortical dendritic arborization phase depending on the actin nucleator Cobl.","authors":"Jule González Delgado,Katrin Pickrodt,Yuanyuan Ji,Sarah Krüger,Jana-Fabienne Rieß,Natja Haag,Britta Qualmann,Michael Manfred Kessels","doi":"10.1523/jneurosci.2062-24.2025","DOIUrl":"https://doi.org/10.1523/jneurosci.2062-24.2025","url":null,"abstract":"Puberty triggers significant changes. However, besides the pruning of synapses, little is known about more long-range alterations during brain maturation. Actin filament formation - a process ignited by actin nucleators - is crucial for life and also a driving force behind cellular morphology changes. Yet, the physiological importance of especially the more recently discovered, evolutionary younger actin nucleators largely remain elusive. We demonstrate the consequences of deficiency for the actin nucleator Cobl in the mouse brain. We identify remarkably layer- and age-restricted cortical Cobl KO phenotypes in dendritic arborization that first transiently emerge in layer V in rather young adolescent male mice and then manifested in a similar but more pronounced manner in layer II/III during the age of emerging adulthood. Cobl KO phenotypes were observed in the somatosensory cortex, prefrontal cortex and motor cortex. In WT mouse cortices, we discovered an increase in dendritic arbor complexity occurring during emerging adulthood and thereby identified a long-range process for cortical rewiring upon brain maturation. This dendritic arbor expansion is transient and largely erased during mature adulthood. The transient dendritic arbor expansion during emerging adulthood was accompanied by transient length changes of dendritic spines. Molecularly, the process thus seems to relate to alterations in actin dynamics. Importantly, both of these changes were completely absent in Cobl KO mice. Increased risk-taking of Cobl KO mice point towards a lack of maturity. These observations revealed the actin nucleator Cobl as first molecular component crucial for the identified emerging adulthood-related changes of neurons towards brain maturation.Significance statement Puberty triggers significant changes. We discovered a transient increase in dendritic arbor complexity occurring during emerging adulthood. This identified a long-range process for cortical rewiring during the age of emerging adulthood. Also dendritic spines were transiently rearranged. Both processes turned out to be dependent on the actin nucleator Cobl. We discovered remarkably layer- and age-specific cortical Cobl KO phenotypes in dendritic arborization. These first transiently emerged in layer V in adolescent mice and then manifested in a similar but more pronounced manner in layer II/III during the age of emerging adulthood. This identified the actin nucleator Cobl as the first crucial component for the discovered reorganizations towards brain maturation.","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":"9 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ALS mutations shift the isoelectric point of the KIF5A C-terminal inducing protein aggregation and TDP-43 mislocalization. ALS突变使KIF5A c端等电点移位,诱导蛋白聚集和TDP-43错定位。
IF 5.3 2区 医学
Journal of Neuroscience Pub Date : 2025-06-24 DOI: 10.1523/jneurosci.1658-24.2025
Pietro Zanella,Isabel Loss,Rosanna Parlato,Jochen H Weishaupt,Carlo Sala,Chiara Verpelli,Tobias M Boeckers,Alberto Catanese
{"title":"ALS mutations shift the isoelectric point of the KIF5A C-terminal inducing protein aggregation and TDP-43 mislocalization.","authors":"Pietro Zanella,Isabel Loss,Rosanna Parlato,Jochen H Weishaupt,Carlo Sala,Chiara Verpelli,Tobias M Boeckers,Alberto Catanese","doi":"10.1523/jneurosci.1658-24.2025","DOIUrl":"https://doi.org/10.1523/jneurosci.1658-24.2025","url":null,"abstract":"Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease characterized by death of lower and upper motor neurons. Although the mechanism behind the selective neuron loss is still unclear, several heterogenous genes have been causally linked to ALS. KIF5A encodes for a neuronally enriched kinesin involved in protein transport and mutations within this gene have been causally linked to different motor neuron diseases. The mutations identified in ALS patients are mostly predicted to alter its mRNA splicing, leading to a frameshift mutation and an aberrant 39 amino acid-long sequence in the C-terminal domain of KIF5A.Here we found that ALS-related KIF5A mutations induce the accumulation of the mutant form of the protein in human motoneurons, which are also characterized by the cytosolic mislocalization of TDP-43. This ALS hallmark was even exacerbated upon overexpression of the ALS-KIF5A protein in cells differentiated from healthy controls and primary neurons, suggesting a pathological connection between the cellular load of the mutant protein and TDP-43 pathology. While the terminal domain of the WT isoform is characterized by an acid isoelectric point (pI), the ALS variant presents a basic pI due to the altered aminoacidic composition of this sequence. We thus generated a KIF5A ALS isoform that retained part of the aberrant sequence but with lower pI. The overexpression of this mutated variant led to significantly lower protein aggregation and TDP-43 mislocalization than the ALS mutant. Our data show that re-establishing the correct pI rescues KIFA aggregation and significantly reduces the cytoplasmic mislocalization of TDP-43.Significance Statement Amyotrophic Lateral Sclerosis is a lethal neurodegenerative disease to which no cure is still known. Heterogenous genes have been causally linked to ALS, yet, the exact pathomechanism responsible for neuronal death remains unclear. One such gene is KIF5A which encodes for a neuronally enriched kinesin. Identified mutations cause incorrect mRNA splicing resulting in an aberrant C-terminal aminoacidic sequence. Here, we identified TDP-43 cytosolic enrichment, a hallmark common to many ALS models, in two distinct hiPSC-derived motoneuron lines harboring the ALS mutation KIF5Ac2993-1 G>A Moreover, we generated a KIF5A isoform that retained most of the aberrant sequence but did not promote protein aggregation nor TDP-43 mislocalization upon overexpression. These results shed further light on the pathobiochemistry of the ALS-KIF5A cases.","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":"16 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hearing loss and audiogenic seizures induced by hypofunctional prestin variants. 功能低下的prestin变异引起的听力损失和听源性癫痫发作。
IF 5.3 2区 医学
Journal of Neuroscience Pub Date : 2025-06-24 DOI: 10.1523/jneurosci.0922-25.2025
Satoe Takahashi,Yingjie Zhou,Frédéric Dépreux,Donna Whitlon,Mary Ann Cheatham,Kazuaki Homma
{"title":"Hearing loss and audiogenic seizures induced by hypofunctional prestin variants.","authors":"Satoe Takahashi,Yingjie Zhou,Frédéric Dépreux,Donna Whitlon,Mary Ann Cheatham,Kazuaki Homma","doi":"10.1523/jneurosci.0922-25.2025","DOIUrl":"https://doi.org/10.1523/jneurosci.0922-25.2025","url":null,"abstract":"Prestin's voltage-driven motor activity confers sound-elicited somatic electromotility on auditory outer hair cells (OHCs) and is essential for the exquisite sensitivity and frequency selectivity of mammalian hearing. Lack of prestin results in ∼50 dB hearing threshold shifts across frequency, supporting the causal association of the prestin-coding gene, SLC26A5, with hereditary hearing loss, DFNB61. However, ∼50% reduction in prestin-mediated OHC electromotility barely affects cochlear function, and it is currently unknown how much electromotility is minimally required to support normal hearing. We generated mouse models harboring two deafness-associated prestin variants, p.A100T and p.P119S, and found that these missense variants do not deprive prestin of its fast motor function but significantly reduce membrane expression, leading to 70-80% reductions in OHC electromotility. Homozygous and compound heterozygous mice of either sex for these missense variants suffered congenital hearing loss; however, they still retained relatively low hearing thresholds at lower frequencies, pointing to the clinical possibility that a small augmentation of OHC electromotility could benefit those with DFNB61 hearing loss. These mice were also found to be prone to audiogenic seizures. This study thus provides insights into the minimum OHC electromotility required for normal cochlear operation and reveals the unappreciated importance of prestin for central gain control.Significance statement Prestin is abundantly expressed in the auditory outer hair cells and is essential for normal cochlear operation. Hence, reduction of prestin expression is often taken as indicative of reduced cochlear function in diseased or aged ears. However, this assumption overlooks the fact that cochlear function can tolerate surprisingly large reductions in prestin motor activity. DFNB61 mouse models generated and characterized in this study provide an opportunity to gauge the amount of prestin motor activity needed to sustain normal hearing sensitivity. This knowledge is crucial not only for understanding the pathogenic roles of deafness-associated variants that impair OHC electromotility but also for unraveling how prestin contributes to cochlear amplification.","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":"66 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A positive allosteric modulator of the SERCA pump rescues hippocampal neuronal circuits dysfunction and cognitive defects in a mouse model of Alzheimer's disease. SERCA泵的正变构调节剂可拯救阿尔茨海默病小鼠模型中的海马神经元回路功能障碍和认知缺陷。
IF 5.3 2区 医学
Journal of Neuroscience Pub Date : 2025-06-24 DOI: 10.1523/jneurosci.2337-24.2025
Evgenii Gerasimov,Anastasiya Rakovskaya,Ekaterina Pchitskaya,Olga Vlasova,Russell Dahl,Ilya Bezprozvanny
{"title":"A positive allosteric modulator of the SERCA pump rescues hippocampal neuronal circuits dysfunction and cognitive defects in a mouse model of Alzheimer's disease.","authors":"Evgenii Gerasimov,Anastasiya Rakovskaya,Ekaterina Pchitskaya,Olga Vlasova,Russell Dahl,Ilya Bezprozvanny","doi":"10.1523/jneurosci.2337-24.2025","DOIUrl":"https://doi.org/10.1523/jneurosci.2337-24.2025","url":null,"abstract":"Alzheimer's disease (AD) is a common neurodegenerative disorder that affects normal neuronal functioning, alters neuronal circuits activity and memory formation and storage. Disrupted neuronal calcium (Ca²⁺) signaling is one of the drivers of AD pathogenesis. Previously we suggested that positive allosteric modulators (PAMs) of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) pump may help to stabilize cytosolic Ca2+ levels and exert neuroprotective effects in AD neurons. In the current manuscript we demonstrate synaptoprotective properties of several SERCA PAMs using an in vitro model of amyloid toxicity. Based on in vitro experiments, we selected the SERCA PAM NDC-9009 for in vivo evaluation in male and female 5xFAD transgenic mice model of Alzheimer's disease. Using the miniscope imaging technique, we observed hyperactivity and abnormal connectivity of hippocampal neuronal ensembles 5xFAD mice. We further discovered that the function of the hippocampal neuronal circuits in 5xFAD mice was normalized by NDC-9009 intraperitoneal administration. NDC-9009 intraperitoneal administration also rescued memory defects in 5xFAD mice as quantified by the fear conditioning behavioral test and significantly reduced accumulation of amyloid plaques in hippocampal region of these mice. The obtained results support the potential utility of NDC-9009 and other SERCA PAMs as lead molecules for development of disease-modifying treatments for AD and potentially other neurodegenerative disorders.Significance statement Alzheimer's disease (AD) is a significant medical and social burden, yet no treatment currently exists. One of the hallmarks of AD is disrupted Ca²⁺ signaling, which contributes to neuronal dysfunction and degeneration. In the current study, we demonstrate the potential of the SERCA pump positive allosteric modulators (PAMs) as promising disease-modifying agents. Through an in vitro screening, we identified NDC-9009 as the most effective SERCA PAM, promoting robust cytosolic calcium clearance and exhibiting neuroprotective properties. Furthermore, using miniature fluorescence in vivo imaging, a significant restoration of hippocampal neuronal ensembles activity and cognitive function after chronic administration of NDC-9009 in the transgenic AD mouse model was demonstrated.","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":"58 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural and Behavioral Markers of Negative Symptoms and Cognitive Impairment in Patients with Psychosis. 精神病患者阴性症状和认知障碍的神经和行为标志物
IF 5.3 2区 医学
Journal of Neuroscience Pub Date : 2025-06-24 DOI: 10.1523/jneurosci.0039-25.2025
Raquel van Gool,Mariesa Cay,Hanne van der Heijden,Emma Golden,Amanda Cao,Boyu Ren,Joseph Gonzalez-Heydrich,Ann K Shinn,Jaymin Upadhyay
{"title":"Neural and Behavioral Markers of Negative Symptoms and Cognitive Impairment in Patients with Psychosis.","authors":"Raquel van Gool,Mariesa Cay,Hanne van der Heijden,Emma Golden,Amanda Cao,Boyu Ren,Joseph Gonzalez-Heydrich,Ann K Shinn,Jaymin Upadhyay","doi":"10.1523/jneurosci.0039-25.2025","DOIUrl":"https://doi.org/10.1523/jneurosci.0039-25.2025","url":null,"abstract":"Negative and cognitive symptoms impair functioning in patients with psychotic illnesses (i.e., schizophrenia spectrum disorders (SZ) and bipolar I disorder with psychotic features (BD)). Disruptions in mesocorticolimbic circuitry are hypothesized to underpin negative symptoms and cognitive impairment in patients with psychosis and may also facilitate reward-motivational deficits. In male and female patients with psychosis (N=44) and healthy controls (HC=27), we used neuroimaging to define gray matter morphology and white matter microstructure. We examined negative symptom severity with the Clinical Assessment Interview for Negative Symptoms (CAINS), effort allocation during reward processing with the Effort Expenditure for Rewards Task (EEfRT), and cognitive performance with the MATRICS Cognitive Consensus Battery (MCCB). Reduced nucleus accumbens volumes in patients with psychosis were associated to higher CAINS total and Motivation and Pleasure subscale scores as well as lower effort expenditure for medium (50%) and high (88%) reward probability conditions during the EEfRT. The fornix showed reduced fractional anisotropy in patients with psychosis. Negative associations were present between CAINS Motivation and Pleasure subscores and MCCB composite and subscale scores. Lower gray matter volume in cerebellar lobule VI corresponded with impaired effort allocation during medium and high reward probability conditions and lower cognitive performance. However, lobule VI was not correlated with CAINS scores. While nucleus accumbens volume may serve as marker of negative symptoms in psychotic illnesses, cerebellar lobule VI morphology may inform on cognitive impairment in patients with SZ and BD. The nucleus accumbens and lobule VI may each contribute to reduced effort allocation during reward processing.Significance Statement Improving negative symptoms and cognitive impairment in SZ and BD remains an unmet clinical need. This study reveals that, in SZ and BD, structural changes in the nucleus accumbens and cerebellar lobule VI are associated with negative symptoms and cognitive impairments, respectively. The current findings also suggest that reductions in nucleus accumbens and cerebellar lobule VI volume may also underpin impaired reduced effort allocation during reward processing. This study provides impetus for further probing supratentorial and cerebellar circuitry to further understand negative and cognitive symptoms experienced by patients with psychotic illness and their associations with reward-motivational deficits.","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":"141 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fine-tuning the details: post-encoding music differentially impacts general and detailed memory. 微调细节:编码后的音乐对一般记忆和细节记忆的影响不同。
IF 5.3 2区 医学
Journal of Neuroscience Pub Date : 2025-06-23 DOI: 10.1523/jneurosci.0158-25.2025
Kayla Clark,Stephanie L Leal
{"title":"Fine-tuning the details: post-encoding music differentially impacts general and detailed memory.","authors":"Kayla Clark,Stephanie L Leal","doi":"10.1523/jneurosci.0158-25.2025","DOIUrl":"https://doi.org/10.1523/jneurosci.0158-25.2025","url":null,"abstract":"Music can effectively induce emotional arousal, which is associated with the release of stress hormones that are important for the emotional modulation of memory. Thus, music may serve as a powerful modulator of memory and mood, making it a promising therapeutic tool for memory and mood disorders such as Alzheimer's disease or depression. However, music's impact on memory depends on its features, timing, and ability to elicit emotional arousal. In the current study, we manipulated various features of music played during post-encoding memory consolidation to elicit emotional arousal and impact subsequent memory in men and women. We found that larger increases and moderate decreases in post-encoding music-induced emotional arousal from baseline resulted in gist vs. detail trade-offs in memory, with improved general memory but impaired detailed memory, while moderate increases in arousal from baseline corresponded to improved detailed memory, but impaired general memory. Importantly, relative to controls, music-induced emotional arousal demonstrated unique impacts on detailed memory that are crucial in supporting episodic memory. These findings suggest that music intervention does not uniformly impact memory and has important implications in developing personalized music-related interventions for those with memory and mood impairments.Significance Statement Music may be a powerful tool for modulating memory and mood, offering therapeutic potential for disorders like Alzheimer's and depression. We found that individual differences in emotional arousal following music exposure influenced both general memory and detailed memory performance. Compared to controls, music specifically impacted memory for details, highlighting its potential to target specific memory aspects. These findings suggest that music interventions may not uniformly enhance memory, emphasizing the need for personalized approaches in treating memory and mood impairments.","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":"48 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diverse firing profiles of Crhbp-positive neurons in the dorsal pons suggestive of their pleiotropic roles in REM sleep regulation in mice. 脑桥背crhbp阳性神经元的不同放电谱提示其在小鼠快速眼动睡眠调节中的多效性作用。
IF 5.3 2区 医学
Journal of Neuroscience Pub Date : 2025-06-23 DOI: 10.1523/jneurosci.2365-24.2025
Yoshifumi Arai,Mitsuaki Kashiwagi,Takeshi Kanda,Iyo Koyanagi,Masanori Sakaguchi,Masashi Yanagisawa,Yoshimasa Koyama,Yu Hayashi
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