IF 0.2 4区医学

生殖医学杂志 Pub Date : 2017-05-01

Patricia Rekawek, Frederick Friedman, Bertille Gaigbe-Togbe, Joseph Lee, Alan B Copperman

{"title":"Human Embryo Morphokinetics Correlation with Obstetric Outcomes and Antepartum Biomarkers.","authors":"Patricia Rekawek, Frederick Friedman, Bertille Gaigbe-Togbe, Joseph Lee, Alan B Copperman","doi":"","DOIUrl":"","url":null,"abstract":"OBJECTIVE: To evaluate the correlation between em-bryo morphology and antepartum biomarker levels and obstetric outcomes following single embryo transfers (SETs).\u0000\u0000STUDY DESIGN: In vitro fertilization patients who delivered at the study site’s partnering hospital were included. Embryo morphology was compared to antepartum biomarkers and pregnancy outcomes.\u0000\u0000RESULTS: At a single academic reproductive endocrinology/infertility center, 2,882 SETs (day 3, 5, or 6) were performed from July 1, 2001, to June 30, 2013. Embryologic, serologic, and obstetric outcomes were available for 78 patients (cleavage [n=23]; blastocyst [n=55]). Embryos with a lower quality inner cell mass (ICM) demonstrated higher second trimester maternal serum alpha-fetoprotein (AFP) (p=0.0241) and AFP multiple of median (MoM) (p= 0.0036). After adjusting for age, body mass index, parity, and smoking status, this statistical significance remained (p=0.0319 for AFP; p=0.0026 for AFP MoM).\u0000\u0000CONCLUSION: Embryo morphokinetics did not correlate with perinatal outcome or a majority of placental biomarkers. A low ICM score was associated with higher second trimester maternal serum AFP values. This warrants further investigation, especially due to the risks of potential adverse obstetric outcomes associated with high AFP levels. Despite these findings, no difference in obstetric outcomes between low and high ICM scores was observed after controlling for maternal confounding variables. Patients should be reassured that embryo implantation, regardless of morphological score, results in similar obstetric outcomes.","PeriodicalId":50063,"journal":{"name":"生殖医学杂志","volume":"62 5-6","pages":"241-9"},"PeriodicalIF":0.2,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36328282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Randomized Controlled Trial of Autologous Endometrial Coculture Versus Traditional in Vitro Fertilization. 自体子宫内膜共培养与传统体外受精的随机对照试验。

IF 0.2 4区医学

生殖医学杂志 Pub Date : 2017-05-01

Kristin Van Heertum, Stephen Somkuti, Jennifer Nichols, Jay Schinfeld, Michael Sobel, Larry Barmat

{"title":"Randomized Controlled Trial of Autologous Endometrial Coculture Versus Traditional in Vitro Fertilization.","authors":"Kristin Van Heertum, Stephen Somkuti, Jennifer Nichols, Jay Schinfeld, Michael Sobel, Larry Barmat","doi":"","DOIUrl":"","url":null,"abstract":"OBJECTIVE: To determine if autologous endometrial cell coculture improves embryo development and clinical outcomes.\u0000\u0000STUDY DESIGN: Patients who met the inclusion criteria were randomized to either traditional in vitro fertilization (IVF) (control, n=73) or autologous endometrial cell coculture (AECC) (n=61). All patients underwent endometrial biopsy on cycle day 5–10 post luteinizing hormone surge. A total of 129 patients underwent embryo transfer (69 control, 60 AECC). Clinical outcomes as well as embryonic quality measures were then compared between the 2 groups.\u0000\u0000RESULTS: The mean age, day 3 follicle-stimulating hormone, number of oocytes collected, and clinical outcomes were similar between the 2 groups. Embryo development was overall similar, with the exception that embryonic grade was significantly better with AECC than with control: 1.5 (0.04) vs. 2.6 (0.03), p<0.0001. There was no difference in implantation, live birth or multiple gestation rates.\u0000\u0000CONCLUSION: This is one of the largest prospective randomized controlled trials of AECC versus traditional IVF. There was significant improvement in embryo morphology in the coculture group, although clinical outcomes were similar between the groups. Further studies are necessary to achieve enough power to fully delineate the effects of coculture on IVF outcome.","PeriodicalId":50063,"journal":{"name":"生殖医学杂志","volume":"62 5-6","pages":"329-32"},"PeriodicalIF":0.2,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36329627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Birth of a Mosaic Non–Down Syndrome Offspring to a 45,XY,t(21;21)(q10;q10) Homologous Robertsonian Translocation Carrier: A Case Report. 45,XY,t(21;21)(q10;q10)同源罗伯逊易位载体嵌合非唐氏综合征后代的诞生:一例报告。

IF 0.2 4区医学

生殖医学杂志 Pub Date : 2017-05-01

Junhao Yan, Qian Zhang, Yanqin Chen, Zi-Jiang Chen

引用次数: 0

Effect of Obesity on Clinical Parameters and Pregnancy Rates in Women with Polycystic Ovary Syndrome Undergoing Ovulation Induction Cycles. 肥胖对诱导排卵周期多囊卵巢综合征患者临床参数及妊娠率的影响

IF 0.2 4区医学

生殖医学杂志 Pub Date : 2017-05-01

Aytekin Tokmak, Ali Irfan Guzel, Gürhan Güney, Umit Tasdemir, Coskun Umit, Nafiye Yilmaz

{"title":"Effect of Obesity on Clinical Parameters and Pregnancy Rates in Women with Polycystic Ovary Syndrome Undergoing Ovulation Induction Cycles.","authors":"Aytekin Tokmak, Ali Irfan Guzel, Gürhan Güney, Umit Tasdemir, Coskun Umit, Nafiye Yilmaz","doi":"","DOIUrl":"","url":null,"abstract":"OBJECTIVE: To evaluate the effect of obesity on clinical parameters and pregnancy rates in infertile women with polycystic ovary syndrome (PCOS), who have undergone ovulation induction.\u0000\u0000STUDY DESIGN: This retrospective study included 177 women with PCOS who presented to our gynecological endocrinology outpatient clinic for diagnosed infertility. All of the patients initially received clomiphene citrate (CC), and if CC resistance was noted, gonadotropins were used. The patients were classified into 2 groups according to BMI (<30 kg/m2=control group and ≥30 kg/m2=study group). Pregnancy was assessed by β-hCG levels and a visible gestational sac in the endometrium.\u0000\u0000RESULTS: The demographic and hormonal parameters were similar between the groups. The mean duration of infertility was longer in the study group (p<0.05). In the study group, cycle cancellation due to CC resistance (p=0.039) and mean baseline LH levels (p=0.026) was statistically more likely than in the control group. On follow-up, 4 (9.3%) patients in the study group had conceived and 26 (19.4%) patients in the control group had conceived (p=0.041).\u0000\u0000CONCLUSION: Obesity adversely affects pregnancy rates in women with PCOS who undergo ovulation induction cycles. Clinicians should recommend weight loss in these patients before ovulation induction.","PeriodicalId":50063,"journal":{"name":"生殖医学杂志","volume":"62 5-6","pages":"300-4"},"PeriodicalIF":0.2,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36329601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long Bone Fractures Associated with Abdominal Breech Deliveries: A Report of Two Cases. 长骨骨折与腹部臀位分娩:附2例报告。

IF 0.2 4区医学

生殖医学杂志 Pub Date : 2017-05-01

Natasha Gupta, Nirbhay Parashar, Richard Trester, Josef Blankstein

引用次数: 0

Contribution of Magnetic Resonance Imaging to Ultrasound for the Evaluation of Fetal Central Nervous System Anomalies. 磁共振成像对超声评估胎儿中枢神经系统异常的贡献。

IF 0.2 4区医学

生殖医学杂志 Pub Date : 2017-05-01

Jae Eun Shin, Jong Chul Shin, Sa Jin Kim, Young Lee, Soo Ah Im, In Yang Park

{"title":"Contribution of Magnetic Resonance Imaging to Ultrasound for the Evaluation of Fetal Central Nervous System Anomalies.","authors":"Jae Eun Shin, Jong Chul Shin, Sa Jin Kim, Young Lee, Soo Ah Im, In Yang Park","doi":"","DOIUrl":"","url":null,"abstract":"OBJECTIVE: To evaluate whether magnetic resonance imaging (MRI) contributes to ultrasound for the evaluation of fetal central nervous system (CNS) anomalies. The secondary objective was to investigate whether MRI adds more information regarding the evaluation of specific pathologies or conditions.\u0000\u0000STUDY DESIGN: We retrospectively compared fetal MRI findings with ultrasound findings in CNS anomalies with respect to certain pathologic groups. Additionally, we evaluated diagnostic accuracy by comparing fetal MRI and ultrasound findings with postnatal findings.\u0000\u0000RESULTS: A total of 34 patients had 40 provisional diagnoses by fetal ultrasound, and of those patients 14 had a provisional diagnosis of ventriculomegaly and 14 had a provisional diagnosis of cerebellar or posterior fossa anomalies. MRI added to or changed the diagnosis in 52.5% of the patients with CNS abnormalities. The contribution rate in ventriculomegaly was 71.4%, and MRI changed the diagnosis in all indefinite diagnoses by ultrasound. Additionally, of the 15 patients with postnatal findings, there were no cases in which only the ultrasound findings were correct, but the MRI findings were incorrect.\u0000\u0000CONCLUSION: MRI contributes to ultrasound in the diagnosis of CNS anomalies. Cases of indefinite diagnosis and ventriculomegaly by ultrasound had greater benefit from MRI.","PeriodicalId":50063,"journal":{"name":"生殖医学杂志","volume":"62 5-6","pages":"295-9"},"PeriodicalIF":0.2,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36329598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Varicocele Repair in Patients with Nonobstructive Azoospermia. 精索静脉曲张修复在非梗阻性无精子症患者中的作用。

IF 0.2 4区医学

生殖医学杂志 Pub Date : 2017-05-01

Teppei Takeshima, Yasushi Yumura, Shinnosuke Kuroda, Yoshitake Kato, Kazumi Noguchi, Akira Iwasaki

{"title":"Effect of Varicocele Repair in Patients with Nonobstructive Azoospermia.","authors":"Teppei Takeshima, Yasushi Yumura, Shinnosuke Kuroda, Yoshitake Kato, Kazumi Noguchi, Akira Iwasaki","doi":"","DOIUrl":"","url":null,"abstract":"OBJECTIVE: To evaluate the efficacy of varicocele repair in patients with nonobstructive azoospermia.\u0000\u0000STUDY DESIGN: Ten patients with nonobstructive azoospermia and clinical varicoceles who underwent varicocele repair were retrospectively investigated. According to the postoperative appearance of motile spermatozoa in the ejaculate, the patients were divided into 2 groups: Responder and Nonresponder. The outcomes of each group were investigated.\u0000\u0000RESULTS: There were 4 (40%) patients in the Responder group. Serum follicle-stimulating hormone levels were significantly higher in the Nonresponder group than in the Responder group (19.9±6.4 IU/mL vs. 10.8± 4.0 IU/mL, p<0.05). Mean sperm concentration was 5.4 million spermatozoa/mL in the Responder group. One patient achieved a spontaneous pregnancy, and another achieved an assisted pregnancy. In the Nonresponder group 5 patients underwent microdissection testicular sperm extraction (micro-TESE) postoperatively. In 1 patient, motile spermatozoa were successfully retrieved. Histopathological findings in the other 4 patients were Sertoli-cell-only.\u0000\u0000CONCLUSION: The present study suggested that varicocele repair could be considered in men with nonobstructive azoospermia who have clinical varicoceles. Moreover, varicocele repair seemed to improve sperm retrieval rate during micro-TESE for those in the Nonresponder group.","PeriodicalId":50063,"journal":{"name":"生殖医学杂志","volume":"62 5-6","pages":"311-6"},"PeriodicalIF":0.2,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36329599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene Expression Analysis Identifies Common and Distinct Signatures Underlying Ductal and Lobular Breast Cancers. 基因表达分析确定导管和小叶乳腺癌的共同和独特特征。

IF 0.2 4区医学

生殖医学杂志 Pub Date : 2017-05-01

Quan Huang, Jian Liu, Tenghui Chen, Lei Li, Lu Wang, Yelin Wu

{"title":"Gene Expression Analysis Identifies Common and Distinct Signatures Underlying Ductal and Lobular Breast Cancers.","authors":"Quan Huang, Jian Liu, Tenghui Chen, Lei Li, Lu Wang, Yelin Wu","doi":"","DOIUrl":"","url":null,"abstract":"OBJECTIVE: To uncover potential genes and biological processes that contribute to breast cancer development.\u0000\u0000STUDY DESIGN: We studied gene expression profiles, which are publicly available from the Gene Expression Omnibus database, for the 2 most prevailing subtypes of breast cancer: lobular and ductal invasive breast carcinomas.\u0000\u0000RESULTS: We identified a total of 98 genes that shared regulation pattern in both subtypes of breast carcinoma. Further functional annotations indicated that 124 biological processes and 8 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were over-represented, such as cell surface receptor signaling pathway. We also identified unique gene expression profiles in each subtype of breast cancer. A total of 460 genes were solely differentially expressed between ductal cancer cells and normal cells, and 75 biological processes and 10 KEGG pathways were enriched by these 460 differential genes, including cell proliferation and regulation of cell death. Meanwhile, 308 genes were found to be differentially expressed between lobular cancer cells and normal cells. Intriguingly, only 11 biological processes and 8 KEGG pathways showed overrepresentation among these 308 genes, such as collagen metabolic process.\u0000\u0000CONCLUSION: Cumulatively, our results indicate that the invasive lobular and ductal carcinomas share a similar profile of gene expression and pathway alteration but also harbor subtype-specific mechanisms of tumorigenesis.","PeriodicalId":50063,"journal":{"name":"生殖医学杂志","volume":"62 5-6","pages":"271-83"},"PeriodicalIF":0.2,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36326817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cesarean Section Rates and Clinical Indications at a Large North African Hospital. 北非某大型医院剖宫产率及临床指征

IF 0.2 4区医学

生殖医学杂志 Pub Date : 2017-05-01

Bo Xu, Haidong Cheng, Xiaotian Li, Nebhani Mouna

引用次数: 0

Cesarean Section Revealing an Unsuspected Renal Angiomyolipoma in a Woman with Severe Hypertension During Pregnancy: A Case Report. 剖宫产术发现妊娠期严重高血压妇女肾血管平滑肌脂肪瘤1例。

IF 0.2 4区医学

生殖医学杂志 Pub Date : 2017-03-01

Stefano R Giannubilo, Sara D'Eusanio, Andrea Ciavattini

引用次数: 0

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