Journal of the American Chemical Society最新文献

{"title":"High-Resolution 6Li Solid-State Nuclear\u0000Magnetic Resonance Reveals Hidden Lithium Dynamics in All-Solid-State\u0000Cathodes","authors":"Houyi Liu,Bao Zhang,Yuhao Duan,Jiuwei Lei,Wen Yin,Wei Xia,Hongzhang Zhang,Kuizhi Chen,Xiaofei Yang,Guangjin Hou,Xianfeng Li","doi":"10.1021/jacs.6c17473","DOIUrl":"https://doi.org/10.1021/jacs.6c17473","url":null,"abstract":"Abstract The decisive chemistry of iron-based halide cathodes─where lithium resides, how it evolves, and how disorder governs multielectron redox─has remained largely inaccessible, limiting the rational design of catholyte-free composite cathodes in all-solid-state lithium batteries. Here we make the lithium sublattice directly visible in paramagnetic LiFeCl3 using a 6Li solid-state NMR strategy combining high isotopic enrichment, optimized acquisition, and variable-temperature control. This method resolves and quantifies three Li+ environments, revealing that local Li/Fe disorder drives in-place Fe2+ reduction as the root cause of highly reversible intercalation-conversion chemistry. It further uncovers trace irreversible Fe0 species invisible to conventional spectroscopic and imaging techniques. Guided by this hidden degradation signature, optimization of the voltage window enables 85.9% capacity retention after 500 cycles with a 16.3% energy-density penalty, whereas full-depth cycling retains 68.6% after 100 cycles. Our work establishes lithium-resolved NMR as a platform linking disorder, hidden redox, and reversibility in paramagnetic cathodes.","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"42 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asymmetric Alkylation\u0000of α-Cyanoketimines\u0000with Alkyl Bromides Catalyzed by Bis-Cinchonium Salts","authors":"Yiqun Zeng,Yang Yu,Xiangyuan Liu,Dongshun Ni,Baomin Wang,Jisheng Luo,Li Deng","doi":"10.1021/jacs.6c17310","DOIUrl":"https://doi.org/10.1021/jacs.6c17310","url":null,"abstract":"Abstract The SN2 reaction constitutes one of the most fundamental bond-forming transformations in organic chemistry, finding numerous synthetic applications across pharmaceutical, agrochemical, and materials science. However, the development of new catalysts for asymmetric SN2 reactions with nucleophiles beyond enolate derivatives remains a formidable challenge. Herein, we report the development of a new class of bis-cinchonium catalysts for an unprecedented enantioselective SN2 alkylation of cyanoketimines with alkyl bromides. This reaction features a broad substrate scope with respect to both reaction partners, thereby providing a useful approach to enantioenriched α,α-dialkyl aminonitriles. Computational studies revealed that the bis-cinchonium catalyst, through a network of weak bonding interactions, activated both cyanoketimines and alkyl bromides and preorganized them along the trajectory toward the transition state of an SN2 reaction.","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"12 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Four-Photon Molecular Upconversion","authors":"Seamus S. Lowe,&nbsp;Maxwell Sun,&nbsp;Jesse A. Wisch,&nbsp;Kostubh Gaur,&nbsp;Chiao-Jung Su,&nbsp;Azka Arshad,&nbsp;Felix N. Castellano,&nbsp;John E. Anthony,&nbsp;Noel C. Giebink,&nbsp;Barry P. Rand","doi":"10.1021/jacs.6c17238","DOIUrl":"10.1021/jacs.6c17238","url":null,"abstract":"<p>Triplet-triplet annihilation(TTA) upconversion converts low-energyphotons into higher-energy emission, but conventional TTA is limitedby its two-photon nature, as the emitted photon energy cannot exceedtwice the excitation photon energy. Here, a fully organic solid-statethin-film architecture cascades two TTA upconversion stages throughan intermediate Förster resonance energy transfer (FRET) bridgeto achieve molecular four-photon upconversion. The first sensitizer/annihilatorbilayer upconverts near-infrared (NIR) excitation into intermediatesinglets, which are transferred through the FRET bridge to the sensitizerof the second TTA stage. The second sensitizer/annihilator bilayerperforms a second TTA step to generate blue emission. The device converts904 nm excitation into 445 nm emission, corresponding to a 1.41 eVanti-Stokes shift and an emitted photon energy 2.03 times the excitationphoton energy, exceeding the maximum possible energy gain with conventionaltwo-photon TTA. Because two quadratic TTA stages are coupled in series,the ideal low-intensity response of the four-photon device is quarticwhen both stages operate below threshold, providing a steeper nonlinearitydesirable for nonlinear sensing. Experimentally, power-dependent measurementsreveal a superquadratic slope of 3.03, followed by quadratic and linearregimes as the constituent TTA stages cross their thresholds. Independentstage measurements and time-resolved photoluminescence dynamics supportthe four-photon mechanism.</p>","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"148 40","pages":"43952–43961"},"PeriodicalIF":16.6,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149152057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing Cooperative Molecular Glues for FKBP12-MAPRE1 with Enhanced-Sampling Molecular Dynamics Simulations","authors":"Shu-Yu Chen,&nbsp;Riccardo Solazzo,&nbsp;Marianne Fouché,&nbsp;Hans-Jörg Roth,&nbsp;Birger Dittrich,&nbsp;Sereina Riniker","doi":"10.1021/jacs.6c12127","DOIUrl":"https://doi.org/10.1021/jacs.6c12127","url":null,"abstract":"<p>Molecular glues (MGs) offer a unique modality for inducingprotein–proteininteractions (PPIs), yet their rational design is often hindered bythe limitations of static structural data. Here, we present a computationalpipeline for the design of cooperative MGs for the FKBP12-MAPRE1 systemusing replica exchange with solute scaling (REST2) for enhanced samplingin molecular dynamics (MD) simulations. By sampling the conformationalensembles of binary and ternary complexes, we identified a “stabilizedconfigurational space” that facilitates ternary-complex formationthrough a combination of conformational selection and induced-fitmechanisms. Based on the simulations, we developed a model that correlatesPPI induction information from the simulations with the experimentalcooperativity. This model was subsequently used to select and ranka small library of compounds prospectively, of which five were selectedfor synthesis and testing. Three of the five new compounds exhibitedapparent cooperativity equal to or greater than that of the best previouslyknown variants. This study demonstrates that targeting shared configurationswithin dynamic ensembles is a viable strategy for the rational optimizationof cooperative molecular glues.</p>","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"148 40","pages":"43321–43333"},"PeriodicalIF":16.6,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diisonitrile Chalkophore Structure and Function in Mycobacterial Copper Acquisition","authors":"Pooja B. Pandya,&nbsp;Chad E. Hatch,&nbsp;John A. Buglino,&nbsp;Yaprak Ozakman,&nbsp;Kate Ryan,&nbsp;Ruofei Faye Li,&nbsp;Farhan A. Chowdhury,&nbsp;Michael S. Glickman,&nbsp;Derek S. Tan","doi":"10.1021/jacs.6c09506","DOIUrl":"https://doi.org/10.1021/jacs.6c09506","url":null,"abstract":"<p>Tuberculosis, the disease caused by <em>Mycobacterium tuberculosis</em> infection, is a leading cause of deathworldwide. While first-line treatments are effective for many patients,multidrug-resistant tuberculosis poses a continued threat to globalpublic health, and new approaches are needed to provide effectivechemotherapy against drug-resistant disease. Diisonitrile lipopeptidechalkophores are a novel class of natural products that play criticalroles in copper homeostasis and virulence in <em>M. tuberculosis</em> by supplying copper to the heme:Cu oxidase of the respiratory chain.However, the molecular mechanisms by which the bacteria use diisonitrilesto mediate copper homeostasis are poorly understood. Herein, we investigatestructure–activity relationships of synthetic diisonitrilesto identify structural features required for biological function inmycobacterial copper acquisition. We have developed a modular syntheticapproach that allows efficient construction of diisonitrile naturalproducts and diverse analogues. We confirmed that a short-chain analogueof the natural products binds tightly to Cu(I) and Cu(II), but notZn(II), and estimated its Cu(I) binding affinity. We then used theseanalogues to probe the impacts of diisonitrile acyl chain length,amino acid backbone, and C-terminal motif on the rescue of <em>M. tuberculosis</em> and <em>Mycobacterium marinum</em> growth in copper-restricted conditions. Theobserved structural preferences align with current knowledge of thecorresponding natural product structures in these bacteria, but bothspecies also exhibited surprising flexibility in accepting diversediisonitrile analogues for this function. This work provides new insightsinto the structural features of diisonitrile chalkophores requiredfor function in mycobacterial copper homeostasis, and the distinctstructural preferences between species, while suggesting some structuralplasticity in their cellular copper acquisition systems.</p>","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"148 40","pages":"43041–43049"},"PeriodicalIF":16.6,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revealing the Proton Slingshot Mechanism in Solid Acid Electrolytes through Machine-Learning Molecular Dynamics","authors":"Menghang Wang,&nbsp;Jingxuan Ding,&nbsp;Grace Xiong,&nbsp;Ni Zhan,&nbsp;Cameron Owen,&nbsp;Albert Musaelian,&nbsp;Yu Xie,&nbsp;Nicola Molinari,&nbsp;Ryan Adams,&nbsp;Boris Kozinsky,&nbsp;Sossina Haile","doi":"10.1021/jacs.5c21965","DOIUrl":"https://doi.org/10.1021/jacs.5c21965","url":null,"abstract":"<p>In solid acid electrolytes CsH₂PO₄ and CsHSO₄, the origin of fast proton conduction haslong been debated,attributed either to local proton hopping or to polyanion rotation.However, the precise role of polyanion rotation and its interplaywith proton hopping remains unresolved. Nanosecond-scale moleculardynamics simulations, driven by equivariant neural-network force fields,reveal a nuanced proton slingshot mechanism: a rotating polyanionfirst carries the proton, O–H bond reorientation then extendsits displacement, and the combined motion enables long-range jumps.This mechanism refines the conventional Grotthuss-type picture, revealingthat long-range transport arises from significant O–H bondreorientation assisted by only limited polyanion rotation. Despitetheir structural similarity, CsH₂PO₄ and CsHSO₄ exhibit qualitatively different transport behavior associatedwith their distinct proton concentrations. In CsH₂PO₄, two rotation rates with different activation energies emerge,while CsHSO₄ displays a single-rate process with fasterproductive polyanion dynamics. The higher proton concentration inCsH₂PO₄ is associated with greater rotationalfrustration and slower dynamics of PO₄ compared with SO₄ in CsHSO₄. In CsH₂PO₄, wefurther identify a unique correlation between oxygen sharing and protontransport, arising from the extra proton per polyanion. Together,our findings establish a unified framework linking polyanion rotation,proton coordination, and long-range transport, and suggest that tuningproton concentration could accelerate rotation and enhance conductivity.</p>","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"148 40","pages":"42913–42927"},"PeriodicalIF":16.6,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microlightning: Avalanche-Driven Blue Emission and Reactive-Species Formation in Charged Microdroplets","authors":"Dai-Bei Yang,&nbsp;Xiangyu Chen,&nbsp;Tarek Trabelsi,&nbsp;Joseph S. Francisco","doi":"10.1021/jacs.6c14162","DOIUrl":"https://doi.org/10.1021/jacs.6c14162","url":null,"abstract":"<p>Charged microdroplets have recently been observed inexperimentsperformed without a strong externally imposed field to emit flashesof blue light and initiate chemical reactions, a new phenomenon referredto as “<em>microlightning</em>.” This observationadds to a growing body of evidence that charged microdroplets canhost redox chemistry not accessible in bulk solution, yet the mechanisticorigin and chemical consequences of this emission remain poorly understood.A fundamental chemical question regarding spontaneous microdropletreactivity thus naturally arises: can electrostatic energy storedon a microdroplet be converted into chemical activation, includingmolecular excitation, ionization, and reactive-species formation?Here, we establish a framework that links droplet charging, avalanchedynamics, and the resulting reactive-species and photon production.Under the local-field approximation, Townsend theory establishes analyticalscaling for finite avalanches in isolated heavily charged droplets;particle-in-cell Monte Carlo simulations quantify multiplication upto ∼1000 and resolve electron fates via ionization, excitation,and attachment, generating reactive oxygen and hydrogen species (e.g.,OH^•, O₂^•–, andH^•) or their precursors relevant to microdroplet-acceleratedorganic reactions and atmospheric chemistry. Further, pairs of oppositelycharged droplets create intensified fields that enable detectableN₂ second-positive-system emission and promote significantreactive-species formation. Finally, we identify the necessary conditionsfor microlightning: micrometer-scale droplets carrying substantialfractions of the Rayleigh limit, seed electrons, and ionization-enhancinggas environments, providing a predictive basis for understanding microdropletreactivity in electrospray and other reaction platforms. These findingscharacterize <em>microlightning</em> as a form of finite-sizeinterfacial plasma-chemistry, bridging microscopic discharges withmacroscopic lightning.</p>","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"148 40","pages":"43608–43622"},"PeriodicalIF":16.6,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistically Agnostic Aliphatic N–H Transmutations Enabled by Interrupted Nitrogen Deletion","authors":"Isabelle E. Petrucci,&nbsp;Jeanne Masson-Makdissi,&nbsp;Zisheng Xue,&nbsp;Caroline McCleary,&nbsp;Michal P. Glogowski,&nbsp;Mark D. Levin","doi":"10.1021/jacs.6c13570","DOIUrl":"https://doi.org/10.1021/jacs.6c13570","url":null,"abstract":"<p>Reactions which promotethe replacement of skeletal atomsare emergingas a valuable class of synthetic tools. Despite significant recentprogress on transmutations of aromatic systems, aliphatic replacementsare comparatively underexplored. Herein, we demonstrate three aliphatictransmutations on heteroaryl-fused piperidines via an interruptednitrogen deletion. These piperidines react with an anomeric amideto form dearomatized vinylcyclopropanes that can undergo Rh-catalyzed[5 + 1] cycloadditions with carbon monoxide to afford the correspondingcyclohexanone, polar ring-opening in the presence of I₂ and H₂O followed by base-mediated ring closure to givethe corresponding dihydropyran, or photochemically promoted radicalcyclization with a sulfonothioate to provide the corresponding thiane.The propensity for the key isodiazene intermediate to partition tothe requisite vinylcyclopropane or its isomeric cyclopentene deletionproduct was systematically examined across a range of heterocycles.The dearomatization penalty of each heterocycle, measured computationallyvia isodesmic calculations, was found to predict the likelihood ofproductive vinylcyclopropane formation. This work demonstrates threenovel aliphatic transmutations: NH-to-CO, NH-to-O, and NH-to-S, leveragingthe unique reactivity of an interrupted nitrogen deletion to allowaccess to ketones, dihydropyrans, and thianes from the correspondingpiperidines.</p>","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"148 40","pages":"43491–43498"},"PeriodicalIF":16.6,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traversing the Regioselectivity of Intermolecular Pericyclic Aryne Reactions: Total Syntheses of Laetevirenol A and Isoampelopsin D","authors":"Long Huu Nguyen,&nbsp;Seoyeong Kim,&nbsp;Jiah Kim,&nbsp;EunHyeon Kim,&nbsp;Sugyeong Ha,&nbsp;Myeonggyo Jeong,&nbsp;Ki Wung Chung,&nbsp;Yeonjoon Kim,&nbsp;Seokwoo Lee,&nbsp;Hwayoung Yun","doi":"10.1021/jacs.6c07493","DOIUrl":"10.1021/jacs.6c07493","url":null,"abstract":"<p>Resveratrol-derivednatural products feature a diverse group ofstilbenoids, characterized by extensive structural variation and pharmacologicalpotential. Herein, we document our innovation in the synthesis oflaetevirenol A, a biologically captivating resveratrol dimer, andisoampelopsin D enabled by operating an aryne-based synthetic program.The synthetic strategy involves the incorporation of aryne buildingblocks into methylene indane/indene nuclei by harnessing their innatereactivity. A dehydro Diels–Alder cycloaddition and an aryne-enereaction were developed to construct the carbon framework of laetevirenolA and isoampelopsin D. Attempts were made to rationalize the unexpectedregioselectivity behavior of crucial benzyne reactions from both empiricaland computational perspectives. Ultimately, laetevirenol A and itsanalogs were also biologically investigated to uncover their potentialantioxidant activities. This work offers valuable insights into theregioselectivity of intermolecular pericyclic aryne reactions andserves as an example of controlling aryne regioselectivities in thesynthesis of molecular targets.</p>","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"148 40","pages":"42876–42882"},"PeriodicalIF":16.6,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overcoming Barriers in Solid Tumors: Lactate-Fueled Nanomotors Enhance Penetration and Reverse Immunosuppression","authors":"Juan José Esteve-Moreno,&nbsp;Andrea Escudero,&nbsp;Francisco J. Hicke,&nbsp;Víctor Sanz-Álvarez,&nbsp;María Miralles-Buleo,&nbsp;María Dolores Marcos,&nbsp;M. Carmen Martínez-Bisbal,&nbsp;Alba García-Fernández,&nbsp;Paula Díez,&nbsp;Ramón Martínez-Máñez","doi":"10.1021/jacs.6c05546","DOIUrl":"10.1021/jacs.6c05546","url":null,"abstract":"<p>Solid tumors presenta therapeutic challenge due to their denseextracellular matrix and metabolically immunosuppressive microenvironment,which limit drug penetration and immune clearance. To overcome thesebarriers, we describe an engineered lactate-powered Janus nanomotor(NM(dox)-LOx) composed of a platinum (Pt) nanodendrite and a mesoporoussilica nanoparticle (MSN), loaded with doxorubicin (Dox) and functionalizedwith the enzyme lactate oxidase (LOx). In this design, LOx acts asa protease-sensitive molecular gate for controlled Dox release andcatalyzes the oxidation of tumor-accumulated lactate, using this metaboliteas a biofuel to generate hydrogen peroxide, which is catalyzed byPt into oxygen and water. This cascade generates a self-propulsiveforce that drives the nanomotor. Concurrently, catalytic lactate depletionreprograms the tumor microenvironment, promoting cytotoxic T cellinfiltration and restoring immune activity. NM(dox)-LOx demonstratesefficient tumor accumulation and potent antitumor activity in humanSK-MEL-103 and murine B16–F10 melanoma models, including 2Dcultures, 3D spheroids, and <em>in vivo</em> tumors. Remarkably,treatment in an <em>in vivo</em> B16–F10 melanoma modelachieved pronounced tumor regression and enhanced cytotoxic T cellinfiltration, while maintaining minimal systemic toxicity. Overall,this multifunctional nanomotor couples enhanced drug delivery withimmune activation, effectively overcoming the structural and metabolicbarriers of solid tumors, and represents a promising strategy forself-propelled therapeutic nanoparticles in cancer treatment.</p>","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"148 40","pages":"42949–42968"},"PeriodicalIF":16.6,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148718147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}