Journal of Research in Medical Sciences最新文献

{"title":"Evaluation of miR-146a as a potential biomarker for diagnosis of cardiotoxicity induced by chemotherapy in patients with breast cancer.","authors":"Nasrin Zare, Nasim Dana, Azam Mosayebi, Golnaz Vaseghi, Shaghayegh Haghjooy Javanmard","doi":"10.4103/jrms.jrms_840_22","DOIUrl":"10.4103/jrms.jrms_840_22","url":null,"abstract":"<p><strong>Background: </strong>Cardiotoxicity from chemotherapy may result in cardiomyopathy and heart failure. Clinicians can use the evaluation of cardiotoxicity-specific biomarkers, such as microRNA, as a tool for the early detection of cardiotoxicity. The study's objective was to assess miR-146a levels as a potential biomarker for the detection of cardiotoxicity brought on by chemotherapy in patients with breast cancer.</p><p><strong>Materials and methods: </strong>Using quantitative reverse transcription-polymerase chain reaction, the levels of miR-146a were assessed in the blood of 37 breast cancer patients receiving anthracyclines without cardiotoxicity and 33 breast cancer patients experiencing cardiotoxicity brought on by chemotherapy after chemotherapy. Left ventricular ejection fraction (LVEF) ≥50% was used to define heart failure by echocardiography.</p><p><strong>Results: </strong>MiR-146a did not show any significant difference in expression between these two study groups (P = 0.48, t-test). The expression level of miR-146a was not significantly associated with LVEF, age, and body mass index (P > 0.05), according to Pearson correlation.</p><p><strong>Conclusion: </strong>MiR-146a may be a diagnostic or prognostic biomarker for cardiotoxicity brought on by chemotherapy, even though there was no discernible difference in the expression level of miR-146a between the control group and the breast cancer patients who were experiencing this side effect of chemotherapy. Therefore, miR-146a expression needs to be examined in a sizable cohort of breast cancer patients who are experiencing cardiotoxicity brought on by chemotherapy.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"4"},"PeriodicalIF":1.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The alarming rise of lifestyle diseases and their impact on public health: A comprehensive overview and strategies for overcoming the epidemic.","authors":"Ram Kumar Garg","doi":"10.4103/jrms.jrms_54_24","DOIUrl":"10.4103/jrms.jrms_54_24","url":null,"abstract":"<p><p>The rising prevalence of lifestyle diseases, including cardiovascular conditions, diabetes, obesity, and mental health disorders, poses a significant threat to global health. The aim of the study is to highlight the impact of sedentary lifestyles, poor diets, and chronic stress on individuals and communities. It advocates for comprehensive strategies involving public health policies, education, and community engagement. Overcoming challenges through lifestyle modifications and policy interventions is crucial. The study also discusses successful global interventions and their application in low-resource settings to combat lifestyle diseases and improve public health. Lifestyle diseases pose a serious global health threat. Urgent action is needed to address sedentary lifestyles, poor diets, and chronic stress. Coordinated efforts through policy, education, and community engagement are crucial. Promoting healthy habits and leveraging global interventions can lead to significant progress. Collaboration among stakeholders is essential for improving global well-being.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"1"},"PeriodicalIF":1.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of cardiac troponin I level with in-hospital and late mortality in dialysis patients.","authors":"Shahram Taheri, Golbarg Ghomi, Alireza Nematollahi, Sayed Mohsen Hosseini","doi":"10.4103/jrms.jrms_658_23","DOIUrl":"10.4103/jrms.jrms_658_23","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular diseases (CVDs) are highly prevalent among the end-stage renal disease (ESRD) patients. Prognostic value of cardiac troponin I (cTnI) in patients with asymptomatic ESRD is less conclusive. This study was an observational study to evaluate correlation of first admitted cTnI level with early and late (during 6 months) hospitalization and mortality of ESRD patient admitted due to non-acute coronary and non-heart failure causes in ESRD patients.</p><p><strong>Materials and methods: </strong>In this prospective observational study, 460 dialysis patients without overt CVD who were admitted at two university hospital were included and followed during 6 months. Patients' demographic information and laboratory investigations including cTnI level and cause of admission were recorded. The association between cTnI level with in-hospital and late mortality was evaluated.</p><p><strong>Results: </strong>cTnI level was higher in female (35.9%), hemodialysis patients (28.1%), and patients with permanent catheter vascular access (29.4%). There were significant differences in level of triglyceride (TG), low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol between patients with normal and abnormal cTnI levels (<i>P</i> < 0.05). Patients with abnormal cTnI levels had higher level of TG and LDL cholesterol and lower level of HDL cholesterol. cTnI levels were associated with higher in-hospital and 6-month follow-up mortality rate. In logistic regression analysis, only female gender (odds ratio [OR] =1.89, confidence interval [CI] =1.22-3.076) and TG (OR = 1.007, CI = 1.003-1.01) were positively and HDL cholesterol level (OR = 0.994, CI = 0.98-0.99) was negatively associated with increased cTnI level. cTnI level was associated with early (OR = 4.81, CI = 1.64-14.89) and late (OR = 4.31, CI = 1.61-10.96) mortality.</p><p><strong>Conclusion: </strong>Although in this study, cTnI level is not directly associated with cardiovascular disorders and admission and readmission causes, it is a strong predictor of early and late mortality.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"8"},"PeriodicalIF":1.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the impact of intermittent fasting diet alone or in conjunction with probiotic supplementation versus calorie-restricted diet on inflammatory, oxidative stress, and antioxidant capacity biomarkers in women with polycystic ovary syndrome: A randomized placebo-controlled trial.","authors":"Sepide Talebi, Sakineh Shab-Bidar, Gholamreza Askari, Hamed Mohammadi, Ashraf Moini, Kurosh Djafarian","doi":"10.4103/jrms.jrms_280_24","DOIUrl":"10.4103/jrms.jrms_280_24","url":null,"abstract":"<p><strong>Background: </strong>The objective of this study was to compare the effects of early time-restricted eating (eTRE) and eTRE plus probiotic supplementation to daily caloric restriction (DCR) alone in terms of biomarkers of oxidative stress (OS), antioxidant capacity, inflammation, and blood pressure (BP) in obese women with polycystic ovary syndrome (PCOS).</p><p><strong>Materials and methods: </strong>The research was conducted as a randomized, parallel, placebo-controlled clinical trial with an 8-week follow-up period. Participants were randomly assigned to one of three groups: 14:10 eTRE with probiotic supplementation (<i>n</i> = 30), 14:10 eTRE with placebo supplementation (<i>n</i> = 30), or DCR with placebo supplementation (<i>n</i> = 30). At the beginning and 8 weeks of the intervention, systolic blood pressure (SBP) and diastolic BP, inflammation, and OS parameters were evaluated.</p><p><strong>Results: </strong>A total of 90 participants (mean age, 30.49 years and mean weight, 81.45 kg) were enrolled in this trial. After 8-week intervention, we observed SBP significantly decreased in both the eTRE + probiotic group (-0.31 mmHg [95% confidence interval (CI): -0.55, -0.07]) and the eTRE + placebo group (-0.24 mmHg [95% CI: -0.43, 0.04]), with no significant differences observed between groups. Moreover, C-reactive protein (CRP) levels were significantly reduced in all groups (<i>P</i> < 0.005). Total antioxidant capacity (TAC) also showed notable improvement in both the eTRE + probiotic group (<i>P</i> = 0.012) and the DCR group (<i>P</i> = 0.032). However, there were no significant differences between the three groups regarding BP, OS, TAC, and CRP markers.</p><p><strong>Conclusion: </strong>It was not found that eTRE alone or eTRE with probiotics intervention resulted in improving BP, inflammatory, OS, and antioxidant capacity biomarkers than a standard DCR diet among obese women with PCOS. The present study did not reveal significant improvements in BP, inflammatory markers, OS, or antioxidant capacity with either eTRE alone or eTRE combined with probiotics compared to a standard DCR among obese women diagnosed with PCOS.Trial Register no: IRCT20121110011421N5.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"5"},"PeriodicalIF":1.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of common COL2A1 gene variants in Iranian patients suspected with Stickler syndrome type I.","authors":"Fatemeh Abolhasani, Hossein Abdali, Mohammad Kazemi, Bijan Movahedian Attar, Fatemeh Derakhshandeh, Majid Hosseinzadeh","doi":"10.4103/jrms.jrms_447_24","DOIUrl":"10.4103/jrms.jrms_447_24","url":null,"abstract":"<p><strong>Background: </strong>Stickler syndrome, also known as hereditary progressive arthro-ophthalmopathy, is a connective tissue disorder that arises from mutations in multiple genes, each with distinct hereditary patterns. Stickler syndrome type I, which is inherited in an autosomal dominant manner, is specifically linked to mutations in the <i>COL2A1</i> gene. The objective of this study is to investigate the prevalence of common variants of the <i>COL2A1</i> gene among individuals suspected of having Stickler syndrome type I.</p><p><strong>Materials and methods: </strong>Twenty-six Iranian patients suspected of having Stickler syndrome type I referring to Al-Zahra Hospital of Isfahan were employed in this cross-sectional study. The DNA was extracted from the patient's peripheral blood samples, and the selected exons of the <i>COL2A1</i> gene were amplified by polymerase chain reaction. Subsequently, the purified amplicons were subjected to Sanger sequencing to identify common variants associated with Stickler syndrome type I.</p><p><strong>Results: </strong>All patients exhibit cleft abnormalities (palate, lip, and alveolar), 84.6% of patients exhibit ocular abnormalities, 53.8% of patients exhibit hearing abnormalities, and 34.6% of patients exhibit skeletal abnormalities. As the data displays, the highest phenotype presentation prevalence rate was related to cleft lip and palate, while hemiparesis was the lowest clinical finding among the patients. Molecular analysis which conducted to screen the <i>COL2A1</i> gene of patients, identified two different variants, including a novel nonsense variant, (c.1030C>T), consistent with dominantly inherited Stickler syndrome type I, also synonymous mutation (c.213C>T) affecting in exon 2, which have been reported in database.</p><p><strong>Conclusion: </strong>Genetic analysis of Twenty-six unrelated families with Stickler syndrome type I disorder discovered one novel pathogenic variant in the <i>COL2A1</i> gene in a patient with Stickler syndrome type I. Genetic analysis is helpful for the diagnosis of this clinically variable and genetically heterogeneous disorder.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"6"},"PeriodicalIF":1.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Editor: Serum zinc levels in hemodialysis and peritoneal dialysis patients: A retrospective observational study.","authors":"Mehdi Nematbakhsh","doi":"10.4103/jrms.jrms_587_24","DOIUrl":"10.4103/jrms.jrms_587_24","url":null,"abstract":"","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"3"},"PeriodicalIF":1.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of traumatic liver injury on computed tomography using machine learning algorithms and radiomics features: The role of artificial intelligence for rapid diagnosis in emergency rooms.","authors":"Hanieh Alimiri Dehbaghi, Karim Khoshgard, Hamid Sharini, Samira Jafari Khairabadi","doi":"10.4103/jrms.jrms_847_23","DOIUrl":"10.4103/jrms.jrms_847_23","url":null,"abstract":"<p><strong>Background: </strong>The initial assessment of trauma is a time-consuming and challenging task. The purpose of this research is to examine the diagnostic effectiveness and usefulness of machine learning models paired with radiomics features to identify blunt traumatic liver injury in abdominal computed tomography (CT) images.</p><p><strong>Materials and methods: </strong>In this study, 600 CT scan images of people with mild and severe liver damage due to trauma and healthy people were collected from the Kaggle dataset. The axial images were segmented by an experienced radiologist, and radiomics features were extracted from each region of interest. Initially, 30 machine learning models were implemented, and finally, three machine learning models were selected including Light Gradient-Boosting Machine (LGBM), Ridge Classifier, and Extreme Gradient Boosting (XGBoost), and their performance was examined in more detail.</p><p><strong>Results: </strong>The two criteria of precision and specificity of LGBM and XGBoost models in diagnosing mild liver injury were calculated to be 100%. Only 6.00% of cases were misdiagnosed by the LGBM model. The LGBM model achieved 100% sensitivity and 99.00% accuracy in diagnosing severe liver injury. The area under the receiver operating characteristic curve value and precision of this model were also calculated to be 99.00% and 98.00%, respectively.</p><p><strong>Conclusion: </strong>The artificial intelligence models used in this study have great potential to improve patient care by assisting radiologists and other physicians in diagnosing and staging trauma-related liver injuries. These models can help prioritize positive studies, allow more rapid evaluation, and identify more severe injuries that may require immediate intervention.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"29 ","pages":"77"},"PeriodicalIF":1.5,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between alcohol consumption and sleep difficulty in a nationwide Korean survey.","authors":"In Cheol Hwang, Yujin Park, Hong Yup Ahn, Kwan Jung Kim, So-Jung Park","doi":"10.4103/jrms.jrms_805_23","DOIUrl":"10.4103/jrms.jrms_805_23","url":null,"abstract":"<p><strong>Background: </strong>The data on the association between alcohol intake and sleep quality in a community-based setting are lacking. This study examined overall sleep difficulty according to alcohol habits among Korean adults.</p><p><strong>Materials and methods: </strong>We analyzed data from 4937 adults who responded to questions about sleep difficulty and drinking habits from the 2019 Korea National Health and Nutrition Examination Survey. Multivariate logistic regression analyses were used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for substantial sleep difficulty based on the frequency or amount of alcohol consumption in total and age- and sex-stratified subgroup analyses.</p><p><strong>Results: </strong>Approximately 8.5% of the study population had substantial sleep difficulty. Individuals who drank <1 per week (frequency) or 1-2 cups per time (amount) had the lowest prevalence of substantial sleep difficulty, even compared with nondrinkers. Among drinkers, the association between alcohol use and sleep difficulty was significant in a dose-dependent manner (<i>P</i> for trend: 0.003 in frequency and < 0.001 in amount). Subgroup analysis revealed that significant linear relationships were robust for adults aged <50 years ([ORs] 1.20 [95% CIs 1.03-1.40] for frequency and 1.25 [1.10-1.42] for amount) and females (1.26 [1.10-1.44] for amount).</p><p><strong>Conclusion: </strong>Alcohol consumption is associated with increased sleep difficulties, especially in younger adults and women, underscoring the need for targeted interventions and in-depth research on the effects of alcohol on sleep.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"29 ","pages":"73"},"PeriodicalIF":1.5,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of gemstone spectral imaging for chemotherapy response in colorectal cancer liver metastases: A retrospective study.","authors":"Hou-Fa Ning, Yun-Long Qin, Kui-Tao Yue, Shuai Wang, Wei-Guang Shao, Guang-Zhi Wang","doi":"10.4103/jrms.jrms_630_23","DOIUrl":"10.4103/jrms.jrms_630_23","url":null,"abstract":"<p><strong>Background: </strong>Accurate and timely assessment of tumor response after chemotherapy is crucial in clinical settings. The aim of this study was to explore the feasibility of Gemstone Spectral Imaging (GSI) for early assessment of chemotherapy responses in patients with colorectal cancer liver metastasis (CRCLM).</p><p><strong>Materials and methods: </strong>From October 2012 to October 2018, 46 patients (28 males and 18 females) with CRCLM received GSI followed by chemotherapy were retrospectively reviewed. The patients were divided into a response group (<i>n</i> = 32) and a nonresponse group (<i>n</i> = 14) according to the tumor response to chemotherapy. The iodine concentration images and virtual monoenergetic images (VMIs) with an optimal contrast-to-noise ratio at the arterial phase (AP) and portal venous phase (PVP) were obtained by GSI viewer. The iodine concentration value and computed tomography (CT) value on VMIs and slope of spectral attenuation curves of all lesions were compared. A logistic regression analysis was used to determine the predictor of chemotherapy response.</p><p><strong>Results: </strong>The difference of extrahepatic metastasis (<i>P</i> = 0.001), CT value on 68 keV VMIs at the AP (<i>P</i> = 0.005) and PVP (<i>P</i> = 0.001), slope of CT value attenuation curves at the AP (<i>P</i> = 0.013) and PVP (<i>P</i> = 0.001), and iodine concentration value at PVP (<i>P</i> = 0.003) between the response and nonresponse groups were statistically significant. The CT value of the 68 keV VMIs (OR: 1.206; 95% confidence interval [CI]: 1.021-1.425, <i>P</i> = 0.027) and the iodine concentration value at PVP (OR: 1.952; 95% CI: 1.034-3.684, <i>P</i> = 0.039) were independent prognostic factors for predicting chemotherapy response.</p><p><strong>Conclusion: </strong>Baseline GSI may help predict the response to chemotherapy and provide a good tumor-response indicator through single-energy CT value of 68 keV at the PVP and iodine concentration.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"29 ","pages":"76"},"PeriodicalIF":1.5,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persian medicine's novel approach: Cholagogue laxatives in the treatment of cutaneous leishmaniasis.","authors":"Mehdi Shafiei-Bafti, Maryam Taghavi-Shirazi, Iraj Sharifi, Farzane Safa","doi":"10.4103/jrms.jrms_364_24","DOIUrl":"10.4103/jrms.jrms_364_24","url":null,"abstract":"","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"29 ","pages":"78"},"PeriodicalIF":1.5,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}