Journal of Research in Medical Sciences最新文献

{"title":"Epidemiology of malaria in saravan city and its suburbs from 2018 to 2023, Southeast Iran.","authors":"Shaghayegh Dabirzadeh, Hamidaldin Bayegan, Mahdi Rezaei Kahkhazhaleh, Mansour Dabirzadeh","doi":"10.4103/jrms.jrms_781_23","DOIUrl":"https://doi.org/10.4103/jrms.jrms_781_23","url":null,"abstract":"<p><strong>Background: </strong>Malaria, transmitted by <i>Plasmodium</i> parasites and anopheline mosquitoes, continues to be a leading cause of global disease and death. This retrospective investigation from 2018 to 2023 examines the epidemiological attributes of malaria in Saravan, southeastern Iran. It seeks to evaluate the prevalence, transmission causes, local population impact, and health system effects.</p><p><strong>Materials and methods: </strong>Blood samples from suspected malaria cases in Saravan health centers were collected for this analysis. Each positive case was detailed with demographic data in a questionnaire. The SPSS 26 statistical program scrutinized data with <i>t</i>-tests comparing the variables.</p><p><strong>Results: </strong>The study indicated fluctuating malaria cases peaking in 2023, with an annual parasite incidence. (API) of 17.27. <i>Plasmodium vivax</i> was the predominant species (<i>P</i> < 0.001), with the majority of cases in individuals over 15, notably males. A significant number of cases were reported in September (20.7%).</p><p><strong>Conclusion: </strong>The findings emphasize the persistent malaria challenges in Saravan, accentuating the urgent need to strengthen prevention and control strategies. Reducing disease burden demands focused approaches, including improving prevention and treatment programs, enhancing surveillance systems, developing health infrastructures, and implementing localized therapies, especially considering recent climatic and rainfall patterns.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"29 ","pages":"50"},"PeriodicalIF":1.5,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11472872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of cardiovascular risk factors in diabetic and nondiabetic patients with nonalcoholic fatty liver disease.","authors":"Mona Barati, Azam Teimouri, Awat Feizi, Bijan Iraj, Mozhgan Karimifar","doi":"10.4103/jrms.jrms_830_23","DOIUrl":"https://doi.org/10.4103/jrms.jrms_830_23","url":null,"abstract":"<p><strong>Background: </strong>The current study aims to assess cardiovascular risk factors (CVRFs) among diabetic versus nondiabetic nonalcoholic fatty liver disease (NAFLD) patients. NAFLD is the most common hepatic disorder worldwide which is directly associated with diverse CVRFs such as type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS).</p><p><strong>Materials and methods: </strong>The current cross-sectional population-based study has been conducted on 1031 NAFLD patients. After excluding 340 prediabetes patients, the NAFLD patients were divided into T2DM and normal blood glucose (NBG). Then, CVRFs were compared between the two groups.</p><p><strong>Results: </strong>Out of 691 NAFLD cases included in the study, 337 (48.8%) patients had T2DM. In the T2DM and NBG groups, the body mass index (BMI) was 31.2 ± 4.6 and 29.9 ± 4.3 kg/m2, respectively (P = 0.001). The waist circumference was 102.2 ± 10.2 and 97.6 ± 10.6 cm, respectively (P < 0.001). The systolic blood pressure was 123.3 ± 15.6 and 119.6 ± 13.6 mmHg, respectively (P = 0.043). The triglyceride levels were 191.9 ± 104.7 and 176.5 ± 89.6 mg/dL, respectively (P = 0.042). Generally, these factors were significantly higher among the diabetic patients. Besides, cardiovascular disease (CVD), hypertension, and MS were statistically more prevalent in NAFLD patients with T2DM (<i>P</i> < 0.001) than nondiabetic NAFLD patients. In multiple logistic regression models, the odds ratio of CVD, hypertension, and MS was 2.18, 2.12, and 6.63 for patients with T2DM compared with NBG, respectively. Adjustment was made for age, sex, BMI, smoking, and physical activity.</p><p><strong>Conclusion: </strong>CVRFs were higher in NAFLD patients with T2DM than NAFLD patients with NBG.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"29 ","pages":"51"},"PeriodicalIF":1.5,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11472873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The STOP-BANG score and lung function in a general population.","authors":"In Cheol Hwang, Hong Yup Ahn, Yujin Park, Young Sung Kim","doi":"10.4103/jrms.jrms_814_23","DOIUrl":"https://doi.org/10.4103/jrms.jrms_814_23","url":null,"abstract":"<p><strong>Background: </strong>Obstructive sleep apnea (OSA) commonly coexists with lung disease. However, the association between OSA components and lung function remains unclear. This study estimated STOP-BANG scores according to lung function using nationwide Korean data.</p><p><strong>Materials and methods: </strong>Three thousand and two hundred eighty adults with available STOP-BANG scores and spirometry data were analyzed. Multivariate regression models were applied to estimate STOP-BANG scores according to lung function.</p><p><strong>Results: </strong>Approximately 28% of participants had abnormal lung function, and the characteristics were diverse. The significant factors associated with abnormal lung function included the STOP-BANG score. In multivariate regression analyses, individuals with abnormal lung function had significantly higher STOP-BANG scores than those with normal lung function (odds ratio: 1.19; 95% confidence interval: 1.10- 1.29; <i>P</i> < 0.001), and this difference was remarkable in men.</p><p><strong>Conclusion: </strong>Our results suggest that screening and management of OSA components are warranted to prevent impaired lung function.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"29 ","pages":"52"},"PeriodicalIF":1.5,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11472869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multistate survival model in rectal cancer surgery research for locally advanced patients.","authors":"Fatemeh Shahabi, Abbas Abdollahi, Mahboobeh Rasouli","doi":"10.4103/jrms.jrms_95_23","DOIUrl":"https://doi.org/10.4103/jrms.jrms_95_23","url":null,"abstract":"<p><strong>Background: </strong>One of the most appropriate methods for analyzing longitudinal data is multistate model. This study has aimed to evaluate the risk factors of transfer to local recurrence (LR), distant metastasis (DM), and death in rectal cancer patients through multistate survival analysis.</p><p><strong>Materials and methods: </strong>This is a retrospective cohort of rectal cancer patients in Mashhad, Iran. Multistate models were applied to show the difference between the significant risk factors affecting death and recurrence in different defined transitions. Risk factors include age, sex, primary surgical technique, tumor location, postoperative tumor stage, circumferential or distal resection involvement, surgery time, and surgical complications.</p><p><strong>Results: </strong>A total of 280 eligible patients with a median (interquartile range) survival time of 60 (42-76.2) months were investigated. Based on Cox proportional multistate model, the hazard ratio (HR) of DM increases by 3%/1-year increase in age (<i>P</i> = 0.018). The HR of DM and the HR of LR in patients with postoperative disease Stage II/III were 3.06 and 2.53 times higher than patients with cancer Stage 0/I (<i>P</i> < 0.05). When the resection margins of distal or circumferential were involved, the HR of DM was 3.58 times higher than those patients without involvement. In the extended multistate model, time of DM was a significant predictor of death (<i>P</i> = 0.006).</p><p><strong>Conclusion: </strong>Age and margin involvement in DM path and stage in LR and DM path had a significant effect; however, no effective variable was seen on the death of patients with recurrence. The time of metastasis also had an effect on the path of death.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"29 ","pages":"54"},"PeriodicalIF":1.5,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11472875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethical guidelines for human research on children and adolescents: A narrative review study.","authors":"Gholamreza Askari, Mahdi Vajdi, Saeede Jafari-Nasab, Sahar Golpour-Hamedani","doi":"10.4103/jrms.jrms_610_23","DOIUrl":"https://doi.org/10.4103/jrms.jrms_610_23","url":null,"abstract":"<p><p>The implementation of human research involving children and adolescents necessitates a nuanced understanding of the distinct ethical complexities and sensitivities that arise. This study aimed to conduct a comprehensive review of ethical guidelines for research with these populations by extensively examining existing standards and applied studies. The review revealed a myriad of challenges inherent in the involvement of children and adolescents as research subjects. The most important ethical challenges relate to the principles of bioethics and their compliance with human studies involving children/adolescents, informed consent, and risk assessment in studies on children/adolescents. To facilitate appropriate participation of youth in research endeavors, meticulous planning is required, in conjunction with a re-examination of the definitions of ethical principles in pediatric research, close monitoring of potential risks and benefits, and the utilization of a combination of innovative and traditional approaches to obtain informed consent that adheres to ethical standards. Performing research with children and adolescents requires special considerations to address the unique ethical issues that can emerge. By adhering to ethical guidelines tailored specifically to these vulnerable populations, researchers can help ensure that studies are conducted in an appropriate and responsible manner.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"29 ","pages":"53"},"PeriodicalIF":1.5,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11472871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the new modified apnea test in confirmation of brain death.","authors":"Parviz Kashefi, Saeed Abbasi, Koosha Kiani, Maryam Khalifehsoltani Khajoei, Mojtaba Akbari","doi":"10.4103/jrms.jrms_913_22","DOIUrl":"https://doi.org/10.4103/jrms.jrms_913_22","url":null,"abstract":"<p><strong>Background: </strong>Apnea testing is mandatory to confirm brain death; however, it is unsafe for patients who have substantial hypoxemia without ventilator support. We used a new modified apnea test without the need to disconnect the patient from the ventilator in the present study and compared the outcomes and complications of the new method to the widely used old method.</p><p><strong>Materials and methods: </strong>The current study was conducted on people suspected of having brain death. Both the old and new apnea tests were carried out on the same individual. In the new modified method, instead of hyperventilating and then separating the brain death from the ventilator, the induced hypercapnia method was used, and instead of performing repeated arterial blood gas (ABG), the target ETCO₂ was obtained, and at the time of the target ETCO₂, ABG was also checked followed by comparing ETCO₂ with PaCO₂.</p><p><strong>Results: </strong>Thirty patients, including 25 (83.3%) males and 5 (16.75%) females, were included in the study. The results showed significant improvement in terms of O₂ saturation and heart rate (HR) using the new modified apnea test compared to the common test. Systolic blood pressure, diastolic blood pressure, and the frequency of complications were improved in the new modified test.</p><p><strong>Conclusion: </strong>The modified apnea test produced better results in terms of O₂ saturation, HR, and other clinical factors, while it does not require disconnection from the ventilator and repeated ABG assessment. Therefore, it can be used to successfully diagnose brain death in high-risk individuals suffering from severe hypoxia.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"29 ","pages":"48"},"PeriodicalIF":1.5,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11472870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of laparoscopic pneumoperitoneum on patient's respiratory variation of inferior vena cava and stroke volume index: A randomized controlled study.","authors":"Dawei Liu, Jingfei Sun, Kun Chen, Yanfeng Yao, Fan Zhang","doi":"10.4103/jrms.jrms_526_22","DOIUrl":"https://doi.org/10.4103/jrms.jrms_526_22","url":null,"abstract":"<p><strong>Background: </strong>The establishment of pneumoperitoneum has impacts on patient's cardiovascular function. In this study, the respiratory variation of inferior vena cava (IVC), stroke volume (SV) index, and other parameters was monitored to determine how the pneumoperitoneum affects the patient's hemodynamic and acknowledge how to resolve it.</p><p><strong>Materials and methods: </strong>Fifty-five patients were randomly divided into Group A (8 mmHg), Group B (10 mmHg), Group C (12 mmHg), Group D (14 mmHg), and Group E (12 mmHg, infusion with 7 mL/kg crystalloid solution). The parameters including IVC variability, SV index, mean artery pressure (MAP), heart rate (HR), cardiac output index (CI), and airway pressure were measured, to compare the changes before and after pneumoperitoneum.</p><p><strong>Results: </strong>Among Group A, Group B, Group C, and Group D, there were no significant differences in patients' prepneumoperitoneum information. Compare with prepneumoperitoneum, the difference in IVC variability, SV index, MAP, HR, CI, and airway pressure was statistically significant (<i>P</i> < 0.05). After the establishment of pneumoperitoneum, the difference in IVC variability, SV index, and airway pressure among Group A, Group B, Group C, and Group D was statistically significant (<i>P</i> < 0.05). Compare with Group C, the change rates of IVC variability, SV index, MAP, HR, and CI were smaller in Group E (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>The establishment of pneumoperitoneum could increase the patient's IVC variability and reduce SV index, and with the increase of pressure, IVC variability had an increasing trend, SV index had a decreasing trend. Fluid transfusion could reduce the relative influence of the pneumoperitoneum.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"29 ","pages":"46"},"PeriodicalIF":1.5,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The predictive value of neutrophil-lymphocyte ratio combined with the Global Registry of Acute Coronary Events score for inhospital adverse cardiovascular events in patients with acute ST-elevation myocardial infarction.","authors":"Caoyang Fang, Zhenfei Chen, Jing Zhang, Xiaoqin Jin, Mengsi Yang","doi":"10.4103/jrms.jrms_485_22","DOIUrl":"https://doi.org/10.4103/jrms.jrms_485_22","url":null,"abstract":"<p><strong>Background: </strong>The research explores the predictive efficacy of the neutrophil-to-lymphocyte ratio (NLR) in conjunction with the Global Registry of Acute Coronary Events (GRACEs) score for inhospital major adverse cardiovascular events (MACEs) among acute ST-segment elevation myocardial infarction (STEMI) subjects with primary percutaneous coronary intervention (PCI) history.</p><p><strong>Materials and methods: </strong>Patients were categorized into MACE (<i>n</i> = 58) and non-MACE cohorts (<i>n</i> = 184) based on MACE occurrence events during hospitalization. The predictive value of the NLR, GRACE score, and their combination for inhospital MACE events in STEMI subjects was assessed by the receiver operating characteristic curve (ROC).</p><p><strong>Results: </strong>NLR (8.99 [5.06, 12.01] vs. 5.15 [3.13, 7.66]) and GRACE scores (159.62 ± 43.39 vs. 116.96 ± 28.15) within MACE group notably surpassed the non-MACE group (<i>P</i> < 0.05). ROC curve analysis demonstrated that the area under the curve (AUC) for NLR in forecasting inhospital MACE events was 0. 72 (95% confidence interval [CI]: 0.645-0.795), with 0.655 sensitivity and 0.723 specificity, and optimal cutoff value as 7.01. The AUC for the GRACE score was 0.791 (95% CI: 0.717-0.865), with 0.862 sensitivity and 0.598 specificity, and the optimal cutoff value was 121.5. The combined AUC of NLR and GRACE score was 0.814 (95% CI: 0.745-0.884), with 0.707 sensitivity and 0.837 specificity.</p><p><strong>Conclusion: </strong>Both NLR and GRACE score independently predict inhospital MACE events in STEMI patients post-PCI. Integration of the NLR and GRACE score enhances accuracy in forecasting inhospital MACE event occurrences.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"29 ","pages":"41"},"PeriodicalIF":1.5,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regenerative mechanisms of stem cells and their clinical applications for degenerative eye diseases.","authors":"Baodong Zhang, Shusong Gao, Shibo Liu, Xuewu Gong, Jing Wu, Yu Zhang, Li Ma, Lijie Sheng","doi":"10.4103/jrms.jrms_358_23","DOIUrl":"https://doi.org/10.4103/jrms.jrms_358_23","url":null,"abstract":"<p><p>There are different types of treatment for eye diseases. Although the majority of eye diseases are curable with primary treatments and surgery, some of degenerative eye damages need regeneration that is not gained by conventional procedures. Stem cells, such as mesenchymal stem cells, human embryonic stem cell-derived retinal pigmented epithelium, and inducible pluripotent stem cells, are now considered one of the most important and safe methods for regeneration of various damaged tissues or organs. However, how will stem cell therapy contribute to regeneration and overcome degenerative eye diseases? This review discusses the regenerative mechanisms, clinical applications, and advantages of different types of stem cells for restoring degenerative eye diseases.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"29 ","pages":"42"},"PeriodicalIF":1.5,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of diagnostic performance between diffusion models parameters and mono-exponential apparent diffusion coefficient in patients with prostate cancer: A systematic review and meta-analysis.","authors":"Hamide Nematollahi, Mohammad Reza Maracy, Masoud Moslehi, Daryoush Shahbazi-Gahrouei","doi":"10.4103/jrms.jrms_359_23","DOIUrl":"https://doi.org/10.4103/jrms.jrms_359_23","url":null,"abstract":"<p><strong>Background: </strong>The importance of diffusion in prostate cancer (PCa) diagnosis has been widely proven. Several studies investigated diffusion models in PCa diagnosis.</p><p><strong>Materials and methods: </strong>This systematic review and meta-analysis study was performed to evaluate the ability of three diffusion models to diagnose PCa from the scientific electronic databases Embase, PubMed, Scopus, and Web of Science (ISI) for the period up to March 2022 to identify all relevant articles.</p><p><strong>Results: </strong>Eighteen studies were included in the systematic review section (7 diffusion kurtosis imaging [DKI] studies, 4 diffusion tensor imaging [DTI] studies, 4 intravoxel incoherent motion [IVIM] studies, and 3 IVIM-DKI studies). Pooled sensitivity, specificity, accuracy, and summary area under each diffusion model's curve (AUC) and 95% confidence intervals (CIs) were calculated. The pooled accuracy and 95% CI on detection (differentiation of tumor from normal tissue and benign prostatic hyperplasia/prostatitis) were obtained for apparent diffusion coefficient (ADC) at 87.97% (84.56%-91.38%) for DKI parameters (Gaussian diffusion [DK] 87.94% [78.71%-97.16%] and deviation from Gaussian diffusion [K] 86.84% [81.83%-91.85%]) and IVIM parameters (true molecular diffusion [DIVIM] 81.73% [72.54%-90.91%], perfusion-related diffusion [D*] 65% [48.47%-81.53%] and perfusion fraction [f] 80.36% [64.23%-96.48%]). The AUC values and 95% CI in the detection of PCa were obtained for ADC at 0.95 (0.92-0.97), for DKI parameters (DK 0.94 [0.89-0.99] and K 0.93 [0.90-0.96]) and for IVIM parameters (DIVIM 0.85 [0.80-0.91], D* 0.60 [0.43-0.77] and f 0.73 [0.63-0.84]). Two studies showed that the DTI accuracy values were 97.34% and 85%. For IVIM-kurtosis model in PCa detection, two studies stated that the DIVIM-K and KIVIM-K accuracy values were 85% and 84.44% (the pooled accuracy; 84.64% with 95% CI 75.78%-93.50%), and 72.50% and 71.11% (the pooled accuracy, 72.10% with 95% CI 64.73%-79.48%), respectively.</p><p><strong>Conclusion: </strong>Our findings showed that among the DKI, IVIM, and ADC parameters, it seems that ADC, Dk, DIVIM, and K are the most important, which can be used as an indicator to distinguish PCa from normal tissue. The DKI model probably has a higher ability to detect PCa from normal tissue than the IVIM model. DKI probably has the same diagnostic performance in PCa detection and grading compared to diffusion-weighted imaging and ADC.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"29 ","pages":"43"},"PeriodicalIF":1.5,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}