IF 0.2 4区医学

生殖医学杂志 Pub Date : 2017-05-01

Seung-Hyuk Shim, Sun Joo Lee, Seung Woo Yang, Ji Young Lim, Soo-Hyun Cho, Wook Youn Kim, Hee Sun Kim, Soo-Nyung Kim

{"title":"Comparison of Loop Electrosurgical Excision Procedure Using a Ring-Shaped Loop Versus a Right-Angled Triangular Loop.","authors":"Seung-Hyuk Shim, Sun Joo Lee, Seung Woo Yang, Ji Young Lim, Soo-Hyun Cho, Wook Youn Kim, Hee Sun Kim, Soo-Nyung Kim","doi":"","DOIUrl":"","url":null,"abstract":"OBJECTIVE: To compare the resection margin (RM) status and postoperative severe hemorrhage using different loop electrosurgical excision procedure (LEEP) techniques for cervical intraepithelial neoplasia (CIN) 2/3 treatment.\u0000\u0000STUDY DESIGN: We retrospectively reviewed 278 patients who underwent LEEPs for CIN 2/3 treatment at our institute between 2005–2014. In type A surgery (N=148), a ring-shaped loop was used. If the first pass failed to remove the entire lesion, separate loop excisions for the intracervical portion were performed. In type B surgery (N=130), a right-angled triangular loop in a single pass was used. Surgical outcomes and postoperative severe hemorrhage were compared between the two groups. Logistic regression analysis was performed to identify the independent predictors of RM status.\u0000\u0000RESULTS: The mean LEEP depth was larger after type A surgery (2.2 vs. 2.0 cm, respectively; p=0.04). Type B surgery showed lower rate of 30-day postoperative hemorrhage (13.8% vs. 26.4%, p<0.05) and higher rate of negative RM (68.9% vs. 82.3%, p<0.05). Multivariate analysis identified the surgery type (p=0.01, OR=0.45 [0.24–0.83]) and a postoperative pathological diagnosis of CIN3 (p=0.01, OR=2.53 [1.22–5.26]) as independent risk factors for positive RM.\u0000\u0000CONCLUSION: LEEPs using a right-angled triangular loop could reduce positive RMs.","PeriodicalId":50063,"journal":{"name":"生殖医学杂志","volume":"62 5-6","pages":"265-70"},"PeriodicalIF":0.2,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36326815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low Expression of LEFTY1 in Placental Villi Is Associated with Early Unexplained Miscarriage. 胎盘绒毛LEFTY1低表达与早期不明原因流产有关

IF 0.2 4区医学

生殖医学杂志 Pub Date : 2017-05-01

Huiqin Xue, Lan Ma, Jinjie Xue, Xiayu Sun, Ming Li, Hongyong Lu, Yan Zhou, Yuezhen Guo, Yuping Zhang, Jigeng Bai

{"title":"Low Expression of LEFTY1 in Placental Villi Is Associated with Early Unexplained Miscarriage.","authors":"Huiqin Xue, Lan Ma, Jinjie Xue, Xiayu Sun, Ming Li, Hongyong Lu, Yan Zhou, Yuezhen Guo, Yuping Zhang, Jigeng Bai","doi":"","DOIUrl":"","url":null,"abstract":"OBJECTIVE: To investigate the function and underlying mechanism of transforming growth factor–beta (TGF-β)/bone morphogenetic protein (BMP) signaling pathway in early unexplained miscarriage.\u0000\u0000STUDY DESIGN: Expression profiles of genes involved in TGF-β/BMP signaling pathway were compared between placental villous tissue samples from 2 women with missed abortion and those from 2 women with induced abortion by microarray assay. The protein expression level of the most downregulated gene—LEFTY1—was further measured using western blotting in another 8 women with missed abortion and 7 women with induced abortion.\u0000\u0000RESULTS: A total of 24 genes showed differential expression level between the 2 groups. Their functions were further investigated, of which 6 of 13 upregulated genes were TGF-β responsive genes. The most reduced gene is LEFTY1, an antagonist of TGF-β ligand. The protein expression level of LEFTY1 was confirmed to show the same trend as microarray using western blotting.\u0000\u0000CONCLUSION: A reduced expression of LEFTY1 in women with missed abortion was identified as com-pared with women with induced abortion, which may result in a dysregulation of TGF-β signaling and may be the underlying mechanism of missed abortion.","PeriodicalId":50063,"journal":{"name":"生殖医学杂志","volume":"62 5-6","pages":"305-10"},"PeriodicalIF":0.2,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36326820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Status of Prostaglandins for Cervical Ripening. 前列腺素在宫颈成熟中的应用现状。

IF 0.2 4区医学

生殖医学杂志 Pub Date : 2017-05-01

Javine McLaughlin, Lawrence D Devoe

引用次数: 0

Use of Concomitant FSH with hCG at the Time of Trigger May Improve Success Rates of Couples with Poor Ovarian Response Undergoing Gonadotropin Therapy with IUI. 在触发时使用促性腺激素和促性腺激素可提高卵巢反应差的夫妇接受促性腺激素联合人工授精治疗的成功率。

IF 0.2 4区医学

生殖医学杂志 Pub Date : 2017-05-01

Elie Hobeika, Shaveta Malik, Michael L Traub, Seleshi Demissie, Eric S Knochenhauer

{"title":"Use of Concomitant FSH with hCG at the Time of Trigger May Improve Success Rates of Couples with Poor Ovarian Response Undergoing Gonadotropin Therapy with IUI.","authors":"Elie Hobeika, Shaveta Malik, Michael L Traub, Seleshi Demissie, Eric S Knochenhauer","doi":"","DOIUrl":"","url":null,"abstract":"OBJECTIVE: To investigate if administration of an additional dose of gonadotropins concomitantly to human chorionic gonadotropin (hCG) trigger increases pregnancy rates in patients undergoing intrauterine insemination (IUI) with controlled ovarian hyperstimulation (COH).\u0000\u0000STUDY DESIGN: This is a retrospective cohort study of all gonadotropin-IUI cycles performed by a single physician in a private practice between January 2012 and September 2013. Control cycles were those in which follicle-stimulating hormone (FSH) was discontinued prior to the day of hCG trigger shot, and study cycles received continuous FSH including the day of hCG trigger shot. A total of 423 cycles from 239 patients were included; 275 (65.5%) were control cycles (137 patients), and 146 (34.7%) were study cycles (102 patients).\u0000\u0000RESULTS: Pregnancy rates were comparable in both control and study groups (15.27% vs. 15.07%, respectively, p=0.956). There was a 42% increase in multiple gestations in the study group; however, the difference was not statistically significant (p=0.155). Upon multivariate logistic regression, male factor infertility was the only variable that was associated with pregnancy outcomes.\u0000\u0000CONCLUSION: Continuous administration of FSH including the day of hCG trigger in patients undergoing COH with IUI does not seem to increase pregnancy rates. Our suggested protocol might be beneficial in patients with poor ovarian response.","PeriodicalId":50063,"journal":{"name":"生殖医学杂志","volume":"62 5-6","pages":"229-33"},"PeriodicalIF":0.2,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36328280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HER-2 Expression and Response to Radiotherapy in Patients with Advanced Cervical Cancer. HER-2在晚期宫颈癌患者中的表达及放疗反应。

IF 0.2 4区医学

生殖医学杂志 Pub Date : 2017-05-01

Glauco Baiocchi, Maria Dirlei Begnami, Michael Jenwei Chen, Elza Mieko Fukazawa, Levon Badiglian-Filho, Antonio Cassio Assis Pellizzon, Fernando Augusto Soares, Ademar Lopes

{"title":"HER-2 Expression and Response to Radiotherapy in Patients with Advanced Cervical Cancer.","authors":"Glauco Baiocchi, Maria Dirlei Begnami, Michael Jenwei Chen, Elza Mieko Fukazawa, Levon Badiglian-Filho, Antonio Cassio Assis Pellizzon, Fernando Augusto Soares, Ademar Lopes","doi":"","DOIUrl":"","url":null,"abstract":"Glauco Baiocchi, M.D., Ph.D., Maria Dirlei Begnami, M.D., Ph.D., Michael Jenwei Chen, M.D., Elza Mieko Fukazawa, M.D., Ph.D., Levon Badiglian-Filho, M.D., Ph.D., Antonio Cassio Assis Pellizzon, M.D., Ph.D., Fernando Augusto Soares, M.D., Ph.D., and Ademar Lopes, M.D., Ph.D. \u0000 OBJECTIVE: To evaluate HER-2 expression as a predictor of the response to radiotherapy and its value as a prognostic marker.\u0000\u0000STUDY DESIGN: A retrospective analysis was performed in a series of 34 individuals with advanced stage cervical cancer who underwent radiotherapy followed by radical hysterectomy. HER-2 expression was measured by immunohistochemistry in biopsies from all patients prior to radiotherapy and in 14 patients with residual tumors after radiotherapy. The presence of gene amplification was also examined.\u0000\u0000RESULTS: Eighteen (53%) patients had residual disease after radical hysterectomy. HER-2 was expressed in 26.5% of cases. Gene amplification by FISH was detected in 2.9% of cases. HER-2 expression was associated with a higher risk of residual disease after radiotherapy (p= 0.019). HER-2 expression did not correlate with the risk of recurrence or death.\u0000\u0000CONCLUSION: The prevalence of HER-2 expression is low in cervical cancer, and although HER-2 can predict the response to radiotherapy, it does not correlate with poor outcomes.","PeriodicalId":50063,"journal":{"name":"生殖医学杂志","volume":"62 5-6","pages":"234-40"},"PeriodicalIF":0.2,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36328281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 0.2 4区医学

生殖医学杂志 Pub Date : 2017-05-01

Sen-lin Shi, Zhao-feng Peng, Gui-dong Yao, Hai-xia Jin, Wen-yan Song, Hong-yi Yang, Ying-pu Sun

{"title":"Analysis of Related Causes for No Embryos Transferred and Corresponding Coping Measures in Assisted Reproductive Technology.","authors":"Sen-lin Shi, Zhao-feng Peng, Gui-dong Yao, Hai-xia Jin, Wen-yan Song, Hong-yi Yang, Ying-pu Sun","doi":"","DOIUrl":"","url":null,"abstract":"OBJECTIVE: To analyze the related causes for no embryos transferred in assisted reproductive technology (ART) in order to provide corresponding coping measures for infertile couples.\u0000\u0000STUDY DESIGN: The data of 607 couples who underwent ART and had no embryos transferred in our reproductive center between January 2010 and January 2014 were retrospectively analyzed.\u0000\u0000RESULTS: The cycles of no embryos transferred accounted for 3.99% (607/15,224) of total cycles. Of those, complete fertilization failure, oocyte retrieval failure, and complete abnormal fertilization accounted for 28.3% (172/607), 25.7% (156/607) and 22.24% (135/607), respectively. The incidence of complete abnormal fertilization was higher in IVF than in ICSI (p<0.05). In both IVF and ICSI cycles, the incidences of no embryos transferred were higher in the patients retrieving ≤3 oocytes than in the patients retrieving >3 oocytes (p<0.05). In IVF cycles the incidences of no embryos transferred were higher in the patients with primary infertility than in those with secondary infertility (p<0.05).\u0000\u0000CONCLUSION: The main causes of no embryos transferred are complete fertilization failure, oocyte retrieval failure, and complete abnormal fertilization. Retrieving adequate number of mature oocytes is the key to success of ART. Patients who experienced complete abnormal fertilization in IVF or the patients with primary infertility who experienced complete fertilization failure or normal fertilization without cleavage should receive ICSI in the next treatment.","PeriodicalId":50063,"journal":{"name":"生殖医学杂志","volume":"62 5-6","pages":"284-90"},"PeriodicalIF":0.2,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36326818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Gene Expression in Mice Testes Exposed to 1.765 GHz Microwave in Utero. 子宫内1.765 GHz微波对小鼠睾丸基因表达的影响。

IF 0.2 4区医学

生殖医学杂志 Pub Date : 2017-05-01

Ji Yeon Lee, Jong Yun Hwang

引用次数: 0

Initial hCG Levels in Ectopic Pregnancies After Embryo Transfer: Use of the Bayes Classifier for Risk Assessment. 胚胎移植后异位妊娠的初始hCG水平:使用贝叶斯分类器进行风险评估。

IF 0.2 4区医学

生殖医学杂志 Pub Date : 2017-05-01

Miriam S Krause, Kristine Holthouser, Jeremy T Gaskins, Henry C L Bohler, Steven T Nakajima

{"title":"Initial hCG Levels in Ectopic Pregnancies After Embryo Transfer: Use of the Bayes Classifier for Risk Assessment.","authors":"Miriam S Krause, Kristine Holthouser, Jeremy T Gaskins, Henry C L Bohler, Steven T Nakajima","doi":"","DOIUrl":"","url":null,"abstract":"OBJECTIVE: To determine whether the Bayes classifier can be used to distinguish between an ectopic and intrauterine pregnancy following embryo transfer based on early human chorionic gonadotropin (hCG) levels.\u0000\u0000STUDY DESIGN: Retrospective chart review of patients undergoing in vitro fertilization and diagnosed with a singleton intrauterine or with an ectopic pregnancy. Blood was drawn for hCG levels between days 12 and 20 after transvaginal oocyte aspiration. Statistical analysis was performed using a mixed effects model and the Bayes classifier.\u0000\u0000RESULTS: Singleton intrauterine (n=91) and ectopic gestations (n=14) were analyzed. hCG levels increased by 51% daily in both groups, but levels in ectopic pregnancies were only 14% of those from the control group on the same day (p<1×10-15). Using the Bayes classifier, an hCG value <18 IU/L indicated a large probability (>75%) that the pregnancy was ectopic. There was no statistically significant difference in regards to endometrial thickness (p=0.77), fresh or frozen embryo transfer (p=0.53), number of embryos transferred (p=0.13), donor or autologous oocytes (p=0.76), or the day of hCG draw (p=0.13 and 0.43 for first and second measurement).\u0000\u0000CONCLUSION: The Bayes classifier can be used as a tool to alert the healthcare provider of a possible ectopic gestation.","PeriodicalId":50063,"journal":{"name":"生殖医学杂志","volume":"62 5-6","pages":"257-64"},"PeriodicalIF":0.2,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36329638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histomorphometric Alterations Induced in the Testicular Tissues by Variable Sizes of Silver Nanoparticles. 不同大小的银纳米颗粒在睾丸组织中引起的组织形态学改变。

IF 0.2 4区医学

生殖医学杂志 Pub Date : 2017-05-01

Mansour Almansour, Qais Jarrar, Abdelkader Battah, Bashir Jarrar

引用次数: 0

Role of Capecitabine in the Management of Gestational Trophoblastic Neoplasia: A Drug for Two Settings. 卡培他滨在治疗妊娠滋养细胞瘤中的作用:两种情况下的药物。

IF 0.2 4区医学

生殖医学杂志 Pub Date : 2017-05-01

María Inés Bianconi, Silvina Otero, Claudio Storino, Gustavo Jankilevich

{"title":"Role of Capecitabine in the Management of Gestational Trophoblastic Neoplasia: A Drug for Two Settings.","authors":"María Inés Bianconi, Silvina Otero, Claudio Storino, Gustavo Jankilevich","doi":"","DOIUrl":"","url":null,"abstract":"OBJECTIVE: To evaluate the role of capecitabine in the management of gestational trophoblastic neoplasia (GTN).\u0000\u0000STUDY DESIGN: The medical records of 155 patients with GTN were reviewed. All patients were treated and followed at our center.\u0000\u0000RESULTS: All patients were scored and stratified with the FIGO 2000 staging and risk factor scoring system for gestational trophoblastic disease. In the low-risk group (118 patients), 4 selected patients received capecitabine as second line of treatment, with a 75% response rate and long-term disease-free survival, and 1 of those patients needed EMA/CO to achieve cure. The cure rate was 100%. In the high-risk group 37 patients were reviewed. Capecitabine was indicated after EMA/CO or EMA/PE failure in the second, third, or sixth line. Six patients received capecitabine, with a 50% response rate, and remain as long-term survivors. Two patients who progressed with capecitabine were cured with TP/TE and EMA/PE regimens. One patient was refractory to all lines of chemotherapy.\u0000\u0000CONCLUSION: The use of capecitabine avoids multi-ple drug schemes and further toxicity for patients with curative disease, where long-term effects of therapy should be considered a second target. Its convenient oral route of administration and efficacy make capecitabine a drug to be taken into account in future studies of patients with GTN showing progression to standard regimens. Its use as new regimen in these patients must be evaluated. A greater number of cases and ideally a randomized study is needed to confirm our observation.","PeriodicalId":50063,"journal":{"name":"生殖医学杂志","volume":"62 5-6","pages":"250-6"},"PeriodicalIF":0.2,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36326814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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