Journal of Psychiatry & Neuroscience最新文献

{"title":"Brief pup separation during lactation confers resilience in behavioural deficits induced by chronic restraint stress in postpartum C57BL/6J dams.","authors":"Lin Zhou,&nbsp;Zuotian Wu,&nbsp;Dan Zhao,&nbsp;Gaohua Wang,&nbsp;Ling Xiao,&nbsp;Huiling Wang,&nbsp;Yumeng Xie,&nbsp;Limin Sun","doi":"10.1503/jpn.220079","DOIUrl":"https://doi.org/10.1503/jpn.220079","url":null,"abstract":"<p><strong>Background: </strong>The postpartum period is a complex time for females that affects health recovery. Stress during this period is one of the main risk factors for depression. Therefore, preventing stress-induced depression in the postpartum period is of great importance. Pup separation (PS) is a natural paradigm of postpartum care; however, the effect of different PS protocols during lactation on stress-induced depressive behaviours in dams is unknown.</p><p><strong>Methods: </strong>Lactating C57BL/6J mice were subjected to no pup separation (NPS), brief PS (15 min/day, PS15) or long PS (180 min/day, PS180) from postpartum day 1 to postpartum day 21 and were then subjected to chronic restraint stress (CRS) for 21 days. Behavioural tests, specifically the open field test (OFT), elevated plus maze (EPM) test and tail suspension test (TST), were performed. The expression of mRNA and protein in the hippocampus and microbiota composition were also assessed.</p><p><strong>Results: </strong>We observed CRS-induced anxiety- and depression-like behaviours in NPS dams. In addition, in NPS dams, microglial activation and the levels of NOD-like receptor pyrin domain containing 3, caspase-1 and interleukin-1β were increased, whereas expression levels of collapsing response mediator protein 2 (CRMP2) and α-tubulin were decreased. However, immobility time in the TST was lower in PS15+CRS dams than in NPS+CRS dams, and time spent in the centre during the OFT and in the open arms during the EPM test was higher in PS15+CRS dams, indicating resilience. Expression of hippocampal biomarkers of neuroinflammation was inhibited and levels of CRMP2-mediated neuroplasticity were increased in PS15+CRS dams. Notably, we observed taxonomic changes in the cecal microbiota across different PS groups, as well as relationships between gut microbiota composition and some biomarkers of hippocampal neuroinflammation and neuroplasticity.</p><p><strong>Limitations: </strong>The sample size for gut microbiota analysis in this study was small.</p><p><strong>Conclusion: </strong>Collectively, the results of this study confirm that brief PS confers stress resilience in CRS-induced behavioural deficits and reverses hippocampal neuroinflammation-neuroplasticity injury and gut microbiota imbalance.</p>","PeriodicalId":50073,"journal":{"name":"Journal of Psychiatry & Neuroscience","volume":"48 3","pages":"E154-E170"},"PeriodicalIF":4.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/36/5e/48-3-E154.PMC10185353.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9634542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opening up mental health research.","authors":"Isabel O L Bacellar,&nbsp;Geneviève Morin,&nbsp;Sylvanne Daniels,&nbsp;Gustavo Turecki,&nbsp;Lena Palaniyappan,&nbsp;Martin Lepage","doi":"10.1503/jpn.220199","DOIUrl":"https://doi.org/10.1503/jpn.220199","url":null,"abstract":"<p><p>Open science provides a compelling framework for accelerating global collaborations and enabling discoveries to understand and treat mental health disorders. Herein, we discuss the advantages and obstacles to adopting open science in mental health research, considering the particularities of sensitive and diverse data types, the potential of co-designing projects with research participants and the opportunity of amplifying open science by integration with mental health care. We present a practical example of how this landscape may be navigated to adopt open science across an entire research centre, in 5 steps, namely leadership committing to open science; finding models, resources and allies; identifying needs; defining open science principles; and putting principles into practice. We derive lessons learned that can be built upon by researchers and research organizations joining the open science movement in mental health.</p>","PeriodicalId":50073,"journal":{"name":"Journal of Psychiatry & Neuroscience","volume":"48 3","pages":"E209-E216"},"PeriodicalIF":4.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6e/33/48-3-E209.PMC10234619.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9629172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consistent terminology for medication-related problems in pharmacogenomic cases.","authors":"Thomas M Polasek,&nbsp;Sam Mostafa,&nbsp;Carl M J Kirkpatrick","doi":"10.1503/jpn.230022-l","DOIUrl":"https://doi.org/10.1503/jpn.230022-l","url":null,"abstract":"We read with interest the case report by Korchia and colleagues in which pharmacogenomic testing was used to investigate a young man’s adverse effects to 3 different antipsychotics.1 The test results (CYP2D6 poor metabolizer) provide a plausible explanation for the adverse effects he experienced with ari piprazole, risperidone and haloperidol, which are all metabolized, at least in part, to a mix of active and inactive metabolites via CYP2D6. For each drug, CYP2D6 poor metabolizers on average have higher exposures to total active drug moieties (e.g., risperidone + 9-hydroxyrisperidone [paliperidone]) compared with CYP2D6 normal metabolizers.2–4 Pharma co genomics then guided the subsequent prescribing of paliperidone, a predominantly renally cleared antipsychotic with no active metabolites, which is less depend ent on CYP2D6 for metabolic clearance.5 Pleasingly, this drug was well tolerated and effective in treating the patient’s first-episode psychosis.1 Despite pharmacogenomics helping the case, we were confused when “treatment failure” was used in the explanation to describe the outcomes of treatment with aripiprazole, risperidone and haloperidol in patients who were CYP2D6 poor metabolizers. We assume the authors used this phrase to mean cessation of drug because of significant adverse effects. However, when applying pharmacogenomics for the major drug metabolizing enzymes and transporters involved in pharmacokinetics, the terminology “treatment failure” indicates poor efficacy due to low exposure (i.e., low concentration) following an adequate therapeutic trial.6,7 Indeed, the Clinical Pharmacogenomic Implementation Consortium and the Dutch Pharmacogenetics Working Group guidelines use “treatment failure,” “pharmacotherapy failure,” “diminished response” or “therapy failure” interchangeably in this context.8–11 Not helping in the matter is the retrospective cohort study used to support this language (reference 6 in the case report).12 The original study simplistically defined treatment failure as the number of patients who switched from risperidone or aripiprazole to another antipsychotic within 1 year. The explicit reasons for switching were not provided. On closer inspection, the incidences of switching from risperidone were higher in CYP2D6 ultra-rapid metabolizers (odds ratio [OR] 2.934), which results in lower exposures to total active drug moieties (risperidone + 9-hydroxyrisperidone), and CYP2D6 poor metabolizers (OR 1.874), which results in higher exposures to total active drug moieties, compared with CYP2D6 normal metabolizers, suggesting that both poor efficacy and adverse effects contributed to the treatment failure end point.12 The authors do explain that “risperidone is likely to be too slowly converted to its active metabolite, leading to a greater risk of adverse effects.”1 This too is confusing for the nonexpert, since it implies that risperidone is inactive until metabolized to 9hydroxyrisperidone via CYP2D6 (akin to the met","PeriodicalId":50073,"journal":{"name":"Journal of Psychiatry & Neuroscience","volume":"48 3","pages":"E151-E152"},"PeriodicalIF":4.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/14/5f/48-3-E151.PMC10185347.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9634546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mindfulness-based intervention for benzodiazepine deprescription in hemodialysis patients with anxiety and depressive symptoms.","authors":"Nicolas Garel,&nbsp;Christina Rigas,&nbsp;Mona Ben M'rad,&nbsp;Katie Bodenstein,&nbsp;Ridha Joober,&nbsp;Harmehr Sekhon,&nbsp;Soham Rej","doi":"10.1503/jpn.220216","DOIUrl":"https://doi.org/10.1503/jpn.220216","url":null,"abstract":"","PeriodicalId":50073,"journal":{"name":"Journal of Psychiatry & Neuroscience","volume":"48 3","pages":"E149-E150"},"PeriodicalIF":4.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ae/02/48-3-E149.PMC10185346.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9634543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From research of mental disorders to clinical application - lessons from diabetes.","authors":"Georg Northoff","doi":"10.1503/jpn.230078","DOIUrl":"https://doi.org/10.1503/jpn.230078","url":null,"abstract":"We are facing a crisis of translation of research into clinical application in psychiatry. Most diagnoses are thus still observer-based in clinical practice (rather than being based on objective neuronal and/or psychological markers). Moreover, therapy is often based on trial and error, hence the look toward research that may yield biomarkers for both objective diagnosis and therapeutic monitoring and guidance beyond trial and error. However, most research, including brain imaging and molecular, genetic and biochemical research, has not yet led to biomarkers for clinical diagnosis and therapy. We seem to miss some key ingredient that links basic pathophysiological mechanisms to the various symptoms in a symptomor disease-specific way. I here propose that the missing link is what the early psychiatrist Eugène Minkowski described as basic or generative disturbance1: rather than being the main cause, the basic or generative disturbance operates at an intermediate level, which is key in generating those pathophysiological mechanisms that drive and lead to the various psychopathological symptoms. Let me first draw an analogy and comparison of mental disorders with another disorder, diabetes mellitus (DM).","PeriodicalId":50073,"journal":{"name":"Journal of Psychiatry & Neuroscience","volume":"48 3","pages":"E240-E244"},"PeriodicalIF":4.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/47/77/48-3-E240.PMC10281718.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9707162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct and shared therapeutic neural mechanisms of mindfulness-based and social support stress reduction groups in adults with autism spectrum disorder.","authors":"Broc A Pagni, Ethan Hill, Melissa J M Walsh, Shanna Delaney, Destiny Ogbeama, Leanna Monahan, James R Cook, Nicolas Guerithault, Maria V Dixon, Lisa Ballard, B Blair Braden","doi":"10.1503/jpn.220159","DOIUrl":"10.1503/jpn.220159","url":null,"abstract":"<p><strong>Background: </strong>Mindfulness-based stress reduction (MBSR) alleviates depression and anxiety in adults with autism spectrum disorder (ASD); however, underlying therapeutic neural mechanisms and mindfulness-specific effects have yet to be elucidated.</p><p><strong>Methods: </strong>We randomly assigned adults with ASD to MBSR or social support/education (SE). They completed questionnaires that assessed depression, anxiety, mindfulness traits, autistic traits and executive functioning abilities as well as a self-reflection functional MRI task. We used repeated-measures analysis of covariance (ANCOVA) to evaluate behavioural changes. To identify task-specific connectivity changes, we performed a generalized psychophysiological interactions (gPPI) functional connectivity (FC) analysis on regions of interest (ROIs; insula, amygdala, cingulum and prefrontal cortex [PFC]). We used Pearson correlations to explore brain-behaviour relationships.</p><p><strong>Results: </strong>Our final sample included 78 adults with ASD - 39 who received MBSR and 39 who received SE. Mindfulness-based stress reduction uniquely improved executive functioning abilities and increased mindfulness traits, whereas both MBSR and SE groups showed reductions in depression, anxiety and autistic traits. Decreases specific to MBSR in insula-thalamus FC were associated with anxiety reduction and increased mindfulness traits, including the trait \"nonjudgment;\" MBSR-specific decreases in PFC-posterior cingulate connectivity correlated with improved working memory. Both groups showed decreased amygdala-sensorimotor and medial-lateral PFC connectivity, which corresponded with reduced depression.</p><p><strong>Limitations: </strong>Larger sample sizes and neuropsychological evaluations are needed to replicate and extend these findings.</p><p><strong>Conclusion: </strong>Together, our findings suggest that MBSR and SE are similarly efficacious for depression, anxiety and autistic traits, whereas MBSR produced additional salutary effects related to executive functioning and mindfulness traits. Findings from gPPI identified shared and distinct therapeutic neural mechanisms, implicating the default mode and salience networks. Our results mark an early step toward the development of personalized medicine for psychiatric symptoms in ASD and offer novel neural targets for future neurostimulation research.</p><p><strong>Clinical trial registration: </strong>ClinicalTrials.gov identifier NCT04017793.</p>","PeriodicalId":50073,"journal":{"name":"Journal of Psychiatry & Neuroscience","volume":"48 2","pages":"E102-E114"},"PeriodicalIF":4.3,"publicationDate":"2023-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9b/bf/48-2-E102.PMC10065804.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9233295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dexamphetamine widens temporal and spatial binding windows in healthy participants.","authors":"Faiz M Kassim,&nbsp;Samra Krakonja Lahooti,&nbsp;Elizabeth Ann Keay,&nbsp;Rajan Iyyalol,&nbsp;Jennifer Rodger,&nbsp;Matthew A Albrecht,&nbsp;Mathew T Martin-Iverson","doi":"10.1503/jpn.220149","DOIUrl":"https://doi.org/10.1503/jpn.220149","url":null,"abstract":"<p><strong>Background: </strong>The pathophysiology of psychosis is complex, but a better understanding of stimulus binding windows (BWs) could help to improve our knowledge base. Previous studies have shown that dopamine release is associated with psychosis and widened BWs. We can probe BW mechanisms using drugs of specific interest to psychosis. Therefore, we were interested in understanding how manipulation of the dopamine or catecholamine systems affect psychosis and BWs. We aimed to investigate the effect of dexamphetamine, as a dopamine-releasing stimulant, on the BWs in a unimodal illusion: the tactile funneling illusion (TFI).</p><p><strong>Methods: </strong>We conducted a randomized, double-blind, counterbalanced placebo-controlled crossover study to investigate funnelling and errors of localization. We administered dexamphetamine (0.45 mg/kg) to 46 participants. We manipulated 5 spatial (5-1 cm) and 3 temporal (0, 500 and 750 ms) conditions in the TFI.</p><p><strong>Results: </strong>We found that dexamphetamine increased funnelling illusion (<i>p</i> = 0.009) and increased the error of localization in a delay-dependent manner (<i>p</i> = 0.03). We also found that dexamphetamine significantly increased the error of localization at 500 ms temporal separation and 4 cm spatial separation (<i>p</i> _interaction = 0.009; <i>p</i> _{500ms|4cm v. baseline} = 0.01).</p><p><strong>Limitations: </strong>Although amphetamine-induced models of psychosis are a useful approach to understanding the physiology of psychosis related to dopamine hyperactivity, dexamphetamine is equally effective at releasing noradrenaline and dopamine, and, therefore, we were unable to tease apart the effects of the 2 systems on BWs in our study.</p><p><strong>Conclusion: </strong>We found that dexamphetamine increases illusory perception on the unimodal TFI in healthy participants, which suggests that dopamine or other catecholamines have a role in increasing tactile spatial and temporal BWs.</p>","PeriodicalId":50073,"journal":{"name":"Journal of Psychiatry & Neuroscience","volume":"48 2","pages":"E90-E98"},"PeriodicalIF":4.3,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/30/af/48-2-E90.PMC10019325.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9210697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut-brain axis volatile organic compounds derived from breath distinguish between schizophrenia and major depressive disorder.","authors":"Daniush Henning,&nbsp;Marian Lüno,&nbsp;Carina Jiang,&nbsp;Gabriela Meyer-Lotz,&nbsp;Christoph Hoeschen,&nbsp;Thomas Frodl","doi":"10.1503/jpn.220139","DOIUrl":"https://doi.org/10.1503/jpn.220139","url":null,"abstract":"<p><strong>Background: </strong>Signatures from the metabolome and microbiome have already been introduced as candidates for diagnostic and treatment support. The aim of this study was to investigate the utility of volatile organic compounds (VOCs) from the breath for detection of schizophrenia and depression.</p><p><strong>Methods: </strong>Patients with a diagnosis of major depressive disorder (MDD) or schizophrenia, as well as healthy controls, were recruited to participate. After being clinically assessed and receiving instruction, each participant independently collected breath samples for subsequent examination by proton transfer-reaction mass spectrometry.</p><p><strong>Results: </strong>The sample consisted of 104 participants: 36 patients with MDD, 34 patients with schizophrenia and 34 healthy controls. Through mixed-model and deep learning analyses, 5 VOCs contained in the participants' breath samples were detected that significantly differentiated between diagnostic groups and healthy controls, namely VOCs with mass-to-charge ratios (<i>m</i>/<i>z</i>) 60, 69, 74, 88 and 90, which had classification accuracy of 76.8% to distinguish participants with MDD from healthy controls, 83.6% to distinguish participants with schizophrenia from healthy controls and 80.9% to distinguish participants with MDD from those with schizophrenia. No significant associations with medication, illness duration, age of onset or time in hospital were detected for these VOCs.</p><p><strong>Limitations: </strong>The sample size did not allow generalization, and confounders such as nutrition and medication need to be tested.</p><p><strong>Conclusion: </strong>This study established promising results for the use of human breath gas for detection of schizophrenia and MDD. Two VOCs, 1 with <i>m</i>/<i>z</i> 60 (identified as trimethylamine) and 1 with <i>m</i>/<i>z</i> 90 (identified as butyric acid) could then be further connected to the interworking of the microbiota-gut-brain axis.</p>","PeriodicalId":50073,"journal":{"name":"Journal of Psychiatry & Neuroscience","volume":"48 2","pages":"E117-E125"},"PeriodicalIF":4.3,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/05/4f/48-2-E117.PMC10095255.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10008967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dr. Francis Wayne Quan Memorial Prize 2022.","authors":"","doi":"10.1503/jpn.230050","DOIUrl":"https://doi.org/10.1503/jpn.230050","url":null,"abstract":". In a well-powered study, Steinman and colleagues showed a blunted neural fMRI response to loss, but not reward, in de-pressed individuals with anhedonia, possibly defining a sub-phenotype of depression. These changes may be linked with reduced motivation or apathy in patients that contributes to severe anhedonia. This study provides novel mechanistic insights into neural mechanisms underlying anhedonia in individuals with major depressive disorder","PeriodicalId":50073,"journal":{"name":"Journal of Psychiatry & Neuroscience","volume":"48 2","pages":"E116"},"PeriodicalIF":4.3,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/27/21/48-2-E116.PMC10095243.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9301094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chaos analysis of the cortical boundary for the recognition of psychosis.","authors":"Alexandra I Korda,&nbsp;Christina Andreou,&nbsp;Mihai Avram,&nbsp;Marina Frisman,&nbsp;Mariya Aliqadri,&nbsp;Anita Riecher-Rössler,&nbsp;Heinz Handels,&nbsp;Thomas Martinetz,&nbsp;Stefan Borgwardt","doi":"10.1503/jpn.220160","DOIUrl":"https://doi.org/10.1503/jpn.220160","url":null,"abstract":"Background: Structural MRI studies in people with first-episode psychosis (FEP) and those in the clinical high-risk (CHR) state have consistently shown volumetric abnormalities that depict changes in the structural complexity of the cortical boundary. The aim of the present study was to employ chaos analysis in the identification of people with psychosis based on the structural complexity of the cortical boundary and subcortical areas. Methods: We performed chaos analysis of the grey matter distribution on structural MRIs. First, the outer boundary points for each slice in the axial, coronal and sagittal view were calculated for grey matter maps. Next, the distance of each boundary point from the centre of mass in the grey matter was calculated and stored as spatial series, which was further analyzed by extracting the Largest Lyapunov Exponent (lambda [λ]), a feature depicting the structural complexity of the cortical boundary. Results: Structural MRIs were acquired from 77 FEP, 73 CHR and 44 healthy controls. We compared λ brain maps between groups, which resulted in statistically significant differences in all comparisons. By matching the λ values extracted in axial view with the Morlet wavelet, differences on the surface relief are observed between groups. Limitations: Parameters were selected after experimentation on the examined sample. Investigation of the effectiveness of the method in a larger data set is needed. Conclusion: The proposed framework using spatial series verifies diagnosis-relevant features and may contribute to the identification of structural biomarkers for psychosis.","PeriodicalId":50073,"journal":{"name":"Journal of Psychiatry & Neuroscience","volume":"48 2","pages":"E135-E142"},"PeriodicalIF":4.3,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7f/02/48-2-E135.PMC10139064.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9628209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}