{"title":"The Forgotten Truth About Proximal Isovelocity Surface Area Correction in Tricuspid Regurgitation","authors":"Ratnasari Padang MBBS, PhD, Jeremy J. Thaden MD","doi":"10.1016/j.echo.2024.11.007","DOIUrl":"10.1016/j.echo.2024.11.007","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":"38 3","pages":"Pages 208-211"},"PeriodicalIF":5.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zsuzsanna Ladányi, Bálint Károly Lakatos, Alexandra Clement, Michele Tomaselli, Alexandra Fábián, Noela Radu, Tímea Katalin Turschl, Andrea Ferencz, Béla Merkely, Elena Surkova, Attila Kovács, Denisa Muraru, Luigi P Badano
{"title":"Mechanical adaptation of the right ventricle to secondary tricuspid regurgitation, and its association with patients' outcomes.","authors":"Zsuzsanna Ladányi, Bálint Károly Lakatos, Alexandra Clement, Michele Tomaselli, Alexandra Fábián, Noela Radu, Tímea Katalin Turschl, Andrea Ferencz, Béla Merkely, Elena Surkova, Attila Kovács, Denisa Muraru, Luigi P Badano","doi":"10.1016/j.echo.2025.02.011","DOIUrl":"https://doi.org/10.1016/j.echo.2025.02.011","url":null,"abstract":"<p><strong>Background: </strong>Data regarding the right ventricular (RV) mechanical adaptation to secondary tricuspid regurgitation (STR) is scarce.</p><p><strong>Objectives: </strong>We investigated the changes in RV contraction pattern in patients with different STR severity and etiology, and their association with outcomes.</p><p><strong>Methods: </strong>We enrolled 205 patients with STR (60% female, age: 77±12 years), in a single-center prospective observational study. We used three-dimensional echocardiography to measure RV ejection fraction (RVEF), the absolute contribution of the RV longitudinal (LEF), radial (REF), and anteroposterior (AEF) ejection fraction components, and their relative contribution by indexing to global RVEF (LEF/RVEF; REF/RVEF; AEF/RVEF). The patients were followed for a median of 9 months. The primary outcome was defined as heart failure hospitalization or all-cause death.</p><p><strong>Results: </strong>Patients with different STR severity did not differ in terms of RVEF (mild vs. moderate vs. severe, RVEF: 50±11 vs. 49±9 vs. 50±10%, respectively, p=0.085). However, LEF/RVEF was significantly lower in severe STR (0.39±0.08 vs. 0.39±0.09 vs. 0.35±0.10, respectively, p=0.049). Patients with ventricular STR had lower global RVEF (48±10% vs. 53±8%, p=0.001), LEF (18±6% vs. 20±5 %, p=0.043), REF (23±9% vs. 28±8%, p=0.002), and REF/RVEF (0.48±0.012 vs. 0.52±0.09; p=0.040) than patients with atrial STR. In a multivariable Cox regression model, REF/RVEF was a significant and independent predictor of outcomes in the entire cohort (hazard ratio, 0.980 [CI, 0.961-1.000] per 0.01 unit change, p=0.047), while global RVEF was not.</p><p><strong>Conclusions: </strong>Patients with STR demonstrate significant functional RV remodelling. Patients with severe STR show a significant decrease in the RV longitudinal shortening. Apart from STR severity, STR etiology also influences the RV contraction pattern, which was associated with outcomes in our cohort.</p>","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Edith L Posada-Martinez, Juan B Ivey-Miranda, Xochitl A Ortiz-Leon, Jose A Arias-Godinez, Juan F Fritche-Salazar, Hugo G Rodriguez-Zanella, Maria E Ruiz Esparza-Dueñas, Diana Romero-Zertuche, Ivan I Silvestre-Flores, Julieta Morales-Portano, Arturo Orea-Tejeda, Jorge Rojas-Serrano, Robert L McNamara, Pedro A Reyes Lopez, Lissa Sugeng
{"title":"Association Between Three-Dimensional Right Ventricular Ejection Fraction and In-Hospital Outcomes in Patients Undergoing Cardiac Surgery: A Multicenter Study.","authors":"Edith L Posada-Martinez, Juan B Ivey-Miranda, Xochitl A Ortiz-Leon, Jose A Arias-Godinez, Juan F Fritche-Salazar, Hugo G Rodriguez-Zanella, Maria E Ruiz Esparza-Dueñas, Diana Romero-Zertuche, Ivan I Silvestre-Flores, Julieta Morales-Portano, Arturo Orea-Tejeda, Jorge Rojas-Serrano, Robert L McNamara, Pedro A Reyes Lopez, Lissa Sugeng","doi":"10.1016/j.echo.2025.02.008","DOIUrl":"10.1016/j.echo.2025.02.008","url":null,"abstract":"<p><strong>Aims: </strong>Cardiac surgery is the cornerstone of treatment of several heart conditions, but accurate risk stratification is critical. Commonly used scores do not include right ventricular (RV) function. We aimed to evaluate whether three-dimensional (3D) RV ejection fraction (RVEF) predicts outcomes in patients undergoing cardiac surgery after adjusting for the EuroSCORE II.</p><p><strong>Methods and results: </strong>This is a prospective multicenter study of adult patients undergoing cardiac surgery at 3 centers. Right ventricular function parameters were analyzed with transesophageal echocardiogram before the surgery. We evaluated the association of 3D RVEF with the primary outcome (composite of in-hospital mortality or need of temporary ventricular assist device) after adjusting for the EuroSCORE II. Exploratory end points were time on mechanical ventilation and time on inotropes. We included 248 patients (median age, 69 years; 43% female). Sixty-nine percent had normal RVEF (≥45%). Right ventricular function parameters (tricuspid annular plane systolic excursion, fractional area change, and RV free-wall longitudinal strain) were lower in the group of decreased RVEF (P < .001 for all). The primary outcome occurred in 28 patients (11%). After adjusting for the EuroSCORE II, decreased RVEF was independently associated with the primary outcome (hazard ratio = 2.46; 95% CI, 1.10, 5.50; P = .028). Importantly, 3D RVEF was superior to all other parameters of RV systolic function to predict the primary outcome (P = .006). At 30 days, survival free of the primary end point was 72% ± 8% versus 93% ± 3% (P < .001) in decreased versus normal RVEF, respectively. Right ventricular ejection fraction was associated with shorter time on mechanical ventilation (r = -0.27, P < .001) and shorter time on inotropes (r = -0.20, P = .01).</p><p><strong>Conclusions: </strong>Among the RV function parameters, 3D RVEF is the strongest predictor of in-hospital mortality or need of temporary ventricular assist device in patients undergoing cardiac surgery. This multicenter study suggests that 3D RVEF should be included in the evaluation of patients undergoing surgery because it might improve stratification.</p>","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mai Terada, Nobuyuki Kagiyama, Yuki Izumi, Ryosuke Higuchi, Mike Saji, Mitsunobu Kitamura, Itaru Takamisawa, Mamoru Nanasato, Tomohiro Iwakura, Mitsuaki Isobe
{"title":"Mitral Annular Dynamics After Transcatheter Edge-to-Edge Repair for Functional Mitral Regurgitation: Comparison With Surgical Annuloplasty.","authors":"Mai Terada, Nobuyuki Kagiyama, Yuki Izumi, Ryosuke Higuchi, Mike Saji, Mitsunobu Kitamura, Itaru Takamisawa, Mamoru Nanasato, Tomohiro Iwakura, Mitsuaki Isobe","doi":"10.1016/j.echo.2025.02.005","DOIUrl":"10.1016/j.echo.2025.02.005","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessment of Diastolic Function: Is It Time to Relax? Rethinking Echocardiographic Approaches.","authors":"Thor Edvardsen, Lars Gunnar Klæboe","doi":"10.1016/j.echo.2025.02.004","DOIUrl":"10.1016/j.echo.2025.02.004","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Are AI foundation models efficient for segmentation of echocardiograms?","authors":"Danielle L Ferreira, Rima Arnaout","doi":"10.1016/j.echo.2025.02.001","DOIUrl":"10.1016/j.echo.2025.02.001","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hema Krishna MD, Carlos Dohse MD, Dale Smith PhD, Matthew Frost, Cyril Equilbec MEng, Glenda Chin BS, Michael Hill MD, Mary Carolina Rodriguez Ziccardi MD, Brody Slostad MD, Ashley Carter DNP, David Tiu BS, Dawood Darbar MBCHB, MD, Patricia A. Pellikka MD, Mayank Kansal MD
{"title":"Application of Machine Learning Technology to Automate Thoracic Aorta Dimensions by Echocardiography","authors":"Hema Krishna MD, Carlos Dohse MD, Dale Smith PhD, Matthew Frost, Cyril Equilbec MEng, Glenda Chin BS, Michael Hill MD, Mary Carolina Rodriguez Ziccardi MD, Brody Slostad MD, Ashley Carter DNP, David Tiu BS, Dawood Darbar MBCHB, MD, Patricia A. Pellikka MD, Mayank Kansal MD","doi":"10.1016/j.echo.2024.10.017","DOIUrl":"10.1016/j.echo.2024.10.017","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":"38 2","pages":"Pages 127-129"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sean W. Dooley MD, Naveena V.K. Yanamala PhD, Nora Al-Roub MBBS, Nicholas Spetko MD, Madeline A. Cassidy BS, Constance Angell-James MPH, Partho P. Sengupta MD, Jordan B. Strom MD, MSc
{"title":"Machine Learning to Stratify Risk in Low-Gradient Aortic Stenosis Among Medicare Beneficiaries","authors":"Sean W. Dooley MD, Naveena V.K. Yanamala PhD, Nora Al-Roub MBBS, Nicholas Spetko MD, Madeline A. Cassidy BS, Constance Angell-James MPH, Partho P. Sengupta MD, Jordan B. Strom MD, MSc","doi":"10.1016/j.echo.2024.10.010","DOIUrl":"10.1016/j.echo.2024.10.010","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":"38 2","pages":"Pages 129-132"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abhishek Gami MD , Vivek P. Jani MS , Hoda Mombeini MD , Ryan Osgueritchian MD , Ilton M. Cubero Salazar MD , Matthew Kauffman MS , Catherine E. Simpson MD, MHS , Rachel L. Damico MD, PhD , Todd M. Kolb MD, PhD , Ami A. Shah MD, MHS , Stephen C. Mathai MD, MHS , Ryan J. Tedford MD , Steven Hsu MD , Paul M. Hassoun MD , Monica Mukherjee MD, MPH
{"title":"Prognostic Value of Echocardiographic Coupling Metrics in Systemic Sclerosis–Associated Pulmonary Vascular Disease","authors":"Abhishek Gami MD , Vivek P. Jani MS , Hoda Mombeini MD , Ryan Osgueritchian MD , Ilton M. Cubero Salazar MD , Matthew Kauffman MS , Catherine E. Simpson MD, MHS , Rachel L. Damico MD, PhD , Todd M. Kolb MD, PhD , Ami A. Shah MD, MHS , Stephen C. Mathai MD, MHS , Ryan J. Tedford MD , Steven Hsu MD , Paul M. Hassoun MD , Monica Mukherjee MD, MPH","doi":"10.1016/j.echo.2024.09.010","DOIUrl":"10.1016/j.echo.2024.09.010","url":null,"abstract":"<div><h3>Background</h3><div>Ineffective right ventricular (RV) adaptation to increasing pulmonary arterial (PA) afterload in pulmonary vascular disease (PVD) significantly contributes to morbidity and mortality. Pulmonary vascular disease in systemic sclerosis (SSc) arises through various mechanisms, yet detecting abnormal contractile response remains challenging. Here we examine whether echocardiographic RV-PA coupling metrics correlate with invasive pressure-volume (PV) loops, enhancing the prediction of adverse clinical outcomes in SSc-PVD patients.</div></div><div><h3>Methods</h3><div>Prospectively enrolled patients with SSc-PVD with paired echocardiogram and PV loops were included. Linear regression and receiver-operating curve analysis were used to assess the relationship between tricuspid annular plane systolic excursion/PA systolic pressure (PASP), fractional area change/PASP, tissue Doppler velocityS’/PASP, and RV free wall strain (RVFWS)/PASP and coupling thresholds defined by end-systolic to end-arterial elastance (Ees/Ea), obtained by the multibeat method. The contribution of right atrial strain (RAS) to RV-PA coupling parameters was also investigated. Kaplan-Meier analysis was used to identify the relationship between coupling ratios and composite outcomes including clinical worsening, lung transplant, and death.</div></div><div><h3>Results</h3><div>Forty-two patients with SSc were studied, 91% female, with a mean age of 59 ± 12 years and varying degrees of PVD: mean pulmonary artery pressure 29.5 ± 12.8 mm Hg, PVR 4.7 ± 4.2 WU, and PCWP 10.3 ± 4.1 mm Hg. Echocardiographic coupling metrics including tricuspid annular plane systolic excursion/PASP, fractional area change/PASP, tissue Doppler velocity S’/PASP, RVFWS<sub>global</sub> and RVFWS<sub>basal</sub>/PASP, and RAS<sub>reservoir</sub>/PASP were linearly associated with Ees/Ea. At cut points obtained through receiver-operating curve analysis, all ratios were predictive of RV-PA uncoupling, defined by Ees/Ea, and composite outcomes. Additionally, RAS<sub>reservoir</sub>/RVFWS correlated with Ees/Ea even after adjustment for PASP, suggesting that diminished RAS further impacts RV performance and coupling.</div></div><div><h3>Conclusion</h3><div>Echocardiographic RV-PA coupling ratios strongly correlate with invasive Ees/Ea and predict adverse clinical outcomes in SSc patients across the spectrum of PVD. Further, we demonstrate how RAS impacts RV performance. These findings may refine risk stratification and prognostication in this at-risk cohort.</div></div>","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":"38 2","pages":"Pages 115-126"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}