Journal of Rheumatology最新文献

{"title":"Regional Trends and Patterns of Axial Spondyloarthritis in Latin America: A Study From the ESPALDA Registry (2019-2024).","authors":"Cristian Mesa-Pedraza, Rodrigo García-Salinas, Fernando Sommerfleck, Wilson Bautista-Molano, Guillermo Arturo Guaracha Basañez, Julio César Casasola Vargas, Daniel Fernández-Ávila, Diego Vila, María Lorena Brance, Jossiell Then Báez, Francisco Zevallos Miranda, Lysseth Macías Oviedo, Marilú Mestanza Peralta, Daisy Yelena Sánchez Cantos, Lyn Chinchay, Patricia Melgarejo, Ángel Alejandro Castillo Ortiz, Gimena Gómez, Leandro Grabiel Ferreyra Garrot, Dora Liliana Candia Zúñiga, Gustavo Medina, María Fernanda Egüez Del Pozo, Einer Sánchez Prado, Daniel Palleiro, John Londoño","doi":"10.3899/jrheum.2025-1266","DOIUrl":"10.3899/jrheum.2025-1266","url":null,"abstract":"<p><strong>Objective: </strong>To compare demographic, clinical, functional, and therapeutic characteristics of patients with axial spondyloarthritis (axSpA) across 3 Latin American regions using data from the <i>Registro de Espondiloartritis Axial de America</i> (ESPALDA) registry between January 2019 and December 2024.</p><p><strong>Methods: </strong>This cross-sectional study included 418 patients diagnosed with axSpA who fulfilled the Assessment of SpondyloArthritis international Society classification criteria. Participants were recruited from 3 Latin American regions: northern (Mexico), Andean (Colombia, Ecuador, Peru, Venezuela), and southern (Argentina, Chile, Paraguay, Uruguay). Collected data included demographic characteristics, HLA-B27 status, extraarticular manifestations, disease activity, radiographic damage, and treatments.</p><p><strong>Results: </strong>The northern region showed the highest prevalence of HLA-B27 (81%) and uveitis (36.3%), along with lower frequencies of peripheral involvement and fewer patients with magnetic resonance imaging-defined sacroiliitis (7.3%; all <i>P</i> ≤ 0.003). In contrast, the southern region reported a later onset of inflammatory back pain (median 39 vs 22 years; <i>P</i> = 0.01), higher Bath Ankylosing Spondylitis Functional Index scores (median 4.6 vs 3.3, <i>P</i> = 0.005), and a lower response to nonsteroidal antiinflammatory drugs (59.8% vs 79%; <i>P</i> = 0.001). Use of biologic disease-modifying antirheumatic drugs was lowest in the northern region (34.7%) compared with the Andean (57.9%) and southern (53.8%) regions (<i>P</i> ≤ 0.002 for northern vs other regions). The median diagnostic delay was 40.9 (IQR 12.0-121.1) months, with no significant regional differences.</p><p><strong>Conclusion: </strong>Two clinical phenotypes of axSpA appear to exist in Latin America: a predominantly axial, HLA-B27-positive phenotype in the northern region, and a second phenotype in the Andean and southern regions characterized by greater peripheral involvement and, in the southern region, later symptom onset and worse functional status.</p>","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"885-893"},"PeriodicalIF":3.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"If Treat-to-Target Works for Gout, Who Will Implement It in Primary Care?","authors":"Juan Sebastián Therán-León, Andrés Felipe Otero-Rueda","doi":"10.3899/jrheum.2025-1354","DOIUrl":"10.3899/jrheum.2025-1354","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"937-938"},"PeriodicalIF":3.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147950134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dr. Singh replies.","authors":"Jasvinder A Singh","doi":"10.3899/jrheum.2026-0307","DOIUrl":"10.3899/jrheum.2026-0307","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"938-940"},"PeriodicalIF":3.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147949992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel <i>DNASE2</i> Variants Linked With Neonatal Acute Liver Failure and Monogenic Systemic Lupus Erythematosus.","authors":"Melissa C Misztal, Tapas Mukherjee, Madeline Couse, Dilan Dissanayake, Daniela Dominguez, Samuel A Killackey, Andrea Knight, Deborah M Levy, Lawrence Ng, Vicky L Ng, Tara A Paton, Michelle Spivak, Dana J Philpott, Linda T Hiraki","doi":"10.3899/jrheum.2025-1111","DOIUrl":"10.3899/jrheum.2025-1111","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"934-937"},"PeriodicalIF":3.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Features and Outcome Measures Across Still Disease (Systemic Juvenile Idiopathic Arthritis and Adult-Onset Still Disease) Cohorts Worldwide: A Systematic Literature Review.","authors":"Erin Balay-Dustrude, Mariana Correia Marques, Simone Appenzeller, Claudia Bracaglia, Fatma Dedeoglu, Esraa Eloseily, Penelope Martinez Jimenez, Michael J Ombrello, Karen Onel, Marinka Twilt, Xurong Zhao, Francesca Minoia, Susan Shenoi","doi":"10.3899/jrheum.2025-0822.C1","DOIUrl":"10.3899/jrheum.2025-0822.C1","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"940"},"PeriodicalIF":3.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Ecological Relationship Between Food Access and Disease Activity in Canadian Children Newly Diagnosed With Juvenile Idiopathic Arthritis.","authors":"Alexandra Welten, Shiran Zhong, Jason Gilliland, Michael Miller, Jaime Guzman, Molly Dushnicky, Kristin Houghton, Lillian Lim, Tania Cellucci, Roberta Berard","doi":"10.3899/jrheum.2025-1200","DOIUrl":"10.3899/jrheum.2025-1200","url":null,"abstract":"<p><strong>Objective: </strong>A healthy diet may contribute to improved disease activity in juvenile idiopathic arthritis (JIA). In Canada, access to healthy food is variable. This study examined the relationship between food accessibility, disease activity measures, and weight in children with JIA.</p><p><strong>Methods: </strong>Clinical data from children newly diagnosed with JIA (2017-2021) collected in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry were linked to neighborhood-level food accessibility measures using postal codes. Data were analyzed at enrollment and at 1-year follow-up. Associations were assessed using Spearman rho correlations, Mann-Whitney <i>U</i> test (<i>P</i> < 0.05), and mixed-effects linear regression.</p><p><strong>Results: </strong>Among 641 patients with JIA, 21.9% were overweight or obese (BMI > 85th percentile) and lived in areas with less access to chain grocery stores (<i>P</i> = 0.02) compared with those with underweight or healthy BMI. At baseline, healthy-weight (<i>P</i> = 0.02) and overweight (<i>P</i> = 0.04) patients had lower disease activity (Clinical Juvenile Arthritis Disease Activity Score in 10 joints) than those with obesity; this association was not observed at 1-year follow-up. At baseline, a greater proportion of fast food restaurants in the neighborhood was linked to fewer active joints (<i>r</i> _s = -0.09, <i>P</i> = 0.04). At 1 year, higher densities of fast food restaurants and convenience stores were associated with lower disease activity (<i>r</i> _s = -0.14, <i>P</i> = 0.02).</p><p><strong>Conclusion: </strong>Obesity was linked to higher disease activity and reduced access to healthy food in chain grocery stores. However, greater access to both healthy and unhealthy food was associated with lower disease activity, possibly reflecting the general benefits of urban living.</p>","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"899-904"},"PeriodicalIF":3.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147950099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the Gap: Rheumatology Meets Palliative Care.","authors":"Adam Amlani, Alexandra Saltman","doi":"10.3899/jrheum.2026-0457","DOIUrl":"10.3899/jrheum.2026-0457","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"840-841"},"PeriodicalIF":3.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148145267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When Infection Leaves Its Mark: Calcinosis in Systemic Sclerosis.","authors":"Jakob S Cepus, Torsten Diekhoff, Gerhard Krönke, Robert Biesen","doi":"10.3899/jrheum.2025-1029","DOIUrl":"10.3899/jrheum.2025-1029","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"929-930"},"PeriodicalIF":3.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Canadian Rheumatology Association Living Guidelines for Rheumatoid Arthritis: Update #3.","authors":"Roko P A Nikolic, Arnav Agarwal, Jordi Pardo Pardo, Pooneh Akhavan, Hugues Allard-Chamard, Claire E H Barber, Cheryl Barnabe, Shahin Jamal, Bindee Kuriya, Alexandra Legge, Janet E Pope, Laurie Proulx, Dawn P Richards, Orit Schieir, Regina Taylor-Gjevre, J Carter Thorne, Peter Tugwell, Glen S Hazlewood","doi":"10.3899/jrheum.2026-0228","DOIUrl":"10.3899/jrheum.2026-0228","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"932-934"},"PeriodicalIF":3.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Mouth to Joint: Citrullinated Bacteria in Driving Synovial Autoimmunity.","authors":"Eddie A James","doi":"10.3899/jrheum.2026-0410","DOIUrl":"10.3899/jrheum.2026-0410","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"837-839"},"PeriodicalIF":3.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148145257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}