Journal of Psychiatry & Neuroscience最新文献

{"title":"Weight loss leading to reduction in clozapine levels and symptomatic worsening.","authors":"Akash Prasanna Kumar, Sang Ik Song, Margaret Hahn, Robert Zipursky, Gary Remington, Sri Mahavir Agarwal","doi":"10.1503/jpn.250076","DOIUrl":"10.1503/jpn.250076","url":null,"abstract":"","PeriodicalId":50073,"journal":{"name":"Journal of Psychiatry & Neuroscience","volume":"50 4","pages":"E275-E276"},"PeriodicalIF":3.3,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144856840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of depressive and negative symptoms in individuals with schizoaffective disorders using serotoninergic psychedelics: a case report.","authors":"Michel Sabé, Federico Seragnoli, Gabriel Thorens, Daniele Zullino, Othman Sentissi, Marco Solmi, Kerem Böge, Stefan Kaiser, Matthias Kirschner","doi":"10.1503/jpn.250005","DOIUrl":"10.1503/jpn.250005","url":null,"abstract":"","PeriodicalId":50073,"journal":{"name":"Journal of Psychiatry & Neuroscience","volume":"50 4","pages":"E234-E236"},"PeriodicalIF":3.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of grey matter cerebral blood flow with white matter integrity in relation to youth bipolar disorder.","authors":"Anahit Grigorian, Yi Zou, Kody G Kennedy, Mikaela K Dimick, Bradley J MacIntosh, Benjamin I Goldstein","doi":"10.1503/jpn.250019","DOIUrl":"10.1503/jpn.250019","url":null,"abstract":"<p><strong>Background: </strong>Both cerebral blood flow (CBF) and fractional anisotropy (FA) are altered in bipolar disorder (BD). We sought to investigate the unexplored CBF-FA association in relation to youth BD.</p><p><strong>Methods: </strong>We recruited youth with BD, high-risk youth with a family history of BD, and healthy controls. Using 3 T magnetic resonance imaging, we measured global and regional grey matter CBF using arterial spin labelling and we measured regional FA using diffusion tensor imaging. We explored the CBF-FA association across groups, between groups, and by sex. Analyses of the BD group further examined mood effects. We conducted region-of-interest analyses of global CBF and FA, anterior cingulate cortex (ACC) CBF, and cingulate FA.</p><p><strong>Results: </strong>We included 59 youth with BD, 19 high-risk youth with a family history of BD, and 47 healthy controls. There were no significant CBF-FA associations in the overall sample. Within the BD group, higher ACC CBF was associated with higher cingulum FA (β-weight 0.30, <i>p</i> = 0.03), with larger effect sizes among females and asymptomatic participants. Among controls, higher global CBF was associated with lower global FA (β-weight -0.40, <i>p</i> = 0.05). Within-sex analyses in the overall sample revealed a small effect size association between ACC CBF and cingulum FA among females only.</p><p><strong>Limitations: </strong>Our small sample size limited power, and our cross-sectional observational design precluded directional inferences about CBF-FA associations.</p><p><strong>Conclusion: </strong>We found preliminary evidence that ACC CBF was positively associated with cingulum FA among youth with BD, which may be driven by asymptomatic female participants. These associations may relate to differences in cerebral metabolism or white matter perfusion. Prospective and experimental studies are warranted to better understand CBF-FA associations in BD.</p>","PeriodicalId":50073,"journal":{"name":"Journal of Psychiatry & Neuroscience","volume":"50 4","pages":"E210-E217"},"PeriodicalIF":3.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decriminalization or more treatment? Comparing 2 approaches to the drug overdose crisis.","authors":"Charlotte Caswell, R Michael Krausz, Marco Leyton","doi":"10.1503/jpn.250084","DOIUrl":"10.1503/jpn.250084","url":null,"abstract":"","PeriodicalId":50073,"journal":{"name":"Journal of Psychiatry & Neuroscience","volume":"50 3","pages":"E197"},"PeriodicalIF":4.1,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Familial risk of major mood disorders and brain functional connectivity in the default mode, cognitive executive, and salience networks\".","authors":"","doi":"10.1503/jpn.250095","DOIUrl":"10.1503/jpn.250095","url":null,"abstract":"","PeriodicalId":50073,"journal":{"name":"Journal of Psychiatry & Neuroscience","volume":"50 3","pages":"E196"},"PeriodicalIF":4.1,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Familial risk of major mood disorders and brain functional connectivity in the default mode, cognitive executive, and salience networks.","authors":"Daniel Murage, Anna Nazarova, Vladislav Drobinin, Nitya Adepalli, Carl A Helmick, Matthias H Schmidt, Aaron J Newman, Christopher V Bowen, Rudolf Uher","doi":"10.1503/jpn.250002","DOIUrl":"10.1503/jpn.250002","url":null,"abstract":"<p><strong>Background: </strong>Mood disorders, including depressive and bipolar disorders, begin in late adolescence to early adulthood, tend to run in families, and present early with subthreshold symptoms. They have been associated with differential connectivity in 3 core networks: the default mode network (DMN), cognitive executive network (CEN), and salience network (SN), but it remains unclear whether differences in connectivity in the DMN, CEN, and SN are associated with familial risk for mood disorders.</p><p><strong>Methods: </strong>We recruited youth aged 9-19 years, including offspring of parents with major depressive or bipolar disorders (familial high risk [FHR]) and offspring of parents with no mood disorder (controls) for a resting-state functional magnetic resonance imaging study. We tested associations between family history of major mood disorders and connectivity within and between the DMN, CEN, and SN.</p><p><strong>Results: </strong>We included 215 youth: 126 at FHR with a mean age of 13.38 (standard deviation [SD] 2.91) years and 79 controls with a mean age of 13.17 (SD 2.67) years. Mean connectivity in the DMN (β = 0.003, 95% confidence interval [CI] -0.023 to 0.029), CEN (β = -0.009, 95% CI, -0.070 to 0.089), and SN (β = -0.010, 95% CI -0.071 to 0.051) in the FHR group was similar to that of controls. Moreover, DMN, CEN, and SN connectivity was not significantly associated with depressive symptoms.</p><p><strong>Limitations: </strong>Given that brain connectivity changes over the developmental period, longitudinal studies would improve understanding of how this change occurs in familial risk groups to identify critical time periods for intervention or prevention of mood disorders.</p><p><strong>Conclusion: </strong>Connectivity within and between the DMN, CEN, and SN is not a neural indicator of familial risk for major mood disorders.</p>","PeriodicalId":50073,"journal":{"name":"Journal of Psychiatry & Neuroscience","volume":"50 3","pages":"E181-E193"},"PeriodicalIF":4.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dr. Francis Wayne Quan Memorial Prize 2024.","authors":"","doi":"10.1503/jpn.250060","DOIUrl":"https://doi.org/10.1503/jpn.250060","url":null,"abstract":"","PeriodicalId":50073,"journal":{"name":"Journal of Psychiatry & Neuroscience","volume":"50 2","pages":"E125"},"PeriodicalIF":4.1,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12029296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint and distinct neural structure and function deficits in major depressive disorder with suicidality: a multimodal meta-analysis of MRI studies.","authors":"Shiqi Lin, Ziqi Chen, Youjin Zhao, Qiyong Gong","doi":"10.1503/jpn.240112","DOIUrl":"https://doi.org/10.1503/jpn.240112","url":null,"abstract":"<p><strong>Background: </strong>Suicide risk is a major concern for patients with major depressive disorder (MDD). Neuroimaging studies have demonstrated that patients with MDD with suicidal ideation or suicide attempt (MDD-S) are accompanied by neurostructural or functional abnormalities, but there is no consensus of opinion on neural substrate alterations involved in MDD-S.</p><p><strong>Methods: </strong>We performed a whole-brain multimodal meta-analysis of existing magnetic resonance imaging (MRI) studies to identify conjoint and separate alterations of grey matter volume (GMV) and spontaneous brain activity characteristics (regional homogeneity and amplitude of low-frequency fluctuations) between patients with MDD-S and patients with MDD without suicidal ideation or suicidal attempt (MDD-NS) via the seed-based <i>d</i> mapping software. We excluded studies that used other modalities, had overlapping data, or had insufficient information.</p><p><strong>Results: </strong>Our systematic search identified 13 structural MRI studies (471 patients with MDD-S and 508 patients with MDD-NS) and 16 resting-state functional MRI studies (704 patients with MDD-S and 554 patients with MDD-NS) published up to Dec. 5, 2023. Compared with patients with MDD-NS, those with MDD-S showed increased GMV with hypoactivity in the left postcentral gyrus, decreased GMV with hypoactivity in the right inferior parietal gyri, decreased GMV with hyperactivity in the right insula, and separate GMV and functional changes within the bilateral parietal, occipital, and frontal lobes, and the left thalamus.</p><p><strong>Limitations: </strong>We were unable to analyze the association between brain features and clinical detail because of a lack of data. Included studies showed considerable heterogeneity and publication bias.</p><p><strong>Conclusion: </strong>These findings provide a comprehensive overview of brain morphological and spontaneous functional impairments linked to impulsivity, impaired positive reward modulation, emotional disturbances, abnormal emotional processing, and cognitive deficits in MDD-S. These results support an understanding of the relationship between neural substrates and clinical symptoms in MDD-S, and these alterations provide useful insight into pathophysiological mechanisms and intervention strategies to decrease suicide risk in MDD.</p>","PeriodicalId":50073,"journal":{"name":"Journal of Psychiatry & Neuroscience","volume":"50 2","pages":"E126-E141"},"PeriodicalIF":4.1,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12029312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Greening the lab: fighting climate change to enhance mental health.","authors":"Paul R Albert, Marie Marotel, Carole Doré, Rebecca C Auer","doi":"10.1503/jpn.250040","DOIUrl":"https://doi.org/10.1503/jpn.250040","url":null,"abstract":"","PeriodicalId":50073,"journal":{"name":"Journal of Psychiatry & Neuroscience","volume":"50 2","pages":"E142-E144"},"PeriodicalIF":4.1,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12029299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of topiramate in the treatment of behavioural disorders in Prader-Willi syndrome.","authors":"Cécile Louveau, Mylène Moyal, Adrien Legrand, Christine Poitou, Marie-Odile Krebs, Anton Iftimovici, Boris Chaumette","doi":"10.1503/jpn.240107","DOIUrl":"https://doi.org/10.1503/jpn.240107","url":null,"abstract":"","PeriodicalId":50073,"journal":{"name":"Journal of Psychiatry & Neuroscience","volume":"50 2","pages":"E145-E146"},"PeriodicalIF":4.1,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12029298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}