Jaehyun Lim, Soongu Kwak, Min-Ha Jeong, Jae Yeong Cho, Chan-Soon Park, Jiesuck Park, Hong-Mi Choi, Ga Hui Choi, Jihoon Kim, Jin-Oh Na, Sun Hwa Lee, Mi-Hyang Jung, Hae Ok Jung, Sang-Chol Lee, Hyung-Kwan Kim, Kye Hun Kim, Goo-Yeong Cho
{"title":"The Effect of Mavacamten on Left Atrial Strain Dynamics in Obstructive Hypertrophic Cardiomyopathy.","authors":"Jaehyun Lim, Soongu Kwak, Min-Ha Jeong, Jae Yeong Cho, Chan-Soon Park, Jiesuck Park, Hong-Mi Choi, Ga Hui Choi, Jihoon Kim, Jin-Oh Na, Sun Hwa Lee, Mi-Hyang Jung, Hae Ok Jung, Sang-Chol Lee, Hyung-Kwan Kim, Kye Hun Kim, Goo-Yeong Cho","doi":"10.1016/j.echo.2025.09.014","DOIUrl":"https://doi.org/10.1016/j.echo.2025.09.014","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nathanael Tran, Shani Dahan, Jagdip Kang, Michael H Picard, Jacob P Dal-Bianco, Judy Hung
{"title":"Left Ventricular Global Longitudinal Strain: An Imaging Marker Associated with Outcomes in Paradoxical Low-Flow, Low-Gradient Severe Aortic Stenosis.","authors":"Nathanael Tran, Shani Dahan, Jagdip Kang, Michael H Picard, Jacob P Dal-Bianco, Judy Hung","doi":"10.1016/j.echo.2025.09.012","DOIUrl":"https://doi.org/10.1016/j.echo.2025.09.012","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reply to \"Intraoperative Factors Should Be Considered in Assessing the Association Between 3D RVEF and Early Postoperative Outcomes\".","authors":"Posada-Martinez Edith L, Ivey-Miranda Juan B","doi":"10.1016/j.echo.2025.09.011","DOIUrl":"https://doi.org/10.1016/j.echo.2025.09.011","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intraoperative Factors Should Be Considered in Assessing the Association Between 3D RV EF and Early Postoperative Outcomes.","authors":"Aibek Mirrakhimov","doi":"10.1016/j.echo.2025.08.029","DOIUrl":"https://doi.org/10.1016/j.echo.2025.08.029","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xi Zhang, Yuxin Zhang, Bijun Tan, Han Li, Ying Hou, Pingan Zhou, Lijun Yuan, Changyang Xing
{"title":"A Revised Grading Scheme for Secondary Tricuspid Valve Regurgitation.","authors":"Xi Zhang, Yuxin Zhang, Bijun Tan, Han Li, Ying Hou, Pingan Zhou, Lijun Yuan, Changyang Xing","doi":"10.1016/j.echo.2025.09.010","DOIUrl":"https://doi.org/10.1016/j.echo.2025.09.010","url":null,"abstract":"<p><strong>Background: </strong>The conventional three-grade scheme recommended by American Society of Echocardiography (ASE) for secondary tricuspid regurgitation (STR) are limited by the frequent disagreement between multiparametric and single-parameter classifications, and heterogeneous prognosis within the moderate group. We tested the hypothesis that the expert-recommended four-grade scheme has better inherent agreement compared to ASE scheme, and further improved it as a revised four-grade scheme using the corrected proximal isovelocity surface area (PISA) method to calculate effective orifice area (EROA) and regurgitant volume (RegVol), along with the integration of other quantitative parameters.</p><p><strong>Methods: </strong>A total of 178 patients with STR were included. The moderate grade according to the three-grade ASE-recommended scheme was split into mild-moderate and moderate-severe grades following the recent experts' suggestions. The agreement between the multiparametric and single-parameter grading in TR severity was analyzed using the weighted Kappa test. The structure and function of tricuspid valve and right heart, including the conventional parameters, strains, and the right ventricular‒pulmonary artery (RV-PA) coupling, were compared across grade severities. The partition values of quantitative regurgitation parameters were further determined by ROC curve analyses to develop the revised four-grade scheme with involvement of corrected proximal isovelocity surface area (PISA) method.</p><p><strong>Results: </strong>The expert-recommended four-grade scheme demonstrated better multiparametric and single-parameter agreement of RegVol (к=0.901) in TR grading compared to the ASE-recommended three grade scheme (к=0.506). Both RV strain and RV-PA coupling were significantly lower in patients with moderate-severe STR compared to those with mild-moderate STR (P < 0.05). The new cut-off values of EROA (0.34 cm<sup>2</sup>; AUC = 0.945) and RegVol (35 mL; AUC = 0.958), obtained using the corrected PISA method, demonstrated excellent accuracy in distinguishing mild-moderate from moderate-severe STR.</p><p><strong>Conclusions: </strong>The revised four-grade scheme for STR severity exhibited better inherent agreement than the ASE recommended scheme, and matching with the right heart functional variations.</p>","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"VExUS in Decompensated Heart Failure: Prognostic Strength Signals Readiness for Therapeutic Evaluation.","authors":"Michele Nanna, Jing Lu","doi":"10.1016/j.echo.2025.09.009","DOIUrl":"https://doi.org/10.1016/j.echo.2025.09.009","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Davide Genovese, Marco Previtero, Giacomo Prete, Michele Strosio, Carlo Cernetti, Luigi Paolo Badano, Denisa Muraru, Chiara Palermo, Giuseppe Tarantini, Martina Perazzolo Marra
{"title":"Comparison of the Right Atrial Expansion Index with Inferior Vena Cava Assessment for Echocardiographic Estimation of the Right Atrial Pressure.","authors":"Davide Genovese, Marco Previtero, Giacomo Prete, Michele Strosio, Carlo Cernetti, Luigi Paolo Badano, Denisa Muraru, Chiara Palermo, Giuseppe Tarantini, Martina Perazzolo Marra","doi":"10.1016/j.echo.2025.09.005","DOIUrl":"https://doi.org/10.1016/j.echo.2025.09.005","url":null,"abstract":"<p><strong>Background: </strong>Evaluating right atrial pressure (RAP) is essential for managing cardiac diseases. Right heart catheterization (RHC) measures RAP directly but is invasive. In contrast, transthoracic echocardiography (TTE) provides a non-invasive estimate of RAP through inferior vena cava (IVC) assessment despite some limitations. The right atrial expansion index (RAEI) reflects RA compliance by measuring the relative increase in volume during the reservoir phase. This study aimed to validate RAEI as a non-invasive parameter for estimating RAP.</p><p><strong>Methods: </strong>We retrospectively enrolled 1020 patients (728 in the derivation and 292 in the validation cohort) with various chronic cardiac diseases who underwent clinically indicated RHC and TTE within 24 hours. RAP was measured during the RHC and defined as elevated when above 10 mmHg. RAEI and other TTE parameters were measured offline and blinded to RHC results.</p><p><strong>Results: </strong>In the derivation cohort, RAEI showed a logarithmic correlation with RAP (lnRAEI-RAP: r=-0.65, p<0.001). lnRAEI was an independent and additive predictor of RAP, outperforming clinical, hemodynamic, and echocardiographic parameters, including IVC assessment. lnRAEI was more accurate than IVC assessment for identifying RAP≥10 mmHg (AUC lnRAEI: 0.840, p<0.001; optimal cut-off: lnRAEI<3.53); this finding was replicated in the validation cohort (AUC lnRAEI: 0.826, p<0.001). Furthermore, lnRAEI<3.53 was confirmed as an optimal cut-off for identifying RAP≥10 mmHg also in the validation cohort (Sensitivity: 74%, Specificity: 79%, Accuracy: 78%). Finally, the equation RAP=19.3-(3.29xlnRAEI) derived from the derivation cohort estimated RAP more accurately (-0.2±3.1 mmHg) than IVC assessment (1.5±4.2 mmHg) in the validation cohort.</p><p><strong>Conclusions: </strong>In this patient cohort, lnRAEI was more accurate than IVC assessment for non-invasive RAP estimation.</p>","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Venous Cannula Positioning in ECMO.","authors":"Jamel Ortoleva, Andrew P Notarianni","doi":"10.1016/j.echo.2025.08.027","DOIUrl":"https://doi.org/10.1016/j.echo.2025.08.027","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the Editor: \"Transaortic Flow Rate and Risk Stratification in Moderate Aortic Stenosis - From Ventricle to Vasculature\".","authors":"Sara Hungerford","doi":"10.1016/j.echo.2025.08.028","DOIUrl":"https://doi.org/10.1016/j.echo.2025.08.028","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paolo Springhetti, Michele Tomaselli, Leonardo Portolan, Marco Penso, Jessica Pizzini, Denis Leonardi, Alexandra Clement, Luca Ciceri, Noela Radu, Giorgia Benzoni, Roberto Scarsini, Flavio Ribichini, Denisa Muraru, Giovanni Benfari, Luigi P Badano
{"title":"Reply to \"Transaortic Flow Rate and Risk Stratification in Moderate Aortic Stenosis - From Ventricle to Vasculature\".","authors":"Paolo Springhetti, Michele Tomaselli, Leonardo Portolan, Marco Penso, Jessica Pizzini, Denis Leonardi, Alexandra Clement, Luca Ciceri, Noela Radu, Giorgia Benzoni, Roberto Scarsini, Flavio Ribichini, Denisa Muraru, Giovanni Benfari, Luigi P Badano","doi":"10.1016/j.echo.2025.09.006","DOIUrl":"https://doi.org/10.1016/j.echo.2025.09.006","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}