Journal of the American Society of Echocardiography最新文献

{"title":"Echocardiographic Evaluation of Carcinoid Heart Disease.","authors":"Chadi Ayoub, Isabel G Scalia, S Allen Luis, Juan A Crestanello, William J Mauermann, Thorvardur R Halfdanarson, Heidi Connolly, Patricia A Pellikka","doi":"10.1016/j.echo.2025.05.013","DOIUrl":"https://doi.org/10.1016/j.echo.2025.05.013","url":null,"abstract":"<p><p>Carcinoid heart disease (CaHD) is a complication that occurs in patients with metastatic neuroendocrine tumors (usually to the liver) and carcinoid syndrome. Hormonal release causes endocardial thickening, typically affecting right-sided cardiac valves. Symptomatic patients with CaHD have a poor prognosis, and management of valvular heart disease is complicated by metastasis and other associated conditions and carries a higher risk than management of other acquired valve disease. Clinical and biomarker assessment are used for screening and echocardiography is the diagnostic imaging backbone used for identification of CaHD, as well as grading of severity of valvular lesions and associated chamber dysfunction. Echocardiography is critical in the evaluation for surgical intervention, as well as in guiding surgery and postoperative surveillance. This article reviews in detail applications of echocardiography in patients with CaHD.</p>","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feeding the Diagnostic Beast that is Diastolic Dysfunction: Are LA Coupling and Stiffness Indices Core Nutrients or Impractical Supplements?","authors":"Bradley S Lander, Brian D Hoit","doi":"10.1016/j.echo.2025.05.009","DOIUrl":"https://doi.org/10.1016/j.echo.2025.05.009","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Invasive Pressure-Volume Analysis by Three-Dimensional Echocardiography: A Novel Powerful Method for Evaluating Left Ventricular Function.","authors":"Lars-Egil R Hammersboen, Espen Boe, Jürgen Duchenne, John M Aalen, Hans Henrik Odland, Manuel Villegas-Martinez, Vetle C Frostelid, Faraz H Khan, Ole Jakob Sletten, Marit Witsoe, Helge Skulstad, Filip Rega, Olivier Gheysens, Jens-Uwe Voigt, Otto A Smiseth, Marie Stugaard, Espen W Remme","doi":"10.1016/j.echo.2025.05.008","DOIUrl":"https://doi.org/10.1016/j.echo.2025.05.008","url":null,"abstract":"<p><strong>Background: </strong>Pressure-volume (PV) analysis is the gold standard for evaluating left ventricular (LV) function but is rarely used clinically due to its invasiveness. We validated a non-invasive method for PV analysis by 3D echocardiography against invasive reference measurements and a novel index of LV efficiency against LV efficiency derived from metabolism by positron emission tomography-computed tomography (PET/CT).</p><p><strong>Methods: </strong>In 22 canines, LV volume was measured invasively using piezoelectric crystals and LV pressure by micromanometer. Echocardiography and peak pressure were used to obtain 3D LV volume traces and LV pressure trace estimates. Stroke work, single-beat contractility indices, arterial elastance and an index of LV efficiency were derived from echocardiography and compared with their invasively measured counterparts at baseline and different interventions. In 12 sheep, the LV efficiency index was compared with efficiency calculated as stroke work divided by total LV glucose metabolism from PET/CT. The sheep underwent 8 weeks of rapid dyssynchronous pacing to induce heart failure (HF). Recordings were performed during synchronous and dyssynchronous electrical activation, at baseline, and after 8 weeks pacing-induced HF.</p><p><strong>Results: </strong>In canines, there was a very good correlation and agreement between non-invasive and invasive measurements of LV stroke work (r=0.98, P<0.0001; difference 237±212 mmHg×ml, mean±SD). The non-invasive and invasive efficiency indices also showed very good agreement (r=0.95, P<0.0001; difference 0.4±3.4%). The changes in LV function by the different interventions resulted in similar changes in the non-invasive and invasive PV indices (both P<0.005). In sheep, the efficiency index showed similar decline compared to efficiency by PET/CT after induction of HF and after switching from synchronous to dyssynchronous electrical activation (r=0.67, P<0.001 for all interventions).</p><p><strong>Conclusions: </strong>Non-invasive PV analysis by 3D echocardiography is feasible and accurate, making PV-loop parameters for evaluating LV function accessible for clinical use. Further studies should explore the clinical utility of this method.</p>","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safe Sedation in the Echo Lab Using Intranasal Dexmedetomidine Does Not Require Fasting.","authors":"Meaghan Boeker, Deborah Walbergh, Sara Shreve, Sravya Bagli, Peter Frommelt, David Saudek","doi":"10.1016/j.echo.2025.04.017","DOIUrl":"https://doi.org/10.1016/j.echo.2025.04.017","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semi-Invasive Pressure-Flow Plots Obtained Using Exercise Echocardiography Relate to Clinical Status and Exercise Capacity in Patients With a Fontan Circulation.","authors":"Aleksandra Cieplucha, Hannah Van Belle, William R Miranda, Youri Bekhuis, Elise Decorte, Mathijs Michielsen, Pieter De Meester, Els Troost, Irene Cattapan, Thomas Rosseel, Jan Verwerft, Guido Claessen, Véronique A Cornelissen, Kaatje Goetschalckx, Marc Gewillig, Werner Budts, Alexander Van De Bruaene","doi":"10.1016/j.echo.2025.05.007","DOIUrl":"10.1016/j.echo.2025.05.007","url":null,"abstract":"<p><strong>Aims: </strong>Exercise echocardiography with peripheral venous pressure measurement (CPETecho-PVP) may provide superior insights into the pathophysiology of Fontan failure compared to standard cardiopulmonary exercise testing. Accordingly, we assessed (1) the clinical and hemodynamic correlates of pressure-flow plots obtained from CPETecho-PVP in Fontan patients and (2) the relationship between pressure-flow plots and exercise capacity.</p><p><strong>Methods: </strong>Forty-one consecutive Fontan patients underwent CPETecho-PVP. Peripheral venous pressure was measured in the distal upper extremity using an 18- to 20-gauge intravenous line. A multipoint PVP/cardiac output (CO) slope was calculated as a linear approximation using linear regression analysis from individual pressure-flow plots. A PVP/CO >3 mm Hg/L/min was considered elevated.</p><p><strong>Results: </strong>Median age was 28 (range, 17-60) years; left ventricle dominance was present in 32 (78%) patients. Compared to patients with a PVP/CO slope ≤3 mm Hg/L/min (n = 29), those with a PVP/CO slope >3 mm Hg/L/min were more likely to have New York Heart Association functional class III to IV (P = .005), lung pathology (P = .004), history of atrial arrhythmia (P = .009), or thromboembolism (P = .02). Additionally, a PVP/CO slope >3 mm Hg/L/min was associated with higher N-terminal prohormone of natriuretic peptide levels (325.0 [176.3-590.0] vs 150.5 [61.3-255.0] ng/L; P = .034), lower peak oxygen consumption (peak VO₂) 48.7% ± 13.3% vs 65.2% ± 15.3% predicted; P = .003), lower heart rate reserve (65% [42%-105%] vs 100% [75%-127%] predicted; P = .010), and lower peak cardiac index (3.8 ± 0.8 vs 6.3 ± 1.5 L/min.m²; P < .001). Rest-to-peak change in heart rate (P < .001) and cardiac index (P = .006), percentage predicted forced vital capacity (P = .044), and PVP/CO slope (P = .009) were all related to percentage predicted peak VO₂.</p><p><strong>Conclusions: </strong>A steeper PVP/CO plot is associated with worse clinical status, including lower exercise capacity. This supports the notion of implementing the CPETecho-PVP in the standard of care for Fontan patients.</p>","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Speckle-Tracking Echocardiography Parameters Associated With Ventricular Arrhythmia Recurrence-Free Survival After Ablation in Structural Heart Disease.","authors":"Siddharth J Trivedi, Richard G Bennett, Karen Byth, Timothy Campbell, Samual Turnbull, Luke Stefani, Saurabh Kumar, Liza Thomas","doi":"10.1016/j.echo.2025.05.004","DOIUrl":"10.1016/j.echo.2025.05.004","url":null,"abstract":"<p><strong>Background: </strong>Catheter ablation (CA) is indicated for drug-refractory ventricular arrhythmias (VAs). Predicting adverse outcomes (recurrent VA or mortality) after CA is important, but current tools are imperfect. Speckle-tracking echocardiography quantifies global longitudinal strain (GLS), a measure of myocardial deformation, and mechanical dispersion (MD) and delta contraction duration (DCD) (measures of myocardial contraction heterogeneity). The aim of this study was to examine the associations between clinical, procedural, and echocardiographic parameters and subsequent VA recurrence or death.</p><p><strong>Methods: </strong>One hundred eighty-one patients (ischemic cardiomyopathy, n = 82; nonischemic cardiomyopathy, n = 99) with VAs undergoing CA underwent echocardiography, including measurements of left ventricular GLS, MD, and DCD. Patients were longitudinally followed for first occurrence of VA recurrence or death; in the absence of VA recurrence or death, a patient was deemed to have VA recurrence-free survival.</p><p><strong>Results: </strong>Median follow-up duration was 21.0 months. After the procedure, 20 patients (11%) died without any prior VA recurrence, and 77 patients (43%) experienced VA recurrence, of whom 11 subsequently died. Cox proportional-hazards regression analysis identified acute procedural failure, at least two inducible VAs, DCD, and the interaction between GLS and DCD as significant predictors of VA recurrence-free survival. When GLS and DCD were dichotomized by their median values (GLS ≤ -11.5% vs >-11.5%; DCD ≤ 190 vs >190 ms), DCD > 190 ms was a predictor of the composite endpoint irrespective of GLS status. MD was not as strong a predictor as DCD.</p><p><strong>Conclusions: </strong>In patients undergoing CA for VAs, the only echocardiographic predictor of VA recurrence-free survival was prolonged DCD, irrespective of GLS and clinical and procedural factors. Hence, DCD may facilitate risk stratification before CA.</p>","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echocardiographic Features of Right Ventricular Reverse Remodeling in Adults With Repaired Tetralogy of Fallot After Pulmonary Valve Replacement and Impact of Age at Time of Intervention.","authors":"Rebecca L Moore, Jan Leonard, Alexis Z Tomlinson, Stephanie Fuller, Yan Wang, Laura Mercer-Rosa, Yuli Y Kim","doi":"10.1016/j.echo.2025.04.022","DOIUrl":"10.1016/j.echo.2025.04.022","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of Noninvasive Measures of Ventricular Diastolic Stiffness in Single Right Ventricle Patients: A Pilot Study.","authors":"William A Harris, Eric M Graham, Carolyn L Taylor, Andrew Savage, Kimberly E McHugh, Stephanie Gaydos, Arni C Nutting, Andrew M Atz, Donald R Menick, Drew Bickel, Meara Walkley, Shahryar M Chowdhury","doi":"10.1016/j.echo.2025.04.021","DOIUrl":"10.1016/j.echo.2025.04.021","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardization of Three-Dimensional Tricuspid Valve Annular Size Among Echocardiographic Vendors: The Power of Interchangeable Three-Dimensional Echocardiography.","authors":"Emily Jimenez, Matthew Peters, Tatyanna Somsak, Benjamin Wordell, Priscilla Wessly, Renuka Jain","doi":"10.1016/j.echo.2025.04.019","DOIUrl":"10.1016/j.echo.2025.04.019","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atrial Right-to-Left Shunting After Tetralogy of Fallot Repair Is Associated With Improved Atrial Function and Shorter Hospital Length of Stay: An Echocardiographic Cohort Study.","authors":"Marc A Delaney, Laura Bennett, Jennifer A Faerber, Andrea L Jones, Anh Duc Mai, Omonigho Ekhomu, Yan Wang, Elizabeth Goldmuntz, Maryam Y Naim, Monique M Gardner, Mark K Friedberg, Laura Mercer-Rosa","doi":"10.1016/j.echo.2025.04.020","DOIUrl":"10.1016/j.echo.2025.04.020","url":null,"abstract":"<p><strong>Background: </strong>Atrial right-to-left (aRL) shunting is often identified on echocardiography in the early postoperative period following repair of tetralogy of Fallot (TOF) and is thought to reflect poor right ventricular (RV) compliance but to be possibly beneficial in serving as a \"pop-off\" for the right ventricle. The aim of this study was to investigate the relationship between aRL shunting and echocardiographic diastolic function and early postoperative outcomes, hypothesizing that aRL shunting would be associated with worse diastolic function and with postoperative length of stay (LOS).</p><p><strong>Methods: </strong>A single-center cohort study was conducted among patients who underwent repair of TOF. Echocardiograms were obtained 2 to 5 days after repair. Patients were grouped as \"elective\" if repaired after 30 days of age without prior palliation, \"staged\" if they underwent neonatal palliation before repair, or \"neonatal\" if repaired at <30 days age. aRL shunting was compared with all others: bidirectional, left-to-right shunt, and no atrial shunt detected. Linear regression tested the relationship of aRL shunting with right atrial volumes and right atrial emptying fraction (RAEF), RV inflow and tissue Doppler velocities, and RA peak longitudinal strain and early strain rate. Multivariable negative binomial regression was conducted to test the association between aRL shunting and LOS, stratified by repair group.</p><p><strong>Results: </strong>There were 197 patients with TOF (60% male, 74% white): (127 [64%]) underwent elective repair, 41 (21%) staged repair, and 29 (15%) neonatal repair. aRL shunting was present in 68 patients (35%). In the overall cohort, aRL shunting was associated with lower right atrial end-diastolic volume, higher RAEF, higher A-wave peak velocity, and higher right atrial peak longitudinal strain. In the subgroup analysis, aRL shunting was associated with higher RAEF and peak longitudinal strain in the elective repair group only, in which aRL shunting was also associated with shorter LOS.</p><p><strong>Conclusions: </strong>aRL shunting after TOF repair is associated with better atrial function and possibly with a combination of robust atrial function in the presence of RV noncompliance and shorter LOS in patients undergoing elective TOF repair, but not in those undergoing neonatal intervention.</p>","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}