Journal of the American Society of Echocardiography最新文献

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Leaflet Modification during Transcatheter Aortic Valve-in-Valve Replacement - Imaging Guidance for the ShortCut™ Procedure. 经导管主动脉瓣内置换术期间的小叶修改-捷径™程序的成像指导。
IF 5.4 2区 医学
Journal of the American Society of Echocardiography Pub Date : 2025-06-05 DOI: 10.1016/j.echo.2025.05.019
Julien Ternacle, Marian Kukucka, Benjamin Seguy, Sabah Skaf, Moody Makar, Shemy Carasso, Daniel Kalbacher, Thomas Modine, Susheel Kodali, Didier Tchetche, Danny Dvir, Philippe Pibarot
{"title":"Leaflet Modification during Transcatheter Aortic Valve-in-Valve Replacement - Imaging Guidance for the ShortCut™ Procedure.","authors":"Julien Ternacle, Marian Kukucka, Benjamin Seguy, Sabah Skaf, Moody Makar, Shemy Carasso, Daniel Kalbacher, Thomas Modine, Susheel Kodali, Didier Tchetche, Danny Dvir, Philippe Pibarot","doi":"10.1016/j.echo.2025.05.019","DOIUrl":"https://doi.org/10.1016/j.echo.2025.05.019","url":null,"abstract":"<p><p>Transcatheter aortic valve-in-valve implantation is a validated alternative to redo surgery in patients with severe bioprosthetic valve dysfunction related to structural valve deterioration. The major life-threatening procedural complication is coronary occlusion related to the displacement of degenerated bioprosthetic leaflets, which can be avoided using leaflet modification. The aim of this article is to present a step-by-step guide for imaging this procedure using the ShortCut™ device.</p>","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic Kidney Disease: Adding Yet Another Piece to the Puzzle in Aortic Stenosis. 慢性肾脏疾病:主动脉瓣狭窄之谜的又一块拼图。
IF 5.4 2区 医学
Journal of the American Society of Echocardiography Pub Date : 2025-06-04 DOI: 10.1016/j.echo.2025.05.018
Jordi S Dahl, Rasmus Carter-Storch
{"title":"Chronic Kidney Disease: Adding Yet Another Piece to the Puzzle in Aortic Stenosis.","authors":"Jordi S Dahl, Rasmus Carter-Storch","doi":"10.1016/j.echo.2025.05.018","DOIUrl":"10.1016/j.echo.2025.05.018","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suboptimal Inter-Rater Reliability Limits Predictive Value of Fetal Echocardiography for Neonatal Balloon Atrial Septostomy in Fetuses with Dextro-Transposition of the Great Arteries. 次优的可靠性限制了胎儿超声心动图对大动脉右转胎儿新生儿球囊房间隔造口术的预测价值。
IF 5.4 2区 医学
Journal of the American Society of Echocardiography Pub Date : 2025-06-04 DOI: 10.1016/j.echo.2025.05.017
Hamsika Chandrasekar, Shiraz A Maskatia, Meaghan J Beattie, Michelle A Kaplinski, Rajesh Punn, Charitha D Reddy, Alexandria Jensen, Theresa A Tacy
{"title":"Suboptimal Inter-Rater Reliability Limits Predictive Value of Fetal Echocardiography for Neonatal Balloon Atrial Septostomy in Fetuses with Dextro-Transposition of the Great Arteries.","authors":"Hamsika Chandrasekar, Shiraz A Maskatia, Meaghan J Beattie, Michelle A Kaplinski, Rajesh Punn, Charitha D Reddy, Alexandria Jensen, Theresa A Tacy","doi":"10.1016/j.echo.2025.05.017","DOIUrl":"https://doi.org/10.1016/j.echo.2025.05.017","url":null,"abstract":"<p><strong>Introduction: </strong>Dextro-transposition of the great arteries (d-TGA) neonates require adequate mixing at the atrial level. Without this, they experience severe cyanosis, necessitating balloon atrial septostomy (BAS). Multiple studies have identified various fetal echocardiogram (FE) findings as risk factors for postnatal BAS. The predictive value of these findings remains poor in clinical use.</p><p><strong>Hypothesis: </strong>We aimed to determine the relationship between inter-rater reliability (IRR) of FE BAS predictors and postnatal BAS, as well as postnatal markers of hypoxia/hypoxemia. We hypothesized that poor IRR may contribute to limited FE predictive value.</p><p><strong>Methods: </strong>We identified d-TGA pregnancies followed at our institution between 2012 and 2022, excluding fetuses with large ventricular septal defects and pregnancies terminated or lost to follow up. Two groups of three independent readers blinded to BAS outcome assessed 7 FE predictors: peak pulmonary vein Doppler velocity > 41 cm/sec, reverse flow in patent ductus arteriosus (PDA), restrictive PDA, restrictive patent foramen ovale (PFO), bidirectional PFO flow, flat septum primum, and hypermobile septum primum. IRR was determined with the S metric. Clinical information before BAS was collected to evaluate postnatal physiology. A multivariable logistic regression was used to determine significant associations between FE findings and postnatal BAS. Multivariable linear regressions were also used to determine significant associations between FE findings and indicators of hypoxia/hypoxemia.</p><p><strong>Results: </strong>Fifty-two fetuses were included, of whom 25 (48%) underwent BAS. FEs were performed at a mean gestational age of 34.02 weeks (SD 2.14 weeks). IRR was lowest for PFO flow direction and highest for restrictive PDA, likely due to its rarity. The remainder of FE predictors had either moderate or substantial IRR. Five FE characteristics could be included in the regression analysis, and none were significantly associated with odds of BAS, postnatal pH, or postnatal oxygen saturation. Reverse PDA flow was statistically significantly associated with lower postnatal pre-BAS paO2.</p><p><strong>Conclusions: </strong>Our results demonstrate substantial but not excellent IRR for current FE BAS predictors. There was no significant association between these predictors and postnatal BAS or postnatal hypoxia/hypoxemia in d-TGA patients, except for reverse PDA flow and lower postnatal paO2. Additional work is needed to identify more reliable FE predictors of postnatal d-TGA physiology.</p>","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Only You Can Control Your Future (Dr. Seuss) 只有你能控制你的未来(苏斯博士)
IF 5.4 2区 医学
Journal of the American Society of Echocardiography Pub Date : 2025-06-01 DOI: 10.1016/j.echo.2025.05.006
Theodore P. Abraham MD, FASE
{"title":"Only You Can Control Your Future (Dr. Seuss)","authors":"Theodore P. Abraham MD, FASE","doi":"10.1016/j.echo.2025.05.006","DOIUrl":"10.1016/j.echo.2025.05.006","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":"38 6","pages":"Pages A15-A16"},"PeriodicalIF":5.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimal Cut Plane for Tricuspid Annular Plane Systolic Excursion Measurement 三尖瓣环状平面收缩偏移测量的最佳切割平面。
IF 5.4 2区 医学
Journal of the American Society of Echocardiography Pub Date : 2025-06-01 DOI: 10.1016/j.echo.2024.12.013
Michito Murayama RMS, JRDCS, PhD, Sanae Kaga RMS, JRDCS, PhD, Hisao Nishino RMS, Yusuke Yanagi RMS, MS, Mana Goto RMS, MS, Fuka Ando AS, Shinobu Yokoyama RMS, Marina Yamaguchi BSc, Kazunori Okada RMS, PhD, Masahiro Nakabachi RMS, JRDCS, MS, Makoto Kambayashi MD, Yui Shimono MD, Kosuke Nakamura MD, Yoji Tamaki MD, PhD, Suguru Ishizaka MD, PhD, Hiroyuki Iwano MD, PhD, Toshiyuki Nagai MD, PhD, Toshihisa Anzai MD, PhD
{"title":"Optimal Cut Plane for Tricuspid Annular Plane Systolic Excursion Measurement","authors":"Michito Murayama RMS, JRDCS, PhD,&nbsp;Sanae Kaga RMS, JRDCS, PhD,&nbsp;Hisao Nishino RMS,&nbsp;Yusuke Yanagi RMS, MS,&nbsp;Mana Goto RMS, MS,&nbsp;Fuka Ando AS,&nbsp;Shinobu Yokoyama RMS,&nbsp;Marina Yamaguchi BSc,&nbsp;Kazunori Okada RMS, PhD,&nbsp;Masahiro Nakabachi RMS, JRDCS, MS,&nbsp;Makoto Kambayashi MD,&nbsp;Yui Shimono MD,&nbsp;Kosuke Nakamura MD,&nbsp;Yoji Tamaki MD, PhD,&nbsp;Suguru Ishizaka MD, PhD,&nbsp;Hiroyuki Iwano MD, PhD,&nbsp;Toshiyuki Nagai MD, PhD,&nbsp;Toshihisa Anzai MD, PhD","doi":"10.1016/j.echo.2024.12.013","DOIUrl":"10.1016/j.echo.2024.12.013","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":"38 6","pages":"Pages 516-519"},"PeriodicalIF":5.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Dyssynchrony to Arrhythmia: Left Ventricle Mechanical Dispersion as an Independent Predictor of Ventricular Arrhythmias in Chronic Chagas Cardiomyopathy 从非同步化到心律失常:左心室机械离散度作为慢性恰加斯心肌病室性心律失常的独立预测因子。
IF 5.4 2区 医学
Journal of the American Society of Echocardiography Pub Date : 2025-06-01 DOI: 10.1016/j.echo.2025.03.002
Luis Eduardo Echeverría MD, Lyda Z. Rojas RN, PhD, Angie Serrano-García MD, Laura Daniela Muñoz MD, María Cantillo-Reines MD, Lisbeth Becerra-Motta RN, Lizeth Alarcón RN, María Alejandra Quintero-Santana RN, Paola Andrea Mendez-Hernández MD, Ángela Torres MD, Karen Andrea García-Rueda MD, Carlos Luengas MD, Angel M. Chaves MD, Jaime A. Rodríguez MD, Rafael Campo MD, Sergio Alejandro Gómez-Ochoa MD, MSc
{"title":"From Dyssynchrony to Arrhythmia: Left Ventricle Mechanical Dispersion as an Independent Predictor of Ventricular Arrhythmias in Chronic Chagas Cardiomyopathy","authors":"Luis Eduardo Echeverría MD,&nbsp;Lyda Z. Rojas RN, PhD,&nbsp;Angie Serrano-García MD,&nbsp;Laura Daniela Muñoz MD,&nbsp;María Cantillo-Reines MD,&nbsp;Lisbeth Becerra-Motta RN,&nbsp;Lizeth Alarcón RN,&nbsp;María Alejandra Quintero-Santana RN,&nbsp;Paola Andrea Mendez-Hernández MD,&nbsp;Ángela Torres MD,&nbsp;Karen Andrea García-Rueda MD,&nbsp;Carlos Luengas MD,&nbsp;Angel M. Chaves MD,&nbsp;Jaime A. Rodríguez MD,&nbsp;Rafael Campo MD,&nbsp;Sergio Alejandro Gómez-Ochoa MD, MSc","doi":"10.1016/j.echo.2025.03.002","DOIUrl":"10.1016/j.echo.2025.03.002","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":"38 6","pages":"Pages 519-523"},"PeriodicalIF":5.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Information for Readers 读者资讯
IF 5.4 2区 医学
Journal of the American Society of Echocardiography Pub Date : 2025-06-01 DOI: 10.1016/S0894-7317(25)00243-3
{"title":"Information for Readers","authors":"","doi":"10.1016/S0894-7317(25)00243-3","DOIUrl":"10.1016/S0894-7317(25)00243-3","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":"38 6","pages":"Pages A13-A14"},"PeriodicalIF":5.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitral Annular Dynamics After Transcatheter Edge-to-Edge Repair for Functional Mitral Regurgitation: Comparison With Surgical Annuloplasty 经导管边缘对边缘修复功能性二尖瓣返流后的二尖瓣环动力学:与手术环成形术的比较。
IF 5.4 2区 医学
Journal of the American Society of Echocardiography Pub Date : 2025-06-01 DOI: 10.1016/j.echo.2025.02.005
Mai Terada MD, PhD, Nobuyuki Kagiyama MD, PhD, Yuki Izumi MD, Ryosuke Higuchi MD, Mike Saji MD, PhD, Mitsunobu Kitamura MD, PhD, Itaru Takamisawa MD, Mamoru Nanasato MD, PhD, Tomohiro Iwakura MD, PhD, Mitsuaki Isobe MD, PhD
{"title":"Mitral Annular Dynamics After Transcatheter Edge-to-Edge Repair for Functional Mitral Regurgitation: Comparison With Surgical Annuloplasty","authors":"Mai Terada MD, PhD,&nbsp;Nobuyuki Kagiyama MD, PhD,&nbsp;Yuki Izumi MD,&nbsp;Ryosuke Higuchi MD,&nbsp;Mike Saji MD, PhD,&nbsp;Mitsunobu Kitamura MD, PhD,&nbsp;Itaru Takamisawa MD,&nbsp;Mamoru Nanasato MD, PhD,&nbsp;Tomohiro Iwakura MD, PhD,&nbsp;Mitsuaki Isobe MD, PhD","doi":"10.1016/j.echo.2025.02.005","DOIUrl":"10.1016/j.echo.2025.02.005","url":null,"abstract":"","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":"38 6","pages":"Pages 532-533"},"PeriodicalIF":5.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Risk Predictors for Abnormal Left Ventricular and Atrial Function in Lupus Erythematosus 红斑狼疮左室和心房功能异常的临床危险预测因素。
IF 5.4 2区 医学
Journal of the American Society of Echocardiography Pub Date : 2025-06-01 DOI: 10.1016/j.echo.2025.03.001
Matteo Morello MD , Bethany Gholson RCS, ACS , Weiting Huang MD , William Lain BS , Maxwell Malter BS , Antonio Abbate MD, PhD , Brittany N. Weber MD, PhD , Jonathan R. Lindner MD
{"title":"Clinical Risk Predictors for Abnormal Left Ventricular and Atrial Function in Lupus Erythematosus","authors":"Matteo Morello MD ,&nbsp;Bethany Gholson RCS, ACS ,&nbsp;Weiting Huang MD ,&nbsp;William Lain BS ,&nbsp;Maxwell Malter BS ,&nbsp;Antonio Abbate MD, PhD ,&nbsp;Brittany N. Weber MD, PhD ,&nbsp;Jonathan R. Lindner MD","doi":"10.1016/j.echo.2025.03.001","DOIUrl":"10.1016/j.echo.2025.03.001","url":null,"abstract":"<div><h3>Background</h3><div>In systemic lupus erythematosus (SLE), ventricular dysfunction can occur from primary immune injury or secondarily from SLE-related comorbidities. The aim of this study was to determine clinical predictors of reduced left ventricular (LV) systolic and diastolic function in an effort to understand potentially mitigating strategies.</div></div><div><h3>Methods</h3><div>The authors retrospectively studied 76 patients with SLE who underwent comprehensive transthoracic echocardiography within 3 months of an appointment with a rheumatologist to correlate clinical, laboratory, and echocardiographic features. All key echocardiographic measurements were reviewed and remeasured, when appropriate, by an expert blinded to other study data. Abnormal LV systolic function was defined as a global longitudinal strain threshold of −18.0%. Hierarchical cluster analysis was used to define feature interaction.</div></div><div><h3>Results</h3><div>The mean age of the population was 49 ± 15 years, and 83% were women. Reduced GLS was found in 24% of the population, of whom 44% had LV ejection fractions &lt;50%. Previously documented heart failure symptoms were more prevalent in the reduced GLS cohort (50% vs 12%, <em>P</em> = .002). Those with reduced GLS had clinical features indicating greater SLE severity over time, including reduced renal function and prior pericardial involvement. GLS was strongly associated with right ventricular free wall strain (<em>r</em> = 0.67, <em>P</em> &lt; .01) and degree of LV diastolic dysfunction. Worsening grades of diastolic dysfunction, like GLS, were associated with renal disease and pericardial involvement. Patients with SLE with reduced GLS and diastolic function also had abnormal left atrial reservoir strain (LASr). Hierarchical cluster analysis segregated populations with reduced GLS, reduced LASr, pericardial and renal involvement, and an additional feature of C-reactive protein known to be associated with chronic disease activity.</div></div><div><h3>Conclusions</h3><div>Reduced GLS is common in patients with SLE and is associated with heart failure symptoms and markers of increased disease activity over time, particularly pericardial involvement, suggesting common immune mechanisms. The associations of GLS with right ventricular function, diastolic dysfunction, and impairment in LASr suggests a common mechanistic basis involving immune injury.</div></div>","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":"38 6","pages":"Pages 486-497"},"PeriodicalIF":5.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stress Echocardiography in Patients With Moderate or Severe Myocardial Ischemia: Insights From the ISCHEMIA Trial 中度或重度心肌缺血患者的应激超声心动图:缺血试验的启示。
IF 5.4 2区 医学
Journal of the American Society of Echocardiography Pub Date : 2025-06-01 DOI: 10.1016/j.echo.2025.03.006
Michael H. Picard MD , Kyle Saysana MD , Derek D. Cyr PhD , Xin Zeng MD, PhD , Marielle Scherrer-Crosbie MD, PhD , Leslee J. Shaw PhD , Roxy Senior MD, DM , Kian Keong Poh MD , Sripal Bangalore MD, MHA , Jonathon A. Leipsic MD , GB John Mancini MD , Matthew J. Budoff MD , Cameron J. Hague MD , James K. Min MD , Sean M. O'Brien Ph.D , Judith S. Hochman MD , David J. Maron MD , Harmony R. Reynolds MD , ISCHEMIA Research Group
{"title":"Stress Echocardiography in Patients With Moderate or Severe Myocardial Ischemia: Insights From the ISCHEMIA Trial","authors":"Michael H. Picard MD ,&nbsp;Kyle Saysana MD ,&nbsp;Derek D. Cyr PhD ,&nbsp;Xin Zeng MD, PhD ,&nbsp;Marielle Scherrer-Crosbie MD, PhD ,&nbsp;Leslee J. Shaw PhD ,&nbsp;Roxy Senior MD, DM ,&nbsp;Kian Keong Poh MD ,&nbsp;Sripal Bangalore MD, MHA ,&nbsp;Jonathon A. Leipsic MD ,&nbsp;GB John Mancini MD ,&nbsp;Matthew J. Budoff MD ,&nbsp;Cameron J. Hague MD ,&nbsp;James K. Min MD ,&nbsp;Sean M. O'Brien Ph.D ,&nbsp;Judith S. Hochman MD ,&nbsp;David J. Maron MD ,&nbsp;Harmony R. Reynolds MD ,&nbsp;ISCHEMIA Research Group","doi":"10.1016/j.echo.2025.03.006","DOIUrl":"10.1016/j.echo.2025.03.006","url":null,"abstract":"<div><h3>Background</h3><div>This study examined stress echocardiography in relation to coronary artery anatomy and outcome in subjects randomized in the International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial.</div></div><div><h3>Methods</h3><div>Of 5,179 patients randomized to initial invasive or conservative strategy, stress echocardiography was performed in 1,079. Coronary computed tomographic angiogram (CCTA) excluded left main disease and quantified coronary lesions. Degree of ischemia was defined by number of segments with stress-induced wall motion abnormalities (mild &lt; 3, moderate = 3, and severe &gt; 3). Transient ischemic dilation was defined as a 10% increase in stress left ventricular end-systolic volume. Primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest.</div></div><div><h3>Results</h3><div>On CCTA, 607/715 (84%) with CCTA evaluable for ≥70% lesion had 1 such lesion. Features associated with coronary lesions ≥70% were number of ischemic/infarcted segments, 3 or more ischemic segments in the anterior territory, and inability to augment left ventricular ejection fraction 10 percentage points. Transient ischemic dilation, present in 28.5% of cases, was significantly associated with severity of ischemia. For every 0.10 increase in peak wall motion score index, there was a 12% increased risk of cardiovascular death or myocardial infarction (adjusted hazard ratio = 1.12; 95% CI, 1.04, 1.21; <em>P</em> = .003).</div></div><div><h3>Conclusion</h3><div>In patients with chronic coronary disease and moderate or severe myocardial ischemia receiving contemporary therapies, stress echocardiography identified subjects with significant coronary artery disease and wall motion score index provided prognostic value.</div></div>","PeriodicalId":50011,"journal":{"name":"Journal of the American Society of Echocardiography","volume":"38 6","pages":"Pages 465-481"},"PeriodicalIF":5.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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