{"title":"Preference and Perception of Indian Caregivers Towards Formal Long–Term Supportive Services – A Mixed–Methods Study","authors":"Subharati Ghosh, Arvind Mathur","doi":"10.1101/2023.12.01.23299284","DOIUrl":"https://doi.org/10.1101/2023.12.01.23299284","url":null,"abstract":"<strong>Purpose of the Study</strong> In India, the rate of population aging, the greater burden of chronic disease-related care, and smaller families question the sustainability of traditional family based, home long term support and services (LTSS). However, little is still known about Indians’ perception of formal LTSS.","PeriodicalId":501025,"journal":{"name":"medRxiv - Geriatric Medicine","volume":" 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138492662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrea B. Ganz, Meng Zhang, Frank Koopmans, Ka Wan Li, Suzanne S.M. Miedema, Annemieke J.M. Rozemuller, Marc Hulsman, Netherlands Brain Bank, Philip Scheltens, Jeroen J.M. Hoozemans, Marcel J.T. Reinders, August B. Smit, Henne Holstege
{"title":"Proteomic profiling of aging brains identifies key proteins by which cognitively healthy centenarians defy their age by decades","authors":"Andrea B. Ganz, Meng Zhang, Frank Koopmans, Ka Wan Li, Suzanne S.M. Miedema, Annemieke J.M. Rozemuller, Marc Hulsman, Netherlands Brain Bank, Philip Scheltens, Jeroen J.M. Hoozemans, Marcel J.T. Reinders, August B. Smit, Henne Holstege","doi":"10.1101/2023.11.30.23299224","DOIUrl":"https://doi.org/10.1101/2023.11.30.23299224","url":null,"abstract":"Some individuals reach extreme ages without any signs of cognitive decline. Here, we show that based on key proteins, cognitively healthy centenarians have a biologically younger brain. We compared the brain proteomic signatures of 58 self-reported cognitively healthy centenarians with 61 non-demented individuals and 91 AD patients. The abundance of 472 proteins strongly associated with AD Braak stages of which 64 were differentially regulated in centenarians. With increasing Braak stages, the abundance of toxic peptides of MAPT increased in AD patients, while these remained low in centenarians. Furthermore, the abundance of 174 proteins strongly changed with age, of which 108 were differentially regulated in centenarians. In fact, in brains from centenarians the abundances of essential proteins were representative of brains from individuals who were a median 18- and up to 28-years ‘younger’. The proteins involved represent diverse cellular processes, and suggest that maintained protein homeostasis is central in maintaining brain-health.","PeriodicalId":501025,"journal":{"name":"medRxiv - Geriatric Medicine","volume":" 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138492581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stylianos Paraschiakos, Fatih A. Bogaards, Arno Knobbe, P. Eline Slagboom, Marian Beekman
{"title":"Changes in the physical behaviour of older adults during the 13 weeks GOTO intervention explain a boost in immuno-metabolic health","authors":"Stylianos Paraschiakos, Fatih A. Bogaards, Arno Knobbe, P. Eline Slagboom, Marian Beekman","doi":"10.1101/2023.11.26.23299026","DOIUrl":"https://doi.org/10.1101/2023.11.26.23299026","url":null,"abstract":"<strong>Background</strong> The aging population faces numerous health challenges, with sedentary behavior and decreased physical activity being paramount. We explore the physical behaviour of older adults in the GOTO combined lifestyle intervention study and its related immuno-metabolic health effects.","PeriodicalId":501025,"journal":{"name":"medRxiv - Geriatric Medicine","volume":" 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138492580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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