Journal of the American Society of Echocardiography最新文献

{"title":"Association of Impaired Relaxation Mitral Inflow Pattern (Grade 1 Diastolic Function) With Long-Term Noncardiovascular and Cardiovascular Mortality","authors":"Kathleen A. Young MD,&nbsp;Richard J. Rodeheffer MD,&nbsp;Jared G. Bird MD,&nbsp;William R. Miranda MD,&nbsp;Horng H. Chen MB, BCh,&nbsp;Jae K. Oh MD,&nbsp;Garvan C. Kane MD, PhD","doi":"10.1016/j.echo.2025.01.005","DOIUrl":"10.1016/j.echo.2025.01.005","url":null,"abstract":"<div><h3>Background</h3><div>Abnormalities of left ventricular diastolic function are established independent predictors of heart failure and mortality. The aim of this study was to determine whether the association of diastolic function with all-cause mortality is driven by cardiovascular or noncardiovascular death and if impaired relaxation mitral inflow filling pattern is a risk marker.</div></div><div><h3>Methods</h3><div>Diastolic function was graded by the Mayo Clinic algorithm using the well-characterized prospective Olmsted County Heart Function Study. Those with reduced left ventricular ejection fraction, moderate or greater valve disease, clinical diagnosis of heart failure, or indeterminate diastolic function were excluded. Notably, all patients with an impaired relaxation pattern (E/A ratio &lt; 0.8) were classified as abnormal (grade 1) regardless of ejection fraction and clinical or other echocardiographic abnormalities. Individuals were followed for a median of 19.7 years (interquartile range, 18.9-20.6 years) for mortality outcomes.</div></div><div><h3>Results</h3><div>In a community cohort of 1,005 subjects 63 years (interquartile range, 57-71 years) of age, grade 1 diastolic function was common (26%) and associated with all-cause mortality (hazard ratio [HR], 4.05; 95% CI, 3.22-5.09; <em>P</em> &lt; .0001). This association persisted in a subgroup of those with impaired myocardial relaxation and no other clinical or echocardiographic abnormalities (HR, 2.71; 95% CI, 1.89-3.88; <em>P</em> &lt; .0001). The association of diastolic function with noncardiovascular death was not significant after adjustment for age, sex, and comorbidities, though there was an association with grade 1 diastolic function and risk for death of dementia (age- and sex-adjusted HR, 2.30; 95% CI, 1.54-3.45; <em>P</em> &lt; .001). The association of diastolic function and cardiovascular mortality persisted in multivariable model, including for grade 1 diastolic function (HR, 2.43; 95% CI, 1.16-5.05; <em>P</em> = .02).</div></div><div><h3>Conclusions</h3><div>Impaired relaxation mitral inflow pattern (grade 1) is common in older adults in the community and found to be associated with cause-specific death, highlighting this simple echocardiographic finding as a potential biomarker of cardiovascular and cognitive risk and not necessarily a benign finding that is normal with age.</div></div>","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":"38 5","pages":"Pages 367-377"},"PeriodicalIF":5.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Diastolic Function: Is It Time to Relax? Rethinking Echocardiographic Approaches","authors":"Thor Edvardsen MD, PhD ,&nbsp;Lars Gunnar Klæboe MD, PhD","doi":"10.1016/j.echo.2025.02.004","DOIUrl":"10.1016/j.echo.2025.02.004","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":"38 5","pages":"Pages 378-379"},"PeriodicalIF":5.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moving ASE into the Innovation Fast Lane: The Expanding IRT and the Launch of the First ASE Accelerator Program","authors":"Steven Lester MD, FASE,&nbsp;Meredith Morovati MBA,&nbsp;Samantha King","doi":"10.1016/j.echo.2025.03.007","DOIUrl":"10.1016/j.echo.2025.03.007","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":"38 5","pages":"Pages A9-A10"},"PeriodicalIF":5.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Readers","authors":"","doi":"10.1016/S0894-7317(25)00182-8","DOIUrl":"10.1016/S0894-7317(25)00182-8","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":"38 5","pages":"Pages A7-A8"},"PeriodicalIF":5.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the Left Atrioventricular Coupling Index: A Promising Marker for Diastolic Dysfunction and Prognosis","authors":"Yong-Huai Wang MD, PhD,&nbsp;Yu Dong MD,&nbsp;Guang-Yuan Li MD,&nbsp;Chun-Yan Ma MD, PhD","doi":"10.1016/j.echo.2024.12.014","DOIUrl":"10.1016/j.echo.2024.12.014","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":"38 5","pages":"Page 448"},"PeriodicalIF":5.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence in Echocardiography-Revolution or Replacement?","authors":"Nihil Abraham, Thriveni Sanagala, Mariya Stoilova, Ilya Karagodin","doi":"10.1016/j.echo.2025.04.012","DOIUrl":"10.1016/j.echo.2025.04.012","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normal Values of Echocardiographic Left Atrioventricular Coupling Index and Left Atrial Stiffness Index Reflecting Left Ventricular Diastolic Function: A Multicenter Study.","authors":"Tian-Xin Dong, Shi-Wen Li, Xiao-Fang Pan, Chun-Feng Wang, Ying Liu, Jun Wu, Xiang-Ping Guan, Su-Li Zhang, Peng-Fei Zuo, Yi-Lin Liu, Li-Yan Wang, Lei Cui, Yan Liu, Yu-Qiong Lai, Ming-Yan Ding, Gui-Lin Lu, Jing Tan, Xin-Jian Yang, Yi-Hong Li, Yong-Huai Wang, Xin-Tong Zhang, Wei-Dong Ren, Chun-Yan Ma","doi":"10.1016/j.echo.2025.04.011","DOIUrl":"10.1016/j.echo.2025.04.011","url":null,"abstract":"<p><strong>Background: </strong>The left atrioventricular coupling index (LACI) and left atrial stiffness index (LASI) have recently demonstrated significant correlations with left ventricular (LV) diastolic function. However, the absence of reference values limits their widespread use. This study aimed to establish normal reference ranges for LACI and LASI.</p><p><strong>Methods: </strong>A total of 1,648 healthy participants from 55 centers were enrolled. The LACI was defined as the ratio of left atrial (LA) minimum volume to LV end-diastolic volume. The LASI was calculated as the ratio of the average E/e' ratio to LA reservoir strain.</p><p><strong>Results: </strong>Both LACI and LASI increased with age in both sexes. The LACI was higher in women than in men (P < .001), whereas no significant sex difference was observed for LASI (P = .868). Age, sex, LV global longitudinal strain (GLS), and LA reservoir strain independently predicted LACI. Age, body mass index, LV GLS, and LA volume index were independently associated with LASI. Elevated LACI and LASI were observed in participants with high-normal blood pressure, overweight status, and indeterminate LV diastolic function.</p><p><strong>Conclusions: </strong>Sex- and age-stratified reference values for LACI and LASI were established. Left ventricular GLS, LA reservoir strain, and LA volume index should be considered when interpreting these parameters. Hypertension, obesity, and LV diastolic dysfunction may significantly affect LACI and LASI, suggesting their potential utility in identifying early cardiac dysfunction.</p>","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spotlight on the Right Ventricle: Why We Need to Do Better.","authors":"Mary Acosta, Karima Addetia","doi":"10.1016/j.echo.2025.04.010","DOIUrl":"10.1016/j.echo.2025.04.010","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitation of Primary Mitral Regurgitation: A Fresh Take on an Old Method.","authors":"Gerard P Aurigemma, Matthew W Parker","doi":"10.1016/j.echo.2025.04.009","DOIUrl":"10.1016/j.echo.2025.04.009","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Renal Function on Myocardial Remodeling and Outcomes in Patients With Moderate Aortic Stenosis.","authors":"Hyun-Jung Lee, Kyu Kim, Seo-Yeon Gwak, Iksung Cho, Geu-Ru Hong, Jong-Won Ha, Chi Young Shim","doi":"10.1016/j.echo.2025.04.008","DOIUrl":"10.1016/j.echo.2025.04.008","url":null,"abstract":"<p><strong>Background: </strong>Patients with moderate aortic stenosis (AS) and cardiac damage have poor prognosis, and whether early aortic valve replacement benefits these patients is under investigation. However, besides valvular hemodynamics, comorbidities such as chronic kidney disease (CKD) can contribute to myocardial damage and affect prognosis. The aim of this study was to investigate the impact of renal function on myocardial remodeling and outcomes in patients with moderate AS.</p><p><strong>Methods: </strong>The study cohort included 865 consecutive patients diagnosed with moderate AS (aortic valve area > 1.0 and ≤1.5 cm², mean gradient > 20 mmHg) between 2008 and 2020. Patients were categorized into five stages of CKD according to estimated glomerular filtration rate. Echocardiographic measures of myocardial remodeling and the composite outcome of all-cause mortality and heart failure hospitalization were assessed.</p><p><strong>Results: </strong>Higher CKD stage was associated with greater valvuloarterial impedance, as well as greater left ventricular (LV) hypertrophy, worse LV diastolic function, and lower LV and left atrial strain, despite similar AS severity. These associations were independent of age, sex, comorbidities, and LV pressure overload. During a median follow-up period of 4.0 years, 310 composite outcome events (39.3%) occurred, including 258 deaths (32.7%). Severe CKD (stage 4 or 5) and myocardial dysfunction were independent predictors of the composite outcome, after adjustment for key clinical variables including aortic valve replacement. Mediation analysis showed that myocardial dysfunction partially mediated the impact of renal function on outcome.</p><p><strong>Conclusions: </strong>In patients with moderate AS, renal dysfunction was independently associated with adverse myocardial remodeling and dysfunction, irrespective of valvular hemodynamics. The role of earlier intervention in patients with moderate AS whose cardiac damage is driven by comorbidities, rather than AS itself, warrants further investigation.</p>","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}