Journal of Rheumatology最新文献

{"title":"Clinical Meaningfulness and Improvement Thresholds of Myositis Core Set Measures: Association With Patient-Reported Outcomes.","authors":"Shiri Keret, Raisa Lomanto Silva, Irada Choudhuri, Eugenia Gkiaouraki, Tanya Chandra, Nantakarn Pongtarakulpanit, Shreya Sriram, Vaidehi Kothari, Kaushik Sreerama Reddy, Eaman Alhassan, Anushka Aggarwal, Maha Almackenzie, Niladri Bhowmick, Siamak Moghadam-Kia, Chester V Oddis, Rohit Aggarwal","doi":"10.3899/jrheum.2025-1331","DOIUrl":"10.3899/jrheum.2025-1331","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the clinical meaningfulness and improvement thresholds of the myositis core set measures (CSMs) of disease activity in idiopathic inflammatory myopathies (IIMs), emphasizing associations with patient-reported outcome measures (PROMs).</p><p><strong>Methods: </strong>Adults with IIM were enrolled in a 6-month prospective observational study. PROMs were collected monthly, including patient global assessment (PtGA), Health Assessment Questionnaire- Disability Index (HAQ-DI), pain and fatigue (visual analog scale [VAS]), 36-item Short Form Health Survey (SF-36), and Patient-Reported Outcomes Measurement Information System Physical Function Short Form 20. Physician-reported outcomes (physician global assessment [PGA], extramuscular global disease activity [ExGLB], manual muscle testing 9 [MMT9]) and Total Improvement Score (TIS) of the 2016 American College of Rheumatology/European Alliance of Associations for Rheumatology (ACR/EULAR) Myositis Response Criteria were collected every 3 months. Associations were evaluated using Spearman correlation and linear mixed models to assess construct validity. Responsiveness, effect sizes, and clinically important differences (CIDs) were assessed using the anchors patient-reported and physician-reported global impression of change (PGIC and PhGIC, respectively) at 6 months.</p><p><strong>Results: </strong>Fifty patients (mean age, 51.6 [SD 14.9] years; 60% female) were enrolled. Most CSMs showed strong baseline and longitudinal associations with PROMs, including pain, fatigue, physical function, and quality of life (QOL). Significant improvements were observed in most CSMs with moderate to large effect sizes, using PGIC and PhGIC as anchors. The CIDs according to PGIC were 2.1 for PGA, 1.4 for ExGLB, 1.7 for PtGA, 4.2 for MMT9, 0.5 for HAQ-DI, 1475 IU/L for creatine kinase, and 28.0 for TIS. PhGIC demonstrated similar results.</p><p><strong>Conclusion: </strong>CSMs demonstrate robust validity and responsiveness, closely aligning with patients' symptoms, function, and QOL and supporting their utility in IIM trials. We established CIDs for CSMs and TIS.</p>","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148654949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lumbar Facet Tophus: An Overlooked Cause of Young Back Pain.","authors":"Xiaofang Liu, Weiwei Liao","doi":"10.3899/jrheum.2026-0511","DOIUrl":"https://doi.org/10.3899/jrheum.2026-0511","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148876539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers to Comorbidity Management in Young People With Rheumatic Disease.","authors":"Coziana Ciurtin","doi":"10.3899/jrheum.2026-0392","DOIUrl":"https://doi.org/10.3899/jrheum.2026-0392","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148876549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GRAPPA 2025 Annual Meeting: Advances in Psoriatic Disease Research From Pilot Grant Awardees.","authors":"Amélie Spangenberg, Tina Bhutani, Lyn D Ferguson, Anaïs Makos, Akihiro Nakamura, Anna Piccinelli, Giovanni Adami, Roshan Amarasena, Paolo Gisondi, Oksana Kehoe, Jan Herman Kuiper, Maurizio Rossini, Naveed Sattar, Stefan Siebert, Kurt de Vlam, Vinod Chandran, Wilson Liao","doi":"10.3899/jrheum.2026-0372","DOIUrl":"10.3899/jrheum.2026-0372","url":null,"abstract":"<p><p>Key advances from the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) pilot research grant program were presented at the GRAPPA 2025 annual meeting. Areas of study included hypoxia-inducible factor 1α (HIF1A) as a potential factor in psoriatic arthritis (PsA), plasma extracellular vesicle cytokines as potential biomarkers for predicting response to tumor necrosis factor inhibitors in PsA, bone properties and biomechanics in psoriatic disease (PsD), better understanding of differences in body composition in PsD, and the effect of sleep on PsD severity.</p>","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"28-32"},"PeriodicalIF":3.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147950166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dr. Tsai et al reply.","authors":"Zoe Tsai, Adam M Huber, Kiem Oen, Jean-Philippe Proulx-Gauthier, Gaëlle Chédeville, Gilles Boire, Dax G Rumsey, Kristin M Houghton, Michelle Batthish, Roberta A Berard, Heinrike Schmeling, Y Ingrid Goh, Ciaran M Duffy, Jaime Guzman","doi":"10.3899/jrheum.2026-0543","DOIUrl":"https://doi.org/10.3899/jrheum.2026-0543","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Reveals Extensive Articular and Extraarticular Rheumatoid Arthritis.","authors":"Enmanuel A Leiva-Murillo, José C Milisenda","doi":"10.3899/jrheum.2026-0699","DOIUrl":"https://doi.org/10.3899/jrheum.2026-0699","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Juvenile Arthritis Quality of Life Questionnaire Responder Metrics in Juvenile Idiopathic Arthritis: Clarifying Health-Related Quality of Life Changes Across Treatment Eras.","authors":"Fanli Wang, Huanru Qu","doi":"10.3899/jrheum.2026-0194","DOIUrl":"https://doi.org/10.3899/jrheum.2026-0194","url":null,"abstract":"<p><p>Tsai et al compared 1-year health-related quality of life (HRQOL) after juvenile idiopathic arthritis (JIA) diagnosis between 2 Canadian inception cohorts recruited in 2005-2010 (ReACCh-Out) and in 2017-2023 (CAPRI).¹ Using the multidimensional Juvenile Arthritis Quality of Life Questionnaire (JAQQ), they reported improved overall HRQOL over the first year in both eras (mean total JAQQ change -0.92 and -0.97, respectively).¹.</p>","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148765568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Annular Erythema Associated With Anticentromere Antibody-Positive Sjögren Disease.","authors":"Kenji Ishiguro, Shunta Kaneko","doi":"10.3899/jrheum.2026-0112","DOIUrl":"https://doi.org/10.3899/jrheum.2026-0112","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148654915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral Ulcerative Keratitis in VEXAS Syndrome.","authors":"Rayan Tamba, Nabil Benmahmoud, Frédéric Chiambaretta","doi":"10.3899/jrheum.2026-0449","DOIUrl":"https://doi.org/10.3899/jrheum.2026-0449","url":null,"abstract":"","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148654947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep Learning-Based Comparison of Knee Minimum Joint Space Width in Patients With Rheumatoid Arthritis and Osteoarthritis Before Total Knee Arthroplasty.","authors":"Miguel M Girod, Monty Khela, Sami Saniei, Kellen L Mulford, Cassondra A Hulshizer, Elizabeth J Atkinson, Cody C Wyles, John M Davis, Gavin A McKenzie, Cynthia S Crowson","doi":"10.3899/jrheum.2025-0951","DOIUrl":"10.3899/jrheum.2025-0951","url":null,"abstract":"<p><strong>Objective: </strong>Although both osteoarthritis (OA) and rheumatoid arthritis (RA) can necessitate total knee arthroplasty (TKA), their mechanisms and radiographic patterns of joint space narrowing (JSN) differ. Deep learning (DL) enables compartment-specific measurement of minimum joint space width (mJSW). This study compared JSN patterns between patients with RA and OA undergoing TKA and evaluated the associations between mJSW and RA disease activity.</p><p><strong>Methods: </strong>In this retrospective study, 409 patients with RA undergoing TKA (2000-2021) were age- and sex-matched with OA patients. A validated DL model quantified medial and lateral mJSW from anteroposterior knee radiographs at 2 timepoints: early (> 2 years before TKA) and late (≤ 2 years before TKA). The rate of JSN was calculated in 302 patients with paired radiographs. Mixed-effects models adjusted for BMI and alignment. RA disease activity, serology, and medications were recorded.</p><p><strong>Results: </strong>RA demonstrated narrower lateral mJSW than OA at the late timepoint (5.6 vs 7.0 mm; <i>P</i> < 0.001), with comparable medial values. RA exhibited uniform bicompartmental JSN, whereas OA showed medial narrowing. RA had a faster mean lateral ΔmJSW (0.11 mm/year; <i>P</i> = 0.01), whereas OA had a faster mean medial ΔmJSW (0.21 mm/year; <i>P</i> < 0.001). Longer RA duration and higher inflammatory markers were negatively associated with lateral mJSW. Seronegative patients showed faster lateral ΔmJSW in the surgical knee than seropositive patients (0.12 vs 0.06 mm/year; <i>P</i> = 0.03).</p><p><strong>Conclusion: </strong>Patients with RA demonstrated diffuse, symmetric cartilage loss that contrasted with medial-predominant narrowing in patients with OA. Automated DL-based measurement enables scalable, compartment-specific assessment of joint degeneration patterns.</p>","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":"878-884"},"PeriodicalIF":3.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}