medRxiv - Geriatric Medicine最新文献

{"title":"Daily consumption of ketone ester, bis octanoyl (R)-1,3-butanediol does not impact functional and quality of life outcomes in healthy older adults, a randomized, parallel arm, double-blind, placebo-controlled study","authors":"Brianna J Stubbs, Elizabeth B Stephens, Chatura Senaheera, Sawyer Peralta, Stephanie Roa Diaz, Laura Alexander, Wendie Silverman Martin, Jamie Kurtzig, Thelma Y Garcia, Michi Yukawa, Jennifer Morris, Traci M Blonquist, James B Johnson, John C Newman","doi":"10.1101/2024.09.17.24313811","DOIUrl":"https://doi.org/10.1101/2024.09.17.24313811","url":null,"abstract":"Background: Ketone bodies are metabolites produced during fasting or on a ketogenic diet that have pleiotropic effects on inflammatory and metabolic aging pathways that underpin frailty in laboratory animal models. Ketone esters (KEs) are compounds that induce ketosis without dietary changes, that have been suggested to impact physical and cognitive function in young adults. The functional effects of KEs have not been studied in older adults. Objectives: Our long-term goal is to examine if KEs modulate aging biology mechanisms and clinical outcomes relevant to frailty in older adults. Here we report the exploratory functional and quality of life outcome measures collected during a 12-week safety and tolerability study of KE (NCT05585762) Design: Randomized, placebo-controlled, double-blinded, parallel-group, pilot trial of 12-weeks of daily KE ingestion. Setting: The Buck Institute for Research on Aging, Northern California. Participants: Community-dwelling older adults (≥ 65 years), independent in activities of daily living, with no unstable acute medical conditions (n = 30). Intervention: Subjects were randomly allocated (1:1) to consume 25 g of either KE (bis-octanoyl (R)-1,3-butanediol) or a taste, appearance, and calorie-matched placebo (PLA) containing canola oil daily. Measurements: Physical function, cognitive function and quality of life were assessed before and after the intervention as exploratory outcomes in n = 23 completers. A composite functional outcome was calculated based on previous reports. Heart rate and activity was measured throughout the study. Results: There were no consistent differences between groups in the change in exploratory functional, activity-based or quality of life outcomes.\u0000Conclusion: Daily ingestion of 25 g of KE did not affect our exploratory functional or quality of life end points in this pilot cohort of healthy older adults. Future work will address these endpoints as primary and secondary outcomes in a larger trial of pre-frail older adults.","PeriodicalId":501025,"journal":{"name":"medRxiv - Geriatric Medicine","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal changes in epigenetic clocks predict survival in the InCHIANTI cohort","authors":"Pei-Lun Kuo, Ann Zenobia Moore, Toshiko Tanaka, Daniel W. Belsky, Ake Tzu-Hui Lu, Steve Horvath, Stefania Bandinelli, Luigi Ferrucci","doi":"10.1101/2024.09.13.24313620","DOIUrl":"https://doi.org/10.1101/2024.09.13.24313620","url":null,"abstract":"Importance: Cross-sectional assessment of epigenetic clocks provides information on the pace of aging. Whether longitudinal acceleration or deceleration of epigenetic clocks over time provides additional mortality prediction is unknown. Objective: To test the independent associations of baseline levels and longitudinal changes in epigenetic clocks with mortality Design: Longitudinal study Setting: InCHIANTI, a population-based study of community dwelling individuals in Tuscany, Italy. Participants: 699 InCHIANTI study participants aged 21-95 years at baseline with longitudinal measurements of DNA methylation. Exposure: Baseline levels and longitudinal changes in seven epigenetic clocks, including two first-generation clocks developed using chronological age for reference (Hannum Clock, Horvath Clock), three second-generation clocks developed using time-to-death for references (DNAmPhenoAge, DNAmGrimAge, DNAmGrimAge Version 2), and two third-generation clocks developed using longitudinal rate of change of multiple phenotypes for reference (DunedinPOAm_38, DunedinPACE). Main Outcomes and Measures: Mortality was the primary outcome. Cox regression was used to estimate independent associations of baseline and longitudinal changes in epigenetic clocks with mortality. Results: Adjusting for age, sex, study sites, and epigenetic clock at the baseline, longitudinal changes of the following epigenetic clocks were associated with mortality: Hannum clock (aHR = 1.14, 95% CI:[1.03, 1.26]), DNAmPhenoAge (aHR = 1.23, 95% CI: [1.10,1.37]), DNAmGrimAge (aHR = 1.13, 95% CI: [1.02,1.26]), DNAmGrimAge Version 2 (aHR = 1.18, 95% CI:[1.06,1.31]), and DunedinPOAm_38 (aHR = 1.15, 95%CI: [1.01,1.30]). Conclusions and Relevance: Our findings confirm that epigenetic clocks capture a dimension of health that is predictive of mortality and add the notion that time changes of epigenetic age reflect changes in health that additionally and independently contribute to mortality prediction. Future studies should test whether interventions that slow down the rate of epigenetic aging are associated with longer healthspan and lifespan.","PeriodicalId":501025,"journal":{"name":"medRxiv - Geriatric Medicine","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of rapamycin on healthspan metrics after one year: PEARL Trial Results","authors":"Girish Harinath, Virginia Lee, Andy Nyquist, Mauricio Moel, Jesper Hagemeier, Stefanie L Morgan, Anar Isman, Sajad Zalzala","doi":"10.1101/2024.08.21.24312372","DOIUrl":"https://doi.org/10.1101/2024.08.21.24312372","url":null,"abstract":"Rapamycin has been shown to have longevity-enhancing effects in murine models, but clinical data on its gerotherapeutic effects in humans remains limited. We performed a 48-week double-blinded, randomized, and placebo-controlled decentralized study (Participatory Evaluation of Aging with Rapamycin for Longevity [PEARL]; NCT04488601; registration date 2020-07-28) to evaluate the safety and efficacy of rapamycin in mitigating clinical signs of aging in a normative aging cohort. Participants received 5 or 10 mg / week of compounded rapamycin, or placebo for 48 weeks. Safety, adverse events (AEs) and blood biomarkers were collected. Efficacy was assessed using DEXA scan-based measures and standardized surveys assessing quality of life (QoL) and frailty. We did not detect significant differences in safety blood biomarkers, or moderate to severe AEs between the rapamycin treatment groups and placebo after 48 weeks. We detected dose-dependent (10 mg group) and sex-specific improvements in lean tissue mass, pain, social functioning, overall QoL, and overall osteoarthritis score in females, and in bone mineral content in men. Additionally, some individuals receiving rapamycin experienced significant improvements in body composition metrics that were associated with beneficial changes in gut health and lipid metabolism. We conclude that low-dose, intermittent rapamycin administration over the course of 48 weeks is safe and induces sex-specific improvements in multiple aspects of healthspan, with the most robust improvements in lean tissue mass in women taking 10 mg rapamycin/week. Future work will aim to identify biometric signatures of clinical effectiveness to inform personalized treatment strategies that more broadly maximize efficacy and minimize side effects.","PeriodicalId":501025,"journal":{"name":"medRxiv - Geriatric Medicine","volume":"116 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142181634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the impact of outdoor walk group attendance on health among older adults with mobility limitations in the Getting Older Adults Outdoors (GO-OUT) randomized trial","authors":"Tai-Te Su, Ruth Barclay, Rahim Moineddin, Nancy M. Salbach","doi":"10.1101/2024.08.22.24312456","DOIUrl":"https://doi.org/10.1101/2024.08.22.24312456","url":null,"abstract":"Objective The Getting Older Adults Outdoors randomized trial showed a 10-week outdoor walk group (OWG) program was not superior to 10 weekly phone reminders on increasing physical and mental health; however, OWG attendance varied. This study examined whether a dose-response relationship existed between OWG attendance and improvement in physical and mental health among older adults with mobility limitations. Methods We analyzed data from 98 older adults randomized to a 10-week park-based OWG program. Participants were classified as attending 0–9, 10–15, and 16–20 OWG sessions based on attendance tertiles. Outcomes included change in scores on measures of walking endurance, comfortable and fast walking speed, balance, lower extremity strength, walking self-efficacy, and emotional well-being pre- to post-intervention. Results Seventy-nine older adults with complete information on the seven health outcomes were included (age=74.7±6.6 years, 72% female). Compared to those who attended 0–9 OWG sessions, participants attending 16–20 sessions exhibited a 52.7-meter greater improvement in walking endurance (95% CI:12.3, 93.1); 0.15-meter/second greater improvement in comfortable walking speed (95% CI:0.00, 0.29); and 0.17-meter/second greater improvement in fast walking speed (95% CI:0.02, 0.33). Higher attendance was also associated with higher odds of experiencing an improvement in walking self-efficacy (OR=4.03; 95% CI:1.05, 16.85) and fast walking speed (OR=9.00, 95% CI:1.59, 61.73). No significant dose-response relationships for balance, lower extremity strength, and emotional well-being were observed. Conclusions Higher attendance in outdoor walking interventions is associated with greater improvements in walking endurance, walking speed, and walking self-efficacy among older adults with mobility limitations.","PeriodicalId":501025,"journal":{"name":"medRxiv - Geriatric Medicine","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142181637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic frailty-based determinants of long-term mortality in older patients with newly diagnosed multiple myeloma","authors":"Fiammetta Monacelli, Alessio Nencioni, Michele Cea, Mariya Muzyka, Silvia Ottaviani, Alessio Signori, Luca Tagliafico, Andrea Casabella, Irene Caffa, Marta Ponzano, Cristina Marelli, Roberto Lemoli, Tommaso Bonfiglio, Erica Parisi, Ana Guijarro","doi":"10.1101/2024.08.15.24312039","DOIUrl":"https://doi.org/10.1101/2024.08.15.24312039","url":null,"abstract":"Introduction: Multiple myeloma (MM) is a plasma cell neoplasm predominantly diagnosed in older adults. However, the significance of defining patient frailty, as well as identifying the most suitable and reliable tools for its assessment, remains to be firmly established.\u0000Materials and Methods: This retrospective observational study investigated 36 patients, aged 65 or older, who underwent Comprehensive Geriatric Assessment (CGA). The average patient age was 76 (SD 6.22), with 33.3% being female. Patients were evaluated using the International Myeloma Working Group Frailty Index (IMWG-FI) and the 40-item Rockwood’s Frailty Index (FI) at the Oncogeriatrics clinic of the IRCCS Polyclinic San Martino Hospital, Genoa, Italy, between December 2017 and August 2021. Laboratory, cancer-specific, demographic, and clinical variables were collected. Survival analysis and frailty comparison were conducted using Stata version 17.0.\u0000Results: Stepwise multivariate analysis identified Numerical Rating Scale (NRS) (HR 1.40, 95% CI 1.09-1.78, p=0.008) and Rockwood’s Frailty Index (FI) (HR 2.23, 95% CI 1.29-3.87, p=0.004) as significant prognostic predictors, adjusted for sex, ISS stage, and multimorbility. Comparison between Rockwood’s FI and IMWG-FI using Spearman correlation coefficient showed no statistically significant correlation (r=0.268, p=0.114). Multivariate Cox model, adjusting for sex, International Staging System (ISS) stage, and Cumulative Illness Rating Scale (CIRS) comorbidity index, demonstrated the superior predictive ability of Rockwood’s FI over IMWG-FI (C-index 0.775 vs 0.749).\u0000Discussion: the 40-item Rockwood FI emerges as a valuable tool for prognostication in old MM patients, surpassing the traditional IMWG-FI in predictive accuracy, emphasizing the importance of a comprehensive approach considering both disease-specific and patient-related factors.","PeriodicalId":501025,"journal":{"name":"medRxiv - Geriatric Medicine","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142181481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RANDOM NUMBER GENERATION: A ANALYSIS OF BENFORD'S LAW IN UNDERGRADS STUDENTS AND GERIATRICS PATIENTS","authors":"Pedro Henrique Alves de Freitas Martins, Moacir Fernandes de Godoy","doi":"10.1101/2024.08.17.24312153","DOIUrl":"https://doi.org/10.1101/2024.08.17.24312153","url":null,"abstract":"Objectives: Study the correlation between RNG by human cognition and Benford's Law in undergraduate students at a Medical School in the countryside of the state of Sao Paulo and geriatric clinic patients. Design: The study collected data from the students and patients from the Robust Elderly Clinic of a tertiary Hospital between August 2022 and July 2023. Data collection involved a questionnaire on age, gender, education, ethnicity, occupation, and a table with 5 rows and 10 columns for the insertion of 50 numbers, chosen by the participant. Results: A total of 263 forms were collected. The average age was 27.10 (IQR- 3) years, with 66.5% being female. Frequencies of the first significant digit were: 25.59% for 1; 15.35% for 2; 10.98% for 3; 8.65% for 4; 9.67% for 5; 7.02% for 6; 8.22% for 7; 6.81% for 8, and 7.70% for 9. Applying the Chi-Square test, no statistically significant difference was found (critical χ 2 15.507; obtained χ 2 5.36). Applying Pearson's Coefficient, the value of r was 0.98. Using the Euclidean distance, the P-value was 0.9284. Conclusion: A high correlation between RNG by the human mind, in students and Robust Elderly patients, and Benford's Law was detected.","PeriodicalId":501025,"journal":{"name":"medRxiv - Geriatric Medicine","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142181635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent obesity since childhood or adolescence accelerates biological aging in young adults from Chile’s oldest birth cohort","authors":"mP Correa, R Burrows, C Albala, C Sepúlveda, F Salech, R Troncoso, C Gonzalez-Billault","doi":"10.1101/2024.08.14.24311960","DOIUrl":"https://doi.org/10.1101/2024.08.14.24311960","url":null,"abstract":"Aging and obesity are primary risk factors for chronic conditions such as hypertension and diabetes. However, a mechanistic correlation between these risk factors has not been fully established. Using a historical birth cohort from Chile, we delve into the relationship between obesity and accelerated aging, spanning cellular to systemic levels. The cohort, comprising men and women in their late 20s, had their BMI recorded since birth, with 57% having obesity since childhood or adolescence. Our aim was to investigate if persistent obesity since childhood or adolescence leads to the display of molecular aging features in young adulthood. We also sought to determine whether cardiometabolic health issues accompanied this early aging phenotype. We used inferential statistics and data mining for analysis. Results show that persistent obesity since childhood or adolescence leads to epigenetic changes, telomere shortening, chronic inflammation, impaired nutrient sensing, mitochondrial stress, and diminished intercellular communication, resembling a compound network of interactions. This obesity-induced accelerated aging phenotype coincided with persistent decline of the cardiometabolic profile. Implications of our findings are significant and suggest that integrating molecular markers with clinical and epidemiological data could be valuable in identifying individuals at increased disease risk due to accelerated aging.","PeriodicalId":501025,"journal":{"name":"medRxiv - Geriatric Medicine","volume":"116 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142181480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacogenomic Drug-Gene Interactions in Geriatric Emergency Department Patients That Have Fallen","authors":"Richard D Shih, Gabriella Engstrom, Abhijit S Pandya, Gregg B Fields, Borivoje Furht, Ali A Danesh, Scott M Alter, Humberto Munoz, Lisa M Clayton, Joshua J Solano, Timothy Buckley, Olivia Hung, Alexander Farag, Mike Wells","doi":"10.1101/2024.08.14.24311970","DOIUrl":"https://doi.org/10.1101/2024.08.14.24311970","url":null,"abstract":"Background: Pharmacogenomic assisted prescribing of medications utilizes individual genetic information to identify drug-gene interactions. We aimed to assess potential pharmacogenomic drug-gene interactions in geriatric emergency department (ED) patients that have sustained a fall.\u0000Methods: This was a prospective study involving 25 older adult ED patients with fall related injury. Data collected included current medications, demographics and mechanism of injury. All patients provided a DNA sample for pharmacogenomic testing, MatchMyMeds (DNA Labs, Boca Raton, FL) which assessed genetic data for 23 enzyme systems and reports on potential drug-gene interactions for 134 medications. Each patients medications were reviewed against their pharmacogenomic report and categorized as Green (go), Yellow (caution) or Red (stop) based on their genetic information and published interactions by the Clinical Pharmacogenetics Implementation Consortium (CPIC), Dutch Pharmacogenetics Working Group (DPWG) and Food and Drug Administration-approved drug label information. The main study outcome was pharmacogenomic drug-gene interactions.\u0000Results: Of the 25 patients enrolled (median age, 81 years, IQR: 76-85), 68% were female. Patients were taking a median of 8 medications (IQR: 5-11). The most common types were antihypertensives, statins, anticoagulants, and anti-platelet medications. Significant drug-gene interactions (Yellow or Red) were identified in 14/25 (56%) patients. Further, 6/25 (24%) had one or more potentially serious (Red) interactions identified.\u0000Conclusions: In geriatric ED patients with a fall-related injury, a majority have a significant pharmacogenomic drug-gene interactions. DNA testing identifies these interactions and can assist with pharmacogenomic-guided medication prescribing which may decrease ADEs and improve clinical outcomes.","PeriodicalId":501025,"journal":{"name":"medRxiv - Geriatric Medicine","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142181636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Cognitive, Age, Functioning, and Apolipoprotein E4 (CAFE) Scorecard to Predict the Development of Alzheimer′s Disease: A White-Box Approach","authors":"Yumiko Wiranto, Devin R Setiawan, Amber Watts, Arian Ashourvan","doi":"10.1101/2024.08.02.24311399","DOIUrl":"https://doi.org/10.1101/2024.08.02.24311399","url":null,"abstract":"Objective: This study aimed to bridge the gap between the costliness and complexity of diagnosing Alzheimer′s disease by developing a scoring system with interpretable machine learning to predict the risk of Alzheimer′s using obtainable variables to promote accessibility and early detection.\u0000Participants and Methods: We analyzed 713 participants with normal cognition or mild cognitive impairment from the Alzheimer′s Disease Neuroimaging Initiative. We integrated cognitive test scores from various domains, informant-reported daily functioning, APOE genotype, and demographics to generate the scorecards using the FasterRisk algorithm.\u0000Results: Various combinations of 5 features were selected to generate ten scorecards with a test area under the curve ranging from 0.867 to 0.893. The best performance scorecard generated the following point assignments: age < 76 (-2 points); no APOE ϵ4 alleles (-3 points); Rey Auditory Verbal Learning Test <= 36 items (4 points); Logical Memory delayed recall <= 3 items (5 points); and Functional Assessment Questionnaire <= 2 (-5 points). The probable Alzheimer′s development risk was 4.3% for a score of -10, 31.5% for a score of -3, 50% for a score of -1, 76.3% for a score of 1, and greater than 95% for a score of > 6. Conclusions: Our findings highlight the potential of these interpretable scorecards to predict the likelihood of developing Alzheimer′s disease using obtainable information, allowing for applicability across diverse healthcare environments. While our initial scope centers on Alzheimer′s disease, the foundation we have established paves the way for similar methodologies to be applied to other types of dementia.\u0000Keywords: Alzheimer′s disease; Machine learning; Cognition; Apolipoprotein ϵ4","PeriodicalId":501025,"journal":{"name":"medRxiv - Geriatric Medicine","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141938437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-modulated association between thyroid stimulating hormone and informant-perceived anxiety in non-depressed older adults: prediction models and relevant cutoff value","authors":"Asma Hallab, Alzheimer's Disease Neuroimaging Initiative","doi":"10.1101/2024.07.26.24311073","DOIUrl":"https://doi.org/10.1101/2024.07.26.24311073","url":null,"abstract":"Introduction: The aim of this study was to assess the association between thyroid function and perceived anxiety in non-depressed older adults. Methods: Non-depressed Alzheimer's Disease Neuroimaging Initiative participants with complete Thyroid Stimulating Hormone (TSH) and neuropsychiatric inventory (NPI/NPI-Q) were included. The association between anxiety and thyroid function was assessed by logistic regression and sex stratification. Restricted cubic splines were applied to evaluate non-linearity in the association. Results: The median age of 2,114 eligible participants was 73 years (68-78), 1,117 (52.84%) were males, and the median TSH was 1.69 uIU/mL. There was a significant association between TSH and informant-perceived anxiety in the total study population (OR Model1=0.86, 95% CI 0.76-0.97, p=0.011), even after adjusting for bio-demographical (adj.OR Model2=0.85, 95% CI 0.75-0.96, p=0.007), and socio-cognitive confounders (adj.OR Model3=0.84, 95% CI 0.73-0.96, p=0.009). Sex-stratification showed similar significant results in all models only in males (OR Model1-male=0.71, 95% CI: 0.58-0.85, p Model1-male<0.001). In the general population and males, a TSH value of 2.4 uIU/dL was a significant cutoff under which anxiety odds were significantly high, even after adjusting for confounders. Conclusions: The sex-dependent association between TSH levels and perceived anxiety in non-depressed older adults is a novel finding that has to be further explored for a better understanding of the underlying neurobehavioral biology.","PeriodicalId":501025,"journal":{"name":"medRxiv - Geriatric Medicine","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141785589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}